급성골수성백혈병 환자에서 DAV 병용화학요법 후의 장기생존율

김삼용,최지영,윤환중,전의건,길준영,조덕연 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Background : Despite substantial progress, the treatment of acute myeloid leukemia(AML) has produced complete remission in 60-80% of patients receiving induction chemotherapy, and median remission duration is about 12 months and only 20% to 35% of patients undergoing consolidation chemotherapy achieve long-term disease-free survival(DFS). We evaluated the long-term outcome of AML patients treated with doxorubicin/Ara-C/VP-16(DAV) induction chemotherapy and consolidation/intensification therapy. Method : Induction therapy : From January 1986 to December 1991, twenty three patients with previously untreated acute myelogenous leukemia received a course of 45mg/㎡ doxorubicin daily intravenously for three consecutive days with Ara-C at 100mg/㎡ by continuous intravenous infusion for eight consecutive days and VP-16 at 100mg/㎡ daily intravenously for three consecutive days. A second course of treatment was started if leukemia persisted on 22 days after treatment. Post-remission therapy : Three to six cycles were given at three or four months interval with Ara-C/doxorubicin/VP-16 regimen or other therapy. Results : Twenty two pateints were evaluable and complete remission was achieved in 16 of 22(73%). Median duration of complete remission was 8 months. The relapse rate was 81% and 63% relapsed in first year. 4-year survival rate of patients entering complete remission(n=16) was 19% and median survival duration was 14.5 months. The postremission chemotherapy was the only significant prognostic factor influencing long term disease free survival. No significant correlation was observed between the probability of survival and age (40< or >40), sex, FAR subgroup, and leukocyte count at diagnosis. The median survival duration were 21 months and 12.5 months for patients who received, or not received postremission chemotherapy respectively(P=0.035). Conclusion : Our results show that DAV combination chemotherapy is a useful therapeutic regimen in remission induction and postremission chemotherapy offering survival advantage in patients with AML entering complete remission.

非晶質 Chalcogenide 薄膜의 電氣傳導

김영기,이형재,정길환 全北大學校 文理科大學 1976 論文集 Vol.4 No.-

The Ⅰ-Ⅴ, characteristics in high electric fields have been investigated on vitreous As-Te-Ge films prepared by vacuum evaporation. The characteristics are analysed in terms of space-charge-limited current, Poole-Frenkel effect, and small-polaron mechanism. A simple SCLC model does not appear to explain the conduction properties. The other two mechanisms show good agreements with our experimental results. From these agreements, acceptor-like localized states are assumed to exist in the band gap. The field-assisted-thermal emission of electrons from the localized states in the valence band tail into the assumed states in the gap is likely to explain the electrical properties. Small activation energy E=0ㆍ43ev(Ⅰ~exp(E-/kT)) compared with optical absorption edge E_opt=1ㆍ34ev gives the evidence that the amorphous material cannot be treated as a simple intrinsic semiconducor.

중학교 체육교사의 수업스트레스가 직무만족에 미치는 영향

김환석,이종길 충남대학교 체육과학연구소 2007 體育科學硏究誌 Vol.25 No.1

In order to determine whether there are differences in class stress that middle school physical education teachers experience before, during and after class according to their background characteristics, we distributed a total of 900 questionnaires to physical education teachers in Daejeon and Chungcheongnam do, and excluding 502 not answered or answered unreliably, we used 398 questionnaires in analysis. In order to analyze differences in class stress and job satisfaction according to middle school physical education teachers' background characteristics and the effects of class stress on job satisfaction, we used statistical methods including one way ANOVA, Scheffe test and multiple regression analysis using the SPSS Windows V. 12.0 program. From the results of this study obtained through the research methods and procedures above, conclusions were drawn as follows. 1) there was no significant difference in class stress according to physical education teachers' background characteristics. 2) as to difference in job satisfaction according to physical education teachers' background characteristics, the sub factors of job satisfaction showed significant differences according to gender and school type. That is, satisfaction with human relations and satisfaction with duties were higher in female teachers. By school type, teachers at coeducational middle schools showed higher job satisfaction. 3) according to the results of analyzing the effects of physical education teachers' class stress on their job satisfaction, class stress was found to have a significant effect on job satisfaction. As presented above, physical education teachers' class stress was found to be in a close relation with their job satisfaction. Class stress, which has a considerable effect on job satisfaction, comes from the 7th National Curriculum applied to physical education classes, teachers' specialty (teaching method, teaching materials, program development and teacher training), teachers' characteristics (teachers' demonstration, feedback, explanation and student observation), the condition of educational administration (the principal's behavioral pattern, administrative support from the school, etc.). Thus, teachers should be reeducated in order to enhance their specialty and refine their characteristics, and resolve stress from the poor condition of educational administration and other sources. With these efforts, physical education teachers' job satisfaction will be enhanced. Therefore, we need to invest sufficient time and efforts in developing teaching methods, teaching materials, programs and teacher training, and it is required to improve the conditions of educational administration including support from the principal and the school administration.

私立大學의 外部監査制度 改善에 관한 實證硏究

김길조,박충환 中央大學校經營硏究所 2002 經營學論集 Vol.28 No.2

친환경농업 농가 컨설팅에 대한 반응 조사

오환중,차광홍,정우진,김길용,박노동 全南大學校 農業科學技術硏究所 2011 農業科學技術硏究 Vol.46 No.-

The interactions between Environment-Friendly Agriculture Research Center (EFARC) and farmers in Jeonnam Province area who have practiced environment-friendly agriculture (EFA) under guidances of EFARC were investigated through enquete. The enquete was conducted during July - September, 2010. One hundred and eighty nine farmers responded all inquiries among 200 farmers. The main results are summarized as follows: 1. Rice was the predominant crop grown by farmers (49%), and the next major was hot pepper (12%). Most farmers (95.3%) have practiced environment-friendly agriculture at the levels of no-pesticide (55.6%), lower pesticide (32.8%), and organic (6.9%). 2. Major motivations of practicing EFA are for the production of safe foodstuffs (52.6%) and for an increase of income (40.1%). 3. Around 3 quarters of the environment-friendly agriculture products are shipped through Nonghyup, the cooperative marketing. The price margin between ordinary agriculture products and EFA products was of 5~10% for 63.5% farmers, of 10~20% for 14.3% ones, and of 20~30% for 14.8% ones. 4. Bottlenecks for practicing EFA are in the order of the unstability of shipping price (34.9%), cultivation techniques (20.1%), excess labor input (19.6%), and control of disease and insect pest (18%). 5. It turned out that more than 90% farmers who have practiced EFA under guidance of EFARC recognized the consulting activities of EFARC as to be helpful for them. 6. Establishment of national organizations which are specialized in consultation for EFApracticing farmers has been suggested.

小麥의 稈長 遺傳에 관한 연구

曺章煥,吳正行,蔡濟天,鄭吉雄,金鳳九 단국대학교 1992 論文集 Vol.26 No.-

This study has been conducted to investigate the genetic and ecological variation of wheat culm length measured from those plants grown at greenhouse. The results are as following. 1. The clum length of the winter wheat was higest under 12hrs daylength, while that of the spring wheat was highest under 8hrs daylength. Standard errors of culm length was larger under 12 and 8hrs daylength than that of 24hrs daylength condition. 2. The culm length was shortest under the 24hrs daylength compare to under 12 or 8hrs while it was highest under 12hrs. Short and medium culm length varieties were photo-insensitive but those of long culm length were photo-sensitive. 3. There are many types of varietal differences for the culm length under the daylength conditions. Highest culm length group under 12 and 8hrs conditions was classified. The semi-dwarf varieties that did not change their plant heights under i and 12hrs conditions were Hira, Yecora Resel, Sava, Sturdy, Saric 70, Sekidorisai 66etc. 4. Varietal difference of culm elongation was noticed between 8hrs and 12hrs daylength condition. On the basis of the evidences obtained from this experiment, it may be concluded that the genetic studies related to culm length should be carried out under the most favorable conditions for culm elongation. 5. Correlation coefficients estimated between culm length and heading or maturity were negative but insignificant, but their correlations were highly significant between photo treatments. 6. Culm length of F_1 was intermediate to the range of F_2 population which seems to be distributed normally. In this regard the gene involved with culm length seemingly inherit additively. Statistical analysis for the involved genes for culm length suggested 2 genes for the semidwarf variety Robin #2.

급성골수백혈병에 대한 관해유도화학요법 후의 Granulocyte Colony-stimulating Factor의 효과

윤환중,최지영,전의건,길준영,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Granulocyte colony-stimulating factor(G-CSF) have been shown to hasten the recovery of neutropenia following anti-cancer chemotherapy. There are controversial opinions on the use of G-CSF in acute myelogenous leukemia(AML) because clonogenic studies have shown that G-CSF stimulates leukemic colonies as well as granulocyte colonies. In this study, we evaluated the effectiveness and safety of recombinant human G-CSF after induction chemotherapy with DAV regimen(Ara-C 100mg/㎡ day 1-8, Doxorubicin 45mg/㎡ day 3-5, VP-16 100mg/㎡ day 6-8) in 9 patients with AML. G-CSF therapy(200 ㎍/㎡/day) was begun 2 days after the end of chemotherapy and continued for 10 days. 17 AML patients who recieved the same chemotherapy before the onset of this study were used as historical control. G-CSF shortened the duration of granulocytopenia (less than 500/㎣) significantly (13 vs 23 days, p<0.001), but it had no effect on platelet recovery. Although the incidence of febrile episodes was almost the same, the duration of febrile episodes was shorter in the group treated with G-CSF( 5 vs 12 days, p=0.03). There was no evidence that G-CSF accelerated the regrowth of leukemic cells and the complete remission rates between the 2 groups were not different. These results show that G-CSF accelerates the recovery of granulocytopenia and shortens the febrile days after chemotherpy in patients with AML, without affecting the regrowth of leukemic cells.

초음파 반사 패턴과 주파수 대역 분할 신호처리를 이용한 다층구조인 노내 간극 측정

구길모,심철무,김종환,김상백,김희동,박치승 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.4

모의 원자로내 용융물 냉각 실증 실험 결과 용융물 Al₂O₃/Fe themite 와 lower head vessel사이에 간극이 발생된다. 간극을 정량적으로 측정하기 위한 기존의 초음파 방법은 구조물의 복잡성과 2300℃ 에서 용융되는 thermite Al₂O₃/Fe, Al₂O₃의 영향으로 발생되는 lower head의 열영향부위(HAZ)의 금속학적인 결정입자 크기의 변화로 결정 계면으로부터 발생되는 잡음신호와 초음파 산란, 감쇠, 모드 변환 등이 발생되어 신뢰성이 떨어지고 있다. 간극을 정량적으로 측정하기 위해서 thermite와 lower head 사이에 물이 체워진 형태의 즉 고체, 액체, 고체의 다층구조에서 초음파의 진행 및 반사 형태를 분류 및 분석하였다. 결정립의 잡음을 억제하기 위하여 주파수대역의 확률 처리 방식인 PT(polarity threshold) 알고리즘을 이용하여 약 6dB 신호 대 잡음비의 개선효과를 가져왔다.

노안수술후 각막형태검사 변화

박근성,고길환,김용선,이재림,민병무,최시환 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

We prospectively analyzed the corneal topography of 26 eyes in 26 patients who had undergone scleral expansion for correcting presbyopia. We examined 26 eyes of 26 patients which were devided into 2 groups (mean age: 51 years, range 40-60 years) according to type of scleral expansion band, with computerized corneal topographic analysis system. Preoperatively and 5 times postoperatively (1day, 1week, 2weeks, 1month, 2months), quantitative descriptors of corneal topograpgy such as Sim K (simulated keratometry value), SRI(surface regularity index), and SAI(surface asymmetry index) were measured at each visit. The mean follow-up period was 43 days. Sim K of the operative eyes ranged from 0 to 2.5 (mean, 0.93) before operation, and mean 2.24 at postoperative 1 day in group Ⅰ. In group Ⅱ, Sim K was mean 2.20 at postoperative 1 day and decreased thereafter. SRI was from 0.54 to 1.39 and SAI was from 0.09 to 0.45 before operation. After operation, mean SAI was maximum at postoperative 2 week and mean SRI was maximum at postoperative 1 day and decreased thereafter. After two months, it became minimum. This study demonstrates that quantitative topographic change after scleral expansion for correcting presbyopia were great during first 1 week after surgery but this change diminished thereafter. Further long studies are in progress to evaluate the long term effects of this procedure.

진행암 환자에서 Cisplatin 병용화학요법 시 Ondansetron의 오심 구토 조절 효과

조문준,윤환중,전의건,길준영,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

Ondansetron is a novel agent that selectively binds to the 5-hydroxytryptamine_3 receptor, and has been reported to have a prominent effect in the prevention of anti-neoplastic agent induced nausea and vomiting. Twenty solid tumor patients who were scheduled to receive cisplatin containing combination chemotherapy participated in a prospectively open-labeled study to evaluate the antiernetic efficacy and safety of ondansetron. The male to female ratio was 11 : 9 and median age was 49(16-70). The sites of primary neoplasms and number of patients were as following : head and neck 4, metastatic carcinoma of unknown primary site 3, stomach 3, osteosarcoma 2, ovary 2, esophagus 1, melanoma 1, penile 1, bladder 1, cervix 1, and extragonadal germ cell 1. Ondansetron was given as an 8mg loading dose IV before chemotherapy followed by 8mg IV every 8 hours until 24 hours after chemotherapy completion. Complete or major control(0 to 2 emetic episodes) of emesis was achieved in 17 of 20 patients(85%;complete 50%, major 35%) receiving ondansetron during the first 24hrs of chemotherapy. During the period of day 2 through clay 5 of chemotherapy, 14 of 20(75%) patients had complete or major control of emesis(complete 35%, major 35%). No severe side reactions were recorded in ondansetron treated patients, while mild to moderate headache was noted in 20% of patients. These results show that ondansetron is effective in the control of cisplatin induced nausea and emesis, and can be administered safely with minimal side effects.