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Nuclear Theranostics in Taiwan
Ko-Han Lin,Yi-Wei Chen,Rheun-Chuan Lee,Ling-Wei Wang,Fong-In Chou,Chi-Wei Chang,Sang-Hue Yen,Wen-Sheng Huang 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.2
Boron neutron capture therapy and Y-90 radioembolization are emerging therapeutic methods for uncontrolled brain cancers and hepatic cancers, respectively. These advanced radiation therapies are heavily relied on theranostic nuclear medicine imaging before the therapy for the eligibility of patients and the prescribed-dose simulation, as well as the post-therapy scanning for assessing the treatment efficacy. In Taiwan, the Taipei Veterans General Hospital is the only institute performing the BNCT and also the leading institute performing Y-90 radioembolization. In this article, we present our single institute experiences and associated theranostic nuclear medicine approaches for these therapies.
Jen-Fin Lin,Te-Hua Fang,Cheng-Da Wu,Ko-Han Houng 한국물리학회 2010 Current Applied Physics Vol.10 No.1
The frictional and indented behavior of a diamond asperity on a diamond plate was carried out using a molecular dynamics (MD) and experiments. The contact load, contact area, dynamic frictional force,and dynamic frictional coefficient increased as the contact interference increased at a constant loading velocity. The microcontact and frictional behavior can be evaluated between a rigid smooth hemisphere to a deformable rough flat plane by combined the deformed behavior of the asperity obtained from MD results with the fractal and statistic parameters. The comparison and the discrepancy of simulated results and nanoindentation and scratching experimental results will be discussed.
( Soo Hyun Hahm ),( Jong Hwa Park ),( Sung Il Ko ),( You Ri Lee ),( In Sik Chung ),( Ji Hyung Chung ),( Lin Woo Kang ),( Ye Sun Han ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.5
The effect of human MutY homolog (hMYH) on the activation of checkpoint proteins in response to hydroxyurea (HU) and ultraviolet (UV) treatment was investigated in hMYH-disrupted HEK293 cells. hMYH-disrupted cells decreased the phosphorylation of Chk1 upon HU or UV treatment and increased the phosphorylation of Cdk2 and the amount of Cdc25A, but not Cdc25C. In siMYH-transfected cells, the increased rate of phosphorylated Chk1 upon HU or UV treatment was lower than that in siGFP-transfected cells, meaning that hMYH was involved in the activation mechanism of Chk1 upon DNA damage. The phosphorylation of ataxia telangiectasia and Rad3-related protein (ATR) upon HU or UV treatment was decreased in hMYH-disrupted HEK293 and HaCaT cells. Co-immunoprecipitation experiments showed that hMYH was immunoprecipitated by anti-ATR. These results suggest that hMYH may interact with ATR and function as a mediator of Chk1 phosphorylation in response to DNA damage. [BMB reports 2011; 44(5): 352-357]
Lee, Jin-Wook,Dai, Zhenghong,Lee, Changsoo,Lee, Hyuck Mo,Han, Tae-Hee,De Marco, Nicholas,Lin, Oliver,Choi, Christopher S.,Dunn, Bruce,Koh, Jaekyung,Di Carlo, Dino,Ko, Jeong Hoon,Maynard, Heather D.,Ya American Chemical Society 2018 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.140 No.20
<P>The Lewis acid-base adduct approach has been widely used to form uniform perovskite films, which has provided a methodological base for the development of high-performance perovskite solar cells. However, its incompatibility with formamidinium (FA)-based perovskites has impeded further enhancement of photovoltaic performance and stability. Here, we report an efficient and reproducible method to fabricate highly uniform FAPbI<SUB>3</SUB> films via the adduct approach. Replacement of the typical Lewis base dimethyl sulfoxide (DMSO) with <I>N</I>-methyl-2-pyrrolidone (NMP) enabled the formation of a stable intermediate adduct phase, which can be converted into a uniform and pinhole-free FAPbI<SUB>3</SUB> film. Infrared and computational analyses revealed a stronger interaction between NMP with the FA cation than DMSO, which facilitates the formation of a stable FAI·PbI<SUB>2</SUB>·NMP adduct. On the basis of the molecular interactions with different Lewis bases, we proposed criteria for selecting the Lewis bases. Owed to the high film quality, perovskite solar cells with the highest PCE over 20% (stabilized PCE of 19.34%) and average PCE of 18.83 ± 0.73% were demonstrated.</P> [FIG OMISSION]</BR>
Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase
( In Soo Yoon ),( Ji Hyung Chung ),( Soo Hyun Hahm ),( Min Ju Park ),( You Ri Lee ),( Sung Il Ko ),( Lin Woo Kang ),( Tae Sung Kim ),( Joon Kim ),( Ye Sun Han ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.8
Ribosomal protein S3 (rpS3) is a multifunctional protein involved in translation, DNA repair, and apoptosis. The relationship between rpS3 and cyclin-dependent kinases (Cdks) involved in cell cycle regulation is not yet known. Here, we show that rpS3 is phosphorylated by Cdk1 in G2/M phase. Co-immunoprecipitation and GST pull-down assays revealed that Cdk1 interacted with rpS3. An in vitro kinase assay showed that Cdk1 phosphorylated rpS3 protein. Phosphorylation of rpS3 increased in nocodazole-arrested mitotic cells; however, treatment with Cdk1 inhibitor or Cdk1 siRNA significantly attenuated this phosphorylation event. The phosphorylation of a mutant form of rpS3, T221A, was significantly reduced compared with wild-type rpS3. Decreased phosphorylation and nuclear accumulation of T221A was much more pronounced in G2/M phase. These results suggest that the phosphorylation of rpS3 by Cdk1 occurs at Thr221 during G2/M phase and, moreover, that this event is important for nuclear accumulation of rpS3. [BMB reports 2011; 44(8): 529-534]