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      • 방사선에 조사된 생쥐의 정소에 미치는 Cysteine의 방어 효과에 관한 현미경적 연구

        최춘근,유관희 연세대학교 대학원 1980 延世論叢 Vol.16 No.2

        This study was made to investigate the radioprotective effects of cysteine on the gamma irra diation injury, by means of electron microscopic examination of the testis of mile treated by cysteine before whole body irradiation. Experimental results obtained are as follows: 1. At 30 minutes after irradiation, the nucleus of spermatogonia began to shrink and round swollen mitochondria of spermatocytes were observed in saline treated group, but cysteine treated group showed slight decrease of cytoplasmic granules. 2. At 2 hours after irradiation, spermatocytes show destruction of nuclear membrane and irregular karyoplasm which was caused by aggregations of chromatin of nucleus in saline treated group. It was also observed aggregation of chromatic in cysteine treated group, but they showed lower appearance than saline treated group. 3. In the group of 9 hours after irradiation, the saline treated group appeared large vacuoles in the cytoplasm and irregular electron dense structures in the nucleus and showed significant aggregation of chromatin. And segregation of nucleolus, aggregations of chromatin were observed in cysteine treated group.

      • KCI등재

        대구지역 산업연관모형에 의한 산업구조분석 : 섬유산업과 성장 유망산업을 중심으로

        이춘근,여택동,김영재 한국경상학회, 한국국민경제학회 2003 경제연구 Vol.21 No.4

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        본 연구는 한국은행에서 작성한 전국 산업연관표를 연구목적에 따라 재분류 통합하여 비조사법에 의해 대구지역 산업연관모형을 작성하고, 이를 토대로 지역산업의 산업연관구조를 분석하고 대구지역에 대한 산업정책적 시사점을 도출하고자 한다. 특히 본 연구에서는 대구지역의 주요 전통산업이 섬유산업이며 그 중에서도 폴리에스터 직물제조가 주종을 이루고 있으므로, 섬유산업을 4개 부문(방적, 직조 및 섬유가공업, 편조업, 의복 및 장신품, 기타 섬유제품)으로 세분하여 대구지역 산업연관표를 작성하고 이를 이용하여 지역산업의 연관구조를 분석하고자 한다. 그리고 대구지역 산업연관모형을 이용한 산업구조분석 결과에 따라 대구지역 지역 전통산업인 섬유산업과 성장유망산업에 관한 산업정책적인 함의를 제시하고자 한다. 특히 본 연구에서는 대구지역의 성장유망산업을 선정함에 있어 입지계수법, 지역 산업연관모형과 같은 지역경제 분석기법을 이용하여 분석한 결과를 반영하여 검토하고자 한다. This paper analyzes the industrial structure in Daegu area. employing the regional input-output model. First, this paper explores the current situation of the regional economy and industrial structure in Daegu and attempts to examine the textile industry which has been a key industry in Daegu region. Second, this paper employs the input-output model to show the linkage effects of both forward and backward directions in the whole industry of Daegu region. Particularly, this paper analyzes the structure of Daegu's textile industry. while considering more categorized sub-divisions of the textile industry in order to investigate the structure of that industry. Lastly, this paper intends to provide the industrial policy implications for the local government as well as the central government. Moreover, the current paper intends to present some fruitful policy implications for the Milan Project that would help enhance the international competitiveness of the textile and apparel industry and thus revive the regional economy in Daegu.

      • SCOPUSSCIEKCI등재

        완전뇌허혈후 재관류시에 국소뇌혈류, 체성감각유발전위 및 신경학적 회복에 대한 Mannitol과 Thiopental의 효과

        박춘근,이상원,박영섭,최승진,허필우,정동섭,강준기,최창락 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.2

        The cardiopulmonary bypass or cerebral circulation arrest is often used in the treatment of complex aneurysm or of arteriovenous malformation to decrease the risk of intraoperative aneurysm rupture. Although experimental studies have suggested that some drugs may protect the brain from ischemic injury, there are limitations in maintaining cerebral perfusion arrest without incurring neurologic deficits due to the initiation of detrimental processes including excitotoxic neuronal injury, activation of phospholipases, influx of calcium, and generation of damaging free radicals. The purpose of this study is to determine wheter mannitol or thiopental has any favorable effects on the recovery of neurologic deficits and on the regional cerebral blood flow(rCBF), somatosensory evoked potential(SEP) and electroencephalogram(EEG) in cats which underwent 15 minutes-complete global ishcemia-reperfusion. The complete global ischemia was produced in 38 cats by temporary intrathoracic occlusion of the innominate artery and the subclavian artery following ligation of bilateral mammary arteries and simultaneous induction of hypotension. The cats were allocated randomly to one of 4 treatment groups : (1) control group, 8 cats received equal volume of saline solution : (2) thiopental group, 10 cats received 45㎎/㎏ thiopental intravenously, (3) mannitol group, 10 cats received 2g/㎏ mannitol intravenously, (4) combined mannitol and thiopental group, 10 cats received equal dose of mannitol and thiopental intravenously. The drugs were administrated in a equally divided dosage before and after the ischemic episode. The results were as follos : 1) Eight animals which received saline showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours after the ischemia. 2) Ten thiopental-treated animals also showed the severe postischemic hypoperfusion and poor recovery of SEP and EEG, and 6 of them died within 6 hours the ischemia. 3) Both mannitol-and combined treated groups showed early recovery of EEG, good recovery of SEP and EEG without the severe postischemic hypoperfusion, and 7 of 10 mannitol-treated animals and 8 of 10 combined treated animals were significantly recovered in all parameters. There were not significant differences in all parameters between the mannitol-and combined treated groups. 4) Thirty-four of 38 animals involved in this 15 minutes-ischemia resulted in the severe neurologic deficits inspite of treatment with mannitol, thiopental or both of them. These results suggest that, in cats, mannitol treatment is effective but not thiopental in preventing severe neurologic injury following complete global ischemia and the duration of complete ischemia should be far less than 15 minutes.

      • KCI등재후보

        2-Methylisoborneol(2-MIB)제거를 위한 산화 및 흡착공정의 특성

        최근주,김상구,류동춘,신판세,손인식,오광중 한국환경과학회 2002 한국환경과학회지 Vol.11 No.3

        One of the Musty and earthy smell compounds in raw water is generally attributed to 2-methylisoborneol (2-MIB). It is well known that activated carbon and oxidants such as O_3, ClO_2 are effective ways to control 2-MIB. In isotherm equilibrium experiments, 2-MIB in distilled water was much more adsorbed to the activated carbon(A/C) than raw water containing dissolved organic carbon (DOC). The Freundlich constants(k) of distilled water and raw water were 3.36 and 0.049, and 1/n values were 0.80 and 0.42, respectively. The 2-MIB residual rate were Y = e^(0.55_x)~ e^(-0.54_x) with Ozone(O_3) dose by 5 minutes contact time at the 241 and 353 ng/L initial concentrations. The 2-MIB residual rate were Y = e^(-0.32_X)~ e^(-0.35_X) with Chlorine dioxide(ClO_2) dose by 15 minutes contact time at the 89 and 249 ng/L initial concentrations. 2-MIB was decreased from 1911 ng/L to 569ng/L by post-ozonation(70%removal efficiency) and removal efficiencies of 2-MIB by the following 4 kinds Granular Activated Carbon(GAC) process such as coal base, coconut base, wood base and zeolite+carbon base were 95.8, 89.5, 88.4, and 93.7% respectively.

      • 콘크리트 슬래브의 진동제어에 관한 연구

        변근주,방춘석,노병철 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.2

        In recent years, the design criteria for vibration control are more strict. In this study, the dynamic characteristics of the slab is analyzed and the vibration is controlled for the special peculiarity of structures. First, the procedure of dynamic analysis is developed by the finite element method and then examined by using the slab model tests. Second, in order to improve the dynamic characteristics, the effects of the number of supports, material properties, position of exciting force, added mass and dynamic balance on the dynamic behavior of concrete slabs are analyzed. It is concluded that the vibration can be controlled by the change in the natural frequency of system and the use of the high-strength concrete or polymer impregnated concrete(PIC), and the dynamic characteristics can considerably affected by the arrangement of equipments, and added mass. etc.

      • KCI등재

        서울지역에서의 VOCs 오염원 기여도 추정에 관한 연구

        봉춘근,윤중섭,황인조,김창녕,김동술 한국대기환경학회 2003 한국대기환경학회지 Vol.19 No.4

        A field study was conducted during the summer time of 2002 to determine compositions of volatile organic compounds (VOCs) emitted from vehicles and to develop source emission profiles that is applied to CMB model to estimate the source contribution of certain area. Source emission profile is widely used for the estimation of source contribution by the chemical mass balance model and have to be developed applicable fur the large1 area of estimation. This study was aimed to develop source emission profile and estimation of source contribution of VOCs after application of the chemical mass balance (CMB) receptor model. After considering the emission inventory and other research results for the VOCs in Seoul, Korea, the sources like vehicle emission(tunnel), gas station (gasoline, diesel), solvent usage (painting operation, dry cleaning, graphic att), and gas fuels were selected for the major VOCs sources. Furthermore, ambient air samples were simultanceusly collected from 09:00 to 11:00 for four days at eight different official air quality monitoring sites as receptors in Seoul during summer of 2001. Source samples were collected by canisters, and then about seventy volatile organic compounds were analyzed by gas chromatography with flame ionization detector (GC/FID). Based on both the developed source profiles and the database of the receptors, CMB model was intensively applied to estimate mass contribution of VOCs sources. Examining the source profile from the vehicle, the portion of alkanes of VOCs was highest, and then the portion of aromatics such toluene, m/p-xylene were followed In case of gas fuel, they have their own components: the content of butane. propane. ethane was higher than any other component according tn the fuel usage. The average of the source apportionment on VOCs for 8 sites showed that the major sources were vehicle emission and gas fuels. me vehicle emission source was revealed as having the highest contribution with an average of 49.6% and followed by solvent with 21.3%, gas fuel with 16.1%, gasoline with 13.1%.

      • VOCs의 시료채취 및 보관에 따른 안정성 검토

        봉춘근,김동술,김영두,김광래 경희대학교 환경연구소 2002 環境硏究 論文集 Vol.11 No.-

        This study was fulfilled to evaluate the durability of VOCs for different sampling methods. The sampling methods widely used to collect atmospheric VOCs are Canister method (EPA method TO-141, Absorbtion tube method (EPA method TO-17), and Tedlar-bag method, and those methods are used in this study. The samples were analyzed after 0, 1, 3, 7, 15, 30 days to figure out the durability of components while keeping under low temperature (4℃) and room temperature (about 20 ℃). Each sample collected by above sampling method was analyzed by high resolution gas chromatography (GC) with flame ionization detector (FID). The test results were shown that the compounds in canisters and absorbtion tubs were stable, but the ones in tedlar-bags were not stable. Heavy components such as Toluene, m/p-Xylene in absorbtion tubes were kept their stability for a long time longer than the ones in canisters. However, the reducing rates of heavy components in canisters were not bigger than those of Tedlar-bags. The VOCs sample collected and stored in tedlar-bag are unstable for analysis, even after a days. As a result of this study, it is found that Canister method and Absorbtion tube method are reliable for collection and storage for a variety of ozone precursors compared to Tedlar-bag method. It is strongly recommended that the samples collected using Tedlar-bag need to be analysed shortly after sampling.

      • KCI등재
      • Actinomycin D가 거세된 휜쥐 섭호선의 미세구조에 미치는 영향

        최춘근,고기석,이재익 연세대학교 자연과학연구소 1985 學術論文集 Vol.15 No.-

        정상인 흰쥐의 섭호선 조직과 거세를 시켜서 androgen의 영향을 억제시킨 흰쥐의 섭호선 조직, 그리고 거세시킨 후 actinomycin D를 투여하여 이와 같은 항생물질이 섭호선에 주는 미세구조의 변화를 관찰하고 위의 각 군에서 조직화학적인 방법을 이용하여 acid phosphatase의 반응을 전자 현미경으로 관찰하였다. 이 결과 거세시킨 흰쥐의 섭호선 세포에서 세포소기관의 소멸, 미세융모의 퇴화등 변화를 나타내었고, androgen의 영향이 없을 경우 세포의 대사이상을 나타내었고, actinomycin D를 처리하였을 경우 핵의 chromatin mass의 증가, 세포막의 파괴와 라이소좀이 증가되는 경향을 나타내었다. acid phosphatase의 반응은 거세된 흰쥐 세포에서 핵과 세포질에 분포하나 actinomycin D를 투여한 군에서는 주로 핵에 분포하는 경향을 나타내었다. Ultrastructural changes of prostates of the normal rats, castrated rats and actinomycin D treated castrated rats are studied with electron microscope. In addition, reaction of acid phosphatase is studied by histochemical method in each group. Disappearance of cell organells, (mitochondria, ER) degeneration of microvilli are characteristically observed in the castrated rat prostate. Increase of chromatin mass, destruction of cell membrane are seen in the actinomycin D treated castrated rat prostate. Reaction products of acid phosphatase are ubiquitous in nucleus and cytoplasm of the castrated rat prostate, but this reaction is predominant in nucleus of the actinomycin D treated castrated rat prostate.

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