VIP를 분비하며 신경절신경종의 분화를 가지는 갈색 세포종 1예

나민아,김상수,김동욱,최재훈,이태근,공옥녀,안준협,김지연,성한동,정철호,손석만,김인주,김용기 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

갈색 세포종은 신경내분비종양의 하나로 VIP를 포함한 다양한 신경내분비 펩타이드를 분비할 수 있다. 저자들은 만성 설사와 체중 감소를 주소로 내원한 환자에서 좌측 부신에 VIP를 생성하는 갈색 세포종을 진단하여 성공적으로 제거한 후 증상이 모두 호전된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Vasoactive intestinal peptide (VIP) is a 28-amino acid peptide, which may cause secretory diarrhea by stimulating the production of adenylate cyclase. Neuroendocrine tumors, secreting vasoactive intestinal peptide (VIP), are almost always of a pancreatic in origin. However, a pheochromocytoma may produce several neuropeptides, containing VIP, as they are considered to be neuroendocrine tumors. A 57-year-old woman, who presented with chronic watery diarrhea, hypokalemia, weight loss and a left adrenal mass, is described. Histologically, the tumor was diagnosed as a pheoch-romocytoma, with ganglioneuronal differentiation, and was histochemically confirmed to produce a vasoactive intestinal polypeptide. A left adrenal VIP-producing pheochromocytoma was successfully resected. After surgery, her diarrhea subsided and the electrolytes, affected neuroendocrine hormone levels, blood pressure and blood sugar level were normalized (J Kor SOC Endocrinol 18:227-231, 2003).

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

Metagenomic Analysis of Fungal Communities Inhabiting the Fairy Ring Zone of Tricholoma matsutake

( Miae Kim1 ),( Hyeok Jun Yoon ),( Young Hyun You ),( Ye Eun Kim ),( Ju Ri Woo ),( Yeong Gyo Seo ),( Gyeong Min Lee ),( Young Ja Kim ),( Won Sik Kong ),( Jong Guk Kim ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.10

Tricholoma matsutake, an ectomycorrhiza that has mutual relationships with the rootlet of Pinus denisflora, forms a fruiting body that serves as a valuable food in Asia. However, the artificial culture of this fungus has not been successful. Soil fungi, including T. matsutake, coexist with many other microorganisms and plants; therefore, complex microbial communities have an influence on the fruiting body formation of T. matsutake. Here, we report on the structures of fungal communities associated with the fairy ring of T. matsutake through the pyrosequencing method. Soil samples were collected inside the fairy ring zone, in the fairy ring zone, and outside the fairy ring zone. A total of 37,125 sequencing reads were obtained and 728 to 1,962 operational taxonomic units (OTUs) were observed in the sampling zones. The fairy ring zone had the lowest OTUs and the lowest fungal diversity of all sampling zones. The number of OTUs and fungal taxa inside and outside the fairy ring zone was, respectively, about 2 times and 1.5 times higher than the fairy ring. Taxonomic analysis showed that each sampling zone has different fungal communities. In particular, out of 209 genera total, 6 genera in the fairy ring zone, such as Hemimycena, were uniquely present and 31 genera, such as Mycena, Boletopsis, and Repetophragma, were specifically absent. The results of metagenomic analysis based on the pyrosequencing indicate a decrease of fungal communities in the fairy ring zone and changes of fungal communities depending on the fairy ring growth of T. matsutake.

柴胡疎肝散이 拘束스트레스 흰쥐의 胃潰瘍 및 血中 Catecholamine 含量에 미치는 영향

孔敏準,金塋均 동의대학교 한의학연구소 1998 동의한의연구 Vol.2 No.-

This study was performed to investigate the effect of Shihosogansan chi the gastric ulceration and the plasma catecholamine contents of rats in immobilization stress. The experimental animals was stressed by immobilization for 12 hours in a day during 12 days and administrated 45㎎/44g Shihosogansan extract two times per a day before and after the immobilization stress. Then the plasma catecholamine contents and the number of gastric ulceration were measured. The obtained results were summarized as follows ; 1. Analgesic effect was shown significantly in sample group compared with control group. 2. Anti-inflammatory effect was shown significantly in sample group compared with control group. 3. Gastic ulceration was decreased significantly in sample group compared with control group. 4. Epinephrine contents was decreased significantly in sample group compared with control group. 5. Norepinephrine contents was decreased significantly in sample group compared with control group. 6. Dopamine contents was decreased significantly in sample group compared with control group. According to the above results, it is concluded that Shihosogansan has significant effect in reducing stress.

연속 저항 회로망을 이용한 국소 광적응 윤곽검출 시각칩의 설계

김경문,김정환,박종호,공재성,신장규,이민호 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

하수관거 유량자료의 보정방법에 관한 연구

김대근,공민근 대한상하수도학회 2003 상하수도학회지 Vol.17 No.4

In order to modify incorrect flow data in the sewage system, the method using the stagedischarge rela tion and hydraulic characteristic curve of sewer pipe are applied. The modified data were verified with field measured data and the infiltration analysis using the modified data was carried out. When flowrate were measured using the flow-meter in fair weather, the stage data were comparatively consistent but velocity data were very poor for the most part. Therefore, it was recommended that sewage flowrate variation characteristic curve and infiltration were computed using the modified data on the basis of stage data. Especially, in the case of using the hydraulic characteristic curve, extrapolation results of the rainy season flowrate using regression curve on the basis of the data in fair weather were also reasonable.

기업 e-Learning 프로그램 참여자의 학습전이와 자기주도성, 전이풍도, 학습과의 관계

공민영,김진모 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.3

이 연구는 기업교육훈련에서 e-Learning과 학습전이에 대한 관심이 높아지고 있는 상황에서 학습전이와 학습자의 자기주도성, 전이풍토 및 학습과의 관계에 대한 실증분석을 목적으로 수행되었다. 이를 위해 현재 e-Learning을 실시하고 있는 국내 기업에서 최소 2-6개월 전 사내 e-Learning 과정에 참여했던 경험이 있는 재직 근로자 중 유의표집에 의하여 추출된 근로자를 대상으로 학습전이, 자기주도성, 전이풍토, 그리고 학습에 대한 그들의 인식 수준을 측정하였다. 이 연구의 결과는 첫째, 국내 기업 e-Learning 프로그램에 참여한 근로자는 조직 내에서의 학습전이를 비교적 보통 이상의 수준으로 인식하였다. 둘째, 학습에 대한 자기주도성은 집합교육훈련 참여자의 평균적인 자기주도성 수준과 거의 동일하거나 약간 낮은 수준으로 나타났고, 성별, 연령, 학력, 직급, 직무 및 근무연수에 따른 자기주도성은 통계적으로 차이가 없었다. 셋째, 학습전이 및 학습은 학습에 대한 자기주도성과 중간 수준의 상관을 나타냈다. 넷째, 전이풍토 변인은 모두 학습전이를 유의미하게 설명하였고, 동료의 지원을 제외한 모든 변인이 학습전이와 정적 상관을 나타냈다. 다섯째, 학습전이는 학습과 중간 수준의 상관을 나타냈다. 이러한 연구결과는 교육훈련 설계 및 e-Learning을 고려한 시스템 환경과 학습전이와의 관계, 교육훈련 실시 전과 후, 그리고 근전이, 원전이와 같은 학습전이 유형에 따른 측정시점의 구분, 그리고 교육훈련의 유효성 평가 수준을 반응과 결과 수준으로 확대하는 종합적 고찰을 통해 보다 많은 시사점을 제공할 수 있을 것이다. The purpose of this study was to determine the perceived level of transfer of training, the self-directedness, transfer climate and the learning of corporate employees participated in e-Learning programs and to determine the relationship among those variables. A survey questionnaire is consisted of transfer of training scaled based on Lee(1996), self-directed learning readiness scale based on Lee(2006), transfer climate which have four sub-variables(supervisor's support, peer's support, organizational compensation, and opportunity to transfer) scale based on Kim, Lee & Gil(2006), learning scale based on Lee(l996). Based on the findings of the study, the major conclusions of this study were as follows: 1. The mean of the transfer of training of corporate employees participated in e-Learning programs was 3.6 point. And there were no statistical difference between the transfer of training and the type of e-learning programs. 2. The mean of the self-directedness of corporate employees participated in e-Learning programs was 134.54 point(195 of the maximum response point) which was almost same level compared with that of corporate employees participated in offline learning programs. And there was no statistical difference among the levels of corporate employee's self-directedness and employee's sex, age, educational level, job position, job, and the number of working years. 3. The relationship among transfer of training, learning and the self-directedness of corporate employees participated in e-learning programs had positive middle relationship. 4. The relationship between the transfer climate and the transfer of training was affected by supervisor's support, peer's support, organizational compensation, and opportunity to transfer and had the positive middle relationship except peer's support which had positive low relationship. 5. The relationship between transfer of training and learning had positive middle relationship. Based on the findings and conclusions of this study, further research needs to be followed by more specific classifications for the other variables in the transfer of training, to seek some sophisticated and various methods in measurement for the transfer of training, and to extend the level of the learning effectiveness evaluation from learning and behavior to reaction and result.

인터넷 이용 활성화를 위한 인터넷 기반(Infrastructure)의 확충 및 고도화

김민용,공종렬 경희대학교 지역문제연구부 1998 지역개발연구 Vol.5 No.-

토양환경지도 자료를 이용한 콩밭 토양의 화학성 비교

박지숙,이민진,정재원,김미혜,이서연,지윤미,한준호,김유학,공명석,한광현,노희명 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

It is important to interpret the soil chemical properties in order to effectively manage the farmland. This study was conducted to investigate the soil chemical properties of upland soybean field according to the soil series at 32 upland fields located in the parts of Gangwon-do. Soil sampling sites were selected by using the National Statistics DB and KSIS DB that is a soil environment information system provided by the Rural Development Administration. Soil samples were collected from 0~15 cm of top soil before seeding or transplanting, air-dried, passed through a 2 mm sieve, and analyzed for soil pH, EC, organic matter, available phosphorus (P2O5), exchangeable potassium, exchangeable calcium and exchangeable magnesium. The average chemical properties have exceeded the each nutrient optimum range level of RDA, except the organic matter in experimental soil 2015. And despite application of conventional fertilization, each soil series nutrient contents were change respectively. The results of this study suggest that conventional fertilization should be applied based on the analysis about the amount of accumulated nutrient contents in the soil.

조직확장술및 장골이식을 이용한 하악골 결손부의 재건

이계영,민경인,정수일,박재범,안재진,김도균,김철환 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Soft tissue expansion is widely used technique in oral & maxillofacial reconstruction and provide new method of reconstruction in posttraumatic alopecia, post burn, wide scar, congenital deformity, benign tumor, tattoo, etc. Expanded tissue flaps have the advantage of increased vascularity, proximity to the defect, and similarity of color and texture. They also preclude the need to advance flaps from distant sites. Tissue expansion can be used to form a well vascularized cavity to accomodate and nourish bone grafts. The following report describes the uses of tissue expanders by allowing bone grafting to correct both soft and bony defects of mandibular region