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김기용,조우신,빈성일,백승일 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1
The knee joint is the largest weight bearing joint. As the fractures of Knee joint in volve the articular surface and the surrounding soft tissues, permanent disabilities such as deformities, joint stiffness, instability and post-traumatic arthritis may ensue following treatment. Many authors have recommended various methods of treatment for these fractures. Recently, however, a trend toward internal fixation has become evident and good results have been reported by several authors. This study is to present 40 cases of knee joint fractures which were treated at Asan Medical Center from May 1989 to April 19992. The results were as follows ; 1. The causes of injury were traffic accident(60%), fall down(12.5%), slip down(12.5%) and sports injury(10%). 2. There were 23cases in 22 males and 17 females in series and average was 46.8 years ranging from 19 years to 82 years. 3. In femoral condylar fractures, the most frequent type was C2(8 cases ; 42.2%) and in tibial condylar fractures, B1(7 vases ; 35.5%) by the A.O. classification. 4. 7 Cases were treated by conservative method 32 cases by operative method and 1 cases by amputation. 5. Satisfactory results were obtained 73.3% in femoral condylar fractures and 88.2% in tibial condylar fractures by operative treatment. We concluded that satisfactory results were obtained from operative treatment with procedures of anatomical reduction, rigid fixation and early joint motion.
Centipede Scolopendra subspinipes multilans L. Koch로부터 항균력이 있는 Centipedin의 추출, 정제 및 특성연구
김기태,최진성,민천홍,정일엽,박경배,조기승 한양대학교 이학기술연구소 1999 이학기술연구지 Vol.1 No.-
항균력이 있는 화합물인 Centipeding을 지네 Scolopendra subspinipes multilans L. Koch로부터 지용성 유기용매로 추출하였고, silicic acid column과 high S cation exchange chromatography 및 reverse-phase HPLC 등을 사용하여 고순도로 정제하였다. Gram-positive bacteria인 Staphylococcus aureus ATCC 6538P 및 gram-negative인 Klebsiella pneumoniae ATCC 8308 균주에 대하여 강한 항균력을 나타내었다. Dragendorff 시약에 의한 발색반응을 시행한 결과 Centipedin의 aromatic ring에는 nitrogen이 없음을 확이하였고 IR, Mass, NMR 분석 등에 의하여 Centipedin의 분자량은 162.1, 화학적 구조는 hydroxyl기와 carbonyl기를 함유하는 -hydroxyisocumarin으로 확인되었다. UV-spectrum 검색결과에 의하면 최대 흡수파장이 243 ㎚임을 확인하였고, melting point는 122℃이었으며, 실온에서 3개월간 방치된 Centipedin이 여전히 항균활성 및 화학적 구조를 유지하여 물리화학적 및 생물학적으로 안정한 화합물임으 알 수 있었다. The compound which has antibiotic activity was extracted and purified from centipede Scolopendra subspinipes multilans L. Koch by diethyl ether, silicic acid column and high S cation exchange chromatography followed by reverse-phase HPLC. This compoung named "Centipedin" showed antibiotic activity aganist microorganisms such as Gram^(+) -bacteria Staphylococcus aureus ATCC 6538P and Gram^(-) -bacteria Klebsiella pneumoniae ATCC 8308. Dragendorff test showed that there is no aromatic nitrogen within the Centipedim. The molecular weight of the Centipedin was 162.1 daltons as determined by mass spectrometry. The instrumental analysis of IR and NMR techniques revealed the molecular structure of Centipedim as 8-hydroxyisocoumarin. The UV-spectrum of Centipedin showed maximum absorption at 243 ㎚, and melting point was 122℃. Centipedin was stable at room temperature for three months in appropriate buffers.
Personal Computer를 이용한 반주문형 집적 회로 설계용 Workstation
이문기,이석호,김승환 연세대학교 산업기술연구소 1987 논문집 Vol.19 No.2
LEDISO는 레이아웃을 설계하기 위한 소프트웨어이며, 하드웨어 구성에 따르는 LEDISO의 하드웨어 의존성을 줄이기 위하여 그래픽 소프트웨어 표준인 GKS의 환경조건을 이용하였다. LEDISO의 데이타 구조는 CIF 데이타 구조를 기본으로 Polygon, Box, RFlash, Wire, Label 등을 오브젝트(object)로 가지며, Master를 이용한 SFF로 화일 관리를 한다. GKS의 세그먼트(Segment)를 이용한 아이컨(Icon)을 메뉴에 도입하여 시각적으로 사용자 인터페이스에 도움이 되도록 하였다. LEDISO, Layout EDiting SOftware for IC design, is implemented in C language with the environment condition of GKS which is the graphic standard software in order to reduce the hardware dependency. The data structure of LEDISO with the base of CIF data structure has the object as polygon, box, rflash, wire and label, managing files as SFF using the Master. In order to help user, the menu consisted of string and icon which has the segment of GKS is adopted in LEDISO.
사람 적혈구 막에 있어서 Carnitine acyltransferase 효소에 관한 연구
박중근,김응렬,조기승 漢陽大學校敎養學部 1976 硏究論文集 Vol.- No.1
사람 적혈구막에서 palmitoyl carnitine을 생성하는 효소계의 존재를 확인하였는데 이 효소계에 의해 palmitoyl coenzyme A와 DL-Carnitine(methyl-14C)으로부터 palmitoyl carnitine-14C이 생합성됨을 고찰하였고, 한편 이 효소계에 의해 화학적으로 합성한 palmitoyl-14C-carnitine이 palmitic acid-14C과 carnitine으로 가수분해됨을 확인하였다. 이 효소계에 의해서나 또는 화학적 방법에 의해 만들어진 palmitoyl carnitine은 적혈구막을 용해하며 이때 막에 부착된 효소계인 Adenosine Triphosphatase나 Glucose-6-phosphatase등이 활성화됨을 발견하였다. An enzyme system in human erythrocyte membrane was found to catalyze the formation of palmitoyl carnitine-14C from palmitoyl coenzyme A and carnitine-(methyl-14C). It was also confirmed that the same enzyme acts on the hydrolysis of palmitoyl-14C-carnitine into palmitic acid-14C and carnitine. Palmitoyl carnitine formed from this enzyme system or other chemical method solubilized the erythrocyte membrane and stimulated significantly the membrane bound enzymes, such as Adeno-sine Triphosphatase (ATPase) and Glucose-6-phosphatase (G-6-Pase) tried.
양극성 정동장애와 혈청 Inositol-1-phosphatase 활성도 변화
조현주,김영철,우행원,연규월,조기승 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2
Objects : Several lines of possibilites have been oroposed about the etiology of bipolar attective disorder in biological, genetic and psychosocial aspect. The purpose of this study is to inspect the etiology of bipolar affective disorder in biological aspect by measuring the changes of serum inositol-1-phosphatase activity and investing a causal relationship between clinical symptoms and serum inositol-1-phosphatase activities in patients with bipolar affective disorder. Methods : The subjects were 18 inpatients who met DSM-IV diagnostic criteria for bipolar I affective disorder, manic episode and 15 normal controls. Inositol-1-phosphatase activities were measured in serum by using spectrophotometer. Clinical symptoms of patients were assessed by YMRS at admission day and after 2 weeks lithium treatment. Results : 1) Inositol-1-phosphatase activities of the patients were increased to about 2 times as compared with those of normal controls. And the activity levels were decreased gradually to the normal at 14 days. 2) Young's Mania Rating Scale(YMRS) scores were decreased significantly by lithium treatment. 3) Statistical significance could not be found between the change of YMRS scores and the levels of inositol-1-phosphatase activity. Conclusion : In this study, statistical significance could not be found between clinical improvement and inositol-1-phosphatase activities, but the fact that lithium treatment improve the clinical manifestation shown by YMRS score changes, and reverse the increased inositol-1-phosphatase activities suggests the strong association between pathophysiology of bipolar affective disorders and inositide metabolism.
Kim, Chul-Joong,Shin, Kwang-Soon,Kim, Won-Yong,Lim, Dong-Soo,Yoon, Seung-Kew,Park, Young-Min,Kim, Boo-Sung,Jang, Sung-Key,Cho, Myung-Je 충남대학교 생물공학연구소 1996 생물공학연구지 Vol.4 No.-
Comparative nucleotide sequence studies of the genomes of hepatitis C virus (HCV) revealed that there are at least 6 different genotypes of HCV. The prevalence of HCV genotypes among the patients with liver diseases in Korea was investigated using the polymerase chain reaction (PCR) for the NS5 region. In the 75 HCV RNA positive samples, two genotypes, type 1b and type 2a, were the major causative agents which accounted for 60% and 33% of infections respectively, while 7% could not be assigned a genotype by the methods used. The nucleotide sequences of cDNAs encoding the putative envelope proteins from 10 type 1b and 5 type 2a genotype samples were analyzed. Approximately 31-42% of the nucleotide sequences of type 1b samples examined differed from those of different genotypes. In the case of type 2a samples, 36-42% of the nucleotide sequences differed from those of different genotypes. The diversities of the amino acid sequences were the same or greater than those of the nucleotide sequences. Two hypervariable regions (HVR1 and HVR2) were recognized in both HCV genomes of genotypes 1b and 2a. However, the sequence divergence within the HVR2 region of genotype 2a was less than that of genotype 1b. ⓒ 1995Wiley-Liss, Inc.
( Do Seung Lee ),( Seong Cheol Kim ),( Dong Hern Kim ),( Jae Hoon Kim ),( Se Pill Park ),( Youn Chul Ryu ),( Min Young Kim ),( So Mi Kim Cho ),( Key Zung Riu ),( Dong Sun Lee ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.3
Harmful viruses, including dengue virus, human immunodeficiency virus, and hepatitis B virus are known to be extremely sensitive to glucosidase inhibition. Phellinus linteus, an edible medicinal mushroom, was screened as an α-glucosidase inhibitor. The methanol extract of P. linteus inhibited the trafficking process of Newcastle disease virus-hemagglutinin-neuramidase, a viral glycoprotein, in virus-infected baby hamster kidney cells. These results suggest that P. linteus extract inhibits viral glycoprotein expression on cell surface through inhibition of trafficking process rather than glycoprotein synthesis.