Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

척추분리증이 동반된 요추 추간판 탈출증

신병준,김광섭,윤태경,이재철,김경제,김연일 대한척추외과학회 2001 대한척추외과학회지 Vol.8 No.1

연구계획 : 척추분리증이 동반되어 있는 추간판탈출증의 수술적 치료에 관한 후 후향적 연구이다. 연구목적 : 본 연구의 목적은 추간판탈출증 환자 중 척추분리증이 동반되어 있는 빈도를 알아보고, 추간판탈출증을 단순히 수핵제거술 만으로 치료한 경우에 단순한 추간판탈출증의 치료에 비하여 예후에 차이가 있는지를 비교하고자 하였다. 대상 및 방법 : 1989년 3월부터 1999년 2월까지 수핵제거술을 시행받은 환자 273명 중 척추분리증이 있으나, 척추불안정이 없고, 1년 이상 추시 관찰이 가능하였던 9명을 대상으로 하였다. 남자가 5명, 여자가 4명이었고, 평균 연령은 42.7세(30세 64세)였고, 평균 추시 기간은 54.6개월(15개월 114개월)이었다. 추간판탈출의 형태, 척추분리증이 있는 부위 등을 조사하였고 환자들의 이환 기간, 증상의 정도 및 양상, 신경학적 소견 등을 술 전 및 추시 시의 결과를 Kim등의 평가기준에 따라 평가하였다. 결과 : 척추분리증이 동반된 추간판탈출증의 비율은 3.7%로 나타났다. 임상적 증상을 보면 동통은 7례(78%)에서 양성이었는데, visual analogue scale에 의한 통증평가의 평균은 술전 2.1(0 8), 최종 2.1(0 5)이었고, 방사등 9례(100%)모두에서 나타났으며 통증평가의 평균은 술전 7.6(4 10)에서 최종 0.8(0 3)로 호전되었다. 하지 직거상 검사상 7례(78%)에서 양성 소견을 보였고 7명 모두에서 증상의 호전이 있었다. 근력의 약화는 6례(67%)에서 관찰되었는데 6례모두 증상의 호전이 있었다. 감각의 저하는 8례(89%)에서 나타났으며 ?M 우 7례는 증상의 호전을 보였다. 심부 건반사의 이상은 5례(56%)에서나타났으며 2례에서 증상의 호전을 보였다. 임상적 결과는 탁월 2명, 우수 6명, 양호가 1명이었다 결론 : 추간판탈출증에서 척추분리증이 동반된 비율은 3.7%로 일반적인 척추분리증의 빈도와 큰 차이는 없었다. 술후 임상증상의 회복율이나 동통지수의 변화를 볼 때 척추분리증이 동반된 추간판탈출증환자들의 수술결과도 일반적으로 추간판탈출증만이 있는 환자를 치료한 결과와 큰 차이가 없는 것으로 보아 척추분리증이 동반되었다고 하여 척추고정술을 고려하는 등 추간판탈출증 자체의 수술방법을 변경할 필요는 없다고 판단된다. Study Design : This is a retrospective study determining the surgical result of lumbar HlVD associated with spondylolysis. Objectives : To analyze the incidence of lumbar HlVD associated with spondylolysis and to compare the results of open discectomy for lumbar HlVD associated with spondylolysis to simple lumbar HlVD. Summary of Literature Review : Lumbar HlVD associated with spondylolysis need be treated by spinal fusion. Materials and Methods : Nine patients(5 males and 4 females) who had lumbar HlVD with spondylolysis, no instability. follow-up period of 1yr were identified out of 273 patients with lumbar HlVD, treated by open discectomy from March 1989 to Feb. 1999. The type of HlVD and level of spondylolysis were evaluated, the clinical symptoms and signs including SLR. motor deficit, sensory deficit, change of DTR and severity of radiating pain were periodically followed up on the predesigned protocoL Results : The incidence of lumbar HlVD associated with spondylolysis is 3.7%. The recovery of back pain was 2.1 to 2.1 by visual analogue scale, radiating pain was 7.6 to 0.8. The recovery rate of SLR was 100%, motor deficit; 100%. sensory deficit: 85%, change of DTR 4O%. The clinical evaluation was excellent(2), good(6). fair(1). Conclusions : According to the recovery rate of the clinical symptoms, the results of open discectomy for lumbar HlVD associated with spondylolysis without spinal instability and simple HIVD was not different. Therefore, we conclude that lumbar HlVD associated with spondylolysis need not be treated by spinal fusion.

태양광 발전을 이용한 유도전동기 드라이브의 벡터제어

정병진(Byung-Jin Jung),고재섭(Jae-Sub Ko),최정식(Jung-Sik Choi),김도연(Do-Yeon Kim),정동화(Dong-Hwa Jung) 한국조명·전기설비학회 2008 한국조명·전기설비학회 학술대회논문집 Vol.2008 No.10월

This paper is proposed the vector control of 3-phase induction motor drive system by photovoltaic generation. For performance of vector control using a current control voltage source inverter(CC-VSI). CC-VSI is controlled by torque and flux producing component of motor current, relating with current and and voltage value of photovoltaic arrays at maximum power point that varies follow different level of insolation. The MPPT using a DC-DC converter controlled the duty cycle to track maximum power from PV under different insolation conditions. The simulation results are shown that the characteristics and performance of drive system, which varies as each conditions of light by expresses in voltage(V<SUB>dq</SUB>), current(I<SUB>dq</SUB>), speed of motor and torque.

SPIM 벡터제어를 위한 태양광 발전 시스템

고재섭(Jae-Sub Ko),최정식(Jung-Sik Choi),정병진(Byung-Jin Jung),김도연(Do-Yeon Kim),박기태(Ki-Tae Park),최정훈(Jung-Hoon Choi),정동화(Dong-Hwa Chung) 한국조명·전기설비학회 2007 한국조명·전기설비학회 학술대회논문집 Vol.2007 No.11월

This paper presents the photovoltaic(PV) water pumping system with a maximum power point tracking(MPPT). The water pumping system uses a variable speed single phase induction motor(SPIM) driven a centrifugal pump by field oriented control(FOC) inverter. The MPPT using a DC-DC converter controlled the duty cycle to track maximum power from PV under different insolation conditions. The duty cycle directly relate with a flux producing current control(i<SUB>ds</SUB>). The FOC inverter uses a current control voltage source inverter(CC-VSI). The simulation results are shown that the characteristics and performance of drive system, which varies as each conditions of light by expresses in voltage(V<SUB>dq</SUB>), current(I<SUB>dq</SUB>), speed of motor and torque.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

IPMSM 드라이브의 최대토크를 위한 적응 FNN 제어기

김도연(Do-Yeon Kim),고재섭(Jae-Sub Ko),최정식(Jung-Sik Choi),정병진(Byung-Jin Jung),박기태(Ki-Tae Park),최정훈(Jung-Hoon Choi),정동화(Dong-Hwa Chung) 한국조명·전기설비학회 2007 한국조명·전기설비학회 학술대회논문집 Vol.2007 No.11월

Interior permanent magnet synchronous motor(IPMSM) has become a popular choice in electric vehicle applications, due to their excellent power to weight ratio. This paper proposes maximum torque control of IPMSM drive using adaptive fuzzy neural network controller and artificial neural network(ANN). This control method is applicable over the entire speed range which considered the limits of the inverter's current and voltage rated value. For each control mode, a condition that determines the optimal d-axis current i<SUB>d</SUB> for maximum torque operation is derived. This paper considers the design and implementation of novel technique of high performance speed control for IPMSM using Adaptive-FNN controller and ANN controller. The hybrid combination of neural network and fuzzy control will produce a powerful representation flexibility and numerical processing capability. Also, this paper proposes speed control of IPMSM using Adaptive-FNN and estimation of speed using ANN controller. The back propagation neural network technique is used to provide a real time adaptive estimation of the motor speed. The proposed control algorithm is applied to IPMSM drive system controlled Adaptive-FNN and ANN controller, the operating characteristics controlled by maximum torque control are examined in detail. Also, this paper proposes the analysis results to verify the effectiveness of the Adaptive-FNN and ANN controller.

서비스업종에서의 안전리더십이 안전문화, 안전행동에 미치는 영향연구

김혜리(Hea Lee Kim ),소한섭(Han Sub So),박교식(Kyo Shik Park),김병직(Byung Jick Kim) 안전문화포럼 2023 안전문화연구 Vol.- No.22

최근 통계를 살펴보면 산업군 중 서비스업 종사 근로자 수는 2017년 약 11,714천 명을 넘어 2021년 13,825천 명으로 매년 지속적인 증가 추세이며, 제조업 약 4,217천명, 건설업 약 1,651천명으로 산업군 중 서비스업 종사자가 가장 많은 것으로 나타났다. 또한, 규모별 산업재해 발생률에서는 50인 미만에서 가장 높은 것으로 확인된다. 최근 고용노동부에서 발표된 중대 재해 감축 로드맵은 조직 내 안전의식 및 안전문화 확산 등 기업의 자율적인 안전보건관리 등을 통하여 산업재해를 감소시키려는 목적이 있다. 본 연구에서는 조직의 안전문화는 조직 내 근로자의 역할이 중요하며, 안전리더십은 조직 안전문화, 안전행동에 영향을 미친다는 선행연구를 토대로 서비스업종에서의 안전리더십이 안전문화, 안전행동에 어떠한 영향을 미치는지 확인하고자 하였다. 안전리더십을 독립변수로 조직 내 안전풍토, 절차, 의식, 태도 등 안전문화와 안전 실천 등의 안전행동에 각각 어떠한 영향을 미치는지 설문조사 하였으며, 50인 이상 사업장과 50인 이하 사업장의 서비스업종에 종사하는 근로자 중 설문에 성실히 응답한 206명을 분석에 활용하였다. 도구에 대한 타탕성과 신뢰성을 확보하기 위해 확인적 요인분석을 실시하였으며 Cronbach's alpha 값을 도출하였다. 또한, 연구 대상과 주요 변수의 특성을 파악하기 위해 빈도분석과 기술통계 분석을 하였으며, 주요 변수 간의 상관관계를 알아보기 위하여 Pearson 상관분석을 통해 확인하였다. Process macro를 활용하여 매개 효과 분석을 하였고, 매개 효과의 유의성은 Bootstrapping-test를 통해 확인하였다. 모든 통계 결과의 유의성은 0.05를 기준으로 하였다. 연구 결과, 안전리더십은 안전문화와 안전행동에 정방향 영향을 미치는 것으로 나타났으나 50인 이상과 50인 미만은 다른 양상을 보였다. 즉 50인 이상 사업장에서 안전리더십은 안전문화와 안전행동에 직접적으로 영향을 미치는 결과를 보였으나, 50인 미만 사업장에서는 안전리더십이 안전문화에는 직접적인 영향이 있었으나 안전행동에는 안전문화라는 매개요인이 작용하여야 영향을 미치는 것으로 나타났다. 본 연구결과를 통해 향후 필요한 연구 및 정책적 제언은 다음과 같다. 첫째, 각 변수의 하위 요인에 대한 세부적인 연구가 필요하다. 둘째, 규모별 서비스업종의 안전문화에 영향을 미치는 추가적인 변인을 확인하여 제도적, 단계적으로 안전문화 확산 및 향상방안을 마련할 필요가 있다. According to recent statistics, the number of service workers in the industry exceeded 11,714,000 in 2017 to 13,825,000 in 2021, with about 4,217,000 in manufacturing and 1,651,000 in construction, the largest number of service workers in the industry. In addition, it is confirmed that the incidence of industrial accidents by size is the highest among those with less than 50 employees. The roadmap for reducing serious accidents recently announced by the Ministry of Employment and Labor aims to reduce industrial accidents through autonomous safety and health management of companies, such as the spread of safety awareness and safety culture within the organization. Based on previous studies that the role of workers in the organization is important for the organization's safety culture, and safety leadership affects organizational safety culture and safety behavior, this study attempted to confirm how safety leadership in the service sector affects safety culture and safety behavior. Safety leadership is an independent variable, and 206 workers in the service sector at workplaces with more than 50 employees and workplaces with less than 50 employees were examined to determine how it affects safety behavior, such as well as procedures, consciousness, and attitudes. A confirmatory factor analysis was conducted to secure compatibility and reliability of the tool, and the Cronbach's alpha value was derived. In addition, frequency analysis and descriptive statistics analysis were performed to understand the characteristics of the study subject and major variables, and Pearson correlation analysis was used to determine the correlation between major variables. The mediating effect was analyzed using the Process macro, and the significance of the mediating effect was confirmed through the Bootstrapping-test. The significance of all statistical results was based on 0.05. As a result of the study, safety leadership was found to have a forward effect on safety culture and safety behavior, but more than 50 people and less than 50 people showed different patterns. In other words, safety leadership directly affected safety culture and safety behavior in workplaces with more than 50 employees, but safety leadership directly affected safety culture in workplaces with less than 50 employees.Through the results of this study, the research and policy suggestions necessary in the future are as follows. First, a detailed study on the sub-factors of each variable is needed. Second, it is necessary to identify additional variables that affect the safety culture of the service industry by size and prepare measures to spread and improve the safety culture in institutional and step-by-step ways.

용융아연도금 Flux농도에 따른 백연발생에 관한 연구

김용환,민병승,정원섭 부산대학교 환경문제연구소 2000 環境硏究報 Vol.18 No.-

Zinc ammonium chloride (ZnCl2-NH4Cl)double salt solution, generally used for dry type batch hot dip galvanizing, has the problem so called "White fume omission". In this stay, white fume emission and adhesion with the total salt amount in the flux solutions were investigated. And also the homogenization of flux film on the substrate surface was examined. We decreased the total salt concentration (ZnCl2-NH4Cl) from 500g/l to 50g/l. As the results, the white fume emission amount was decreased with deceasing the total salt concentration. But adhesion and homogenization were injured. We concluded that the optimum range of the flux concentration is 400g/l~200g/l, and excessive flux film cause the heavy white fume.

PDP형 배면광원용 ZnO:Al 투명전도막의 전기적 특성에 미치는 열처리 효과

김병섭,이성욱,박민우,곽동주 경성대학교 공학기술연구소 2004 공학기술연구지 Vol.11 No.-

Aluminium doped zinc oxide transparent conduction film, which is widely used as a transparent electrodes for many optical devices such as solar cell, PDP, heat mirrors, etc. were prepared by the conventional DC/RF magnetron sputtering methods, using commercial ceramic target with a mixture of ZnO and Al_(2)O_(3). All the films were deposited on Corning glass substrate. The films were heat-treated up to maximum ~400℃ in order to study the effects of heat treatment on the morphological and electrical properties of ZnO:Al film. As the annealing temperature increases, both grain sizes of the film and (002) XRD peak decreases, which results in the increase of electrical resistivity. The electrical resistivity increases by 34% with increasing annealing temperature up to 400 ℃.

주정중독 환자에 있어서 우울에 관한 예비적 연구

김용식,최병호,원장섭 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

The present study purported to explore the relationships between alcoholism and depression in 26 chronic alcoholics who were admitted to National Seoul Mental Hospital. Each of these patients was assessed by Minnesota Multiphasic Personality Inventory, Self-Rating Depression Scale at least 2 weeks after admission, and by dexamethasone suppression test at least 3 weeks after admission according to the medical exclusion criteria(except abnormal hepatic enzyme). The results are summarized as follows: The prevalences of depression in chronic alcoholics are 15% on clinical impression, 23% on self rating depression scale, 53% on Hamilton depression rating scale, 0% on Depression scale of MMPI, 16.7% on Mania scale of MMPI, and 61.5% totally. No significant difference between the normal and the abnormal hepatic enzyme groups was found in 2 serum cortisol levels suppressed by dexamethasone. The two of 26 patients(7.8%) were found to be nonsuppressor by the dexamethasone suppression test. These two patients were converted to suppressor 4 weeks after elavil medication.