Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

Kim, Sung Eun,Ko, Il Gyu,Shin, Mal Soon,Kim, Chang Ju,Ko, Young Gwan,Cho, Hanjin Medknow PublicationsMedia Pvt Ltd 2012 Neural regeneration research Vol.7 No.22

<P>Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.</P>

싸이클 경기에서의 타임 트라이얼 성적과 크리티컬 파워와의 관련성 분석

고영완,신대철,류기성,강은균 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The purpose of this study is to examine whether or not critical power of first class cyclists is proper as index for checking aerobic ability and also to review its relationship with outcome of time trial. Fourteen first class cyclists participated in this experiment. In the laboratories their own new record of 40 ㎞ time trial (60.4 +/- 1.9 minutes) during the season and time trial record of 17 ㎞ were measured. Maximum oxygen consumption amount and aentilatory threshold value were obtained from exercise under maximum gradual load. Critical power was calculated from hours of continuous exercise obtained from 4 kinds of load. Value of critical power, aentilatory threshold value and volume of maximum oxygen consumption were respectively 300 +/- 24W, 3623+/-440mℓ/min. and 4612+/- 236mℓ/min, and on the basis of body weight it was 4.2M/㎏, 49.5mℓ/㎏/min and 64.7mℓ/㎏/min. Critical power showed high level of relation with maximum volume of oxygen consumption and aentilatory threshold value. It showed that critical power can become an index of aerobic ability of first class cyclists. the interrelationship between critical power and 40 ㎞ and 17 ㎞ time trial record was stronger than that of interrelationship between maximum oxygen absorption volume and aentilatory threshold value and 40 ㎞ and 17 ㎞ time trial. Based on the result mentioned above it could be concluded that critical power enables aerobic ability of first class cyclist in a relatively simple way and also critical power had high level of relationship with result at time trial.

의복광고에 나타난 소비자 가치의 변화추세 고찰 : 1976∼1996년 남성월간지 의복광고분석을 중심으로 A content analysis of advertisements in men's magazine , 1976∼1996

고선영,이은영 한국의류학회 1998 한국의류학회지 Vol.22 No.1

The purpose of this study was to investigate the change of consumers' values as appeared in advertisements. Advertisements in men's magazine from 1976 to 1996 were classified by VALS1 program. The results were as follows. 1. There was a significant trend that advertisements with outer-directed value decreased while the ones with inner-directed value increased. 2. In case of outer-directed group appeared in advertisements, There was a tendency that the hierarchy of needs shifted from emulators to achievers. However, the shift in hierarchy of needs in inner-directed group was not significant. 3. Even though the advertisements with material value were predominant, there was a tendency that the advertisement with material value decreased while the ones with human value increased.

농축공정이 Kindorase의 생산수율에 미치는 영향

고영환,이은현,장규섭 충남대학교 농업과학연구소 1996 농업과학연구 Vol.23 No.2

In order to improve the production yield of kindorase as complex antiphlogistic agent, molecular weight of concentration membrane, membrane configration, temperature, pressure and pH of concentration solution, fouling, etc. were investigated, and the results obtained are as follows ; 1. High production yield was shown using 10k Dalton molecular weight cut-off concentration membrane and spiral membrane made of polysulfone. 2. And it was reasonable conditions for maintaining the concentration solution at 3Bar in pressure. 3. The optimum pH of solution for improving production yield of kindorase were the range of 7.5 to 8.5, and for obtaining better production yield, clean in place(C.I.P) of membrane was treated with 0.1N NaOH at 40 to 50℃ for 30minutes.

성남시 지역주민의 정신질환에 대한 태도 연구

고영,신수경,황태연,이충순,박연수,김인숙,황은숙,정원재 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.1

쪽파의 callus 배양에 의한 변이체 유기

고영은,고찬훈,임순희,김현정,안장순 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

A. wakegi Araki의 배발생 캘러스 유도에는 2,4-D의 단독 첨가가 보다 효과적이었으나 2,4-D의 농도가 높을수록 기형배의 배발생율이 높았다. BA를 혼합첨가하였을 때는 기형배가 보다 많이 발생하였다. 외식편의 부위별로는 경정, 인편, 엽조직 중, 경정이 배형성을 위한 외식편으로 가장 좋았으며 그 다음 인편, 엽조직 순으로 정상적인 배도 가장 많이 발생하였다. Sucrose 7%에서 배발생 callus 유도가 가장 좋았지만 기형 배의 발생율도 가장 높았다. 재분화 식물체의 염색체 변이는 인편유래 callus에서보다 경정유래 callus에서 높았다. Explant source, growth regulators and sugar contents in the culture media suitable for in vitro plant regenerations through somatic embryogenesis in Allium wakegi Araki were examined. Adition of 2,4-D alone was more effective on embryogenic callus induction than its addition in combination with BA. The embryogenic calluses induced on the media containing 2,4-D at high concentration or 2,4-D in combination with BA produced abnormal embryos at high frequency. Stem apex was the best explant source for normal embryo production, followed in order by scale and in vitro leaf segments. sucrose at 7% resulted in the best embryogenic callus induction though the callus produced abnormal embryos at highest frequency. The highest level of chromosomal variation was shown in the regenerants from the shoot apex-derived embryogenic callus.

서울시내 4개 여자대학교 학생들의 체중 조절 실태와 Diet에 대한 의식구조 조사

고영태,이은주 덕성여자대학교 학생생활연구소 1997 學生生活硏究 Vol.13 No.-

본 연구에서는 서울 시내 4개 여자대학교 재학생 933명을 대상으로 하여 여대생의 식습관, 비만 정도, 체중 조절 실태, 영양지식을 얻는 매체, 다이어트 식품에 관한 견해 등을 조사하였다. 본인의 체형에 관한 질문에는 "통통한 편", "보통", "마른편"이 각각 40.5%, 39.1%, 12.9%로 나타났으나, 브로카의 비만도 측정 법으로 계산한 결과에 의해서는 4.2%만이 "과체중"이었고, 53.2%가 "정상", 34.8%가 "저체중"이었다. 체중관리의 관심정도에 대한 질문에는 답변자의 33.5%가 "높다", 44.1%가 "보통"이라 답하였다. 그러나 답변자의 60.1%가 건강을 위해 특별히 하고 있는 것은 없었다. 답변자의 65.1%가 체중조절 경험이 있었고, 체중 조절을 하는 이유로는 답변자의 34.8%가 "비만 또는 과체중이어서", 44.3%가 "정상체중이지만 미용상"이라고 답했다. 주로 이용하는 체중 조절 방법으로는 답변자의 37.9%가 "꾸준하게 식사량을 조절" 26.8%가 "운동과 다이어트를 병행", 18.9%가 "운동"이었다. 영양에 관한 지식을 주로 얻는 매체로는 "친구나 주위사람"이 37.7%, "신문이나 월간지"가 27.9%, "TV나 방송 매체"가 27.8%로 나타났다. 답변자의 12.0%가 시중 판매 다이어트 식품 또는 약품을 섭취해 본 경험이 있다고 답했고, 그 중 33.0%는 섭취기간에만 효과를 보았고, 31.3%는 효과를 보지 못했고, 25.9%는 약간의 효과를 본 것으로 나타났다. A survey on state of dietary habit, degree of obesity, body weight control, medium of nutritional knowledge and viewpoint of diet food and drug for 933 female students in 4 women's universities in Seoul was undertaken, The results are as follows : (1) In response to the question about body shape, 40.5%, 39.1% and 12.9% of the subjects answered "plump", "normal", and "thin", respectively. However the results calculated from subjects' height and weight by Broca's method were that 4.2% of the subjects were "overweight", 53.2% were "normal", and 34.8% were "underweight". (2) Interest of body weight control was relatively high as 33.5% of the subjects answered "high", and 44.1% did "normal". But 60.1% of the subjects did not practice any particular activity for health 65.1% of the subjects had experience of body weight control. The reasons of body weight control were "obese or overweight" (34.8% of the subjects), "normal weight but for beauty" (44.3% of the subjects). In order to control body weight, 37.9% of the subjects practiced "control of eating volume constantly", 26.8% of the subjects practiced "exercise and diet together" and 18.9% of the subjects practiced "exercise". (3) Nutritional knowledge was obtained "from friends or neighboring persons" (37.7%), "from newspapers or magazines" (27.9%) and "from TV or broadcasting" (27.8%). (4) 12.0% of the subjects had experience of diet food or drug intake. 33.0% of the taken subjects had effect only during taking period. 31.3% had no effect, and 25.9% had some effect.

서울 시내 6개 대학 여대생의 흡연 실태 조사 및 공중보건학적 고찰

고영태,이은주 德成女子大學校 1996 德成女大論文集 Vol.26 No.-

A survey on smoking state, smoking habit and viewpoint on smoking of 897 female students in 6 universities (3 coeducational universities and 3 women's universities) in Seoul was undertaken. The results are as follows : 1) Among 897 subjects investigated, 18.1% and 81.9% of the subjects were smokers and nonsmokers, respectively. Among smokers, 44.4% were coed and 55.6% were women's university students. Among smokers, 48.1% belonged to the art and athletic departments, 34.0% belonged to the liberal arts departments and 17.9% belonged to the science departments. (2) 50.6% of the smokers smoked almost every day. Daily smoking amount of 43.8% of the smokers was less than several pieces. 80.9% of the smokers started smoking after the entrance of university. 50.6% of the smokers smoked in the university neighboring facilities. 32.7% of the smokers enjoyed the smoking. 79% of the smokers responded to yound women's smoking famorably. 49.4% of the smokers responded to the effect of smoking on health unfavorably. 32.1% of the smokers commented on the smoking in the public place and 30.9% of the smokers commented on the juvenile smoking as the social problem. (3) 33.8% of nonsmokers responded to young women's smoking favorably. 79.2% of the nonsmokers responded to the effect of smoking on health unfavorally.

播種期 移動에 따른 차풀의 生育反應, 收量 및 粗成分 變化

玄京卓,趙南棋,吳恩敬,高志棅,趙英一 濟州大學校 亞熱帶農業硏究所 1999 亞熱帶農業硏究 Vol.16 No.-

ABSTRACT This study was conducted to determine influence of planting date, seeding rate and phosphate rate on main growth, characters, yield and chemical composition of senna from March 11, 1998 to December in Cheju Province. Days to flowering was lessened as planting date was delayed. The plant height of senna was the longest at 31 March planting (99cm) than at the other planting date. Stem diameter, number of leaves were increased at 31 March but number of branches was not affected by planting date. And number of withering leaves were increased as planting date was earlier. Fresh forage yield per lOa, for senna was the greatest (4,660kg) at 31 March planting, the second was 4,397kg at 1 April planting and the reduced the 3,473kg at 11 March planting. Also dry matter yield per lOa, crude protein yield and total digestable nutrient (TDN) yield was nearly the same tendency. Crude protein, crude fat percent was the greastest at 11 March planting and than decreased with further increased at planting date. Crude ash and crude fiber percent was decreased tendency as planting date was delayed. Nitrogen free extract (NFE), TDN percent was increased tendency as planting date was delayed. SPAD reading value of leaves had an efficiency increased as planting date was delayed.