급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

肉用種鷄의 育種開發을 위한 交雜試驗 : I. Selection of Superior Stock in Female Line Ⅰ.母系統 優良 交配 組合 選拔試驗

吳鳳國,呂政秀 서울大學校 農科大學 1977 서울대농학연구지 Vol.2 No.1

A Study on crossbreeding of Broiler Production in Poultry This study was carried out to improve broiler production and to estimate a genetic value and to select superior broiler breeder stock by means of crossbreeding under domestic feeding and management conditions. 1. Selection of superior stock in females. The data used in this study were the rocords of two selected superior breeder stocks, one strain of domestic superior broiler parent stock and added one strain of imported parent stock. A total of 1,020 chicks of parent stock were used in this experiment. The results obtained in this study are summarzed as follows; (1) The average viability of brooding period was 95.20% and the highest viability was A strain (98.85%), and lowest viability was D strain. There was significant difference between A and D strains. The death of the chicks was due mainly to paralysis and catarrh of crop. (2) The average viability of growing period was no singificant difference between experimental strains. (3) With respect to the laying hen viability, the average viability was 92.71%and the highest viabllity was 96.55% in C strain, and the lowest viability were 91% in A and D strains. The death of the laying hens was due mainly to Lymphoid Leukosis Complex in D strain, (4) The average body weight at 6 weeks of age was 953g and the highest body weight was 986g in D strain, and the lowest body weight was C strain (936g). The D strain was superior to the other strains in the body weight at 6 weeks of age and there was significant difference between D and others strains. (5) The average feed conversion at 6 weeks of age was 2.11kg and the highest feed effeciency was A strain (2.06kg). The A strain was improved feed efficiency about 0.1kg compared with D strains. (6) The growth rate of growing period was normally developed comparing with breeder pullet mean body weight and feed recommendations. There was no significant difference between experimental strains. (7) The average body weight at 24weeks of age was 2,775g and this body weight was slightly overweighed compared with recommended feeding standard, however there was no signifiicant difference between strains. (8) The average adult body weight at 58 weeks of age was 3,356g and highest body weight was 3,416g in D strain, and the lowest body weight was 3,296g in A strain. The adult body weight of laying period was normally maintained compared with breeder pullet feeding recommend-ations. (9) The average date of sexual maturity was 179days and the earlist sexual maturity was 176days in D strain and the latest sexual maturity was 183 days in C strain. (10) The average hen-day egg production from 24 to 58 weeks of age was 62% and the high-est egg production strain was A strain (66%), and the lowest egg production was D strain (60%). The A strain was about 6% higher than the imported parent stock (D strain). The hen-housed average egg production was 145 eggs and the A strain had about 11 egg higher egg production than the D strain. In statistical analysis for egg production, there was significant difference between A strain and the other strains. (11) In egg weight, the average egg weight was 61g and the highest egg weight was D strain-(62.7g) and the lowest egg weight strain was A strain (60g). It seems to be important to improve egg weight in domestic strains. (12) The average conversion of feed into egg production was 219.8g and the lowest feed requirement strain was A strain(206.6g), and the highest feed requirement strain was C strain(227.3g). It seems to be important in economic point and A strain was superior to the imported parent stock (D strain). (13) In economic analysis of broiler breeder stock, the average net income per layer was 2,661 won and the highest net income was A strain (2,919won) and the lowest net income was imported parent stock (2,402won). With respect to the cost of per egg production, the average egg production cost was 29 won and the lowest production cost was A strain(27.52won). Egg production cost of D strain which was imported broiler breeder stick was 30.29won and the D strain needed more cost 2.77won to produce per egg compared with the A strain. (14) Average fertility of selected superior stock in female lihe was 98.3% and the lowest fertility was B strain (97.9%). The average of hatchability was 93.8% and the highest hatchability was (B ×Y) crossbreds (96.3%) and the lowest hatchability was(B ×X) crossbred(93.6%) and imported parent stock (90.2%).

닭(gallus domesticus)의 經濟形質 改良을 위한 染色體 分染分析과 標識因子의 究明에 관한 硏究 Ⅱ. 卵用種의 系統間의 比較

Jung Sou Yeo(呂政秀),Bong Kug Ohh(吳鳳國),Bong Bo Seo(徐奉甫) 한국육종학회 1985 한국육종학회지 Vol.17 No.1

This experiment was carried out to identify the differences of genetic materials as genetic marker for the four strains of egg type breed. The differences of strains of egg type chick were as follows. It was chracterized with strain A to show less band at distal part of chromosome #3 and dark band at centromere of #4-q. More bands at distal part of #1-q than others was the marker of strain K. In strain M, less band at #2-p and non-band at distal part of #Z-q were observed, and dark band at centromere of Z chromosome like the feature of meat type chick was the chracteristics of strain S.

Bootstrap Analysis and Major DNA Markers of BM4311 Microsatellite Locus in Hanwoo Chromosome 6

Yeo, Jung-Sou,Kim, Jae-Woo,Shin, Hyo-Sub,Lee, Jea-Young Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.8

LOD scores related to marbling scores and permutation test have been applied for the purpose detecting quantitative trait loci (QTL) and we selected a considerable major locus BM4311. K-means clustering, for the major DNA marker mining of BM4311 microsatellite loci in Hanwoo chromosome 6, has been tried and five traits are divided by three cluster groups. Then, the three cluster groups are classified according to six DNA markers. Finally, bootstrap test method to calculate confidence intervals, using resampling method, has been adapted in order to find major DNA markers. It could be concluded that the major markers of BM4311 locus in Hanwoo chromosome 6 were DNA marker 100 and 95 bp.

한우의 염색체 분염분석에 의한 유전적 조성의 특징에 관한 연구

여정수 ( Jung Sou Yeo ) 한국축산학회 1987 한국축산학회지 Vol.29 No.3

Chromosome analysis with the DNA structure is the new approach to identify the characteristics of genetic materials in the Korean Native Cattle. Chromosome number and morphology of the Korean Native Cattle were same as the aspects of other beef breeds reported already. G-banded chromosome pattern measured by densitometric measurement was similar to other reports for number and location of bands, but density of band was quite different. C-banding pattern, heterochromatic region, was estimated by the photo-electric recording and ratio of the band size per total chromosome. Dark bands were located at centromere of all chromosomes and especially banded regions of chromosome # 4, 19, 26, X and Y were above 40% of total size. Density of G-band and size of C-band in the Korean Native Cattle were considered the important tools in order to check the genetic marker related to performance.

한국 재래산양의 염색체 분석

여정수 ( Jung Sou Yeo ) 한국축산학회 1984 한국축산학회지 Vol.26 No.3

According to the sophisticated chromosome spread procedure of Yeo (1984), chromosome analysis of the Korean Native Goat was identified as follows; Chromosome number was 60 at haploid, 29 pairs autosome appeared as telocentric identical to the Korean Native Cattle. And sex chromosome X was acrocentric and Y was found as the smallest metacentric. In banding pattern of the each chromosome complement to classify the homology chromosome, each chromosome pair of the Korean Native Goat was found a considerable degree similarity with banding pattern of the Korean Native Cattle. Three pairs of autosome in the Korean Native Goat; 17, 19, 27 were not quitely corresponded to other domestic goat in comparison standardized banding pattern of the Korean Native Goat with other goat breeds.

G - , C - banding 에 의한 닭의 염색체 분석

여정수 ( Jung Sou Yeo ) 한국축산학회 1985 한국축산학회지 Vol.27 No.12

Precise analysis of chromosomal genetic materials is not only important at cytogenetics field but basic steps of molecular genetics. To approach these aims through this study, G- and C- banding techniques were used. G- banding was found more accurate patterns at macro-chromosomes compared with recent reported banding patterns. While C- banding was gotten precise heterochromatin site of all chromosomes. So genetic markers dependent on economic traits of chicken will be identified based on advanced banding techniques.

Hanwoo(Korean Cattle) Traceability Using DNA Markers

Yeo, Jung-Sou,Rhee, Sung-Won,Choi, Yu-Mi,Kwon, Jae-Chul,Lee, Jea-Young 한국통계학회 2006 Communications for statistical applications and me Vol.13 No.3

To apply and evaluate the effectiveness of genetic markers on Hanwoo traceability systems, samples of 33 Hanwoo individuals from Korean elite sire families were used, and five microsatellite markers were selected finally, which were located on chromosomes different chromosomes with the end sequencing of 100 HW-YUBAC that were recorded in the NCBI by Yeungnam University. Ten major microsatellite markers were selected from alleles amplified, their frequencies, H(Heterozygosity) and PIC(Polymorphism information content) with Hardy-Weinberg equilibrium. Next, in order to evaluate the power of the markers selected on the individual animal identification, the match probability(MP) and the relatedness coefficient(R) were computed.

정신병으로 입원한 환자에서 외래 순응도와 관련 있는 임상적 요인에 대한 후향적 조사

김소정(Sou Jung Kim),김소은(So-Eun Kim),전덕인(Duk-In Jon),홍현주(Hyun Ju Hong),정명훈(Myung Hun Jung),홍나래(Narei Hong) 대한사회정신의학회 2011 사회정신의학 Vol.16 No.2

목 적 : 본 연구는 정신병 환자들의 재발과 밀접한 연관이 있는 것으로 알려진 외래 순응도와 관련된 임상적 요인들을 확인해보고자 실시되었다. 방 법 : 2006년 1월부터 2008년 12월까지 한림대학교성심병원 정신과 병동에 정신병으로 입원 치료 후 퇴원한 환자 213명의 의무기록을 후향적으로 조사하였다. 환자들의 외래 순응도에 따라 순응군과 비순응군으로 분류하였고 사회인구학적 특성, 임상적 특성, 약물 복용력 등을 조사하였다. 결 과 : 순응군에서는 비순응군에 비해 퇴원시 병식이 높았으며, 남성 비율이 더 높고, 진단명의 경우 조현병(편집형)이 많았으며, 발병연 령이 더 이르고, 퇴원시 CGI-S 점수가 낮고(p=0.009), CGI-I 점수가 높았다(p=0.013). 또한 순응군에서 퀘티아핀(Quetiapine)과 클로자핀(Clozapine)을 복용하는 환자의 비율이 더 높았으며, 아미설피라이드(Amisulpiride)와 리스페리돈 서방성 미립구 주사제 (Risperidone Long-Acting Injection)를 사용하는 환자의 비율은 더 낮았다. 외래 순응도와 관계가 가장 큰 요인은 퇴원시 병식이 었으며 부작용 여부, 직업, 결혼, 학력, 유병기간, 나이, 입원 횟수, 다중약 사용여부와 같은 요인은 두 군간에 차이가 없는 것으로 나타났다. 결 론 : 외래 순응도와 상관관계가 가장 큰 임상적 요인은 퇴원시 병식이었다. 따라서 입원 기간 동안 환자들에게 약물 치료 및 교육 등을 실시하여 퇴원시 병식을 높여주는 것이 환자의 외래 순응도를 높이고 재발율을 낮추는데 도움이 될 수 있음을 알 수 있었다. Objective : This study aims to identify variables which predicts the compliance of outpatient treatment that is known to be related to recurrence of psychotic patients. Methods : The medical records of 213 patients who discharged with the diagnosis of psychotic disorder from Department of Psychiatry, Hallym University Sacred Heart Hospital from Jan, 2006 to Dec, 2008 were reviewed. The patients were divided into compliance group and non-compliance group. Data on sociodemographic and clinical variables, and profiles of drug use were analyzed. Results : The patients in compliance group showed better insight at discharge, higher rate of male, earlier onset, higher rate of schizophrenia, paranoid type, lower CGI-S score and higher CGI-I score at discharge than those in non-compliance group. And compliance group consists of higher rate of Quetiapine and Clozapine-use subjects and lower rate of Amisulpiride and Risperidone Long-Acting Injection-use subjects than non-compliance group. The most influential clinical variable on compliance was insight at discharge. Other variables such as side-effect of drugs, occupation, marital status, education, period of illness, age, number of admission, and number of drugs showed no influence on compliance. Conclusion : The most important factor to compliance seems to be the insight at discharge than other clinical factors. Thus improving the insight at discharge by drug treatment and education might be able to improve the compliance of outpatient treatment and reduce the recurrence rate.

난용계에 (卵用鷄) 있어서 상가적 (相加的) 및 모체유전 효과를 이용한 선발지수 추정

여정수(Jung Sou Yeo),오봉국(Bong Kug Ohh) 한국축산학회 1984 한국축산학회지 Vol.26 No.1

The data from the record of 1131 birds of synthetic population (A line) and 1587 birds of selected population (D line) through 3 generations (1977-1980) were used for the estimates of expected genetic gain by selection indices based on the additive effect only and maternal and additive effects. It was found through Hazel`s method considered the only additive effect that in both lines the first egg day and egg weight at 43 weeks of age were decreased while egg number to 43 weeks of age was increased, and body weight at 43 weeks of age was slightly decreased. And A line showed more satisfactory genetic changes compared with D line except body weight. Expected genetic gains in A line based on genetic parameters estimated using additive and maternal genetic effects simultaneously were the most significant for increase of egg number among the four traits studied and egg weight was 2.50g heavier than performance of this generation, while body weight and the first egg day were decreased, which were considered most desirable in genetic changes of layer. In line D genetic gain of egg production could be achieved through maternal genetic effect with maintaining body weight nearly constant. And major profitable egg weight was decreased by 0.87g lower than that of this generation, and the first egg day was also shortened. According to above results genetic improvement using the additive and maternal effects may be achieved more desirable than that using the additive effect only.