65세 이상의 노령층에서 고지혈증의 위험요인

김용배,장원기,황보영,김화성,안규동,이병국,이용진,김세훈,김승수,김승훈,김영록,김웅빈,이성수 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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동종골수이식 후의 이식편대숙주 질환의 빈도와 임상양상 : 단일 병원 치료 경험 A Single Institution Experience

이규형,이제환,이정신,서철원,김상위,김성배,김정균,김신,김우건,김상희 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

배경: 이식편대숙주 질환은 동종골수 이식후 발생할 수 있는 가장 중요한 합병증의 하나이다. 일반적으로 이식편대숙주 질환이 서구에 비하여 한국을 비롯한 아시아 국가에서 드물다고 알려져 있다. 방법: 저자들은 1993년 12월부터 1997년 6월까지 동종골수이식을 받은 전체 44명의 환자를 대상으로 급성 및 만성 이식편대숙주 질환의 빈도와 임상 양상을 조사하여 분석하였다. 대상환자중 남자가 27명 (61%) 이었고, 여자가 17명 (39%)이었다. 중앙연령은 33.5세 (범위, 16-47세)였다. 17명은 급성골수성 백혈병, 6명은 급성림프구성백혈병, 11명은 만성골수성백혈병, 8명은 중증재생불량성빈혈, 1명은 골수이형성증후군, 그리고 나머지 1명은 신경아세포종(neuroblastoma) 환자였다. 이식편대숙주 질환 예방으로 methodtrexate와 cyclosporine복합요법을 시행하였다. 결과: 3명에서 급성 이식편대숙주 질환이 이식후 18일에서 48일 사이에 관찰되었다(빈도, 7%). 급성 이식편대숙주 질환정도는 3도, 2도 그리고 1도가 각 한명씩이었다. 4도 급성 이식편대숙주 질환은 관찰되지 않았다. 13명의 환자가 만성 이식편대숙주 질환을 경험하였다(30%). 이들 중 10예는 제한성 병변이었고 3예는 전신성 병변이었다. 만성 이식편대숙주 질환의 주된 발병 증상 또는 징후는 황달/간기능 이상(8예)과 구강점막병변(4예)이었다. 한 명의 환자가 이식 후 107일에 간 이식편대숙주 질환에 의한 간부전으로 사망하였다. 결론: 한국인 환자에서는 동종골수이식 후 급성 및 만성 이식편대숙주 질환의 빈도가 구미의 환자에 비하여 상대적으로 낮고 그 정도도 덜한 것으로 보인다. 한국인 환자에 가장 적합한 이식편대숙주 질환 예방 방법의 정립을 위한 계속적인 연구가 필요하다고 사료된다. Background: Graft-versus-host (GVHD) disease is one of the most important complications after allogeneic bone marrow transplantation (BMT). Generally, it has been known that graft-versus-host disease is less frequent after allogeneic BMT in Asian countries including Korea when compared to western countries. Methods: We investigated the frequency and clinical pattern of acute and chronic GVHD in 44 consecutive patients who underwent allogeneic BMT between December 1993 and June 1997. There were 27 male (61%) and 17 female (39%) patients with median age of 33.5 years (range, 16-47). Seventeen patients had acute myelocytic leukemia (AML), 6 acute lymphocytic leukemia (ALL), 11 chronic myelocytic leukemia (CML), 8 severe aplastic anemia (SAA), 1 myelodysplastic syndrome, and 1 neuroblastoma. Methotrexate/cyclosporine combination was given for acute GVHD prophylaxis. Results: There patients (7%) developed acute GVHD median 31 days (range, 18-48) after BMT. There were one grade 3 acute GVHD involving the liver. There was no patient with grade 4 acute GVHD. Thirteen patients (30%) developed chronic GVHD median 100 day (range, 53-266) after BMT. Ten cases were limited stage and 3 were extensive stage. Frequent initial manifestations of chronic GVHD were jaundice/liver function abnormality in 8 cases and oral mucosal lesion in 4 cases. One patient died due to liver failure which were felt to be seconday to chronic GVHD 107 days after BMT. Conclusion: Acute and chronic GVHD are less frequent in Korean patients after allogeneic BMT when compared to historical data from patients from western Europe or United States. In cases of chronic GVHD, mild forms of disease predominate. Optimal strategy for GVHD prophylaxis in Korean patients remains to be defined.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

盧天命 硏究 : 그의 前半期 詩를 중심으로

金相培 단국대학교 1983 論文集 Vol.17 No.-

This is the study on Ro Chung Myung's poets of her earlier stage in the poetical circle in Korea, in which she pursued the aesthetics of loneliness and nostalgia. Her earlier stage refers to the period between 1938 and 1945. This period can be accentuated with the first anthropology of her poems, "Coral forest" published in 1938 and the other one, "the border of window" in 1945. Her works in this stage are characteristic of her poetic sucesses. "The forest", particularly, is distingushable from most of other poems in the late of 1930s with showing the stature of self-looking by the image of nostalgia and longing. Compared with the direct expressions of sentimentalisms in other poems, her works express the implicit aspect of them. Particularly in the "stag" among her works, the concretely expressive phrase of poetic image replaces the abstract ambiguity in poetic expressions that is used to be expressed in her poems such as "longing", "nostalgia to sea", "four leaves clover", "corn" and "school yard" in the late of 1930s. The concrete image is more crystalized in her scenery poems style. This scenery style is conspicuous in her second anthropology, "the border of window", which includes "travelling clown", "feast", "country scene", "nostalgia" and "home". The organic interlocking of the scenery images conspicuously condenses the poetic image by composing the dynamic poetic structure. The most of her scenery poems are successful in composition of complex images. With a usage of the past tense, it alivens the retrospective image, characterizing the national sorrowfulness and nostalgia. The most of her poems in this period show her personalistic and physical feature. Expressed in her "self-image", she is indulged and anxious in implicit longing and loneliness. The mirror of her physical stature becomes the motif of her poems. Such a poetic spirit is the expression of her life and living itself. It appears in her poetic sentimental color and such a sentimentalism fires ashed to self-looking. The personalistic characteristics in her works in this stage is rare one in the history of poems in Korea.

수유방법 및 기간이 아동의 타액내 환원효소활성검사성적과 유치우식경험도에 끼친 영향

배상만,노동주,김대업,이광희 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

The purpose of this study was to investigate the effects of the lactation of human or bovine milk and the method of using nursing bottles on the salivary invertase test scores and deciduous caries experience of children. 328 preschool children (boys 178, girls 150) in Iksan city were selected for this study. The parents of the children were asked to answer the questionnaire about the lactation of human or bovine milk and the time of using nursing bottles. The data were obtained from the salvary invertase activity score,(Resazurin Disc Test) deciduous caries experience and the questionnaire. The result were as follows. The invertase activity and caries experience of the human milk higher than that of the bovine milk group(p<0.05). There were significant positive relationships between the lactation period and the invertase activity and between the lactation period and the caries experience(p<0.05). Caries experience had a tendency to increase as the time of using nursing bottles increase(p>0.05).

植民地 時代의 隨筆文學 : 《文章》誌를 中心으로 Laying Stress on A Literary Journal "Munchang"

金相培 단국대학교 1989 論文集 Vol.23 No.-

The purpose of the study on this thesis is to trace the development and character of essay literature in the colonial period, especially since the mid-1930s. The main text book which was investigated in this thesis is a literary journal, "Munchang" which was published in 1939 and had to be discontinued in 1941. I have examined carefully general tendencies in literature from the middle of the 1930s onward. Going through the process of the study on "the Essay Literature." I pointed to the fact that the novelist or essayist who had something that he passionately wants to say might communicate it effectively under difficult circumstances at that time which were out of equilibrium and symmetry, in all respects-in political, social and economical instability; Moreover it is discovered that many sides that novelists and essayists didn't have any strong desire to write stood out in relief. The essayists wanted to make an attempt to approach essay in itself and have an intension to correct their vision about the climate on literary essay. Since then these facts have enabled the direction of the theory which was advanced on essay literature to be presented in a measure so that it can be fundamentally discussed. Limited to essay literature, their efforts were made to overcome the crisis of literature in the difficult environment of the age under which they had undergone all sorts of hardships. However, their endeavor to do so fails to come up to a more thorough understanding of Korea's unique situation, in that their basical theory and point of view on essay literature remains at such a level as we have only common sense to comprehend western essay theory. Their limitations become even more apparent on examining the essays in a literary journal "Munchang." Their theory on essay, to the contrary, the essayists of the time had a tendency to cling to the Korean traditional themes, which were fading away under Japanese colonial occupation. Such traditional themes as were cherished by the contemporary essayists were subject matters of utter value, considering the circumstances of the 1930s. But, with all due respect, it can be stated that their concerns of essay were pretty much restricted on reminiscing the past, thus failing to reach the dimension of creativeness. Owing to such limitations, the discussion on essay as a literary genre had to make a new start all overagain during the socialandcultural upheavals of the postliberation era.

Fay-Doman 法에 依한 腦性마비兒의 治療效果

金重善,裴晟洙 大邱大學校再活科學硏究所 1984 再活科學硏究 Vol.6 No.1

This is a study of Fay-doman's treatment method in the cerebral palsy children. The team was consisted of a physiatrist, a physical therapist, a special educationalist and parents. The aim of this studies are as follows: (1) Release of spasticity and athetosis. (2) To improve individual functional level of muscular strength and coordination. (3)To improve global functional level. 7 cerebral palsy children are used for this study. The program were set for the cerebral palsy children to spent all day on the floor in the prone position, homolateral patterning, cross-patterning and were encouraged to crawl (prone method) or creep(hand-knee method). The duration this study was 5 months, first one month had given patterning by a physical therapist with parents's minutes .4 times a day, six days in a week at Taegu University, Rehabilitation Center which was followed by the same treatment by parents at home fur 4 months. Every children were seen to us 2 times a week regulary. In determing the results of the program, Fay-Doman's developmental mobility scale which described 13 levels of normal development as the criteria of progress was used as pre and post-treatment program. First, The mean improvement of mobility was 2.8 levels. The mean level of mobility 6.1 at the begining of the program and 8.9 at the end of program. Second, Five out of seven increased muscular strength, coordination and relaxation. The range of improvement was 2 to 6 levels. Two of them did not correct of their walking pattern who had abnormal gait pattern before pre-treatment program.

인산염계 실리카 매몰재의 성분변화에 따른 티타늄의 주조특성

김광만,은진원,이상배,김경남 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.2

A large increase in the use of titanium in density is driven by the desire to take advantage of titanium's excellent biocompatibility and its high resistance to corrosion. The development of investments suitable for titanium castings is critical because their mechanical properties are greatly affected by the surface-reacted layer. The purposes of this study were to evaluate the characteristics of Titanium Vest Ⅱ(CO) and experimentally produced four phosphate- bonded SiO₂ investments(EA, EB, EC, ED). A great deal of attention was focused on the influence of investments, such as setting time, compressive strength, casting compatibility, casting defects, surface microhardness and interfacial zone of the cast titanium. The following results were obtained; 1. The setting time of all experimental groups were significantly shorter than control group(p<0.05). 2. Experimental groups were significantly greater than control group in compressive strength of 1hr and 2wks(p<0.05) and there was no significant difference among the experimental groups(->0.05). Compressive strength after 2wks was significantly greater than 1hr in all tested groups(p<0.05). 3. EA was showed the highest casting compatibility and CO the lowest. 4. There was no fin in the casting of all groups. There were small porosities in a dental x-ray inspection of EA. 5. CO was showed the highest microhardness at the distance of 50 ㎛ from the surface. 6. The interfacial zone was composed of four layers in all groups. There was irregular and thick layer in CO. According to these results, titanium is castable with experimentally produced phosphate-bonded SiO₂investments. In addition, there is room for further investigation of investment materials to improve the precise casting of titanium.

RANDOM 진동하중을 받는 구조물용 재료의 피로파괴에 대한 기초적 연구

김귀식,조성배 濟州大學校工科大學附屬産業技術硏究所 1990 尖端技術硏究所論文集 Vol.1 No.-

This paper was to investigate a fatigue damage of structural material under service loading, random loading. This examined irregular factors(α), wave counting methods and equivalent load amplitudes about three random loading waves generated by a personal computer. Results obtained are follows. 1. It is greatly different of counting results between range and rainflow cycle counting methods applied wide band spectrum, but it is similar those applied narrow bane one. 2. A Equivalent load amplitude, Leq, is obtained from m, the index of Paris' rule on a constant load amplitude test, and the result of cycle counting. Here, m is larger, Leq is greater. 3. In relation between irregular factor(α) and the cycle method, when α is near 1.0, Leq calculated by rainflow method is similarly that by range one, but when α is lower than 0.99, the former is large rather than the latter.

李朝 佛敎歌謠의 硏究(Ⅲ-Ⅰ) : 그 史的 展開를 中心으로 With its Historical Development

김성배 명지대학교 1974 明大論文集 Vol.7 No.-