한국인 제2형 당뇨병 환자에 있어 지속적 피하 인슐린 주입법 치료시 Lispro insulin와 Regular insulin의 효과 비교

유재등,박봉안,류하근,류주성,김정수,김치훈,박선민,최수봉 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Objective: The Lispro insulin has faster onset of effects and shorter duration than the human regular insulin, an analog of human insulin. The differences in the pharmacodynamics between the two types of insulin in the continuous subcutaneous insulin infusion(CSII) with insulin pump for treating the Korean Type 2 DM patients were analyzed. The effects on the regulation of blood sugar, the amount of insulin injected, and the frequency of hypoglycemia were compared between the lispro insulin and the regular human insulin. Method and Material: One hundred and three Korean Type 2 DM patients were randomly divided into two groups, 49 Lispro insulin and 54 Regular insulin.(Table 1) Both groups were treated for 14 days. Also at a set time before meal, insulin was injected as bolus, using a portable insulin pump, in both groups, 15 minutes before for lispro insulin and 30 minutes before for human insulin The HbA1C, C-peptide, AC/PC, height and weight were measured for each patients at the time of admission. The peripheral blood sugar level and insulin injection profile were recorded 7 times per day for each patients. Results: After treating for 7 days and 14 days, the blood sugar level normalized in both groups. There weren't any significant differences in blood sugar levels in both groups at point of the study, and also there weren't any differences in the frequency of hypoglycemia. In order to maintain the normalized blood sugar level, the lispro insulin group had higher total daily insulin requirement than the regular insulin group after 14 days of treatment (0.90±0.35 vs 0.73±0.39u/kg/day, p<0.05) This difference is probably due to the difference in basement insulin requirements rather than prandial insulin requirements (0.32±0.1 vs 0.43± 0.09u/kg/day, p<0.001). Discussion: In the hospitalized Korean Type 2 DM patients with CSII treatment, continuous subcutaneous insulin infusion therapy using lispro insulin has convenience in usage compared to the regular insulin. However, there were not any differences in the blood sugar levels. Also lispro insulin requires more insulin in order to maintain normal blood sugar level, which is probably due to the increase in the basal requirement. Also there were not any difference in the frequency of hypoglycemia.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

The synergistic therapeutic effect of cisplatin with Human papillomavirus E6/E7 short interfering RNA on cervical cancer cell lines <i>in vitro</i> and <i>in vivo</i>

Jung, Hun Soon,Erkin, Ozgur Cem,Kwon, Mi Jeong,Kim, Seok Hyung,Jung, Jae In,Oh, Yu‐,Kyoung,Her, Song Wook,Ju, Woong,Choi, Yoon‐,La,Song, Sang Yong,Kim, Joong Kyu,Kim, Young Deug,Shim, Ga Y Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.130 No.8

<P><B>Abstract</B></P><P>Human papillomavirus (HPV) types 16 and 18 are the major etiologic factors in the development of cervical epithelial neoplasia. Our study was designed to validate antiviral short interfering RNA (siRNA) targeting the <I>E6</I> and <I>E7</I> oncogenes as a potential chemosensitizer of cisplatin (<I>cis</I>‐diaminedichloroplatinum II; CDDP) in cervical carcinoma. Specifically, the therapeutic efficacy of combination of CDDP and E6/E7‐specific siRNA was assessed in an <I>in vivo</I> cervical cancer xenograft models. The combination of CDDP and E6/E7‐specific siRNA had greater efficacy than the combination of CDDP and E6‐specific siRNA especially in terms of inducing cellular senescence. Through <I>in vitro</I> and <I>in vivo</I> experiments, the mechanism of synergy between these two treatments was revealed, demonstrating that the combination of E6/E7‐specific siRNA and CDDP therapy was significantly superior to either modality alone. <I>In vitro</I>, long‐term exposure of HeLa cells to the combination of CDDP and E6/E7‐specific siRNA induced apoptosis and cellular senescence. <I>In vivo</I>, E6/E7‐specific siRNA potentiated the antitumor efficacy of CDDP <I>via</I> induction of apoptosis, senescence and antiangiogenesis. Our results suggest that E6/E7‐specific siRNA may be an effective sensitizer of CDDP chemotherapy in cervical cancer.</P>

A comparative analysis of results between antibiotic therapy alone and combined with arthroscopic lavage for low-grade pyogenic arthritis of the knee

Yu-Hun Jung,Woo-Suk Song,Dong-Chan Eun,Sang-Jun Park 대한정형외과 스포츠의학회 2017 Arthroscopy and Orthopedic Sports Medicine Vol.4 No.2

Background: This study aims to compare the results between antibiotic therapy alone and combined with arthroscopic lavage in patients with low-grade pyogenic arthritis of the knee. Methods: Patients with low-grade pyogenic arthritis of the knee were defined as those with symptoms of acute pyogenic arthritis but with a white blood cell count of 20,000 to 50,000/mm3 in the synovial fluid and a polymorphonuclear neutrophil level of 50% to 90%. We analyzed a total of 124 patients retrospectively. Patients treated using antibiotic monotherapy were categorized as Group A, and those treated using antibiotic therapy combined with arthroscopic lavage, as Group B. We compared parameters such as the duration of antibiotic injection, length of hospitalization, and recovery of the range of motion. Clinical outcome, measured as the Lysholm score and the visual analogue scale (VAS) score, was also compared. Results: We found that the parameters duration of antibiotic injection, length of hospital stay, and recovery of range of motion of the knee were significantly better in Group A than in Group B. However, the clinical outcome, denoted by the Lysholm knee score and the VAS score, did not significantly differ between the two treatment groups. Conclusion: We conclude that in patients with low-grade pyogenic arthritis of the knee early antibiotic therapy alone shows more satisfactory results than antibiotic therapy combined with arthroscopic lavage. Thus, our findings suggest that antibiotic monotherapy should be considered without any adjunct procedures such as arthroscopic lavage.

Monitoring and Analysis of 3㎾ Grid-Connected PV System for Performance Evaluation

Jung-Hun So,Young-Seok Jung,Gwon-Jong Yu,Ju-Yeop Choi,Jae-Ho Choi 대한전기학회 2005 KIEE International Transactions on Electrical Mach Vol.5-B No.1

Vertically oriented epitaxial germanium nanowires on silicon substrates using thin germanium buffer layers

Jung, Jae Hun,Yoon, Hyun Sik,Kim, Yu Lee,Song, Man Suk,Kim, Yong,Chen, Zhi Gang,Zou, Jin,Choi, Duk Yong,Kang, Jung Hyun,Joyce, Hannah J,Gao, Qiang,Hoe Tan, H,Jagadish, Chennupati IOP Pub 2010 Nanotechnology Vol.21 No.29

<P>We demonstrate a method to realize vertically oriented Ge nanowires on Si(111) substrates. Ge nanowires were grown by chemical vapor deposition using Au nanoparticles to seed nanowire growth via a vapor–liquid–solid growth mechanism. Rapid oxidation of Si during Au nanoparticle application inhibits the growth of vertically oriented Ge nanowires directly on Si. The present method employs thin Ge buffer layers grown at low temperature less than 600 °C to circumvent the oxidation problem. By using a thin Ge buffer layer with root-mean-square roughness of ∼ 2 nm, the yield of vertically oriented Ge nanowires is as high as 96.3%. This yield is comparable to that of homoepitaxial Ge nanowires. Furthermore, branched Ge nanowires could be successfully grown on these vertically oriented Ge nanowires by a secondary seeding technique. Since the buffer layers are grown under moderate conditions without any high temperature processing steps, this method has a wide process window highly suitable for Si-based microelectronics. </P>

요추부 척추관 협착증의 후방 감압술에서 후방 인대의 보존 여부와 술 후 척추 불안정성과의 연관성: 포트홀(Port-Hole) 감압술과 후궁 아전절제술 간 비교 연구

정유훈(Yu-Hun Jung),나화엽(Hwa-Yeop Na),최세헌(Saehun Choe),김진(Jin Kim),이준하(Joon-Ha Lee) 대한정형외과학회 2020 대한정형외과학회지 Vol.55 No.1

목적: 요추부 척추관 협착증에서의 후방 감압술 시 극간인대 및 극상인대의 보존이 술 후 척추 불안정성의 예방에 미치는 영향에 대하여 밝히고자 했다. 대상 및 방법: 2014년 3월부터 2017년 3월까지 요추부 척추관 협착증에서 후방 감압술을 시행하고 1년 이상 추시관찰한 83명의 환자를 후향적으로 연구하였다. 대상자들을 수술의 종류에 따라 포트홀 감압술을 시행한 56명의 환자는 그룹 A로, 후궁 아전절제술을 시행한 27명의 환자는 그룹 B로 분류하였다. 임상적 결과를 평가하기 위해 Oswestry disability index (ODI), 요통과 방사통에 대한 시각통증점수(visual analogue scale, VAS), 신경성 간헐적 파행(neurogenic intermittent claudication, NIC) 전 보행거리가 수술 전후로 측정되었다. 영상의학적 결과를 평가하기 위해 수술 전 및 수술 후 매 6개월마다 직립상태에서 측면 및 굴곡-신전 단순 방사선 사진을 촬영해 전위 정도(slip percentage), 역동적 전위 정도(dynamic slip percentage), 각변위(angular displacement), 역동적 각변위(dynamic angular displacement)를 측정하였다. 결과: ODI (그룹 A에서 28.1에서 12.8로 호전; 그룹 B에서 27.3에서 12.3으로 호전), 요통에 대한 VAS (그룹 A에서 7.0에서 2.6로 호전; 그룹 B에서 7.7에서 3.2로 호전), 방사통에 대한 VAS (그룹 A에서 8.5에서 2.8로 호전; 그룹 B에서 8.7에서 2.9로 호전), 그리고 NIC 전 보행 거리(그룹 A에서 118.4 m에서 1,496.2 m로 증가; 그룹 B에서 127.6 m에서 1,481.6 m로 증가)는 두 그룹 모두에서 호전되었다. 다른 영상의학적 결과들에서 유의한 차이가 없었던 반면 역동적 각변위는 술 후 두 그룹간에 유의한 차이를 보였다(그룹 A에서 6.2°에서 6.7°로 증가; 그룹 B에서 6.5°에서 8.4°로 증가; p-value=0.019). 결론: 요추부 척추관 협착증에서의 후방 감압술시 극간인대 및 극상인대를 포함한 후방 인대의 제거는 술 후 역동적 각변위의 증가를 초래하며 후방 인대를 보존하는 포트홀(port-hole) 감압술을 통해 이를 예방할 수 있다. Purpose: To determine if sparing the interspinous and supraspinous ligaments during posterior decompression for lumbar spinal stenosis is significant in preventing postoperative spinal instability. Materials and Methods: A total of 83 patients who underwent posterior decompression for lumbar spinal stenosis between March 2014 and March 2017 with a minimum one-year follow-up period, were studied retrospectively. The subjects were divided into two groups according to the type of surgery. Fifty-six patients who underwent posterior decompression by the port-hole technique were grouped as A, while 27 patients who underwent posterior decompression by a subtotal laminectomy grouped as B. To evaluate the clinical results, the Oswestry disability index (ODI), visual analogue scale (VAS) for both back pain (VAS-B) and radiating pain (VAS-R), and the walking distance of neurogenic intermittent claudication (NIC) were checked pre- and postoperatively, while simple radiographs of the lateral and flexion-extension view in the standing position were taken preoperatively and then every six months after to measure anteroposterior slippage (slip percentage), the difference in anteroposterior slippage between flexion and extension (dynamic slip percentage), angular displacement, and the difference in angular displacement between flexion and extension (dynamic angular displacement) to evaluate the radiological results. Results: The ODI (from 28.1 to 12.8 in group A, from 27.3 to 12.3 in group B), VAS-B (from 7.0 to 2.6 in group A, from 7.7 to 3.2 in group B), VAS-R (from 8.5 to 2.8 in group A, from 8.7 to 2.9 in group B), and walking distance of NIC (from 118.4 m to 1,496.2 m in group A, from 127.6 m to 1,481.6 m in group B) were improved in both groups. On the other hand, while the other radiologic results showed no differences, the dynamic angular displacement between both groups showed a significant difference postoperatively (group A from 6.2º to 6.7º, group B from 6.5º to 8.4º, p-value=0.019). Conclusion: Removal of the posterior ligaments, including the interspinous and supraspinous ligaments, during posterior decompression of lumbar spinal stenosis can cause a postoperative increase in dynamic angular displacement, which can be prevented by the port-hole technique, which spares these posterior ligaments.

개정된 도로교통법 수행을 위한 자율주행 자동차 알고리즘 개발

김유중(Yu-Jung Kim),조경근(Kyoung-Geun Cho),조훈희(Hun-Hee Cho),이준우(Jun-Woo Lee),이유빈(Yu-Bin Lee),제프리 자흐라 바툴(Zahra-Batool Jaffrey),강준우(Jun-Woo Kang),이종혁(Jong-Hyeok Lee),강태구(Tae-Koo Kang) 대한전기학회 2022 대한전기학회 학술대회 논문집 Vol.2022 No.11

다운증후군 청소년의 중증 고관절 골관절염에서 고관절 유합술

정유훈(Yu-Hun Jung),신근영(Keun-Young Shin),이주영(Joo-Young Lee) 대한정형외과학회 2021 대한정형외과학회지 Vol.56 No.2

다운증후군은 가장 흔하게 발생하는 염색체 이상 질환으로 일생 동안 약 28%에서 고관절의 골관절염을 동반하게 된다. 다운증후군에서 수술적 치료를 시행하게 될 경우에 의학적 관점에 더불어 환자의 정신적, 경제적인 요건 및 사회적 환경까지 고려하는 포괄적 접근이 필요하다. 청소년기 다운증후군에서 발생한 중증 고관절 골관절염에 대해 고관절 유합술을 시행하여 좋은 결과를 보여 보고하는 바이다. Down syndrome is the most common chromosomal disorder and is accompanied by hip osteoarthritis in approximately 28% of patients. This paper reports a case of hip arthrodesis as a treatment for severe hip osteoarthritis in adolescent Down syndrome patients. When performing surgical treatment of patients with Down syndrome, it is necessary to take a comprehensive approach that considers not only the medical point of view, but also the psychological and economic requirements of the patient and their social environment.

태양광 발전 시스템의 최적 설치 각도 예측에 관한 연구

김정환(Jung-Hwan Kim),유권종(Gwon-Jong Yu),소정훈(Jung-Hun So),차한주(Han-Ju Cha),유병규(Byung-Gyu Yu) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7

The measured solar radiation on tilted surfaces by all directions has been widely used as important solar radiation data in installing photovoltaic system. The photovoltaic systems is much affected by angle and direction of incident rays. The results obtained in this research could be used in installing optimal photovoltaic systems.