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Keiichi Nakahara,Satoshi Yamashita,Katsumasa Ideo,Seigo Shindo,Tomohiro Suga,Akihiko Ueda,Shoji Honda,Tomoo Hirahara,Masaki Watanabe,Taro Yamashita,Yasushi Maeda,Yasuhiro Yonemochi,Tomohiro Takita,Yuk 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background Listeria monocytogenes (L. monocytogenes) is a rare causative pathogen ofbrain abscess that is often found in immunocompromised patients. Although patients with supratentorial listerial abscesses showed a longer survival with surgical drainage, the standardtherapy for patients with subtentorial lesions has not been established. Case Report We report herein a patient with supra- and subtentorial brain abscesses causedby L. monocytogenes infection. These abscesses did not respond to antibiotics, and his symptoms gradually worsened. Drainage was not indicated for subtentorial lesions, and the patientwas additionally treated with hyperbaric oxygen therapy, which dramatically reduced the volume of abscesses and improved the symptoms. Conclusions This is the first report of drastic therapy for a patient with listerial brain abscesses involving combined antibiotics and hyperbaric oxygen therapy. The findings suggestthat hyperbaric oxygen therapy is a good option for treating patients with deep-seated listerialabscesses and for who surgical drainage is not indicated.
A System Concept for EFD/CFD Integration
Shigeya Watanabe,Shigeru Kuchi-ishi,Hiroyuki Kato,Takeshi Aoyama,Keiichi Murakami,Atsushi Hashimoto,Naoyuki Fujita,Yuichi Matsuo 한국항공우주학회 2008 한국항공우주학회 학술발표회 논문집 Vol.- No.-
A trail towards integration of EFD (Experimental Fluid Dynamics) and CFD (Computational Fluid Dynamics), that is. the development of a system called Digital/Analog Hybrid Wind Tunnel, is introduced. The aim of the system is to improve efficiency, accuracy, and reliability of aerodynamic characteristics evaluation in aerospace vehicle developments through mutual support between EFD and CFD. The function of the system consists of optimization of test planning utilizing pretest CFD calculations, an accurate correction of the wind tunnel wall and support interaction effects through CFD, CFD data refinement based on EFD data, the most probable aerodynamic characteristics estimation based on both EFD and CFD data, database including EFD and CFD data at an identical condition, and so forth. Key technical challenges in the system development, such as an automatic grid generation and high-speed solver development for CFD, a highly efficient data reduction technique for image measurement data. and techniques integrating EFD and CFD. are addressed.
Multi-step Metamagnetic Processes of PrPd2Si2 Single Crystal
Toru Shigeoka,Tetsuya Fujiwara,Keiichi Koyama,Shojiro Kimura,Kazuo Watanabe 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
Magnetic studies were performed on PrPd2Si2 single crystals which crystallize in the tetragonalThCr2Si2-type structure. The temperature dependence of the magnetic susceptibility indicates thatthe compound orders antiferromagnetically at temperatures below TN = 3.2 K. The transition wasconfirmed by specific heat measurements. Magnetization measurements at fields up to 18 T showthat the easy magnetization direction is the [100] direction in the basal plane. In the magnetizationprocess, five or four metamagnetic transitions appear; the process is a five (four)-step metamagneticone. The [110] magnetization process is a three-step one. A strong magnetic anisotropy betweenthe [100] and [110] directions is observed within the basal plane for high magnetic fields. Alongthe hard magnetization direction of the c-axis, a metamagnetic transition appears. The B[100] − Tphase diagram was constructed. A magnetic anisotropy between the [100] and [001] directions isalso strong. These behaviors are discussed based on an analysis of crystalline field effects.
Mitsukuri, Yuki,Hara, Ryoichi,Kita, Hiroyuki,Watanabe, Keiichi,Mori, Kenjiro,Kataoka, Yasuhiro,Kogure, Eiji,Mishima, Yuji The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.2
A surge of needs for the low carbon society promotes a spread of electric vehicle (EV). EVs could be charged at night simultaneously, as a result, severe voltage drop may happen. The authors have proposed the method which can compensate the voltage drop caused by EV charging by means of adjusting charging schedules and controlling reactive power. And, we have confirmed the effectiveness of the method by estimating steady state in order to figure out the limitation of the control capability. In this paper, from a practical viewpoint, we propose the method to consider dynamic behavior. In this method, the EV can not only finish charging effectively but also control minimal reactive power to keep admissible voltage with monitoring system voltage.
Yasuaki Fukuda,Masahiro Kanbe,Manami Watanabe,Katsuaki Dan,Keiichi Matsuzaki,Susumu Kitanaka,Shohei Miyata 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.8
We have previously reported that many ingenolcompounds derived from Euphorbia kansui exhibit topoisomerase(topo) II inhibitory activity. Of these compounds,3EZ,20Ac-ingenol inhibited topo I activity. Camptothecin,which inhibits the religation activity of topo I withoutinterfering with the binding of topo I to DNA and inducestopo I-mediated DNA cleavage, was used as a positivecontrol. In this study, we found that 3EZ,20Ac-ingenol didnot hamper the binding of topo I to DNA in the samemanner as camptothecin but affected the inhibition ofcleavage of one DNA strand. 3EZ,20Ac-ingenol inhibitedcell proliferation by blocking cell cycle progression in theG2/M phase. To define the mechanism of inhibition ofDT40 cell proliferation, the change in Akt activity wasobserved because Akt activity is regulated in response toDNA damage. Western blot analysis revealed that3EZ,20Ac-ingenol downregulated the expression of p-Akt,and apoptosis was detected by the presence of DNA double-strand breaks and caspase 3 activation.
Masayuki Ohashi,Toru Hirano,Kei Watanabe,Kazuhiro Hasegawa,Takui Ito,Keiichi Katsumi,Hirokazu Shoji,Tatsuki Mizouchi,Ikuko Takahashi,Takao Homma,Naoto Endo 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.2
Study Design: Retrospective case series. Purpose: To investigate the oncological outcomes, including distant relapse, after en bloc spondylectomy (EBS) for spinal metastases in patients with a minimum of 2-year follow-up. Overview of Literature: Although EBS has been reported to be locally curative and extend survival in select patients with spinal metastases, detailed reports regarding the control of distant relapse after EBS are lacking. Methods: We conducted a retrospective review of 18 consecutive patients (median age at EBS, 62 years; range, 40–77 years) who underwent EBS for spinal metastases between 1991 and 2015. The primary cancer sites included the kidney (n=7), thyroid (n=4), liver (n=3), and other locations (n=4). Survival rates were estimated using the Kaplan–Meier method, and groups were compared using the log-rank method. Results: The median operative time and intraoperative blood loss were 767.5 minutes and 2,375 g, respectively. Twelve patients (66.7%) experienced perioperative complications. Five patients (27.8%) experienced local recurrence of the tumor at a median of 12.5 months after EBS, four of which had a positive resection margin status. Thirteen patients (72.2%) experienced distant relapse at a median of 21 months after EBS. The estimated median survival period after distant relapse was 20 months (95% confidence interval, 0.71–39.29 months). No association was found between resection margin status and distant relapse. Overall, the 2-year, 5-year, and 10-year survival rates after EBS were 72.2%, 48.8%, and 27.1%, respectively. Importantly, the era in which EBS was performed did not impact the oncological outcomes. Conclusions: Our results suggest that EBS by itself, even if margin-free, cannot prevent further dissemination, which occurred in >70% of patients at a median of 21 months after EBS. These results should be considered and conveyed to patients for clinical decision-making.
Aiko Ogasawara,Taro Hihara,Daisuke Shintani,Akira Yabuno,Yuji Ikeda,Kenji Tai,Keiichi Fujiwara,Keisuke Watanabe,Kosei Hasegawa 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Purpose Circulating tumor DNA (ctDNA) is an attractive source for liquid biopsy to understand molecular phenotypes of a tumor non-invasively, which is also expected to be both a diagnostic and prognostic marker. PIK3CA and KRAS are among the most frequently mutated genes in epithelial ovarian cancer (EOC). In addition, their hotspot mutations have already been identified and are ready for a highly sensitive analysis. Our aim is to clarify the significance of PIK3CA and KRAS mutations in the plasma of EOC patients as tumor-informed ctDNA. Materials and Methods We screened 306 patients with ovarian tumors for somatic PIK3CA or KRAS mutations. A total of 85 EOC patients had somatic PIK3CA and/or KRAS mutations, and the correspon-ding mutations were subsequently analyzed using a droplet digital polymerase chain reaction in their plasma. Results The detection rates for ctDNA were 27% in EOC patients. Advanced stage and positive peritoneal cytology were associated with higher frequency of ctDNA detection. Preoperative ctDNA detection was found to be an indicator of outcomes, and multivariate analysis revealed that ctDNA remained an independent risk factor for recurrence (p=0.010). Moreover, we assessed the mutation frequency in matched plasma before surgery and at recurrence from 17 patients, and found six patients had higher mutation rates in cell-free DNA at recurrence compared to that at primary diagnosis. Conclusion The presence of ctDNA at diagnosis was an indicator for recurrence, which suggests potential tumor spread even when tumors were localized at the time of diagnosis.