Cloning, Purification, and Characterization of a New DNA Polymerase from a Hyperthermophilic Archaeon, Thermococcus sp. NA1

( Yun Jae Kim ),( Hyun Sook Lee ),( Seung Seob Bae ),( Jeong Ho Jeon ),( Jae Kyu Lim ),( Yo Na Cho ),( Ki Hoon Nam ),( Sung Gyun Kang ),( Sang Jin Kim ),( Suk Take Kwon ),( Jung Hyun Lee ) 한국미생물생명공학회 2007 Journal of microbiology and biotechnology Vol.17 No.7

식도암과 위암이 동시에 발생한 원발성 중복암 1예

윤혜원,심기남,나선경,송도경,정정화,정가영 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5∼27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.

건설 사업장의 작업 공정별 분진 발생량 평가

장봉기,이종화,박종안,최윤나,이익진 순천향대학교 기초과학연구소 2004 순천향자연과학연구 논문집 Vol.10 No.2

Airborne dust emission among construction industry place of work that locate on Pyeongtaek, Gyeonggi province of 4 processes (a plaster, cutting, hammer drill, concrete grinding) were analyzed. Work did in state that a worker does not exist except measurer as well as is not attained to control group. Investigation period did for 2 months from October to November. It measured 15 times by each process by personal air sampling method that is direct-reading particulate matter measurement device(digital dust indicator). When a plaster work, the dust was class 3 particulate matter, and geometric mean is 2.14㎎/m³, and occasion that exceed 10㎎/m³ that is threshold limit value was 13.3%. Control group was 0.35㎎/m³. plaster work was statisically difference higher than the control group (p<0.001). It was not significant difference between fixed type cutting machine work (0.96㎎/m³) and control group. It were not exceeded for threshold limit value. Geometric mean was 10.44㎎/m³ at movable type cutting machine process. Threshold limit value of this process was exceeded 53% and concentration of total dust was significantly higher than control group (p<0.001). Geometric mean was 3.22㎎/m³ at diameter 13.45㎜ drill work among hammer drill work and all cases not exceeded for threshold limit value, but it was significantly higher than control group(p<0.001). When work diameter 6.5㎜ drill, geometric mean was 4.06㎎/m³ and exceeded for threshold limit value was 13.3%, it was significantly higher than that of control group (p<0.001). It showed higher concentration of dust by diameter is smaller drilling. All 15cases exceeded threshold limit value at concrete grinding work, geometric mean was 78.38㎎/m³, and it was significantly higher than that of control group (p<0.001). As a result of above, countermeasure preparation that concentration of total dust by each process in construction workplace was specially required because exceeded threshold limit value of working environment more than 50% at process of concrete grinding work and movable type cutting machine.

The Conjugated Double Bond of Coniferyl Aldehyde Is Essential for Heat Shock Factor 1 Mediated Cytotoprotection

Choi, Seul-Ki,Mun, Gil-Im,Choi, Eun,Kim, Seo-Young,Kwon, Youngjoo,Na, Younghwa,Lee, Yun-Sil American Society of Pharmacognosy 2017 Journal of natural products Vol.80 No.8

<P>Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice. These results suggested that the vinyl moiety of 1 and 2 is necessary for inducing HSF1, which may be useful for developing small molecules for cytoprotection of normal cells against damage by cytotoxic drugs and radiation.</P>

Thickness of Soybean Seed Coat

Ki Na Yun,Dong Hoon Shin,Ihn Jung Ryu,Min Ho Chong,Tae Jin Hahn,Young Mo Yang,Dong Jin Chon,Seung Keun Jong 한국육종학회 2007 한국육종학회 학술발표회 발표요지 Vol.39 No.1

『국한문신옥편』 한자음 특징 연구

나윤기(Na Yun Ki)(羅潤基) 대한중국학회 2016 중국학 Vol.55 No.-

1908년에 출판된 『국한문신옥편』은 『전운옥편』을 저본으로 하여 한글 뜻풀이를 첨가하고 음운을 정리한 최초의 근대적 성격을 지닌 자전이다. 『전운옥편』과 약 100년의 시간적 차이가 있는 『국한문신옥편』은 편자의 의도에 의해 일부 한자음에 대해 수정을 가하였다. 본 논문은 『국한문신옥편』의 수정 한자음을 대상으로 그 유형과 성격을 『화동정음』 『전운옥편』등과 비교 분석하여, 『국한문신옥편』 한자음의 특징을 제시함으로써 字典史上의 가치를 조명하고자 한다. “Gookhanmun-shinokpyeon” published in 1908 is the first dictionary characterized as a modern one in which meaning explications have been added and pronunciations have been summarized. “Gookhanmun-shinokpyeon” temporally different about 100 years from “Jeonun-okpyeon” was corrected for some sounds of Sino-Korean with the intention of the editor. This paper attempted to highlight the value that this dictionary has in terms of the history of dictionaries by comparing and analyzing the types and natures for the sounds of corrected Sino-Korean in “Gookhanmun-shinokpyeon” and presenting the features of the sounds of the Sino-Korean in the dictionary.

안전성약리시험의 Good Laboratory Practice 평가기술연구

최기환(Ki Hwan Choi),박기숙(Ki Sook Park),이윤희(Yun Hee Lee),나한광(Hang-Kwang Na),윤재석(Jae Suk Yun),김동섭(Dong-Sup Kim),김주일(Joo-Il Kim) 한국독성학회 2006 Toxicological Research Vol.22 No.2

Safety pharmacology studies are conducted to investigated the potential undesirable pharmacodynamic effects of a substance on physiological functions in relation to exposure in the therapeutic range and above. In the International Conference on Harmonisation (ICH), the guideline “S7A : Safety Pharmacology Studies for Human Pharmaceuticals” has been developed and reached Step 5 of the ICH process in 2001. Now the Korea Food and Drug Administration (KFDA) are going to transfer “The Guideline for General Pharmacology” into “The Guideline for Safety Pharmacology”. Safety pharmacology studies should be performed in compliance with Good Laboratory Practice (GLP). Thus, the present paper reviews the Japanese GLP guidelines for pharmaceuticals to help the conduct and inspection of safety pharmacology studies in compliance with GLP. We also reviewed the ICH guidelines “S7B revised : The Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals” and “E14 : The Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-antiarrhythmic Drugs” to apply our drug approval systems.

서울ㆍ아산지역 호흡성먼지의 금속함량에 관한 연구

최윤나(Yun-Na Choi),전용택(Yong-Taek Jeon),장봉기(Bong-Ki Jang),양원호(Won-Ho Yang),염윤기(Yoon-Ki Yom),손부순(Bu-Soon Son) 대한환경위생공학회 2008 대한환경위생공학회지 Vol.23 No.1

The purpose of this study was to characterize background mass concentration of PM₁?, PM2.5 and metallic composition from June 2004 to June 2005 in comparison with Seoul and Asan city. The results were as follows: 1. Annual mean of PM₁₂ concentrations in Seoul and Asan were 56.95(±25.63)㎍/㎥, 57.02(±27.22)㎍/㎥ respectly. 2. Annual mean of PM2.5 concentrations in Seoul and Asan were 46.97(±40.36)㎍/㎥, 42.16(±21.79)㎍/㎥ respectly. 3. The average PM2.5/PM₁? ratio was 0.82 in Seoul and 0.74 in Asan city. 4. The concentration of PM₁?, PM2.5 were the highest in spring and the lowest in summer. Asan was higher than Seoul in spring and summer. 5. The results showed that average PM₁? composition order as Si>Fe>Pb>Zn>]Mn in Seoul and Si>Fe>Zn>Pb>Mn in Asan. The concentration of metals in PM₁? of Seoul that Cr, Cu, Fe, Mn were high in spring and Zn was low in Fall. Fe, Mn were high in spring of Asan. 6. The results showed that average PM2.5 composition order as Si>Pb>Fe>Zn>Mn in Seoul and Si>Fe>Pb>Zn>Cr in Asan. The concentration of metals in PM2.5 of Seoul that Cr was high in spring. 7. The result showed that relation between Cr and Cu, Cu and Fe, Fe and Mn, Mn and Zn, Zn and Si in Seoul, Cr and Zn, Cu and Pb, Zn and Pb, Pb and Mn in Asan. The result showed that PM₁? concentration exceeding 50㎍/㎥(US-EPA Standard) and PM2.5 concentration exceeding 15㎍/㎥(US-EPA Standard). In urban area, the monitoring of PM2.5 permits the anthropogenic sources and the interference of natural sources with respect to PM₁? measurements.

유아의 기질과 순응/불순응 행동 간의 관계에서 어머니의 통제전략의 매개적 효과

신나나(Na Na Shin),도현심(Hyun Sim Doh),김민정(Min Jung Kim),송승민(Seung Min Song),김수지(Soo Jee Kim),윤기봉(Ki Bong Yun),두정일(Jeong Il Doo) 한국아동학회 2014 아동학회지 Vol.35 No.6

The main purpose of this study was to examine the mediating effects of maternal control strategies on the relationship between preschoolers` temperament and compliance/noncompliance. A total of 125 mothers with preschoolers aged 3 and 4 years participated in this study. Preschoolers` temperament was reported by mothers. Maternal control strategies and preschoolers` compliance/noncompliance were observed in the laboratory using a clean-up task. There were four major findings. First, preschoolers with higher levels of activity exhibited less compliance, and preschoolers with higher levels of adaptability and activity displayed more noncompliance. Second, preschoolers whose mothers used fewer commands and more compliments displayed more compliance and less noncompliance. Third, mothers who rated their children higher in activity level used more commands with their children. Finally, the use of maternal commands mediated the association between preschoolers` activity level and compliance/noncompliance. When preschoolers` activity level and maternal control strategies were considered together to predict preschoolers` compliance/noncompliance, the relationship between activity level and compliance/noncompliance became nonsignificant. These findings suggest that the effects of temperament on compliance/noncompliance are indirect through maternal control strategies.

일제강점기 자전의 한글 표기법 양상 연구

나윤기(Na, Yun-Ki) 대한중국학회 2018 중국학 Vol.63 No.-

일제 강점기의 국어는 근대후기 국어와 현대국어를 잇는 과도기로서, 두 시기의 표기상의 특징이 혼재하고 있다. 이 시기에 출판된 근대적 성격을 띤 한자 자전의 한글 뜻풀이 표기 방식은 현대국어 표기법이 점진적으로 형성되는 과정을 보여주고 있다. 본고는 일제강점기 자전의 한글 뜻풀이를 국어의 음운 현상과 연계시켜 그 표기 양상과 특징을 살펴봄으로써 당시의 한자 자전이 지닌 자료적 가치와 시대적 위상을 재조명하고자 한다. Korean language in the Japanese colonial era, which is the transition period that connects post-modern with modern is characterized by its mixed orthography that appear in both periods. The orthography shown in the definitions written in Korean in the Chinese character dictionary that is modernistic and published in this period represents the process that modern Korean language orthography is progressively formed. This paper aims to connect the definitions in Korean in the Chinese character dictionary in the Japanese colonial era with Korean phonological phenomenon to examine the notational patters and characteristics and shed new light on the value and periodic status of then-Chinese character dictionary as academic data.