소뇌연수열 박리를 이용한 상부 뇌교종양의 절제 : 증례보고 a case report

김영규,민경수,이무섭,김동호,김호재 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

뇌교 및 연수에서 발생한 병변은 뇌간에 중요한 신경구조물들이 밀집하여 수술적 적출에 따르는 심각한 신경학적 장애가 발생할 가능성이 매우 높다. 병변이 제 4뇌실 전방에 위치한 경우는 제 4 뇌실바닥을 통하여 뇌간조직을 절개하여야 하므로, 이 부위의 해부학적인 이해와 수술적 접근방법을 알고있어야 신경학적 손상을 최소화 할 수 있다. 저자들은 상부뇌교에서 발생한 낭성 양성 신경교종을 적출하기 위하여 소뇌충수를 보존하면서 좌측 소뇌연수열 접근법으로 제 4 뇌실바닥 상부까지 노출할 수 있었으며, suprafacial triangle을 절개하여 신경학적 후유증 없이 종양을 성공적으로 절제할 수 있어 증례보고와 함께 제 4 뇌실바닥 노출 방법의 하나인 소뇌연수열 접근법과 제 4 뇌실바닥 수술적 절개와 해부학적 특성에 대한 문헌 고찰을 하였다. Surgical removal of brain stem pathology causes high risks for neurologic deficits because of compact aggregation of important neural structures and complex anatomy. For the removal of pathologies which are located anterior to the floor of fourth ventricle in the brain stem, exposure of variable extents of the floor of fourth ventricle and incision of rhomboid fossa are necessary. In order to minimize postsurgery neurologic sequale for the removal of these pathologies, understanding of anatomy and surgical approach is very important. Authors successfully removed upper pontine benign cystic glioma by trans–medullary fissure approach without vermian incision to exposure floor of fourth ventricle and by incision of suprafacial triangle of rhomboid fossa without causing further neurologic deficit. Surgical technique of transcerebellomedullary approach and surgical anatomy of rhomboid fossa are discussed with report of a surgical case.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

Graphene: Position‐ and Morphology‐Controlled ZnO Nanostructures Grown on Graphene Layers (Adv. Mater. 41/2012)

Kim, Yong‐,Jin,Yoo, Hyobin,Lee, Chul‐,Ho,Park, Jun Beom,Baek, Hyeonjun,Kim, Miyoung,Yi, Gyu‐,Chul WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.41

<P>On page 5565, Gyu‐Chul Yi and co‐workers grow position‐ and morphology‐controlled ZnO nanowalls in prescribed positions on graphene layers. The nanowalls are grown to produce a variety of shapes from simple circles to text at the microscale. The selective growth of high quality ZnO nanowalls is investigated by electron microscopy and optical spectroscopy. The hybrid nanostructure can be exploited to fabricate various nanodevices including microarrays of nanotube LEDs. </P>

만성 경막하혈종의 단순 천공 배액술후 재발 및 두개강내 합병증 발생과 관련된 요인

김영규,민경수,이무섭,김동호,복원길,홍석기,김호재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 만성 경막하혈종은 두개골 천두술및 혈종배액으로 쉽게 치료될 수 있는 예후가 양호한 질환으로 알려져 있으나, 혈종의 재발 및 합병증이 드물지 않게 발생하기도 한다. 본 연구는 두개골 천두술 및 혈종배액으로 치료받은 102예의 만성 경막하혈종 환자들을 분석하여 혈종의 재발 및 수술후 합병증과 관련된 요인들을 분석하고자 하였다. 대상 및 방법: 만성 경막하혈종으로 진단되어 두개골 천두술 및 혈종배액술법으로 본원 신경외과에서 수술치료받은 102명의 환자를 대상으로 하였고, 입원진료기록 및 방사선소견을 후향적으로 분석하였다. 재발 및 합병증의 발생과 관련된 요인으로는 수술전 환자의 나이, 의식상태, 양측성여부, 뇌실질의 위축정도, 수술후 기뇌의 양, 전신질환여부에 대하여 분석하였다. 결과: 재발의 빈도는 9.8% 였으며 재발과 관련된 요인으로는 양측성, 고령, 수술후 뇌실질재팽창정도(뇌 실질위축, 잔여수액, 기뇌)가 관계가 있었으나 환자의 예후에는 영향이 없었다. 합병증의 종류에는 수술후 급성출혈 5예 및 경막하 농양 1예가 있었으나 이는 모두 출혈성전신질환 또는 면역결핍증이 동반된 환자에서 발생하였고 예후가 불량하였으며, 긴장성 기뇌가 1예발생 하였다. 결론: 전신질환의 동반여부가 합병증의 발생 및 환자의 예후에 가장 중요한 영향을 미쳤으며, 비록 예후에는 영향이 적으나 혈종의 재발의 빈도가 드물지 않으며 기뇌의 방지 및 배액방법의 개선으로 재발의 빈도를 줄일 수 있을 것으로 생각된다. Purpose : Most of chronic subdural hematomas(SOH) are amenable disease with simple cranoistomy drainage, but the recurrence of SDH or development of complications after surgery is not uncommon. To see the prognostic factors related to outcome the recurrence of chronic subdural hematoma and development of complication were analysed in 102 cases of chronic SDH after craniostomy drainage. Materials and Methods: We studied 102 chronic SDH patients treated with craniostomy drainage. Clinical and radiological records were reviewed retrospectively. We analysed the recurrence and complication rate, factors related to the development of recurrence and complications. Results: The rate of recurrence of chronic SDH was 9.8% and factors related to recurrence were bilaterality, old age, and postoperative intracranial environments for brain reexpansion(degree of brain atrophy, amount of residual fluid, amount of intracranial air). Intracranial complications after surgery were developed in 7 cases(6.9%), 5 postoperative bleedings, 1 tension pneumocephalus, 1 subdural empyema. Conclusion : Preoperative clinical condition and association of serious sytemic disease were of major importance in prognosis. The recurrence of chronc SDH was not uncommon, Even though the recurrence was not related to the outcome, great care should be paid on the patients with high risk group.

정신과 입원환자의 서비스 만족척도의 개발

김철권,이지연,송영선,김규호,김경률,김제원,이동기,최병무 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.3

목적 본 연구의 목적은 국내 정신의료기관(정신병원, 종합병원 정신과)에서 간편하게 사용할 수 있는 신뢰도와 타당도가 검증된 입원환자의 서비스 만족척도를 개발하기 위한 것이다. 방법 여러 단계를 거쳐 국내 실정에 맞는 문항을 개발하였고,정신병원, 종합병원, 대학병원 정신과 병동에서 퇴원하는 348명의 환자들을 대상으로 신뢰도와 타당도를 조사하였다. 요인분석 결과 5개의 요인이 추출되었으며 전체 변량의 63.04%를 설명하였다. 내적 일관성에 대한 신뢰도 계수 (Crohnbach's α)는 0.95로 상당히 높은 수준이었고, 수정된 개별문항-총점 상관계수는 0.50부터 0.72까지의 범위에 속하였다. 요인분석을 통해 추출된 서비스 만족척도의 각 하위척도 점수와 서비스 만족척도에 첨부된 각 영역에 대해 전반적인 만족도를 묻는 세 개의 문항 점수 간의 상관성 역시 유의하게 높았다. 결과 진단명에 따른 서비스 만족척도의 전체 점수에서는 불안/신체형/강박장애 환자군과 기분장애 환자군이 각각 정신분열병 및 기타 정신병 환자군과 알코올중독 장애 환자군에 비하여 유의하게 높은 점수를 보였으며, 입원형태에 있어서는 자발적 입원군이 강제 입원군에 비하여 전체 만족점수가 유의하게 높았다. 그러나 성별, 월수입, 학력, 직업, 종교, 결혼상태 등의 변수에서는 서비스 만족척도의 전체 점수에서 유의한 차이가 발견되지 않았으며, 마찬가지로 연령, 입원일수, 입원횟수, 첫 발병나이, 유병기간 등의 임상적 변수에서도 서비스 만족척도의 전체 점수와 유의한 관계를 보이지 않았다. 서비스 만족척도의 전체점수에서 대학병원 환자군이 정신병원 환자군과 종합병원 환자군에 비하여 각각 유의하게 높았다. 결론 결론적으로 국내 정신의료기관에 입원한 환자들의 서비스 만족을 평가하기 위한 목적으로 개발된 본 척도는 높은 수준의 신뢰도와 타당도를 보였으며, 또 국내 정신의료 환경에 맞는 요인구조를 보였다. 따라서 정신의료 서비스에 대한 정신과 환자의 만족도에 대한 연구가 거의 없는 실정에서 본 척도의 개발은 향후 국내 정신의료의 질과 치료결과를 높이는 도구로 활용될 수 있을 것으로 기대된다. Objectives : To develop and test the validity and reliability of a brief self-completed questionnaire (Service Satisfaction Scale : SSS) for routinely assessing the quality of service in psychiatric ward inpatients. Methods : A 30-item multidimensional questionnaire was developed by several steps of face validity and content validity. The questionnaire was administered to inpatients (n=348) discharged from psychiatric hospitals, general hospitals, and University hospitals. Construct validity was supported by performing principal component analysis. Reliability was estimated by calculating internal consistency of Cronbach's alpha. Results : Factor analysis yielded five factors comprising staff attitude, treatment quality, ward environment, access/cost, and ward rule, which account for 63.04% of the common variance. The internal consistency of the scale was high (Cronbach's alpha=0.95). The concurrent validity was supported by the significant correlation of each of five factors with item that measured overall satisfaction of SSS. Patients with neurosis (anxiety disorder, somatoform disorder, obsessive compulsive disorder) and mood disorders were significantly satisfied than those with psychosis and alcoholic disorders. Patients who admitted voluntarily were more significantly satisfied than those who admitted involuntarily. Sociodemographic variables such as age, gender, marital status, monthly income, education level, employment status and religion were not significantly different at the total scores of SSS. Similarly, clinical characteristics such as age of onset, duration of illness, lengths of hospital stay and number of previous hospitalization did not associate significantly with the total scores of SSS. Patients discharged from university hospitals were significantly more satisfied than those of the general and psychiatric hospitals. Conclusion : SSS performed well in the validity and reliability, indicating that it can be a useful tool for measuring Satisfaction of psychiatric inpatients in Korea.

Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats

Kwon, O Jun,Kim, Min Yeong,Shin, Sung Ho,Lee, Ah Reum,Lee, Joo Young,Seo, Bu-il,Shin, Mi-Rae,Choi, Hyun Gyu,Kim, Jeong Ah,Min, Byung Sun,Kim, Gyo-Nam,Noh, Jeong Sook,Rhee, Man Hee,Roh, Seong-Soo Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-

<P>The purpose of this study was to investigate the antioxidant and anti-inflammatory effects of the combined extract of Rhei rhizoma and Coptidis rhizoma (RC-mix) in experimental model of acute reflux esophagitis. The antioxidant activity was assessed by<I> in vitro</I> 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. RC-mix was given at 100, 200, and 400 mg/kg body weight 2 h prior to induction of reflux esophagitis (RE). After 5 h, the effects of RC-mix treated rats were compared with those of normal and control rats. The representative flavonoid contents of RC-mix, such as sennoside A, epiberberine, coptisine, palmatine, and berberine, were detected using HPLC. The elevated esophageal mucosa damage was markedly ameliorated by RC-mix treatment in a dose-dependent manner. Furthermore, the administration of RC-mix reduced the increase of serum reactive oxygen species (ROS) and peroxynitrite (ONOO<SUP>−</SUP>). The improvement of superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) levels were marked in the group given RC-mix. Moreover, the elevation of inflammatory mediators and cytokines by nuclear factor-kappa B (NF-<I>κ</I>B) activation in control rats decreased by RC-mix pretreatment. These results indicate that RC-mix treatment reduces the pathological states of esophagitis<I> via</I> regulating NF-<I>κ</I>B mediated inflammation related to oxidative stress. </P>

Sauchinone Suppresses Pro-inflammatory Mediators by Inducing Heme Oxygenase-1 in RAW264.7 Macrophages

Li, Bin,Lee, Dong-Sung,Choi, Hyun-Gyu,Kim, Kyoung-Su,Kang, Dae-Gil,Lee, Ho-Sub,Jeong, Gil-Saeng,Kim, Youn-Chul Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.10

<P>Sauchinone, a biologically active lignan isolated from the roots of <I>Saururus chinensis</I> (L<SMALL>OUR</SMALL>.) B<SMALL>AILL</SMALL>. (Saururaceae), is reported to exert a variety of biological activities, such as hepatoprotective, anti-inflammatory actions and inhibitory effects on bone resorption. In this study, we investigated the effect of sauchinone in suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, leading to a reduction in COX-2-derived prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated RAW264.7 macrophages. Present study also demonstrates the effects of sauchinone in inducing heme oxygenase-1 (HO-1) expression and an increase in heme oxygenase (HO) activity in RAW264.7 macrophages. The effects of sauchinone on LPS-induced PGE<SUB>2</SUB>, NO, tumor necrosis factor-α (TNF-α) and interlukine-1β (IL-1β) production were partially reversed by the HO-1 inhibitor Tin protoporphyrin was also seen in this study. In addition, we found that treatment with extracellular signal-regulated kinase (ERK) inhibitor (PD98059) reduced sauchinone-induced HO-1 expression. Sauchinone also increased ERK phosphorylation. These results suggest that sauchinone inhibits pro-inflammatory mediators through expression of anti-inflammatory HO-1 <I>via</I> ERK pathway.</P>

Omeprazole 투여시 위산분비 억제능에 대한 CYP2C19 의 영향

박수헌(Soo Heon Park),김종원(Jong Won Kim),이수연(Soo Youn Lee),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Gyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6

Background/Aims: CYP2C19 has an important role in the catabolism of several proton pump inhibitors. However, the relative contribution of CYP2C19-mediated metabolism varies among the different proton pump inhibitors. We investigate to determine the effect of CYP2C19 genotype status on intragastric pH during dosing with omeprazole. Methods: The subjects were 16 healthy volunteers. Their CYP2C19 genotype status was determined by a polymerase chain reaction-restriction fragment length polymorphism method. Twenty-four-hour monitoring of intragastric acidity were performed on the day without medication and day 4 after omeprazole administration. Results: A single dose of omeprazole significantly decreased 24 hour intragastric acidity (1.7±0.3 vs. 5.1±0.4). Subjects were divided into three groups on the basis of their CYP2C19 genotype status: homozygous extensive metabolizers (Ho-EMs, n=5), heterozygous extensive metabolizers (Ht-EMs, n=6), and poor metabolizers (PMs, n=5). Median 24 hour intragastric pH in the Ho-EM group was 3.1 compared with 5.5 in Ht-EM group and 5.9 in PM group(P<0.05). The median pH during omeprazole administration was influenced by CYP2C19 genotype. On the other hand, the Helicobacter pylori infection did not influence the median intragastric pH during omeprazole administration (p= NS). Conclusions: The effects of omeprazole on intragastric acidity is influenced by the CYP2C19 polymorphism. (Korean J Gastroenterol 2001;38:399-404)

측정값의 상황 의존성

김명석,최상돈,조상규,김정호,전헌무,김호일 慶北大學校 師範大學 科學敎育硏究所 1998 科學敎育硏究誌 Vol.22 No.-

We review the contextuality of measured values in quantum mechanics from point of view of a conventional interpretation of quantum mechanics. We will, in particular, concentrate on Bell-KS theorem which, seemingly, disproved the existence of a hidden-variable interpretation of quantum mechanics. We introduce ways to accommodate the contextuality so that Bell-Ks theorem no longer holds and therefore the existence of a hidden-variable interpretation becomes possible.

벼 大單位 增産團地栽培에 關한 經營實態調査 : 慶南地方의 5個 團地를 中心으로

金厚根,金正敎,尹泰圭,河湖成,張權烈 慶尙大學校 1975 論文集 Vol.14 No.-

Recently large scale cooperative rice production system has been promoted. This cooperative rice production system is intended to promote introducing a set of new technology which may not be suitable for individual small scale farms to adopt. And this system is believed to be one of important public programs to achieve productivity growth policy goal in Korea. Nevertheless, there seem to exist several problems for this public program to widely introduce to over-all nation. This is one of main objectives that this study intends to investigate. In order to study comparative characteristics of the large scale rice cooperative farm in terms of resource base and organization 99 farms which are member farms and 100 farms which are non-member individual farms have been selected and interviewed from five large scale cooperative farm areas in Gyeong-Nam Province in 1974. The important findings can be summarized as follows: 1) Most of operators af both classes belong to age cohert 40∼50, but the average educational level for member farm operators is higher than that for non-member. 2) The average scale Of rice paddy for member farms, 13.1 tanbO, is larger than that for non-member, 10.6, and the same thing is true for average size of rice paddy plots which is, respectively, 805 pyeong and 690. 3) Completely irrigated paddy for member farms is 99 percent of total paddy owned whereas that for non-member is 81, and consolidated paddy for member farms is 67 percent while that for non-member is 26.4. On the other hand, technically improved paddy other than indicated above for member farms is 32 percent, but that for non-member is only 8.3. 4) Number of rice varieties adopted is 9 for both classes. The most popular variety for member farm is Akibare(36%) whereas that for non-member is Sadominori(29.3%) and Akibare (28.4%). 5) Labor used is 13.5 man per tanbo for member farms and 12.4 for non-member. More labor is used for improving soil quality and protection for member farms whereas less labor is used for preparatory works such as seed bed, sterilization, and water management in the case of the member farm. 6) In the case of member farms, the type of work which is achieved cooperatively by more than 70 percent is purchasing or exchaging seeds, sterilization, and plant protection. Despite seed bad, water management, transplanting and the like being more or less suitable for cooperative work, the proportion of those works done cooperatively is relatively small as compared to what we expected. 7) According to farmers interviewed, variety selection, plant protection, seed bed, transplanting fertilization, water management, and harvesting works are more easier for cooperation, in order importance. 8) Cooperative farmers were cultivating a leading variety, Tongil, which showed higher yields than ordinary varieties and had a desire to be released a new high yielding variety which has a characteristics of highly resistance to dsease and insect. 9) Cooperative farmers were forced to begin the nusery bed earlier than the individual farmers and to emphasize on the disease and insect control with more frequencies. 10) Cooperative farmers had benefits in the seedling transplanting earlier and higher planting density than individual farmers. 11) Cooperative farmers had an intention to apply a deep fertilization method arid to dress heavier nitrogen with a reasonable ratio of the basal fertilization to the top dressing. 12) Cooperative farmers had a convenient irrigation system and were available to adopt a summer drainage method. 13) Cooperative farmers controlled the weed with agricultural chemicals arid recognized the control effect of weedcides. 14) In general, it was recognized that there happened somewhat benefit result in disease control in the cooperative farm while a reasonable control effect was not found in heavy prevailing case. The dominant diseases found in the cooperative farm were sheath bright, strip disease and they were to he prevented with a strong efforts. 15) Rice stem borer and grass leaf roller were effelctivey controlled in the cooperative farm, however, plant hoppers was not completely controlled by the usual method because of its unexpected prevalence. 16) The most difficult thing to cooperate they indicate is to supply an adequate amount of labor at appropriate time in tire labor peak season. In this sense, it seems necessary to introduce field machinary in order to achieve the objective of large scale cooperative rice production. 17) Farmers interviewed believe that technology concerning yield increase is most important. in this respect, it is important to develop such new technology, to diseminate its results and to train good quality extension workers. 18) 42 percent of member farm operators indicate that the cooperative system was successful and 25 percent indicate failed. 29 percent of non-member farmers think that the cooperative farm system was successful and 7 percent of them think failed. Thus 55 percent of non-member farmers indicate they are willing to join to the system in the next year, 7 percent of them are not and others have not decided yet. 19) 60 percent of member farmers think that the scale and number of members of the system were too much large to successfully cooperate and 67 percent of them believe that cooperation among members were not very developed, and 42 percent of members suppose what the leader of individual active farms were not very well functioning. 20) Number of member farmers who believe that the yield level in this year is increased as compared that before joining to the system is 3,4 percent, and no one indicated that the yield level is decreased. On the other hand, 22 percent of them believe that by participating to the system the same quality of paddy could produce more rice. 21) About 93 percent of member farmers believe that the system may not lie survived without support of government and i priority must be given to yield technology. 22) About 80 percent of member operators indicate that they would partioipate to the program in the next production year and 23 percent of them indicate that they would participate with the same amount of paddy land as this year. 23) The rice yield level for member and non-member farms is, respectively, 406kg and 346 per tanbo, and the former is 17.3 percent higher than the latter. 24) The cash expenses per tanbo for member and non-member farms is, respectively, 12,311 won and 10,398. 25) The gross revenud per tanbo for both classes is, respectively, 60,024 won, and 51,303 when evaluated by the official price level, and the net income is, respectively, 47,713 won and 40,905. As seen above, the fact that the rice yield level of member farmers, hence, the income level turns out to be higher seems to stem from two basic factors; that is, on the average, the member farmers are operating farm with an improved resource base and they seem to use more the so called conventional inputs with a better yield technology and management. Thus we may conclude that it is important to invest to improve resource quality, to innovate new yield technology and diseminate this innovation. At the same time, in order to more promote the cooperative system, it seems desirable to solve the following problem areas: 1) Number of member farms and paddy area covered by one cooperaitve unit seems better not to he very large. This seems so because there is on much scale economies owing to the nature of technology available to adopt, whereas a large member unit may restrict opportunity of individual members to deeply involve in the process of decision making. Thus we recommend to continue to study finding an optimum size of the unit. 2) As implied already, quality as well as quantity of extension workers and other local officers who lead this program area crucial factor to expand number of unit of the system and hence to achieve the objective of the program. 3) In order to get rid of labor deficit, especially in the labor peak season farm mechanization seems necessary. For this matter, it is worthwhile to promote, first of all, to invent suitable field machinery, secondly, land consolidation and other land improvement projects, and thirdly to innovate a new technology system suitable to mechanized farming. At any rate, it is also necessary for the government to supply an adequate amount of credit and other administrative support.