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1983년에 분리된 Pseudomonas aeruginosa의 항균제내성 및 Pyocin형
백태원,이유철,조동택,전도기 대한화학요법학회 1984 대한화학요법학회지 Vol.2 No.2
1983년 각종의 병원검체에서 92주의 녹농균을 분리하였는데, 농에서 59주(64.1%)로 가장 많이 분리되었다. 16종의 항균제에 대란 감수성 검사를 실시한 결과 rifampin(Rf)에 11주(12.0%)로 가장 내성빈도가 낮았으며, cefotaxime(Ct)에 14주(15.2%), moxalactam(Mx)에 18주(19.6%), amikacin(Ak)에 26주(28.3%)가 내성이었고, carbenicillin, gentamicin(Gm), tobramycin에는 절반이, 그리고 기타의 항균제에는 90% 이상의 군주가 내성이었다. 내성유형을 보면 분리된 군주를 모두 5가지 이상의 항균제에 내성을 나타내었고, chloramphenicol, tetracycline(Tc), streptomycin, sulfisomidine, ampicillin, kanamycin, trimethoprim, cephalothin 및 nalidixic acid의 9개 항균제에 내성을 나타내는 형이 23주로 가장 많았고, Rf을 제외한 나머지 15개 항균제에 모두 내성을 나타내는 형도 11주가 있었다. 90%의 균조의 발육을 저지하는 항균제의 농도(90% MIC)를 보면 Mx, Rf의 64㎍/㎖를 제외하고는 모두 실험한 최고 농도인 512 또는 2,048㎍/㎖ 이상이었으며 Gm, Ct 및 Ak에서는 과거의 보고들보다 높아 이들 항균제에 대한 내성의 증가양상을 관찰할 수 있었다. 녹농균의 역학적 조사방법인 pyocin 형별검사를 Gillies 및 Govan법에 따라 시행한 결과 15A형이 28주(30.4%)로 가장 많았으며. 88D, 18D형이 많이 분리되었고, 가장 많이 분리된 15A형이 Ct, Mx, Tc에 대해 기타의 pyocin 형들보다는 더 높은 내성빈도를 나타내었으며, 88D형은 이들 항균제에 대해 감수성의 경향을 나타내었다. Pseudomonas aeruginosa strains which had been suspected of possible agent in nosocomial infection were tested for antimicrobial susceptibility to 16 drugs of common use and studied the distribution by pyocin type. Ninty-two strains were isolated from various clinical specimens in 1983, a d among them 59 strains(64.1%) were obtained from pus. Rifampin(Rf) was found to be most effective drug in vitro assay by the method of agar dilution. Eleven strains(12.0%) were resistant to Rf and followed by cefotaxime(Ct) which showed 14 strains(l5.2%) of resistant strains, 18 strains(l9.6%) of moxalactam(Mx), and 26 strains(28.3%) of amikacin (Ak) increasing order. About half number of strains were resistant to carbenicillia, gentamicin, and tobramycin and more than 9076 of strains were resistant to the rest 9 drugs. A11 the strains tested were multiply resistant to more than 5 drugs and 23 strains showed multiply resistance pattern to the 9 drugs of chlorampenicol, tetracycline (Tc), streptomycin, sulfisomidine, ampicillin, kanamycin, trimethoprim, cephalothin, and nalidixic acid. Eleven strains were multiply resistant to 15 drugs except Rf. Minimum inhibitory concentration needed t o inhibit 90% of strains (MIC90;μg/ml) of Mx and Rf were 64μg/ml but MIC90 of other 14 drugs were more than 512μg/ml or 2,048μg/ml. Compared to the previous reports, there were increasing tendencies of resistance frequency to the drugs especially Gm, Ct, and Ak. As a system for epidemiological studies of Pseudomonas aeruginosa, pyocin typing were performed through the method of Gillies and Govan. Most predominant type were 15A which occupied 28 strains(30.4%) and followed by type 88D and type 1SD. Strains classified to the were 15A showed higher resistance frequency to the drugs of Ct, Mx, and Tc than those of any other types whereas those of type 88D were more susceptible.
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강진무,서은숙,허상명,백태원 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.4
We experienced a case of alobar type holoprosencephaly without extracranial abnormalities except microcephaly in a 8 months old male infant. The diagnosis was made by brain CT scan, which showed the findings compatible to alobar type of holoprosencephaly. The patient is living up to the age 18 months with severe mental retardation. A brief review of literature was made.
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김성호,백태원 啓明大學校 醫科大學 1984 계명의대학술지 Vol.3 No.2
Etiologic analysis was done on 46cases of hydrocephalus which were proved by brain CT scan under the hospitalization of Pediatric Department of Keimyung University, Dong San Hospital during the 4years from April 1980 to June 1984. The following results were obtained. The incidence of hydrocephalus was highest in early infancy, occupied 34.8% of all patients. CNS infection was the leading cause of hydrocephalus under the age of 6years, while the tumors in age group of over 6years. Amoung the CNS infections, purulent meningitis was the the most frequent cause between 1month and 1year and tuberculous meningitis in 1-6 years of age. 73.9% of hydrocephalus were communicating in which CNS infections were most frequent(47.0%). 26.1% were non-communicating and most of them were tumors (66.7%).
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백태원,강진무,김명성 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2
저자들은 최근 계명의대 소아과에 입원한 환자로써 비장종대, 간경화, Kayser-Fleischer ring, 혈청 cerulopasmin의 감소와 뇨중 동배설량의 증가를 보인 Wilson씨병 환아에 D-penicillamine을 투여하여 효과를 보았기에 문헌적 고찰과 아울러 보고하는 바이다 The authors experienced a case of Wilson's disease in a 14 years old boy, which was confirmed by the manifestations with hepatosplenomegaly, Kayser-Fleischer ring and laboratory data with decreased serum ceruloplasmin and copper, increased 24 hours urine copper excertion, brain MRI and liver biopsy. A brief review of literatures was made.
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백태원,김성호 啓明大學校 醫科大學 1985 계명의대학술지 Vol.4 No.2
The clinical observations on 74 cases of acute drug intoxication under the age of 15 years were done. Objectives were hospitalized to pediatric department of Dong San Hospital during the period of 10 years from January 1974 to December 1983. The following results were obtained : 1) 64.8% were seen between 2-6 years of age and male to female ratio was 1.5 : 1. 2) The incidence was relatively higher in summer(40.5%) and spring(31.3%). 3) The motive of drug ingestion was accidental(73.0%) in majority of cases. 4) The intoxication was occured mostly between 8 : 00 AM to 8 : 00 PM. 5) 65.0% of cases were arrived at emergency room around 6 hours following ingestion of drugs. 6) The causative substances were insecticides(27.0%), rodenticides(22.8%), internal medicine (22.8%) and house-hold agent(12.0%) in order. 7) The cardinal symptoms were mental change(25.7%), vomiting(21.6%), irritability(21.6%), convulsions(17.6%), coma(9.5%) in order. 8) Mortality was higher in weed killer, mercury, and insecticides intoxication and overall mortality was 10.8%.
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