The Expression Profile of Novel Gene PCIA1 and Its Potential Function on Carcinogenesis

Xiang He,Yang Mei Shen,Hong Xin Deng,Jia Wen Zhang,Rui Wang,Yu Quan Wei,Bing Kan,Yu Bing Xie,Xia Zhao 한국유전학회 2007 Genes & Genomics Vol.29 No.2

Reliability Evaluation Technique for Electrical Distribution Networks Considering Planned Outages

Hu, Bo,He, Xiao-Hui,Cao, Kan The Korean Institute of Electrical Engineers 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

The reliability evaluation of the electrical distribution networks (EDN) requires sufficient consideration of the effects of planned outages. The planned outages of the EDN can be divided, by outage models and their effects on the reliability into two major categories: by equipment and by feeder. After studying the characteristics of different categories of planned outages, this paper expands the classification of load points by outage time from 4 types to 7 types and defines corresponding reliability parameters for the different types. By using the section algorithm, this paper proposes a reliability evaluation technique of EDN considering equipment random failures and two categories of planned outages. The proposed technique has been applied to the RBTS-BUS6 test system and some practical EDNs in China. The study results demonstrate that the proposed technique is of higher practical value and can be used for evaluating the reliability performance of EDN more efficiently considering the planned outages.

Evidence of the genetic diversity and clonal population structure of Oenococcus oeni strains isolated from different wine-making regions of China

Dongliang Yu,Kan Shi,Xiangyuan Wen,Fangshu Xie,Tao Wang,Shuwen Liu,Ling He 한국미생물학회 2018 The journal of microbiology Vol.56 No.8

Studies of the genetic diversity and population structure of Oenococcus oeni (O. oeni) strains from China are lacking compared to other countries and regions. In this study, amplified fragment length polymorphism (AFLP) and multilocus sequence typing (MLST) methods were used to investigate the genetic diversity and regional evolutionary patterns of 38 O. oeni strains isolated from different wine-making regions in China. The results indicated that AFLP was markedly more efficient than MLST for typing O. oeni strains. AFLP distinguished 37 DNA patterns compared to 7 sequence types identified using MLST, corresponding to discriminatory indices of 0.999 and 0.602, respectively. The AFLP results revealed a high level of genetic diversity among the O. oeni strains from different regions of China, since two subpopulations and an intraspecific homology higher than 60% were observed. Phylogenetic analysis of the O. oeni strains using the MLST method also identified two major phylogroups, which were differentiated into two distinct clonal complexes by minimum spanning tree analysis. Neither intragenic nor intergenic recombination verified the existence of the clonal population structure of the O. oeni strains.

Magnetic, dielectric and optical properties of five-layered Aurivillius phase Bi6Fe2Ti3O18-based ceramics

Xuzhong Zuo,Enjie He,Jin Bai,Shunjin Zhu,Xucai Kan,Zhenzhen Hui,Jie Yang,Xuebin Zhu,Jianming Dai 한국물리학회 2019 Current Applied Physics Vol.19 No.12

The structural, magnetic, dielectric and optical properties of Aurivillius Bi6Fe2Ti3O18-based ceramics were investigated in detail. The replacement of Co for Fe/Ti ions obviously varies the grain morphology. Compared with Bi6Fe2Ti3O18 (BFTO) with antiferromagnetic ordering, a spin glass state can be observed in Bi5.25La0.75Fe2Ti3O18 ceramic, while other samples exhibit the ferromagnetic behavior. The specimen Bi6Fe2Ti2(NbCo)0.5O18 (BFTNCO) represents the largest remanent magnetization Mr of 0.93emu/g among all the samples, which can be attributed to the combination of a short lattice parameter c and a large lattice distortion as well as more magnetic ions in a unit cell. The room-temperature dc conductivity of BFTNCO is one order magnitude lower than that of BFTO. In addition, the band gaps of Co-doped samples are about 0.2eV smaller than these of Co-free samples. This work provides a promising path forward to tailor the multiferroic and optical properties in five-layered Aurivillius compounds.

Reliability Evaluation Technique for Electrical Distribution Networks Considering Planned Outages

Bo Hu,Xiao-Hui He,Kan Cao 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.5

The reliability evaluation of the electrical distribution networks (EDN) requires sufficient consideration of the effects of planned outages. The planned outages of the EDN can be divided, by outage models and their effects on the reliability into two major categories: by equipment and by feeder. After studying the characteristics of different categories of planned outages, this paper expands the classification of load points by outage time from 4 types to 7 types and defines corresponding reliability parameters for the different types. By using the section algorithm, this paper proposes a reliability evaluation technique of EDN considering equipment random failures and two categories of planned outages. The proposed technique has been applied to the RBTS-BUS6 test system and some practical EDNs in China. The study results demonstrate that the proposed technique is of higher practical value and can be used for evaluating the reliability performance of EDN more efficiently considering the planned outages.

Importance of Extract Standardization and In Vitro/Ex Vivo Assay Selection for the Evaluation of Antioxidant Activity of Botanicals: A Case Study on Three Rosmarinus officinalis L. Extracts

Alvin Ibarra,Julien Cases,Antoine Bily,Kan He,Naisheng Bai,Marc Roller,Aure´lie Coussaert,Christophe Ripoll 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.5

The overproduction of free radicals and oxygen reactive species is suspected to be implicated in a wide range of metabolic reactions that can have pernicious consequences in the development of a variety of human diseases. Botanical extracts are sources of antioxidants that counteract both free radicals and oxygen reactive species. The processing conditions used in the botanical extraction may influence the antioxidant composition; therefore, different extracts from the same plant may have different antioxidant properties. To illustrate this fact, we conducted a study using three commercial rosemary (Rosmarinus officinalis L.) leaf extracts. The three extracts were standardized to contain, respectively, 20% carnosic acid, 40% ursolic acid, or 20% rosmarinic acid. They were evaluated for their total (hydrophilic+lipophilic) antioxidant effects on oxygen radical absorbance capacity (ORAC), their ferric reducing/antioxidant power (FRAP), and their capacity to inhibit Cu2+-induced low-density lipoprotein (LDL) oxidation ex vivo. The ursolic acid extract showed the lowest antioxidant capacity on all models. The rosmarinic acid extract had an antioxidant capacity 1.5 times higher on ORAC and four times higher on FRAP than the carnosic acid extract. However, the carnosic acid extract was better than the rosmarinic acid extract in inhibiting the oxidation of LDL ex vivo. These results encourage conducting further studies to evaluate the carnosic acid and rosmarinic acid extracts in vivo. Our study offers an example of the importance of the extraction procedures, on which depends the nature of the antioxidant composition, and highlights interest to proceed with in vitro/ex vivo assay selection for the evaluation of the antioxidant properties of botanical extracts.

Fatty Acid Binding Protein 5 (FABP5) Promotes Aggressiveness of Gastric Cancer Through Modulation of Tumor Immunity

Shu Zhang,Mei-qing Qiu,Hui-jun Wang,Ya-fei Ju,Zhen Liu,Tao Wang,Shi-feng Kan,Zhen Yang,Ya-yun Cui,You-qiang Ke,Hong-min He,Li Sun 대한위암학회 2023 Journal of gastric cancer Vol.23 No.2

Purpose: Gastric cancer (GC) is the second most lethal cancer globally and is associated with poor prognosis. Fatty acid-binding proteins (FABPs) can regulate biological properties of carcinoma cells. FABP5 is overexpressed in many types of cancers; however, the role and mechanisms of action of FABP5 in GC remain unclear. In this study, we aimed to evaluate the clinical and biological functions of FABP5 in GC. Materials and Methods: We assessed FABP5 expression using immunohistochemical analysis in 79 patients with GC and evaluated its biological functions following in vitro and in vivo ectopic expression. FABP5 targets relevant to GC progression were determined using RNA sequencing (RNA-seq). Results: Elevated FABP5 expression was closely associated with poor outcomes, and ectopic expression of FABP5 promoted proliferation, invasion, migration, and carcinogenicity of GC cells, thus suggesting its potential tumor-promoting role in GC. Additionally, RNA-seq analysis indicated that FABP5 activates immune-related pathways, including cytokine-cytokine receptor interaction pathways, interleukin-17 signaling, and tumor necrosis factor signaling, suggesting an important rationale for the possible development of therapies that combine FABP5-targeted drugs with immunotherapeutics. Conclusions: These findings highlight the biological mechanisms and clinical implications of FABP5 in GC and suggest its potential as an adverse prognostic factor and/or therapeutic target.