Evaluation of a rotating packed bed equipped with blade packings for methanol and 1-butanol removal

Chia-Chang Lin,Yu-Chiao Lin,Shu-Ching Chen,Ling-Jung Hsu 한국공업화학회 2010 Journal of Industrial and Engineering Chemistry Vol.16 No.6

Absorption removal of methanol and 1-butanol from gaseous streams with water was investigated in the RPB equipped with blade packings. The removal efficiency (E) of methanol and 1-butanol was found to increase with the RPB speed and the liquid flow rate but decrease with the gas flow rate. Also, the overall volumetric gas-side mass transfer coefficient (KGa) for methanol and 1-butanol absorption was observed to increase with the RPB speed, the gas flow rate, and the liquid flow rate. According to the obtained dependence of KGa on the gas and liquid flow rates, the mass transfer in methanol and 1-butanol absorption was observed to be controlled primarily by the gas-side mass transfer. Furthermore, the height of a transfer unit (HTU) for methanol and 1-butanol absorption decreased with the RPB speed and the liquid flow rate but increased with the gas flow rate. The obtained results demonstrated that mass transfer efficiency of the RPB equipped with blade packing was comparable to that of a hollow fiber absorber. Consequently, the RPB equipped with blade packings has a great potential in the removal of alkanols from the exhausted gases. 2010 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Delay of Surgery for Spinal Metastasis due to the COVID-19 Outbreak Affected Patient Outcomes

Chia-Jung Hsieh,Chun-Yu Wu,Yen-Heng Lin,Yu-Cheng Huang,Wen-Chi Yang,Tom Wei-Wu Chen,Wei-Li Ma,Wei-Hsin Lin,Feng-Ming Hsu,Furen Xiao,Shih-Hung Yang,Dar-Ming Lai,Chang-Mu Chen,Shin-Yi Chao,Fon-Yih Tsuan 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: The present study is to analyze the effects of the coronavirus disease 2019 (COVID 2019) outbreak and the subsequent lockdown on the outcomes of spinal metastasis patients. Methods: The study was a retrospective analysis of data from a prospective cohort study. All patients underwent surgical intervention for spinal metastases between January 2019 and December 2021 and had at least 3 months of postoperative follow-up. The primary outcome was overall mortality during the 4 different stages (pre-COVID-19 era, COVID-19 pandemic except in Taiwan, national lockdown, lifting of the lockdown). The secondary outcomes were the oncological severity scores, medical/surgical accessibility, and patient functional outcome during the 4 periods as well as survival/mortality. Results: A total of 233 patients were included. The overall mortality rate was 41.20%. During the Taiwan lockdown, more patients received palliative surgery than other surgical methods, and no total en bloc spondylectomy was performed. The time from surgeon visit to operation was approximately doubled after the COVID-19 outbreak in Taiwan (75.97, 86.63, 168.79, and 166.91 hours in the 4 periods, respectively). The estimated survival probability was highest after the national lockdown was lifted and lowest during the lockdown. In the multivariate analysis, increased risk of mortality was observed with delay of surgery, with emergency surgery having a higher risk with delays above 33 hours, urgent surgery (below 59 and above 111 hours), and elective surgery (above 332 hours). Conclusion: The COVID-19 pandemic and related policies have altered daily clinical practice and negatively impacted the survival of patients with spinal metastases.

Factors Influencing Breast Symptoms in Breastfeeding Women After Cesarean Section Delivery [Asian Nursing Research 5 (2011) 88e98] The authors regret for the incorrect author affiliation published in this article. The correct affiliation is as follows.

Chia-Fen Hsien,Jung-Chung Fu,Cheng-Yu Long,Huey-Shyan Lin 한국간호과학회 2011 Asian Nursing Research Vol.5 No.3

Purpose: The purpose of this study was to compare smoking prevalence and risk factors of smoking between Korean and Korean-Chinese middle school students. Methods: Data was collected from seventh and eighth grade students from 12 schools in Korea and 6schools in China. Descriptive statistics, Chi-square test, and t test were performed. Results: For data analysis 10,002 usable surveys were utilized. The smoking prevalence was higher in Korean-Chinese students than in Korean students. Risk factors, such as father smoking, friends smoking,gender, grade, academic achievement, alcohol use, and family income were associated with current smoking, and the differences in the two samples were significant. Korean-Chinese students were more likely than Korean students to have friends who smoked and a father who smoked. Smokers had a significantly higher rate of friends smoking, father smoking, and alcohol use. Korean-Chinese male students smoking prevalence was more than three times higher than Korean students. Korean students could sense a more anti-tobacco atmosphere in their environment. Korean-Chinese students were more likely than Korean students to perceive that it was easy to buy cigarettes and to smoke cigarettes in a public computer room. Conclusion: These results highlight the differences of smoking prevalence and risk factors between Korean-Chinese students and Korean students. The findings may help health educators and researchers to better understand adolescent smoking and risk factors cross culturally and aid in the development of more effective education programs, which could lead to preventing tobacco use among these populations.

Anomaly Detection Using LibSVM Training Tools

Jung-Chun Liu,Chu-Hsing Lin,Jui-Ling Yu,Wei-Shen Lai,Chia-Han Ho 보안공학연구지원센터 2008 International Journal of Security and Its Applicat Vol.2 No.4

Intrusion detection is the means to identify the intrusive behaviors and provide useful information to intruded systems to respond fast and to avoid or reduce damages. In recent years, learning machine technology is often used as a detection method in anomaly detection. In this research, we use support vector machine as a learning method for anomaly detection, and use LibSVM as the support vector machine tool. By using this tool, we get rid of numerous and complex operations and do not have to use external tools for finding parameters as needed by using other algorithms such as the genetic algorithm. Experimental results show that high average detection rates and low average false positive rates in anomaly detection are achieved by our proposed approach.

Label-free Detection of Transport Kinetics and Inhibitor Binding of Membrane Transport Proteins with a Two-mode Plasmonic Sensor

Chia-Wei KUO,Tse-Han KUO,Hui-An LEE,Yu-Ting LIN,Cheng-Jung KUO,Kai-Hung HSIAO,Meng-Hua YANG,Kevin TANADY,Shu-Yu CHANG,Tzy-Rong LIN,Ling CHAO 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

Factors Influencing Breast Symptoms in Breastfeeding Women After Cesarean Section Delivery

Chia-Fen Hsien,Jung-Chung Fu,Cheng-Yu Long,Huey-Shyan Lin 한국간호과학회 2011 Asian Nursing Research Vol.5 No.2

Purpose The purposes of this study were to explore postpartum stress and breast symptoms in postpartum breastfeeding of parturient mothers as well as to identify the factors influencing the breast symptoms in breastfeeding women after cesarean section delivery. Methods A cross-sectional survey was conducted. A total of 162 breastfeeding women after cesarean section delivery were recruited from five hospitals in Taiwan. Structured questionnaires were used to collect data. Results The five highest postpartum stress comes from the flabby flesh of maternal belly, the baby getting sick suddenly, interrupted sleep, insufficient breast milk, and discomfort due to breast engorgement. The most two common breast symptoms in breastfeeding encountered by subjects in this study were breast engorgement and breast hardening, whereas the least common one was nipple bloody discharge. Cesarean section women with early suckling on the operating table had more breast symptoms in postpartum breastfeeding; and the higher the postpartum stress of them, the more the breast symptoms. Conclusions Breastfeeding in a comfortable condition is a key factor of precipitating breast milk secretion,so early suckling on the operating table may result in discomfort and stress of the woman and interfere with the secretion or production of breast milk. Additionally, it is a crucial factor of the success in breastfeeding that the nursing personnel can provide women help in maintaining breast milk production and secretion, taking care of a baby, and reminding women’s families (especially their husbands) of giving their assistance, encouragement and praises to relieve women’s postpartum stress.

Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells

Chih-Jung Yao,Jyh-Ming Chow,Shuang-En Chuang,Chia-Lun Chang,Ming-De Yan,Hsin-Lun Lee,I-Chun Lai,Pei-Chun Lin,Gi-Ming Lai 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3

Background: KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the induction of Forkhead Class box O3a (FOXO3a) and autophagy. Methods: Cell viability was determined by sulforhodamine B staining. Apoptosis and cell cycle distribution were analyzed using flow cytometry. The changes of protein levels were determined using Western blot analysis. Autophagy induction was monitored by the formation of acidic vesicular organelles stained with acridine orange. Results: KG-135 effectively arrested the cells in G1 phase with limited apoptosis. Accordingly, a decrease of cyclin-dependent kinase-4, cyclin-dependent kinase-6, cyclin D1, and phospho-retinoblastoma protein, and an increase of p27 and p18 proteins were observed. Intriguingly, KG-135 increased the tumor suppressor FOXO3a and induced the accumulation of autophagy hallmark LC3-II and acidic vesicular organelles without an increase of the upstream marker Beclin-1. Unconventionally, the autophagy adaptor protein p62 (sequestosome 1) was increased rather than decreased. Blockade of autophagy by hydroxychloroquine dramatically potentiated KG-135-induced FOXO3a and its downstream (FasL) ligand accompanied by the cleavage of caspase-8. Meanwhile, the decrease of Bcl-2 and survivin, as well as the cleavage of caspase-9, were also drastically enhanced, resulting in massive apoptosis. Conclusion: Besides arresting the cells in G1 phase, KG-135 increased FOXO3a and induced an unconventional autophagy in A549 cells. Both the KG-135-activated extrinsic FOXO3a/FasL/caspase-8 and intrinsic caspase-9 apoptotic pathways were potentiated by blockade of autophagy. Combination of KG- 135 and autophagy inhibitor may be a novel strategy as an integrative treatment for cancers.

Genetic Algorithm for Shortest Driving Time in Intelligent Transportation Systems

Chu-Hsing Lin,Jung-Chun Liu,Chia-Han Ho,Jui-Ling Yu,Wei-Shen Lai 보안공학연구지원센터 2009 International Journal of Hybrid Information Techno Vol.2 No.1

The route guidance system, which provides driving advice based on traffic information about an origin and a destination, has become very popular along with the advancement of handheld devices and the global position system. Since the accuracy and efficiency of route guidance depend on the accuracy of the traffic conditions, the route guidance system needs to include more variables in calculation, such as real time traffic flows and allowable vehicle speeds. As variables considered by the route guidance system increase, the cost to compute multiplies. Since handheld devices have limited resources, it is not feasible to use them to compute the exact optimal solutions in real time systems by some well-known algorithm, such as the Dijkstra’s algorithm, which is usually used to find the shortest path with a map of reasonable numbers of vertices. To solve this problem, we propose to use the genetic algorithm to alleviate the rising computational cost. We use the genetic algorithm to find the shortest time in driving with diverse scenarios of real traffic conditions and varying vehicle speeds. The effectiveness of the genetic algorithm is clearly demonstrated when applied on a real map of modern city with very large vertex numbers.

Induction of Forkhead Class box O3a and apoptosis by a standardized ginsenoside formulation, KG-135, is potentiated by autophagy blockade in A549 human lung cancer cells

Yao, Chih-Jung,Chow, Jyh-Ming,Chuang, Shuang-En,Chang, Chia-Lun,Yan, Ming-De,Lee, Hsin-Lun,Lai, I-Chun,Lin, Pei-Chun,Lai, Gi-Ming The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.3

Background: KG-135, a standardized formulation enriched with Rk1, Rg3, and Rg5 ginsenosides, has been shown to inhibit various types of cancer cells; however, the underlying mechanisms are not fully understood. In this study, we explored its effects in A549 human lung cancer cells to investigate the induction of Forkhead Class box O3a (FOXO3a) and autophagy. Methods: Cell viability was determined by sulforhodamine B staining. Apoptosis and cell cycle distribution were analyzed using flow cytometry. The changes of protein levels were determined using Western blot analysis. Autophagy induction was monitored by the formation of acidic vesicular organelles stained with acridine orange. Results: KG-135 effectively arrested the cells in G1 phase with limited apoptosis. Accordingly, a decrease of cyclin-dependent kinase-4, cyclin-dependent kinase-6, cyclin D1, and phospho-retinoblastoma protein, and an increase of p27 and p18 proteins were observed. Intriguingly, KG-135 increased the tumor suppressor FOXO3a and induced the accumulation of autophagy hallmark LC3-II and acidic vesicular organelles without an increase of the upstream marker Beclin-1. Unconventionally, the autophagy adaptor protein p62 (sequestosome 1) was increased rather than decreased. Blockade of autophagy by hydroxychloroquine dramatically potentiated KG-135-induced FOXO3a and its downstream (FasL) ligand accompanied by the cleavage of caspase-8. Meanwhile, the decrease of Bcl-2 and survivin, as well as the cleavage of caspase-9, were also drastically enhanced, resulting in massive apoptosis. Conclusion: Besides arresting the cells in G1 phase, KG-135 increased FOXO3a and induced an unconventional autophagy in A549 cells. Both the KG-135-activated extrinsic FOXO3a/FasL/caspase-8 and intrinsic caspase-9 apoptotic pathways were potentiated by blockade of autophagy. Combination of KG-135 and autophagy inhibitor may be a novel strategy as an integrative treatment for cancers.

Development of seven secondary neoplasms in a nevus sebaceous: a case report and literature review

Kuo, Yi-Wen,Lin, Jung-Chia,Tsai, Wei-Hsuan Korean Cleft Palate-Craniofacial Association 2022 Archives of Craniofacial Surgery Vol.23 No.2

Nevus sebaceous of Jadassohn is a congenital cutaneous hamartoma with epidermal, sebaceous, follicular, and apocrine structures that usually appears at birth or in early childhood. It has the potential to generate a variety of secondary neoplasms of different lineages, and the risk increases with patient age. Although multiple neoplasms may occasionally arise within the same lesion, the coexistence of more than five secondary tumors is extremely rare. Here we report a case of seven secondary tumors including syringocystadenoma papilliferum, desmoplastic trichilemmoma, sebaceoma, trichoblastoma, pigmented trichoblastoma, sebaceous adenoma, and tumor of follicular infundibulum arising within a nevus sebaceous. The complete diagnosis relies on the histopathological analysis of multipoint biopsies and delicate pathological sections.