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( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)
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金德原(Kim, Deok-Won) 백산학회 2002 白山學報 Vol.- No.63
There has been little substantial progress in the study of King Jin Ji (眞智王). This is due to a shortage of records regarding his reign that resulted from the political turmoil leading up to his dethronement four years after taking the throne. Negative impressions implanted in the process of evaluating and recording his administrative achievements in comparison to King Jin Pyeong(眞平王) are another reason for this dearth of records. The background information that made it possible for him to become King, however, highlights both his personal ability and internal and external circumstances unique to the era of his accession. In terms of ability, his age was considered an important fact qualifying him to be King, as was his renown as a wise statesman with a keen and accurate sense of judgment. Taking into account the internal and external circumstances both before and after he became king, one must consider the Shilla Kingdom (新羅) suffering frequent attacks mounted by the Paekje Kindgom(百濟) externally given the inroads that King Jin Heung(眞興王) made into the Hang River(漢江) basin. The ideology of Cakravartirajan(轉輪聖王) late emerged as an internal factor, in terms of how it was closely connected to the Buddhist politics of King Jin Heung(眞興王). It was Geo Chil-bu(居柒夫) who played a pivotal role in bringing Jin Ji to the throne. He had been characterized as a symbolic figure that made great contributions to the expansion of Shilla Kingdom(新羅) territory by becoming a member of inner Buddhist circles somewhat earlier than others. In this context he was able to assist Jin Ji's accession to the throne in the following ways: Safeguarding the Shilla Kingdom territory from external threats was always an imminent proposition, while the internal politics of the Kingdom involved a pursuit of inheriting the Buddhist policies of King Jin Heung(眞興王). In addition to the Geo Chil-bu's(居柒夫) loyalty played in the coronation of King Jin Ji(眞智王), the role Kim Mu-ryeok(金武力) played is also worthy of attention. It has been inferred from what few records are available, that the military stronghold Kim Mu-ryeok had in cooperation with Geo Chil-bu(居柒夫) was a major factor in Jin Ji's accession to the throne. The relationship between King Jin Ji(眞智王) and Kim Mu-ryeok(金武力) also played had a significant influence on their kinsfolk. It has, therefore, been suggested that as a result King Yong-chun(金龍春) was nudged toward ties with Kim Seo-hyeon(金舒玄), and Kim Chun-chu(金春秋) affiliated himself with Kim Yu-sin(金庾信). It was perhaps these Saryun(舍輪系) and Kaya(加耶系) clique relationships, upon which a new aristocracy that has come to be known as the spread of ‘the middle ages(中代)’ was based.
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Microbial Contamination Levels of Strawberries at Domestic Farms of South Korea
Won-Il Kim,A-Ra Jo,Se-Ri Kim,Song Hee Ryu,Ki-Woong Nam,Yohan Yoon,Deok-Hoon Yoon,So-Yong Oh,Myeong Hyeon Nam,Jae-Gee Ryu,Hwang-Yong Kim 한국토양비료학회 2014 한국토양비료학회지 Vol.47 No.6
Foodborne illness due to the consumption of contaminated raw strawberries is a continuing food safety concern. This study investigated and evaluated contamination levels of bacteria on strawberries at farms stage to evaluate potential hazards associated with fresh strawberries. A total of 315 samples, 105 samples from 5 sampling sites (A to E) of 21 farms and 210 samples from 1 sampling site of 6 farms, was collected every month for four months and analyzed to enumerate aerobic bacterial counts, Coliforms/E. coli, Bacillus cereus and Staphylococcus aureus. In addition, the prevalence study of five pathogens (S. aureus, E. coli, E. coli O157:H7, Salmonella spp. and Listeria monocytogenes) was performed on each sample. Aerobic bacterial counts ranged from 0.48 to 6.36 Log CFU/g, with the highest bacterial cell counts recorded for D and E sites. Coliforms were detected in 71 samples (22.5%) with a minimum of 0.48 cfu/g and a maximum of more than 4 Log CFU/g. B. cereus was detected in 98 samples (31.1%) among total samples analyzed. S. aureus was detected in 2 samples with a minimum of 0.48 Log CFU/g and a maximum of 1.38 Log CFU/g. E. coli, E. coli O157:H7, Salmonella spp. and L. monocytogenes were not isolated from any of the samples. The microbial contamination levels of strawberries determined in this study may be used as the fundamental data for microbiological risk assessment.
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Dual Effect of Curcumin/BMP-2 Loaded in HA/PLL Hydrogels on Osteogenesis In Vitro and In Vivo
Kim, Eun-Cheol,Yoon, Sun Jung,Noh, Kwantae,Lee, Deok-Won American Scientific Publishers 2017 Journal of nanoscience and nanotechnology Vol.17 No.1
<P>In the present study, we evaluated the potential of poly-L-lysine/hyaluronic acid (HA/PLL) hydrogels containing curcumin (CUR) and bone morphogenetic protein-2 (BMP-2) as bone tissue regeneration scaffolds. Hydrogels HP-1 similar to 2 were formed by amide bonds via the condensation reactions between 0.02 mu mol HA and 0.06-0.12 mu mol poly-L-lysine center dot hydrobromide (PLL center dot HBr). Physical, chemical, and thermal analyses revealed that the amount of PLL center dot HBr significantly influenced hydrogel properties. Based on an in vitro MG-63 cell proliferation test, HP-1 similar to 2 were cytocompatible, and all hydrogels containing different amounts of CUR and BMP-2, except for HA(0.02)/PLL0.06/CUR20/BMP-2(100) (HPCB-4), resulted in cell proliferation above 80%. An in vitro release test showed that CUR and BMP-2 were consistently released from HA(0.02)/PLL0.06/CUR15 (HPC), HA(0.02)/PLL0.06/BMP-2(100) (HPB), HA(0.02)/PLL0.06/CUR15/BMP-2(10,) (50,) (or 100) (HPCB-1 similar to 3), and HA(0.02)/PLL0.06/CUR10 (or 20)/BMP-2(100) (HPCB-4 similar to 5) for 7 and 28 days, respectively. In vitro ALP activity and calcium deposition and in vivo micro-computed tomography (micro-CT) tests demonstrated the potential application of HPCB-3 as bone tissue regeneration scaffolds, suggesting that bone tissue regeneration can be optimized by controlling the amounts of CUR and BMP-2.</P>
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Won-Jun Koh,Jeong-Hyeon Cho,Ji-Hyun Lee,Won-Sik Kang,Min-Kyung Lee,Jun-Hyoung Kim,Deok-kyu Cho 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.2
A 70-year-old male came to the emergency room of the authors’ hospital because of sudden cardiac arrest due to inferior wall ST elevation myocardial infarction. His coronary angiography revealed multiple severe coronary spasms in his very long left anterior descending artery. After an injection of intracoronary nitroglycerine, his stenosis improved. The cardiac arrest relapsed, however, accompanied by ST elevation of the inferior leads, while the patient was on diltiazem and nitrate medication to prevent coronary spasm. Recovery was not achieved even with cardiac massage, intravenous injection of epinephrine and atropine, and intravenous infusion of nitroglycerine. The patient eventually recovered through high-dose nicorandil intravenous infusion without ST elevation of his inferior leads. Therefore, intravenous infusion of a high dose of nicorandil must be considered a treatment option for cardiac arrest caused by refractory coronary vasospasm.
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Kim Seon Min,Lee Hye In,Nam Seung Won,Jin Deok Hyeon,Jeong Gwi-Taek,Nam Soo-Wan,Burns Brendan,Jeon Young Jae 한국미생물·생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.1
The study objective was to evaluate the potential production of polyhydroxyalkanoates (PHAs), a biodegradable plastic material, by Paracoccus haeundaensis for which PHA production has never been reported. To identify the most effective nitrogen-limited culture conditions for PHAs production from this bacterium, batch fermentation using glucose concentrations ranging from 4 g l-1 to 20 g l-1 with a fixed ammonium concentration of 0.5 g l-1 was carried out at 30o C and pH 8.0. A glucose supplement of 12 g l-1 produced the highest PHA concentration (1.6 g l-1) and PHA content (0.63 g g -1) thereby identifying the optimal condition for PHA production from this bacterium. Gas chromatography-mass spectrometry analysis suggests that P. haeundaensis mostly produced copolymer types of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] from glucose concentrations at 12 g l-1 or higher under the nitrogen-limited conditions. When several other single carbon sources were evaluated for the most efficient PHA production, fructose provided the highest biomass (2.8 g l-1), and PHAs (1.29 g l-1) concentrations. Results indicated that this bacterium mostly produced the copolymers P(3HB-co-3HV) from single carbon sources composing a range of 93–98% of 3-hydroxybutyrate and 2–7% of 3-hydroxyvalerate, whereas mannose-supplemented conditions produced the only homopolymer type of P(3HB). However, when propionic acid as a secondary carbon source were supplemented into the media, P. haeundaensis produced the copolymer P(3HBco-3HV), composed of a 50% maximum monomeric unit of 3-hydroxyvaleric acid (3HV). However, as the concentration of propionic acid increased, cell biomass and PHAs concentrations substantially decreased due to cell toxicity.
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Induction of pigmentation by a small molecule tyrosine kinase inhibitor nilotinib
Kim, Kyung-Il,Jo, Jeong Won,Lee, Jeung-Hoon,Kim, Chang Deok,Yoon, Tae-Jin Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.4
<P><B>Abstract</B></P> <P>Skin color is determined by the melanin pigments that are produced in melanocytes then transferred to surrounding keratinocytes. Despite the growing number of commercial products claiming the pigmentation-regulatory effects, there is still a demand for the development of new materials that are safe and more efficacious. We tried to screen the pigmentation-regulatory materials using a commercially available drugs, and found that nilotinib could induce pigmentation in melanoma cells. When HM3KO melanoma cells were treated with nilotinib, melanin content was increased together with increase of tyrosinase activity. Nilotinib increased the expression of pigmentation-related genes such as MITF, tyrosinase and TRP1. Consistent with these results, the protein level for MITF, tyrosinase, and TRP1 was significantly increased by nilotinib. To delineate the action mechanism of nilotinib, we investigated the effects of nilotinib on intracellular signaling. As a result, nilotinib decreased the phosphorylation of AKT, while increased the phosphorylation of CREB. The pretreatment of PKA inhibitor H89 markedly blocked the nilotinib-induced phosphorylation of CREB. In accordance with, pretreatment of H89 significantly inhibited the nilotinib-induced pigmentation, indicating that nilotinib induces pigmentation via the activation of PKA signaling. Together, our data suggest that nilotinib can be developed for the treatment of hypopigmentary disorder such as vitiligo.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The nilotinib induced the pigmentation of HM3KO melanoma cells. </LI> <LI> The nilotinib decreased the phosphorylation of AKT, while increased the phosphorylation of CREB. </LI> <LI> The inhibition of PKA signaling abrogated nilotinib-induced pigmentation. </LI> </UL> </P>
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Microbial Contamination Levels of Strawberries at Domestic Farms of South Korea
Kim, Won-Il,Jo, A-Ra,Kim, Se-Ri,Ryu, Song Hee,Nam, Ki-Woong,Yoon, Yohan,Yoon, Deok-Hoon,Oh, So-Yong,Nam, Myeong Hyeon,Ryu, Jae-Gee,Kim, Hwang-Yong 한국토양비료학회 2014 한국토양비료학회지 Vol.47 No.6
Foodborne illness due to the consumption of contaminated raw strawberries is a continuing food safety concern. This study investigated and evaluated contamination levels of bacteria on strawberries at farms stage to evaluate potential hazards associated with fresh strawberries. A total of 315 samples, 105 samples from 5 sampling sites (A to E) of 21 farms and 210 samples from 1 sampling site of 6 farms, was collected every month for four months and analyzed to enumerate aerobic bacterial counts, Coliforms/E. coli, Bacillus cereus and Staphylococcus aureus. In addition, the prevalence study of five pathogens (S. aureus, E. coli, E. coli O157:H7, Salmonella spp. and Listeria monocytogenes) was performed on each sample. Aerobic bacterial counts ranged from 0.48 to 6.36 Log CFU/g, with the highest bacterial cell counts recorded for D and E sites. Coliforms were detected in 71 samples (22.5%) with a minimum of 0.48 cfu/g and a maximum of more than 4 Log CFU/g. B. cereus was detected in 98 samples (31.1%) among total samples analyzed. S. aureus was detected in 2 samples with a minimum of 0.48 Log CFU/g and a maximum of 1.38 Log CFU/g. E. coli, E. coli O157:H7, Salmonella spp. and L. monocytogenes were not isolated from any of the samples. The microbial contamination levels of strawberries determined in this study may be used as the fundamental data for microbiological risk assessment.
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