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      • 벤조일우레아계 키틴 합성저해 살충제의 QSAR 연구

        박일현 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2

        The benzoylurea insecticides which act as development disruptor provide interesting alternatives to traditional neurotoxic insecticides. For 43 benzoylurea analogues, quantitative structure-activity (QSAR) analysis is performed. Among these, several compounds show high activity against Diamond-Back Moth and Tabacco Cut Worm.

      • 알킬사슬을 가진 우라실 누클레오시드 유사체의 합성 (2)

        박일현,윤효인 충남대학교 1991 忠南科學硏究誌 Vol.18 No.2

        Halo-analogues of pyrimidine nucleoside are of medicinal interest. The best knowns are 5-Fluorouracil and Ftorafur. But 5-Fluorouracil has severe side effects, i.e., toxicity to the central nerve system, which its clinical applications restrict. To overcome such problems we synthesize some derivatives of 5-Fluorouracil : 1-Alkenyl-5 fluorouracil and 1-Hydroxyalkyl-5-Fluorouracil. These are to be used as starting compounds for another derivatives and to be tested for their antitumor activities.

      • SCOPUSKCI등재

        보조 T 림프구 항원 수용체의 대량발현과 정제

        박일현,김영상,조철오 한국유전학회 1993 Genes & Genomics Vol.15 No.4

        T cell antigen receptor (TcR) of T helper clone has been expressed on a T cell hybridoma line by transfecting the chimeric cDNAs of TcR and Thy-1.1 antigen in expression vectors. The transmembrane portions of TcR cDNAs were replaced with glycosyl phosphatidylinositol (GPI) anchorage signal sequences of Thy-1.1 antigen. The positive transfectants were reactive with clonotypic antibodies in FACS analysis. Heterodimeric TcR cleaved by phosphatidylinositol-specific phospholipase C (PIPLC) was purified through affinity column conjugated with 3D3 clonotypic antibody. This approach to purify TcR preserved the determinants for clonotypic antibodies and the purified TcR might be equivalent to TcR expressed on T helper clone.

      • 폴리에틸옥사졸린의 용해도, 점성도 및 밀도에 관한 연구

        박일현 金烏工科大學校 1993 論文集 Vol.14 No.-

        Solubilities of Polyethyloxazoline(PEOx) were investigated in 43 organic solvents. Some non-polar solvents (for example : benzene, cyclohexane ad carbon tetrachloride), diethyl ether and diethylamine etc, appeared as non-solvents for PEOx polymer. Based upon the intrinsic viscosities and huggins coefficients of PEOx measured in various solvents, we were able to conform that methanol and chlorofrom wee the good solvents and that methyl acetate and ethyl acetate were the poor solvents, respectively. The specific volume was obtained by means of two different experimental methods. The average partial specific volume(o.983mL/g) estimated from the specific refractive index increments(s.r.i.i.) using Glastone-Dale equation appeared to be large by 15% than that(0.853mL/g) obtained by the dilatometry. In oder to understand clearly why the difference came out, it needs further experiment. Also from analysis of the s.r.i.i. dta using Glastone-Dale equation, a value of n₂=1.519 was obtained for the refractive index of PEOx at ??, T=35℃

      • SCOPUSKCI등재

        N-Acetyl ${\alpha}$-aminoacrylic Acid의 자유라디칼 중합 및 혼성중합

        박일현,이종광,최재호,진정일,Il Hyun Park,Chong Kwnag Lee,Jae Ho Choi,Jung-Il Jin 대한화학회 1982 대한화학회지 Vol.26 No.4

        본 연구에서는 자유라디칼 메카니즘에 의한 N-acetyl ${\alpha}$-aminoacrylic acid의 단독중합 반응속도와 혼성중합 반응성을 연구하였으며, DMF 용매를 사용하여 $60^{\circ}C$에서 단독중합 시켰을 때의 중합속도 ($R_p$)는 단위체 농도 [M]와 개시제 농도 [I]에 대하여 $R_p$ = $k_p[M]^{0.97}[I]^{0.59}$의 관계를 나타내었다. 또한 이 단위체의 단독중합 총괄 활성화 에너지는 25.2 kcal/mole이었다. N-acetyl ${\alpha}$-aminoacrylic acid를 아크릴산 및 스티렌 단위체와 혼성중합 시켰을 때의 단위체 반응성비는 아래와 같았다. $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.49, $r_2$(acrylic acid) = 1.41; $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.44, $r_2$(styrene) = 0.91. Alfrey-Price 식을 이용하여 계산한 N-acetyl ${\alpha}$-aminoacrylic acid의 Q와 e값은 두 경우 모두 Q=0.51, e=0.16이었다. 단독중합체 및 혼성중합체들의 열적성질을 DTA 및 TGA법으로 분석하여 비교하여 보았다. The free radical polymerization and copolymerization of N-acetyl ${\alpha}$-aminoacrylic acid were investigated. From the result of kinetic investigation of N-acetyl ${\alpha}$-aminoacrylic acid in DMF at $60^{\circ}C$, a rate equation of $R_p$ = $k_p[M]^{0.97}[I]^{0.59}$ was obtained. The overall activation energy for the polymerization was found to be 25.2 kcal/mole. Copolymerization of N-acetyl ${\alpha}$-aminoacrylic acid with acrylic acid and styrene was carried out for the determination of monomer reactivity ratios. The monomer reactivity ratios for the monomer pairs determined at 70.0{\pm}0.1^{\circ}C$ using benzoyl peroxide as an initiator are; $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.49, $r_2$(acrylic acid) = 1.41, $r_1$(N-acetyl ${\alpha}$-aminoacrylic acid) = 0.44, $r_2$(styrene) = 0.91. The values of Alfrey-Price's Q and e parameters for N-acetyl ${\alpha}$-aminoacrylic acid were calculated to be 0.51 and 0.16 for the both systems. Differential thermal analysis and thermogravimetry showed that acrylic acid copolymers have poorer thermal stability as compared with the homopolymer of N-acetyl ${\alpha}$-aminoacrylic acid.

      • SCIESCOPUSKCI등재

        랫드에서의 UTI 의 약물동태학 및 조직 분포

        박일현,조명행,윤효인,정요찬,송동호,박병권,김복환 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.3

        The purpose of this study was to determine pharmacokinetic parameters and tissue distribution pattern of urinary trypsin inhibitor(UTI) in Sprague-Dawley rats. Na^(125)I was conjugated to UTI to make ^(125)I-UTI and the concentrations were determined by γ counter. With the aid of nonlinear least-square regression analysis for i.v. bolus injection of 1,000 unit UTI including ^(125)I-UTI, the temporal concentration curves were best fitted by 2-compartment open model. The distribution phase half-life was 0.39±0.02 hours whereas the elimination half-life was 12.99±1.05 hours in male rats. The volume of distribution and total body clearance in male rats were 0.28±0.01 l/kg and 83.16±1.15 ml/kg/h, respectively. We could not find any difference of pharmacokinetic parameters of UTI between male and female rats. UTI were distributed widely in rat organs. In both male and female rats, the kidney was the highest distributed organ. Amount of UTI in 24 hour cumulative urine in male rats was 36.22±8.74% and that in 48 hours was 43.32±10.55%. Excretion via feces was very scanty, with the 24 hours cumulative amount being only 2.76±0.97%. This data suggest the main excretion route of UTI is urine.

      • 디히드로엽산 환원효소 저해제의 정량적 구조-활성 상관관계 연구

        박일현,권태익,전근 충남대학교 기초과학연구소 1997 忠南科學硏究誌 Vol.24 No.2

        Inhibitors of the enzyme DHFR which is an enzyme of central role in biochemistry, are of great importance in medicine. For pyrimidine- and triazine-type inhibitors, quantitative structure-activity relationship (QSAR) and conformational analysis is performed.

      • 표준 용매 벤젠의 Rayleigh 비의 온도 의존성

        박일현,이종근,윤관한,조동환,민병길,방대석 金烏工科大學校 2000 論文集 Vol.21 No.-

        The Rayleigh ratio of benzene is a very important physical constant with which the integrated scattered intensity of laser light scattering can be converted into the absolute value. In this study temperature dependence of Rayleigh ratio of this solvent has been investigated with two different methods in the temperature range of 25-75℃. It was found that in the direct measurement the non-linear behavior of its Rayleigh ratio were observed as increasing temperature even if the scattering volume correction was applied to the scattered intensity of benzene. However the result of indirect measurement based upon the invariance of molecular weight of standard polystyrene polymer for any polymer solution temperature showed us that its temperature dependence up to 75℃ could be expressed with the Benoit's linear equation rather than the non-linear one. It seems that the scattered intensity in direct method has more complicate contributions at the elevated temperature. Further research works are necessary in order to solve such discrepancy clearly.

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