기술 교과의 ICT 활용 교육을 위한 XML 교수문서시스템의 설계 및 구현

정덕길,이종구,한순희 한국컴퓨터교육학회 2003 컴퓨터교육학회 논문지 Vol.6 No.4

21세기의 교육은 교육 정보화를 기반으로 한 연계·통합 교육으로 발전되고 있으며, ICT 활용교육이 교수-학습 전략과 유형을 제시하며, 기술교과의 수업 지도안에 대한 효율적인 XML 문서 생성 및 저장 시스템에 대한 구현 방안을 제시한다. 그리고 이 논문에서 구현된 XML 교수 문서 시스템을 적용하여 교육 자료의 효율적인 관리과 저장성을 높이고, 동일 업무에 대한 교육 자료의 재편집 과정을 감소시킴으로써 교육 자료의 가치를 높일 수 있는 가능성을 확인하였다. The education of 21st century is developed to the closely connected and integrated education, and the ICT applied education is suggested as an approach to teaching-learning method. In this paper, we suggest an teaching-learning pattern and strategy of Technology course as an example of the ICT applied education, and provide an implementation for the efficient XML document creation and storage system of teacher’s subject data. And we have confirmed the utilization of this system which it improves the efficient management and preservation of educational data and also it raises the value of educational data by decreasing the burden of re-editing the educational documents for similar business.

경기관지폐생검의 진단적 가치

이원식,정태훈,김교선,이국희,유덕종,손명원 대한내과학회 1986 대한내과학회지 Vol.30 No.2

The diagnostic value of transbronchial lung biopsy(TBLB) through fiberoptic bronchoscope was studied in 61 patients with diffuse or localized lung disease in which routine clinical and laboratory examinations revealed no diagnostic clue. By the technique adequate tissue specimen for diagnosis was obtainable in 28 of 33 patients (78.8 percent) and 25 of 28(89.3 percent) with localized and diffuse lung diseases, respectively. A histological diagnosis was possible in more than 75 percent of the patients with lung cancer proved by various means. On the other hand, in patients with tuberculous lesions, diffuse or localized, the incidence of positive diagnosis was less than a half. The complications among 61 patients underwent the TBLB were pneumothorax in one and hemoptysis in three, which subsided spontaneously. These facts suggest that the TRLB is a relatively safe, and more useful in the diagnosis of cancer of the lung than in inflammatory disease.

Amelogenin 유전좌를 이용한 성별검색의 유용성에 관한 연구

이숭덕,이정빈,이윤성 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

The aim of this study was to validate the sex typing based on amplification of X-Y homologous Amelogenin locus in Korean including mutation rate in this locus. It was found that there was no case with reported mutation that may hinder the exact sex typing among 240 Koreans, and the sex typing was successful even with subnanogram quantities of male and female DNA. There was no difference in the sensitivity of reaction among male and female. Differential amplification between X and Y amelogenin bands in some samples was noted, and dilution study revealed that this phenomenon was more frequent when the quantity of sample was low, usually less than 10 ng. That phenomenon was variable between amplification reactions, and was also dependent on different Taq enzyme used for the amplification. When there was differential amplification, the intensity ratio (Y band/X band) ranged about 0.68-0.87.

다량재해에 있어 미토콘드리아 DNA의 다형성을 이용한 개인식별 : 삼풍백화점 사건에 대하여

이숭덕,신창호,김기범,최영태,이윤성,이정빈 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-

축약형 월경전기평가서 표준화 연구 및 인터넷상에서 적용 가능성

이만홍,김지웅,이정현,김덕만 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.1

연구의 목적 : 연구의 목적은 축약형 월경 전기 평가서(Shortened Premenstrual Assessment Form: SPAF)의 신뢰도 및 타당도를 알아보고, 인터넷상에서의 적용 가능성을 알아보기 위하여 시행되었다. 방 법 : 월경전 불쾌장애 환자 28명과 월경 전 불쾌장애에 해당하지 않는 가임 연령의 여자 연구 대상자 27명을 대상으로 세브란스 여성 정신 건강 특수 클리닉 홈페이지를 통하여 축약형 월경전기평가를 시행하게끔 하였다. 월경전 불쾌장애의 진단은 2개월간의 전향적인 평가를 통해 내려졌다. 결 과 : 축약형 월경전기 평가서는 정동요인, 통증 요인, 수분 저류 요인으로 구성되어 있으며, 검사-재검사 신뢰도는 0.80으로 우수하였다. 내적 일치도(Cronbach alpha) 또한 0.91로 우수하였으며, 월경전기평가서 점수와 축약형 월경전기 평가서의 상관계수는 0.92로 나타났다. 월경 전 불쾌장애 환자군과 월경전 불쾌장애에 해당하지 않는 연구 대상군 사이의 축약형 월경정기평가서 점수도 유의한 차이가 있었고(t=5.57, p<0.001), 판별 분석상에서 축약형 월경전기 평가서 점수가 두 집단을 잘 판별할 수 있는 것으로 나타났다(eigenvalue : 0.60, canonical correlation coefficiency : 0.61, Wilk's lamnda : 0.63). 두 집단을 구분하는 최적 절단점은 27점으로 추정되었고, 이때의 민감도(75%)와 특이도 76.9%)는 비교적 우수한 것으로 나타났다. 결 론 : 이상의 결과들을 종합할 때, 축약형 월경전기 평가서는 신뢰도 및 타당도가 우수한 월경전기증상 평가 도구로서 인터넷상에서도 유용하게 사용될 수 있는 도구임이 시사된다. Objectives : The purposes of this study are to investigate the reliability and validity of shortened premenstrual assessment form and the applicability to internet interface. Method : The total of 55 subjects were included in this study. Among them, 28 subjects had premenstrual dysphoric disorder, and the other 27 subjects did not. All subjects performed the shortened premenstrual assessment form through internet interface in the homepage of Severance Woman Clinic. The diagnosis of premenstrual dysphoric disorder was determined by prospective assessment for 2 months. Results : The shortened premenstrual assessment form consists of 3 factors : affect, pain and water retention. The test-retest reliability of this scale was 0.80, and internal consistency(Cronbach alpha) was 0.91. The correlation coeffeciecy between scores of the premenstrual assessment form and the shortened premenstrual assessment form was 0.92. The difference of the scores of the shortened premenstrual assessment form between the group of premenstrual dysphoric disorder and the group of non-premenstrual dysphoric disorder was significant(t=5.57, p<0.001). Discriminant analysis also revealed that the shortened premenstrual assessment form was useful to differentiate between premenstrual dysphoric disorder and non-premenstrual dysphoric disorder(eigenvalue : 0.60, canonical correlation coefficiency : 0.61, Wilk's lambda : 0.63). The cut-off point to differentiate between two groups was 27, and sensitivity(75.0%) and specificity(76.9%) of this scale for premenstrual dysphoric disorder was acceptable. Conclusion : In summary, the shortened premenstrual assessment form appeared to be reliable and valid for the assesment of premenstrual dysphoric disorder. And the results of this study also suggest that the shortened premenstrual assessment form is a useful tool for internet interface application.

채택 빈도수에 의한 교육용 소프트웨어 품질평가 준거의 설정 및 분석

정덕길,이태군 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.1

교육용 소프트웨어가 갖는 여러 가지의 우수한 기능과 장점에도 불구하고 실제적으로 학습 현장인 학교와 가정에서 교육용 소프트웨어의 활용도가 저조한 현상은 교육용 소프트웨어가 교육 전문가나 컴퓨터 소프트웨어 개발 전문가의 입장에서 연구되고 개발되어 학습자의 요구사항이 교육용 소프트웨어에 제대로 반영되지 못한 결과로 볼 수 있다. 이에 따라 이 연구에서는 교육용 소프트웨어의 평가 도구들이 소비자의 요구를 얼마나 수용하고 있는지 알아보는 사전 연구의 일환으로서, 국내외에서 발표된 기존의 교육용 소프트웨어의 평가 도구들이 중요하게 다루고 있는 평가 준거는 무엇인지 교육용 소프트웨어의 평가 도구에서 채택된 빈도수를 통하여 조사 분석하였다. 그리고 이 분석 결과와 비교하여 교육용 소프트웨어의 실수요자인 학습자들은 교육용 소프트웨어에 대한 기존의 품질 평가 도구가 가지고 있는 품질 평가 준거를 어느 정도의 차이점을 가지고 중요하게 생각하는지에 대하여 조사하고 분석하였다. In spite of various good functionalities and merits of educational software products, they are generally not used widely in school and home, One of these reasons is which many of the educational software products are developed by educational professionals without adequate consideration to the requirement of learners. So, in this paper, in order to see the degree of how much learner’s requirement have been met in educational software products, we survey and analyze the evaluation criteria based on the adoption frequencies which have been searched out from domestic and foreign educational software evaluation tools. And, by the learner-centered survey, we compare and analyze the difference of quality estimation criteria for educational software between the viewpoints of students and the selected evaluation criteria treated as important in educational software evaluation tools.

서울지역 의과대학에서의 법의부검 : 서울의대에서 과거 5년동안 실시한 부검 경험 보고

이숭덕,이정빈,이윤성 대한법의학회 2000 대한법의학회지 Vol.24 No.1

This is the statistical analysis about the medicolegal autopsy cases performed by the Department of Forensic Medicine, Seoul National University Medical College during the last 5 years. 1.The total number of cases was 330, among which male took 256(77.5%) cases, female 74(22.5%) cases. The natural death took 134(40.6%) cases, unnatural death 177(53.6%) cases. For remaining 19(5.8%) cases the cause of death was known, although thorough analyses including microscopic examination, toxicology study were done. The thirties were most as 25.4% of the total cases and the forties followed the second. 2.The number of autopsy showed severe variation annually or monthly in a year. 3.Among unnatural death, death by violent injury took 87(49.2%) cases, asphyxia 48(27.1%) cases, intoxication 17(9.6%) cases and death by thermal injuries or electric injuries 25(14.1%) cases. 4.Among natural death the abnormality in cardiovascular system were the most as 73(54.5%) cases, gastrointestinal system 38(28.4%) cases and central nervous system 12(8.9%) cases. 5.There were some differences between these and the data from other institute in the ratio of male to female, ratio of natural death to unnatural death and the ratio of specific cause of death among natural and unnatural death. 6.During this work, there were some difficulties in the aspect the irregularity of the work, in requesting toxicology and in the expense needed for the process. Considering the educational aspect for the students and the residents in pathology, performing medicolegal autopsy in medical college should be encouraged. The small number of autopsy and the closeness of the scene made the scene investigation possible in several cases, which is the ideal form that we must consider when we set up our system for the postmortem investigation.

식물추출물의 Tyrosinase 활성 억제효과

이정숙,채은경,계경채,문석식,조순장,김창덕,박장규,이증훈 大韓皮膚硏究學會 2003 大韓皮膚硏究學會誌 Vol.10 No.4

酸棗仁이 CT105에 의한 신경세포 상해 및 白鼠의 기억에 미치는 영향

정정욱,박창국,박치상,이소연,윤현덕,신오철 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective: This study was designed to research whether demonstrate neuroprotective and memory enhancing effects of Z1BU, suggesting its beneficial actions for the treatment of AD. Methods: The present study investigated effects of the dichloromethane extract of Semen Zizyphi Spinosae(ZIBU) on neurotoxicity and reactive oxygen species(ROS) and nitric oxide(NO) formation in PC 12 cell line overexpressed with carboxyl-terminal 105 amino acid peptide fragment of amyloid precursor protein(CT105). In addition, the present study evaluated its radical scavenging activity and effects on acetylcholinesterase(AChE) activity. Furthermore, effects on neuronal loss in CAl area and cognitive deficits induced by scopolamine treatment were also evaluated in rats. Result: we found in this study that ZIBU significantly inhibited apoptotic neuronal death induced by CT105 overexpression in PC12 cells, with the IC_(50) value of 23 ㎍/ml. Based on phase-contrast and fluorescence microscopic examinations, ZIBU reversed morphological changes of CT105-expressed PC-12 cells. It was also found that Z1BU significantly induced neurite outgrowth and inhibited formation of ROS and NO.Z1BU scavenged DPPH radicals and inhibited AChE activity. Furthermore, it attenuated memory impairment induced by the injection of scopolamine in rats, based on passive avoidance test. Crystal violet staining of rat brain slices exhibited increase in the viability of pyramidal neurons in hippocampal CAI area. Conclusion: these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.

대량재해에 있어 미토콘드리아 DNA의 다형성을 이용한 개인식별

이숭덕,김기범,이윤성,최영태,신창호,이정빈 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1

The mitochondrial DNA(mtDNA) is a small extranuclear DNA molecule that has been sequenced in man. the mtDNA has distinct characteristics over nuclear DNA. First, the evolutionary rate of nucleotide substitution appears to be larger compared with the nuclear DNA. Second, mtDNA is maternally inherited, so the determination of the various haplotype is unequivocal and no recombination has to be involved. Third, there is a 1.1 kb long control region, which shows severe polymorphism. These characteristics have been applied for several evolutionary study. Furthermore, they exist in cytoplasm with numerous copy number and their size, 16,569 bp is small relative to nuclear DNA, so they are more resistant to degradation or can be types in samples with only cytoplasm such as hair shaft without hair root. These presented the possibility of mtDNA as a tool in individual identification, especially when the nuclear DNA be unavailable. Actually, polymorphism in control region has been applied to individual identification for the skeletal remain found in Vietnam war. So we decided to apply the polymorphism of mtDNA in control region for the individual identification in case of mass disaster-"Downfall of Sampoong Department". Human remains from total 27 different individuals and 178 control persons were submitted for the individual identification. As the mtDNA comparison could be done through maternal lineage, 12 individual from 9 families from the control group were ruled out, because these families were consisted of father or were seeking for their father. Sequencing for the mtDNA control region was done using ABI automatic sequencer and DyeDeoxy Terminator Cycle Sequencing Kit. For convenience, sequencing reaction was done for two separate control region, region I from 16016-16401 in Anderson sequence, and regionⅡ from 048-388. First, sequences in regionⅡ of all samples and control persons were compared, and 20 samples were ruled out with no identical sequences in control group. Remaining 7 samples showed identical sequences with some of the control persons in three groups, and these identical pairs underwent mtDNA region I study. After region I study all samples except two dropped out in blood relationship. For the confirmation, STR and VNTR study such as MCT118, apoB, YNZ22, vWF, MBP, D21S11, TC-11 were done for remaining the two samples. The result denied the blood relationship between these two samples and any of the control group.