성장치료를 위한 한약투여의 임상적 효과 및 안전성 평가

정정욱,양태규,구본홍,이세연,Cheong, Jeong-Ook,Yang, Tae-Kyu,Koo, Bon-Hong,Lee, Sea-Yun 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.4

Objective : Recently many studies of herbal medication to promote growth have been implemented. The purpose of this study was to identify the feasibility and safety of herbal medication on short stature. Methods : 143 patients(87 males, 56 Females)who visited with short stature at Kangnam CHA Oriental Hospital From February 1999 to January 2000 and were treated during 6 months, were available for this study. We treated with 5 herbal medications.(Soeumin hyangbujapalmultang-gagambang, Soyangin yukmijihwangtang-gagambang, Taeumin chungsimyunjatang-gagambang, Boa-tang, Boikyangwi tang) At the begining of the treatment and after 6 months treatment, We measured height, weight and body mass index(BMI). And we investigated changes of aspartate aminotransferase(AST), alanine aminotransferase(ALT), blood urea nitrogen(BUN), alkaline phosphatase(ALP), creatinine. Results: The distribution of ages was from 5 years old to 17 years old. After herbal treatment, mean height, mean weight, mean BMI and mean percentile grade increased $138.5{\pm}15.6$ to $141.9{\pm}15.1$, from $36.9{\pm}13.2$ to $38.9{\pm}13.2$, from $18.5{\pm}3.29$ to $18.7{\pm}3.21$, from $3.2{\pm}1.2$ to $3.4{\pm}1.2$. The contents of AST, ALT, BUN, ALP and Creatinine were not showed any significant change. Conclusions : In the results We recognized Short stature was showed prominent feasibility and safety of herbal medication. Herbal Medication in patients with short stature will improve height velocity without liver and kidney function disorders.

Multiple Infarction과 Small Artery Infarction의 독립적 위험인자로서의 Methylenetetrahydrofolate Reductase Gene Mutation

정정욱,박정미,최병옥,김남근,오도연,정우상,Jung, Jung-Uk,Park, Jung-Mi,Choi, Byung-Ok,Kim, Nam-Keun,Oh, Do-Yeun,Jung, Woo-Sang 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.1

Objective : Hyperhomocysteinemia has been proven to be an independent risk factor for stroke. The genetic mutation of methylenetetrahydrofolate reductase(MTHFR) elevates serum homocysteine level, but it still remains controversial whether the MTHFR gene mutation could be a predictor of ischemic stroke. Therefore, we studied if this genetic defect could cause ischemic stroke independently. Methods : We gathered ischemic stroke subjects and age, sex-matched controls. Age, gender, past medical history, smoking habit, serum homocysteine level, and the MTHFR genotype were recorded. General characteristics of ischemic stroke subjects were compared to the controls. We classified the stroke according to the related vessels(small and large artery infarction) and single lesion and multiple infraction. Relevant risk of the MTHFR genotype was evaluated in each stroke subtype with multiple logistic regression analysis. Results : When the controls were compared to the whole ischemic stroke, there was no specific difference except some medical histories. However, further analysis based on stroke subtypes showed important results. The small artery infarction group, multiple infraction group had significant odds ratio of the MTHFR TT genotype adjusted for age, gender, medical history and smoking habit. Conclusions : The MTHFR TT genotype is an independent risk factor for certain types of ischemic stroke, small artery infarction and multiple infarction.

보익양위탕가미방(補益養胃湯加味方)으로 6개월간(個月間) 저신장증(低身長症) 환자(患者)를 치료(治療)한 치험(治驗) 2례(例)

정정욱,양태규,구본홍,이세연,Cheong, Jeong-Ook,Yang, Tae-Kyu,Koo, Bon-Hong,Lee, Sea-Yun 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.4

IShort stature is two standard deviations (SD) below the mean for height (below the third percentile) in a population of children. We treated two cases below the third percentile for height with Boikyangwitang-gamibang(補益養胃湯加味方). During treatment Case I grew 4.2cm and became above the third percentile for height. Case II also grew 5.8cm and became above the third percentile for height. In the results We recognized Short status was showed prominent improvement with Boikyangwitang-gamibang(補益養胃湯加味方).

酸棗仁이 CT105에 의한 신경세포 상해 및 白鼠의 기억에 미치는 영향

정정욱,박창국,박치상,이소연,윤현덕,신오철 대한본초학회 2005 大韓本草學會誌 Vol.20 No.1

Objective: This study was designed to research whether demonstrate neuroprotective and memory enhancing effects of Z1BU, suggesting its beneficial actions for the treatment of AD. Methods: The present study investigated effects of the dichloromethane extract of Semen Zizyphi Spinosae(ZIBU) on neurotoxicity and reactive oxygen species(ROS) and nitric oxide(NO) formation in PC 12 cell line overexpressed with carboxyl-terminal 105 amino acid peptide fragment of amyloid precursor protein(CT105). In addition, the present study evaluated its radical scavenging activity and effects on acetylcholinesterase(AChE) activity. Furthermore, effects on neuronal loss in CAl area and cognitive deficits induced by scopolamine treatment were also evaluated in rats. Result: we found in this study that ZIBU significantly inhibited apoptotic neuronal death induced by CT105 overexpression in PC12 cells, with the IC_(50) value of 23 ㎍/ml. Based on phase-contrast and fluorescence microscopic examinations, ZIBU reversed morphological changes of CT105-expressed PC-12 cells. It was also found that Z1BU significantly induced neurite outgrowth and inhibited formation of ROS and NO.Z1BU scavenged DPPH radicals and inhibited AChE activity. Furthermore, it attenuated memory impairment induced by the injection of scopolamine in rats, based on passive avoidance test. Crystal violet staining of rat brain slices exhibited increase in the viability of pyramidal neurons in hippocampal CAI area. Conclusion: these results demonstrate neuroprotective and memory enhancing effects of ZIBU, suggesting its beneficial actions for the treatment of AD.

하타요가 수련이 폐기능 및 호흡순환 기능에 미치는 영향

정정욱,신현욱,김훈 한국보건교육건강증진학회 2007 한국보건교육·건강증진학회 학술대회 발표논문집 Vol.- No.-

Pseudomonas sp. HJ-2를 이용한 고무탄성 Polyhydroxyalkanoate의 생산

정정욱,최강욱,김영백,이영하 한국미생물학회 2000 미생물학회지 Vol.36 No.2

Pseudomonas sp. HJ-2는 heptanoinc acid를 단일탄소원으로 이용하여 3-hydroxybutyrate (3HB),3-hydroxy-velerate (3HV) 및 3-hydroxybutyrate (3HHp)를 구성 단위체로 하는 고무탄성 polyhydroxyalkanoate (PHA)를 생합성한다. 이 미생물 고분자는 poly(3HB-co-3HV)공중합체와 poly(3HHp) 단일중합체로 이루어진 혼합물임이 밝혀졌다. 본 연구에서는 PHA가 고무탄성체로서의 성질을 유지하는데 필용한 단위체 조성과 HJ-2의 배양조건이 PHA의 생산 및 단위체 조성에 미치는 영향에 대하여 조사하였다. 생합성된 PHA의 탄성률은 poly(3HHp)의 존재로 크게 감소되었으나, 3HV의 함량이 높은 poly(3HB-co-3HV) 자체도 최대변형률 740%로서 고무탄성체로서의 성질을 보였다. HJ-2의 생장 및 PHA 생합성은 탄소원인 heptanoic acid의 초기농도가 40mMdlfEo 가장 높았으나, 50mM의 농도에서는 큰 저해를 받았다. PHA 생합성은 질소와 인이 결핍된 조건에서 크게 증가되었다. 배양액의 pH 및 통기는 HJ-2로부터 생합성되는 PHA의 단위체 조성에 큰 영향을 주는 것으로 나타났다. pH 7.5에서 생합성되는 고분자는 poly(3HB-co-38% 3HV)인 반면에 pH8.0에서의 고분자는 3HHp가 95%를 차지하였다. 발효조의 교반속도를 달리한 실험의 결과 고분자 내 3HHp의 함량은 산소전달 속도가 높아질수록 증가하였다. Pseudomnas sp. HJ-2 is capable of producing a rubber-elastic polyhydroxyalkanoate (PHA) consisting of 3- hydroxybutyrate (3HB), 3-hydroxyvalerate (3HV), and 3-hydroxyheptanoate (3HHp) from heptanoic acid as the sole carbon source. The polyester produced was a blend of poly(3HB-co-3HV) and poly(3HHp). Although the mixing of poly(3HHp) fraction to poly(3HB-co-3HV) resulted in a decrease of modulus, the sole fraction of poly(3HB-co-3HV) with a high molar fraction of 3HV was shown to be an elastomer with the maximum percent strain of 740%. The biomass yield and the PHA synthesis were relatively high when the initial heptanoic acid concentration was 40 mM, and were significantly decreased when the substrate concentration exceeded 50 mM. The accumulation of PHA was stimulated by deficiency of nitrogen and phosphorus in the medium. The PHA contents and its monomeric compositions were greatly affected by pH and oxygen transfer rate. At pH 7.5, poly(3HB-~0.38% 3HV) was produced from heptanoic acid and a mixture of 95% 3HHp and 5% 3HV was produced at pH 8.0. Increased conten1 of 3HHp in the polyesters with lhe increasing oxygen transfer rate by agitation speed a1 a fixed aeration rate was observed.

Effect of iron chelators on photodynamic therapy efficiency in tumor cells

정정욱,정영일,김시현,이혜명,강대환 한국공업화학회 2013 한국공업화학회 연구논문 초록집 Vol.2013 No.-

OECD에 소속된 동유럽 국가와 다른 유럽국가간의 건강행태 비교 연구

정정욱(Jung, Jeong-Wook),김태영(Kim, Tae-Young) 아시아·중동부유럽학회 2010 동유럽발칸학 Vol.12 No.2

이 연구는 OECD에 가입한 국가를 대상으로 하였으며, 체제변화와 함께 보건의료 체제에 변화가 이루어진 동유럽 국가를 중심으로 건강행태의 변화를 알아보고, 다른 유럽국가와의 비교를 통해 건강행태에 대한 정보와 개선방안을 모색하는데 있다. 이에 동유럽 국가의 건강행태에 대해 연구 결과는 다음과 같다. 동유럽 국가의 국민 의료비 비율(GDP대비), 국민 의료비 지출(1인당), 출생 시 기대수명은 다른 유럽 국가의 평균뿐만 아니라 전체 OECD 국가의 평균 보다 낮았으며, 만성질환 사망률은 높은 결과를 보였다. 건강과 관련된 위험 요소로서 흡연은 대부분의 OECD 국가에서 줄어드는 추세에 있으나 여전히 동유럽 국가의 성인 흡연 비율은 높은 것으로 나타났으며, 알코올 섭취량도 다른 유럽 국가 간에는 차이가 없었으나 여전히 높은 결과를 보였다. 비만율은 영국을 제외한 다른 OECD 국가보다 높은 결과를 보였다. 결론적으로 흡연과 알코올 섭취, 비만 등은 고혈압과 당뇨, 고지혈증 등의 대사성 질환과 연관되어 있으며, 이러한 질환은 심혈관 및 뇌혈관 질환의 선행질환으로 간주되기 때문에 동유럽 국가의 국가경쟁력 강화와 국민들의 건강 증진을 위해서 이러한 질환의 예방과 관리가 반드시 필요할 것으로 생각된다. This study targeted the changes on health behaviors in Eastern Europe OECD countries that represent Eastern Europe- Czech Republic, Hungary, Poland, and also focused on major Western Europe countries - France, Germany, United Kingdom, Northern Europe countries - Denmark, Sweden, and Southern Europe countries - Italy and Spain to provide information on current health behaviors by comparing Eastern Europe countries and the other Europe countries. The study on the change in current health behaviors in Eastern Europe after the ideology shift compared to other countries in Europe leads to following conclusions. Comparing to GDP, proportion of medical service, medical expenditure per person, life expectancy at birth in Eastern European countries were lower than the average of entire Europe. Besides, Death rate by chronical diseases was higher in Eastern European countries than not only the average of European countries, but also the entire OECD countries. The rate of smoking is in decreasing tendency in Eastern European countries and most OECD countries as it is widely known as a health threatening factor but still the rate of Eastern European countries is higher than the average of the entire OECD countries. Moreover, the amount of alcohol intake in the region is higher than that of average OECD countries. The obesity rate of OECD countries in Eastern Europe is appeared to be higher than that of average of the entire OECD countries and, except for England, most Europe countries have the rate below the average.

운동생리학 : 걷기형태가 에너지소비량 및 호흡순환기능에 미치는 영향

정정욱(JeongWookChung),김훈(HoonKim) 한국체육학회 2004 한국체육학회지 Vol.43 No.5

This study was performed to investigate that the effect of walking types on energy expenditure, oxygen consumption (VO₂), heart rate (HR), respiratory exchange rate (RER), the rate of perceived exertion (RPE) and walking frequency during submaximal exercise test (@HRmax 60%). Two different walking types either forward walking (FW) or backward walking (BW) were used in this study.Ten male University students were recruited. Energy expenditure was significantly different between BW and FW (p<.001), and it was also significantly different between each sections: 3㎞, 4㎞, 5㎞ and 6㎞. VO₂ also revealed a significant different between BW and FW (p<.01), and there was a significant different between each sections: 4㎞, 5㎞, and 6㎞.Heart rate was significantly different between BW and FW (p<.01), and it was also significantly different between each sections: 2㎞, 3㎞, 4㎞, 5㎞, and 6㎞ However, RER did not show any statistical significance between walking types when repeated measurement was used. In addition, there was an only significant difference at 6㎞ section RPE scale also revealed a significant different between BW and FW (p<.001). When the comparisons made by each sections, there was a significant different at 4㎞, 5㎞, and 6㎞ The results from walking frequency, it was a significant different between BW and FW (p<.01), and there was a significant different between each sections: 2㎞, 3㎞, 4㎞, 5㎞, and 6㎞.While previous studies used only specific walking speed, various walking speeds were used in this study, therefore it was possible to demonstrate that the differences occurred by the change of walking speeds. From these results, it is expected that more effective exercise program can be developed for people who want to maintain and improve their general health conditions, and it could also provide useful information for the determination of exercise intensity which can possibly be used for scientific and systematical guideline for exercise prescription.

白鼠의 局部 腦硬塞에 대한 當歸의 神經保護 效果

정정욱(Jeong-Ook Jeong),장우석(Woo-Seok Jang),오용성(Yong-Seong Oh),이소연(So-Yeon Lee),박치상(Chi-Sang Park),박창국(Chang-Gook Park) 대한한의학회 2003 대한한의학회지 Vol.24 No.2