Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예

김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5

We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)

합성피혁제조업체 근로자들의 요중 N-Methylformamide 농도의 계절적 변이

이광영,변주현,송혜란,김진하,고광욱,이용환 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.2

목적: 본 연구는 여름과 겨울의 계절적 차이에 따른 디메틸포름아미드의 체내 흡수의 변화를 알아보고자 시행되었다. 방법: 일개 합성피혁제조업체에서 직접적으로 디메틸포름아미드를 취급하는 22명의 근로자들을 대상으로 2001년 2월(겨울)과 7월(여름)에 작업환경측정을 통해 기중 DMF농도를 측정하였고 특수건강검진을 실시하여 요중 NMF의 배설량을 측정하고 간기능 검사를 시행하였다. 또한 검사 당일의 평균 기온과 평균 습도를 측정하고 설문지를 통해 알코올 음주 정도, 피부 질환의 유무, 보호구 착용 유무 등을 조사한 후 여름과 겨울의 자료를 비교 분석하였다. 결과: 겨울과 여름의 평균 공기 중의 디메틸포름아미드 기하 평균 농도는 각각 11.55ppm, 13.78ppm으로 통계적으로 유의한 차이는 없었으나 요중엔-메틸포름아미드 배설량의 기하 평균은 겨울이 31.23㎎/g creatinine인 것에 비해 여름이 96.09㎎/g creatinine으로 겨울에 비해 여름의 요중 엔-메틸포름아미드 배설량이 유의하게 높았다(p<0.05). 공기 중 디메틸포름아미드 농도(ppm)에 대한 요중 엔-메틸포름아미드 배설량 (㎎/g creatinine)의 비는 여름(1:6.97)이 겨울(1:2.70)에 비해 약 2.6배 정도 높았다. 결론: 여름과 겨울의 요중 NMF배설량의 차이는 아마도 연구 대상 사업장의 환기 시설이 미약하고 근로자들이 DMF에 적합한 보호구를 적절하게 사용하지도 않았기 때문이고, 무엇보다도 높은 온도와 습도에서 짧은 옷을 입고 근무함으로써 피부 노출면적이 증가되어 DMF의 피부 흡수의 양이 많아졌기 때문으로 판단된다. Objectives: This study was carried out to identify seasonal variations of urinary concentrations of N-methylformamide(NMF) among workers employed at a synthetic leather factory. Methods: Study subjects consisted of 16 male and 6 female workers who were involved in the direct treatment of dimethylformamide(DMF) in a synthetic leather factory. By using health examination data and the results of air measurements and biologic monitoring conducted in February and July, 2001, we identified seasonal variations of the DMF concentrations in the air and NMF concentrations in urine. Results: 1) In winter and summer, average temperatures at the working sites were 3.2℃ and 26.5℃, respectively and average humidities were 35.4% and 84.5%, respectively. 2)Airborne DMF concentrations were not significantly different between summer(13.78ppm) and winter(11.55ppm). 3)NMF concentrations in urine were found to be significantly higher in summer(96.09㎎/g creatinine) than in winter(31.23㎎/g creatinine) (p<0.001). Conclusions: The seasonal difference in the urinary excretion values of NMF may be due to increased dermal absorption of DMF with the higher ambient temperature and humidity in summer and the increased area of exposed skin.

유기용제 노출에 따른 신발제조업체 근무 여성근로자들에서의 후천적 색각이상

변주현,이광영,김영기,고광욱,이용환 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.3

목적 : 복합유기용제에 노출되는 신발제조업체 근무 여성근로자들에서 유기용제 누적노출량과 후천성 색각이상 발현빈도간의 상관성을 조사하기 위해 본 연구를 실시하였다. 방법 : 신발제조업체 근무 여성근로자들 가운데 유기용제에 노출되는 85명과 유기용제에 노출되지 않는 근로자 88명을 대상으로 조사하였다. 조도가 표준화된 방에서 시력검사와 색각이상 검사를 실시하였다. 작업 부서를 접착, 사상 및 선처리 부서로 나누었고 작업 부서별로 현재노출량과 누적노출량을 구하였다. 결과 : 색각이상의 유병률은 노출군이 대조군보다 통계학적으로 유의하게 높았으며 (P=0.017). 유기용제 노출군 85명 가운데 후천적 색각이상인 청황색 색각이상자가 5명(5.9 %)이었다. 안증상도 노출군이 대조군보다 발생빈도가 높았으며 통계학적으로 유의한 차이를 보였다(P=0.001). 색 혼란지수에 영향을 줄 수 있는 변수들인 연령, 교육기간, 누적노출량 등은 유의한 변수로 나타나지 않았다. 결론 : 유기용제 노출군에서 색각이상의 유병률이 대조군보다 유의하게 높았으며, 특히 유기용제 노출군에서 후천적 색각이상인 청황색 색각이상도 발견되었다. 그러나 유기용제 누적노출량과 색 혼란지수와 유의한 연관성은 발견할 수 없었는데 이는 유기용제의 노출량이 너무 낮았으며, 근로자의 이직률 또한 놓아 누적노출량 계산을 위한 추적기간이 제한되었기 때문인 것으로 생각되며 앞으로 고농도 노출 근로자를 대상으로 연구를 하면 분명한 결과를 얻을 수 있을 것으로 기대된다. Objectives : This study was undertaken to investigate the relationship between color vision defects and occupational exposure to mixed organic solvents in women workers who were engaged in the shoe manufacturing industry. Methods : A total of 173 women workers were involved in this study, 85 of whom were exposed to mixed organic solvents and were defined as the exposed group, and 88 workers comprised the non-exposed control group. The patients were questioned as to their drinking history, the year in which they were exposed and whether they had eye symptoms of blureed vision, eye fatigue, and eye irritation. The exposed workers in the shoe manufacturing factory were engaged in 3 work areas which were pasting, trimming, and cleaning. Their Color vision was assessed using the Hahn's double 15 hue test under standard illumination and their current and cumulative exposure levels were measured. Results : The prevalence of color vision defect was 21.2% in the exposed group and 8.0% in the control group, and the blue-yellow defect was found to be 5.9% in the exposed group. The logistic regression for the acquired dyschromatopsia and color confusion index showed that there were no variables that had significant relationships. Eye symptoms were more frequently developed in the exposed group. Conclusions : There is a possibility of developing color vision defects when workers are exposed to mixed organic solvents. However, the results of the color confusion index showed that there was no significant relationship to the coumulative exposure level, because of the low exposure level and high occupational turn over rate of the workers. Because the workers in the present study were exposed to low level solvents it will be necessary to study workers exposed to higher levels of organic solvents.

Metabolic Balance Studies in Normal Korean Child

Ko, Kwang Wook 金原出版 1970 小兒科 Vol.11 No.10

Clinical Study of Hydrochlorothiazide(HCT) in Diabetes Insipidus

Ko, Kwang Wook 醫藥係社 1964 綜合 醫學 Vol.9 No.12

Sensitivity of Escherichia coli Strains to Antimicrobial Agents and Their Profiles of Plasmids with Special References to the Strains with Colonization Factor Antigens

Kwang-Ho Rhee(이광호),Myung-Je Cho(조명제),Jong-Bae Kim(김종배),Han-Wook Yoo(유한욱),Woo-Hyun Chang(장우현),Kwang-Wook Ko(고광욱) 大韓微生物學會 1988 大韓微生物學會誌 Vol.23 No.2

Antibacterial Effects of the Culture Supernatant of Selected Lactobacilli Strains

Kwang Suk Ko,Sungryul Yoo,Misook Kim,Myeonggeun Oh,Yoonhwa Jeong,Kwang-Wook Ko 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

Marchantia polymorpha ( 우산이끼 ) 현탁배양 세포내의 4-methylsterol 들의 동정

고광욱(Kwang Wook Ko),한광석(Kwang Seok Han),남상준(Sang June Nam),곽상수(Sang Soo Kwak),심재국(Jae Kuk Shim),김성기(Seong Ki Kim) 한국식물학회 1995 Journal of Plant Biology Vol.38 No.3

Five kinds of 4-demethylsterol were isolated from suspension cultured cells of a liverworth, Marchantia polymorpha. Four 4-demethylsterols among them were analyzed by a capillary gas chromatography-mass spectrometry and 500 MHz ^1H-NMR, and characterized to be avenasterol, 24-methylene-cholesterol, stigmasterol, and campesterol. And the fifth 4-demethylsterol was characterized to be sitosterol by a capillary gas chromatography-mass spectrometry. The concentration of the 4-demethylsterols in the cell decreased in order of avenasterol>stigmasterol>24-methylene-cholesterol>campesterol>sitosterol. When carbon skeleton and the oxidation state was compared with those of brassinosteroids, these 4-demethylsterols may be potent biosynthetic precusors of brassinosteroids in the cells.

Colonization Factor Antigens in Enterotoxigenic and Non-enterotoxigenic Strains of Escherichia coli Isolated in Korea

Han-Wook Yoo(유한욱),Kwang-Ho Rhee(이광호),Myung-Je Cho(조명제),Jong-Bae Kim(김종배),Woo-Hyun Chang(장우현),Kwang-Wook Ko(고광욱) 大韓微生物學會 1988 大韓微生物學會誌 Vol.23 No.2

Digital Health Technology Use Among Older Adults: Exploring the Impact of Frailty on Utilization, Purpose, and Satisfaction in Korea

Lee Hyejin,Choi Jung-Yeon,Kim Sun-wook,Ko Kwang-Pil,Park Yang Sun,Kim Kwang Joon,Shin Jaeyong,Kim Chang Oh,Ko Myung Jin,Kang Seong-Ji,Kim Kwang-il 대한의학회 2024 Journal of Korean medical science Vol.39 No.1

Background: The importance of digital technology is increasing among older adults. In this study, the digital health technology utilization status, purpose, and satisfaction of older adults were investigated according to frailty. Methods: A face-to-face survey was conducted among adults aged 65 years or older. Frailty was defined using the Korean version of the fatigue, resistance, ambulation, illnesses, and loss of weight scale. Results: A total of 505 participants completed the survey, with 153 (30.3%) identified as pre-frail or frail and 352 (69.7%) as healthy. All respondents used smartphones; 440 (87.1%) were application users, and 290 (57.4%) were healthcare application users. Wearable devices were used by only 36 patients (7.1%). Pre-frail or frail respondents used social media more frequently than healthy respondents (19.4% vs. 7.4%, P < 0.001). Among the respondents, 319 (63.2%) were not able to install or delete the application themselves, and 277 (54.9%) stated that the application was recommended by their children (or partner). Pre-frail and frail respondents used more healthcare applications to obtain health information (P = 0.002) and were less satisfied with wearable devices (P = 0.02). Conclusion: The usage rate of digital devices, including mobile phones among older adults in Korea is high, whereas that of wearable devices is low. There was a notable difference in the services used by pre-frail and frail respondents compared to healthy respondents. Therefore, when developing digital devices for pre-frail and frail older adults, it is crucial to incorporate customized services that meet their unique needs, particularly those services that they frequently use.