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Kentaro Okada,Seiji Ohtori,Gen Inoue,Sumihisa Orita,Yawara Eguchi,Junichi Nakamura,Yasuchika Aoki,Tetsuhiro Ishikawa,Masayuki Miyagi,Hiroto Kamoda,Miyako Suzuki,Gou Kubota,Yoshihiro Sakuma,Yasuhiro Oi 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.3
Study Design: Prospective study. Purpose: To examine the long-term effects of interspinous ligament injections of local anesthetics and steroids for the treatment of Baastrup’s diseases. Overview of Literature: Baastrup’s disease is associated with axial low back pains. Baastrup’s disease has been more recently described as the “kissing spinous processes” disease. Several authors have reported methods for the diagnosis and treatment of the disease. However, there has been only one report of patients receiving interspinous ligament injections of agents for the treatment of Baastrup’s disease. Methods: Seventeen patients showed severe low back pains between spinous processes at L3–L4 or L4–L5. X-ray imaging, computed tomography, and magnetic resonance imaging revealed kissing spinous processes, consolidation of spinous process, or inflammation of an interspinous ligament. Pain reliefs after lidocaine and dexamethasone administration into interspinous ligament as therapy for low back pains were being examined and followed up. Results: Low back pain scores significantly improved immediately after injection of the agents into interspinous ligaments. At final follow-up (1.4 year), low back pain scores significantly improved as compared with before the treatment. Conclusions: Findings from the current study indicate that lidocaine and dexamethasone administration into interspinous ligament in patients diagnosed with Baastrup’s disease is effective for managing the pain associated with this disease.
Tomoaki Okuda,Daiki Shishido,Yoshihiro Terui,Kentaro Fujioka,Ryoma Isobe,Yusuke Iwaki,Koji Funato,Kozo Inoue 한국대기환경학회 2018 Asian Journal of Atmospheric Environment (AJAE) Vol.12 No.1
Filter-based sampling techniques are the conventional way to collect particulate matter, but particles collected and entangled in the filter fibers are difficult to be removed and thus not suited for the following cell- and animal-based exposure experiments. Collecting aerosol particles in powder form using a cyclone instead of a filter would be a possible way to solve this problem. We developed a hybrid virtual-impactor/cyclone high-volume fine and coarse particle sampler and assessed its performance. The developed system achieved 50% collection efficiency with components having the following aerodynamic cut-off diameters: virtual impactor, 2.4 μm; fine-particle cyclone, 0.18-0.30 μm; and coarse-particle cyclone, 0.7 μm. The virtual impactor used in our set-up had good PM2.5 separation performance, comparable to that reported for a conventional real impactor. The newly developed sampler can collect fine and coarse particles simultaneously, in combination with exposure testing with collected fine- and coarse- particulate matter samples, should help researchers to elucidate the mechanism by which airborne particles result in adverse health effect in detail.
Wataru Saito1,Kosuke Mizuno,Gen Inoue,Takayuki Imura1,Toshiyuki Nakazawa,Masayuki Miyagi,Eiki Shirasawa,Kentaro Uchida,Masashi Takaso 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.5
Study Design: Retrospective cohort study. Purpose: To investigate the effect of spinal correction on respiratory muscle strength in patients with Duchenne muscular dystrophy (DMD). Overview of Literature: Several studies have reported that scoliosis correction in patients with DMD does not improve pulmonary function. In these studies, pulmonary function was evaluated using the traditional spirometric values of percent vital capacity (%VC) and percent forced vital capacity (%FVC). However, traditional spirometry may not be suitable for patients with DMD because the results can be influenced by patient fatigue or level of understanding. Therefore, we evaluated respiratory function focusing on respiratory muscle strength using maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and sniff nasal inspiratory pressure (SNIP), in addition to %VC and %FVC. Methods: We retrospectively reviewed 16 patients with DMD who underwent spinal correction surgery between 2006 and 2011 at Kitasato University Hospital. All patients were males, and the mean age was 13.5 years. Respiratory muscle strength was evaluated using MIP, MEP, and SNIP. Measurements were obtained preoperatively and at 1 and 6 months postoperatively, and %VC and %FVC were obtained preoperatively and within 6 months postoperatively. Results: The mean preoperative and postoperative %VC values were 54.0% and 51.7%, whereas the mean %FVC values were 53.9% and 53.2%, respectively. The mean MIP, MEP, and SNIP values obtained preoperatively and at 1 and 6 months postoperatively were as follows: MIP, 40.5, 42.7 and 47.2 cm H2O; MEP, 26.0, 28.0, and 29.0 cm H2O; and SNIP, 33.4, 33.0, and 33.0 cm H2O; respectively. The mean MIP and MEP values significantly improved postoperatively. There were no significant differences in SNIP, %VC, or %FVC preand postoperatively. Conclusions: By focusing on respiratory muscle strength, our results suggest that scoliosis correction in patients with DMD might have a favorable effect on respiratory function.
지방자치제도와 지방자치단체 환경관리체계와의 관계에 관한 연구 -광역자치단체의 환경조례를 중심으로
나승원 ( Seung Weon Na ),성현찬 ( Hyun Chan Sung ),이노우에켄타로 ( Kentaro Inoue ) 한국환경복원녹화기술학회 2009 한국환경복원기술학회지 Vol.12 No.4
This study has focused 302 environmental ordinances enacted from 1974 to 2008 by 16 upper-local governments (7 deignated cities and 9 provinces) and the relationships between them and the development of the Korean local autonomy system. The ordinances have been categorized into three types, the voluntary ones without any obligatory stipulations in laws, the optional ones based on laws, and the law based obligatory ones, which have been examined the enactment years and the contents of them. The local ordinances have been enacted in four periods with a few characteristics, which are "the pre-local-autonomy period (1974-1991)", "the introductory-local-autonomy period (1991-1995)", "the local-autonomy-developing period (1995-1999)", and "the mature-local-autonomy period (after 2000)", along the local autonomy development. 57 ordinances were enacted in the first period, 20 enacted in the second period, 46 enacted in the third period and 179 ordinances in the fourth period. The obligatory ordinances were the most in the first period and in the second period, while the voluntary ordinances were enacted most in the third period. 7 designated cities have pretty more ordinances, 160 in all, than 9 provinces, 142. The tendency to enact earlier in the metropolitan area, SeoulCity, IncheonCity and Gyeonggi province, than the others can be seen. It can be said that the establishment of the local autonomy in Korea had accelerated the development of the local environmental management.
NMR Study of Successive Magnetic Transitions in the A-site Ordered Perovskite LaMn3Cr4O12
Yu Kawasaki,Syota Takase,Yutaka Kishimoto,Takashi Ohno,Ikuya Yamada,Kentaro Shiro,Ryoji Takahashi,Kenya Ohgushi,Norimasa Nishiyama,Toru Inoue,Tetsuo Irifune 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We have investigated the successive magnetic phase transitions of the A-site ordered perovskiteLaMn3Cr4O12 by measuring 139La nuclear magnetic resonance (NMR) spectra. The successivemagnetic transitions are revealed by a very small but clear increase in the full width at half maximum(FWHM) of the 139La NMR signal at TM2 = 150 K and by the disappearance of the signal due to theline broadening at temperatures below TM1 = 50 K. These two magnetic transitions are associatedwith independent orderings within the Cr-site sublattice at TM2 and within the Mn-site sublatticeat TM1. Regarding the magnetic structure of the Cr-site sublattice at temperatures below TM2, thecancellation of internal fields at the La site, ruling out ferromagnetic and multi-q antiferromagneticstructures, is consistent with the typical antiferromagnetic structure for perovskites, such as G-,A- and C-type orders. The uncanceled internal field at the La site at temperatures below TM1is also consistent with these typical antiferromagnetic structures in the Mn-site sublattice. Thedifferences in the temperature dependences of the Knight shift K(T) and the bulk susceptibility χ(T) are consistently explained by the independent magnetic orderings of the Cr- and the Mn-sitesublattices and the cancellation of internal field originating from the Cr-site sublattice at the Lasite at temperatures below TM2.
( Mahmoud Kandeel ),( Mizuki Yamamoto ),( Abdulla Al-taher ),( Aya Watanabe ),( Kentaro Oh-hashi ),( Byoung Kwon Park ),( Hyung-joo Kwon ),( Jun-ichiro Inoue ),( Mohammed Al-nazawi ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.4
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a newly emerging viral disease with fatal outcomes. However, no MERS-CoV-specific treatment is commercially available. Given the absence of previous structure-based drug discovery studies targeting MERS-CoV fusion proteins, this set of compounds is considered the first generation of MERS-CoV small molecule fusion inhibitors. After a virtual screening campaign of 1.56 million compounds followed by cell-cell fusion assay and MERS-CoV plaques inhibition assay, three new compounds were identified. Compound numbers 22, 73, and 74 showed IC<sub>50</sub> values of 12.6, 21.8, and 11.12 μM, respectively, and were most effective at the onset of spike-receptor interactions. The compounds exhibited safe profiles against Human embryonic kidney cells 293 at a concentration of 20 μM with no observed toxicity in Vero cells at 10 μM. The experimental results are accompanied with predicted favorable pharmacokinetic descriptors and drug-likeness parameters. In conclusion, this study provides the first generation of MERS-CoV fusion inhibitors with potencies in the low micromolar range.