장중첩증으로 발현된 원발성 림프종 1예

정태연,손석만,이창화,이원재,백승덕,최우혁,정희철,정소연,김남일,서정일,양창헌,이창우,정기훈,김정란 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.2

위장관은 악성 림프종이 가장 흔히 침범하는 림프절 외 장기이지만, 원발성 소장 악성림프종이 비교적 드물게 발생한다. 장중첩증은 장 림프종의 드문 징후이며, 다양한 영상 검사에 의하여 진단된다. 저자들은 회장 장중첩증에 의해 우연히 발견된 림프종의 예를 보고하는 바이다. 조직학적 소견은 미만성 대 B 세포의 악성 림프종이였고, 중증도의 미만성 대비분열성세포이였다. 환자는 수술적인 절제술과 항암요법을 시행하였고 15개월간 재발이 없는 상태로 추적 관찰 중이다. Although the gastrointestinal tract is one of the most frequent sites of extranodal malignant lymphoma, the occurrence of primary small intestinal lymphoma is relatively uncommon. The intussusception is a rare presenting sign of intestinal lymphoma, and diagnosed by various imaging studies. We report on a case of the lymphoma on ileum manifested by ileo-ileal intussusception. Pathologic type was malignant lymphoma with diffuse large B cell (REAL classification), intermediate grade, diffuse large noncleaved cell (Working formulation). The patient received surgical resection and combined chemotherapy and doing well for 15 months.

편평상피세포암과 동반된 소세포폐암에서 발생한 항이뇨호르몬 분비이상 증후군(SIADH) 1 예

이창우,이영현,이창화,이영실,유석동,장태정,구정태,윤병구,장재식,천우정,정희철,강혁주,서영범 대한내과학회 2001 대한내과학회지 Vol.61 No.5

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the term applied to arginine vasopressin (AVP) excess associated with hyponatremia without edema in the absence of physiologic or pharmacologic stimuli to AVP secretion. SIADH is associated with various conditions such as malignant tumors, infection, central nervous system disorders, and different pharmacological agents. The patient was 73-year-old female. She was admitted to the hospit al because of persistent cough, dizziness, gener al weakness and confusion. On admission, her serum osmolality was 253 mOsm/kg, urine osmolality was 416 mOm/ kg, and urine Na concentration was 159 mEq/ L. Her Chest X- ray and CT scan of lung showed about 4×3.5 cm sized mass at posterior basal segment of left lower lobe of the lung, and CT-guided percutaneous needle aspiration revealed small round cell with clusters of malignant squamous cells. She was treated by salt restriction, hypertonic saline infusion and demeclocycline. We planned chemotherapy for advaned combined lung cancer, but she was discharged because of poor general condition and associated pneumonia without cancer chemotherapy. We report a r are case of SIADH in small cell cancer of lung combined with squamous cell cancer of lung.(Korean J Med 61:562-566, 2001)

Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain

Kang, Young-Jin,Park, Min-Kyu,Lee, Hyun-Suk,Choi, Hyoung-Chul,Lee, Kwang-Youn,Kim, Hye-Jung,Seo, Han-Geuk,Lee, Jae-Heun,Chang, Ki-Churl The Korean Society of Pharmacology 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.5

A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes of cyclooxygenase (COX)-2 during reperfusion time-periods after PC were related to ischemic tolerance. Rats were given PC by occlusion of middle cerebral artery (MCAO) for 10 min and sacrificed after the indicated time-periods of reperfusion (1, 2, 4, 8, 12, 18 or 24 h). In PC-treated rats, focal ischemia was induced by occlusion of MCA for 24 h and brain infarct volume was then studied to determine whether different reperfusion time influenced the damage. We report that the most significant protection against focal ischemia was obtained in rats with 8 h reperfusion after PC. Administration of indomethacin (10 mg/kg, oral) or rofecoxib (5 mg/kg, oral) 48 h prior to PC counteracted the effect of PC. Immunohistochemical analysis showed that COX-2 and HO-l protein were induced in PC-treated rat brain, which was significantly inhibited by rofecoxib. Taken together, we concluded that the kinetic changes of COX-2 expression during the reperfusion period after PC might be partly responsible for ischemic tolerance.

Kinetic Changes of COX-2 Expression during Reperfusion Period after Ischemic Preconditioning Play a Role in Protection Against Ischemic Damage in Rat Brain

Young Jin Kang,Min Kyu Park,Hyun Suk Lee,Hyoung Chul Choi,Kwang Youn Lee,Hye Jung Kim,Han Geuk Seo,Jae Heun Lee,Ki Churl Chang 대한생리학회-대한약리학회 2008 The Korean Journal of Physiology & Pharmacology Vol.12 No.5

A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes of cyclooxygenase (COX)-2 during reperfusion time-periods after PC were related to ischemic tolerance. Rats were given PC by occlusion of middle cerebral artery (MCAO) for 10 min and sacrificed after the indicated time-periods of reperfusion (1, 2, 4, 8, 12, 18 or 24 h). In PC-treated rats, focal ischemia was induced by occlusion of MCA for 24 h and brain infarct volume was then studied to determine whether different reperfusion time influenced the damage. We report that the most significant protection against focal ischemia was obtained in rats with 8 h reperfusion after PC. Administration of indomethacin (10 mg/kg, oral) or rofecoxib (5 mg/kg, oral) 48 h prior to PC counteracted the effect of PC. Immunohistochemical analysis showed that COX-2 and HO-1 protein were induced in PC-treated rat brain, which was significantly inhibited by rofecoxib. Taken together, we concluded that the kinetic changes of COX-2 expression during the reperfusion period after PC might be partly responsible for ischemic tolerance.

Higenamine의 합성 및 가토의 심혈관계에 미치는 영향 : 베타-아드레날린성 효능 약물

장기철(Ki-Churl Chang),임정규(Jung-Kyoo Lim),박찬웅(Chan-Woong Park) 대한약리학회 1986 대한약리학잡지 Vol.22 No.2

최근에 미나라아제비과 (Ranunculaceae)에 속하는 부자(Aconiti tuber)로부터 강심작용을 나타내는 성분을 분리하여 Higenamine이라 명명하였고 그 작용기전을 밝히려는 시도가 활발히 진행되고 있다. 그러나 생약제로 부터 얻을 수 있는 Higenamine은 극히 미량이고 그 과정 또한 복잡하다. 따라서 본 연구에서는 유효성분을 대량 얻기 위한 방법으로서 전합성(total Synthesis)을 시도하였으며 IR, UV, NMR 및 elemental 분석등을 통하여 합성된 물질을 확인하였으며 가토에 대하여 in vivo에서 혈압, 심박동수, 호흡 및 말초저항에 미치는 영향과 아울러 in vitro에서 심근수축 증강작용(positive inotropic action) 및 심박속도 증강작용(positivechronotropic action)을 관찰 분석하여 다음과 같은 결론을 얻었다. 1) Higenamine은 1-10μg/kg/min 정맥주사시 수축기 및 이완기혈압 모두를 용량 의존적으로 하강시켰고 후자가 전자보다 더욱 현저하였으며 호흡은 촉진되었고 말초 혈류량은 증가되었으나 심박동수는 영향이 없었다. 2) 혈압에 대한 Higenamine의 작용은 propranolol 전처치에 의하여 억제되었다. 3) Higenamine의 catechol핵과 커다란 아미노기는 베타 수용체기 대하여 전자는 활성을 후자는 친화력과 관계있을 것으로 추정하였다. 이상의 결과 Higenamine은 adrenergic β-수용체에 작용하여 그 작용을 발휘하는 것으로 사료 되었다. Higenamine, dl-1-( 4-hydroxybenzyl)-6, 7-dihydroxy-1 ,2, 3 ,4-tetrahydroisoquinoline has been synthesized and evaluated for hemodynamic actions using rabbits under pentobarbital anesthesia. Concentration-related fall of mean blood pressure was observed, where diastolic blood presure was significantly lowered at 10 ug/kg/min or above (p<.05), while the systolic blood pressure was slightly increased or unaffected, thereby, causing increment of pulse pressure. No significant change was occured in heart rate, however, carotid artery blood flow was significantly (p<.05) increased. These actions were inhibited with pretreatment of 0.3 mg/kg of propranolol, beta-adrenoceptor antagonist, 5 minutes before infusion of higenamine indicating that higenamine compete with propranolol for the so-called beta adrenergic receptor. As comparison, the same procedure was applied to isoproterenol as well, where typical antagonism of propranolol against isoproterenol was shown. From these findings the vasodilating and diastolic blood pressure lowing effects could be explained in terms of cardiac beta stimulating action, however, dopamine receptor activation could not be excluded because no significant changes observed in chronotropism.

Costs Attributable to Overweight and Obesity in Working Asthma Patients in the United States

Chang, Chongwon,Lee, Seung-Mi,Choi, Byoung-Whui,Song, Jong-hwa,Song, Hee,Jung, Sujin,Bai, Yoon Kyeong,Park, Haedong,Jeung, Seungwon,Suh, Dong-churl Yonsei University, College of Medicine 2017 Yonsei medical journal Vol.58 No.1

<P><B>Purpose</B></P><P>To estimate annual health care and productivity loss costs attributable to overweight or obesity in working asthmatic patients.</P><P><B>Materials and Methods</B></P><P>This study was conducted using the 2003–2013 Medical Expenditure Panel Survey (MEPS) in the United States. Patients aged 18 to 64 years with asthma were identified via self-reported diagnosis, a Clinical Classification Code of 128, or a ICD-9-CM code of 493.xx. All-cause health care costs were estimated using a generalized linear model with a log function and a gamma distribution. Productivity loss costs were estimated in relation to hourly wages and missed work days, and a two-part model was used to adjust for patients with zero costs. To estimate the costs attributable to overweight or obesity in asthma patients, costs were estimated by the recycled prediction method.</P><P><B>Results</B></P><P>Among 11670 working patients with a diagnosis of asthma, 4428 (35.2%) were obese and 3761 (33.0%) were overweight. The health care costs attributable to obesity and overweight in working asthma patients were estimated to be $878 [95% confidence interval (CI): $861–$895] and $257 (95% CI: $251–$262) per person per year, respectively, from 2003 to 2013. The productivity loss costs attributable to obesity and overweight among working asthma patients were $256 (95% CI: $253–$260) and $26 (95% CI: $26–$27) per person per year, respectively.</P><P><B>Conclusion</B></P><P>Health care and productivity loss costs attributable to overweight and obesity in asthma patients are substantial. This study's results highlight the importance of effective public health and educational initiatives targeted at reducing overweight and obesity among patients with asthma, which may help lower the economic burden of asthma.</P>

The Action Mechanism of Higenamine on Smooth Muscle Preparations of Rabbits

CHANG, Ki-churl,LIM, Jung-kyoo,SUH, Man-chul 慶尙大學校 1985 論文集 Vol.24 No.1

The Purpose of this study was to determine if mechanism of action of higenamine on smooth muscle preparations of rabbit is associated with a beta adrenergic receptor stimulation. Muscle strips, about 5×20mm long, were stimulated with a range of concentration of histamine, metacholine(small intestine) and oxytocin (uterus) in an organ bath filled with oxyganated (95% 02-5% CO_2) Krebs' solutions as to obtain concentration-response curves. The effect of higenamine was investigated by comparing pD_2 values (negative logarithm of the molar concentration of the antagonist needed to 50% inhibition of maximum contraction) against histamine and methacholine-provoked contractions as well as comparing pA_2 values (negative logaithm of the molar concentration of the antagonist which produces an agonist dose ratio of 2) against oxytocininduced contractions.

Analysis Characteristics of Heavy Metals(Pb, Cd, Cr, and Hg) on Commercial Wet Wipes and Hygienic Moist Hand Towels for Food Restaurants

Chang-ho Han,Min-su Jang,Bu-churl Choi,Si-jung Kim,So-young Jung,In-soon Cho,Jae-hoon Cha,In-sook Hwang 한국분석과학회 2022 학술대회논문집 Vol.2022 No.11

Responsiveness of Muscarinic and Alpha Adrenergic Activation on Endothelial Cell in Isolated Canine Renal Arteries

Chang, Ki Churl,Chung, Soo Youn,Lim, Jung Kyoo 경상대학교 축산진흥연구소 1989 畜産振興硏究所報 Vol.16 No.1

다발성 골수종 환자에서 척추주위 수질외 형질세포종으로 재발한 1례

정소연,장재식,정희철,천우정,이창화,김성욱,나득영,이상권,박건욱 東國大學校醫學硏究所 2001 東國醫學 Vol.8 No.-

다발성 골수종은 면역글로불린을 분비하는 세포의 클론을 만드는 B림프 전구세포의 형질 전환과 그 증식으로 야기되는 종양이다. 다른 형질세포 종양으로는 골 단독의 형질세포종과 수질외 형질세포종이 있다. 이 종양들은 공통된 기원임에도 불구하고 이들 종양사이엔 병리적, 임상적 차이가 있고 종양간의 관련성에 대해서 잘 알려져 있지 않다. 저자들은 화학치료로 부분 관해를 보인 다발성 골수종 환자에서 혈청이나 요의 골수종 단백질의 증가없이 비전형적인 방식으로 다발성 수질외 형질세포종으로 진행된 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 본 증례는 척수 압박을 야기한 척추주위 종괴로 재발된 경우이다. Multiple myeloma is a neoplastic disorder caused by the proliferation of transformed B lymphoid progenitor cell that gives rise to a clone of immunoglobulin-secreting cells. Other plasma cell tumors include solitary plasmacytoma of bone and extramedullary plasmacytoma(EMP). Despite the common origin, there exists pathological and clinical differences between these neoplasms and associations between them are not completely understood. We are reporting a case of multiple myeloma which, after an initial response to chemotherapy, progressed in an atypical manner, with the development of multiple EMP and abscence of protein of serum or urine. Our case is unusual because the patient had a recurrent paravertebral mass that caused compression the spinal cord.