비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

폐쇄성 수면 무호흡 환자의 측모 두부방사선계측사진 및 치아모형 연구

정미라,황상희,남기영,김종배,권오원 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.3

폐쇄성 수면 무호흡증이란 수면도중 주기적으로 호흡이 멈추는 증상을 말한다. 상악과 하악이 후퇴되어 있거나 하악이 작으며 수평적으로 기도 폭경이 좁고 혀가 후방에 위치하는 등 폐쇄성 수면 무호흡 환자의 전후방적인 악골 및 연조직 특성에 대한 평가는 많았으나 치열 및 악궁에 대한 평가가 부족하여 폐쇄성 수면 무호흡증 환자의 골격적 특징과 악궁의 폭경과 구개깊이와 수면무호흡지수와의 상관관계를 알아보고자 하였다. 계명대학교 의과대학 동산의료원 수면클리닉에 수면장애를 주소로 내원한 환자 중 수면다원검사와 측모 두부방사선계측사진과 치아모형이 갖추어진 38명의 남자를 대상으로 하여 치아모형과 측모 두부방사선계측사진, 수면무호흡지수와 체질량지수를 비교하였다. 수면무호흡지수와 악궁의 횡폭경, 구개깊이, 수직피개량 및 수평피개량과는 상관관계가 없었으며 수면무호흡군에서 상기도 폭경은 좁고, 하기도 폭경은 넓은 경향이 있었다. 수면무호흡지수와 상기도 폭경은 미약한 음의 상관관계를 가졌으나 하기도 폭경은 미약한 양의 상관관계를 가졌고, 수면무호흡지수가 클수록 하악 하연으로터 설골까지의 거리도 멀었다. To evaluate the cephalometric and dental characteristics of obstructive sleep apnea (OSA) patients, 23 OSA patients and 15 control, non-OSA, patients who visited the Sleep Disorder Clinic Center, Keimyung University were investigated. Patients who suffered from apnea-hypopnea episodes over 10 times per hour were diagnosed as having OSA after polysomnograph testing. Impressions were taken with alginate. Cephalometric radiographs were taken at maximum intercuspation. The dental cast measurements, including transpalatal width, intercanine width, intermolar width and palatal depth did not differ between the control and OAS groups and did not have a positive correlation with the apnea-hypopnea index (AHI). Upper airway width was statistically narrower than the control group. Upper airway width had a low negative correlation with AHI, but, lower airway width had a low positive correlation, and, the higher the AHI score, the longer the mandibular border to hyoid distance.

ROC 분석을 이용한 y -glutamyltranspeptidase와 대사증후군과의 관련성 평가

김용배,함정오 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

기상변화에 의한 기관지천식 발생빈도 분석에 지리정보체계의 유용성

김용배,함정오 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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반복측정자료를 통한 적설량과 수확량의 관계

오인배,박흥선,신정아 高麗大學校 統計硏究所 1999 應用統計 Vol.14 No.-

본 연구는 "겨울에 눈이 많이 오면 풍년이 든다"는 속담을 통계적으로 검정하고자 하는 것을 목적으로 하고 있다. 쌀과 보리에 대한 단위 면적 당 수확량과 신적설과 적설을 반복측정모형으로 모형화 함으로써 접근하였는데, 그 결과, 눈이 많이 오면 풍년이 든다는 속담이 통계적으로 유의 하다고 결론 내릴 수 있었다. In Korean proverbs, "The big snowfall makes the big crop yield". We collected the snowfall and the crop yield data for the consecutive 9 years from 1988 to 1996; and we investigate the statistical significance of the relationship appeared in the proverb. In conclusion, the proverb is statistically valid on the rice and the barley yields.

흉추 경막외강으로 침윤한 흉선종 1례 : Metstasis to Thoracic Epidural Space

최정훈,백욱성,박대곤,오경구,최천식,배상도 高麗病院 1987 高醫 Vol.10 No.-

ROC 분석을 이용한 ν-glutamyltranspeptidase와 대사증후군과의 관련성 평가

김용배,함정오 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

This study was accomplished to find out the relationship between γ-glutamyl transpeptidase(γ-GTP) and metabolic syndrome, and to suggest the optimal positive cut off point of γ-GTP using receiver operating characteristic(ROC) analysis. Study subjects were 171 women who participated in health screening at health promotion center in Soonchunhyang Cheonan hospital in 2006. We measured waist circumference, blood pressure, fasting glucose, triglyceride, high density lipoprotein cholesterol and γ-GTP. ROC analysis showed an area under the curve(AUC) of 0.870(95% confidence interval : 0.801 - 0.938), indicating an excellent classification performance of the model. The sensitivity of 88% and specificity of 81% was achieved at the optimal cut off point of γ-GTP around 20.5 U/L. In conclusion, γ-GTP could be used as a screening test for diagnosis of metabolic syndrome in nondrinker.

인산농도의 차이에따른 광합성 세균 Rhodospirillum rubrum의 인산대사에 관한 연구

이정배,김영미,오덕철,이동헌 濟州大學校 基礎科學硏究所 1996 基礎科學硏究 Vol.9 No.2

인산농도의 차이에 따른 광합성 세균 Rhodospirillum rubrum의 인산대사에 대해 인산화합물의 함량변화, 폴리인산의 축적량 및 이에 관련된 효소의 활성, 그리고 총 단백질 양상을 조사하였다. 인산이 처리되지 않는 배지(Pi 0%)에서는 생장이 매우 저조하고, 인산이 정상적으로 처리된 배지(Pi 0.03%)과 인산이 과다한 배지(Pi 0.3%)에서 매우 높은 생장을 나타났다. 인산이 처리되지 않은 배지에서는 모든 인산화합물이 감소하였고, total phosphate와 polyphosphate의 함량은 인산이 제한된 배지(Pi 0.003%)와 인산이 정상적으로 처리된 배지에서보다 인산이 과다한 배지에서 높은 함량을 나타났다. 전반적으로 배지내에 인산농도가 높을수록 세포내의 모든 인산화합물의 함량이 높게 나타났다. 인산이 없는 배지에서 성장한 세포와 인산이 제한된 배지에서 성장한 세포에서는 lipid phosphate의 함량이 유사한 양상을 보였고, 산불용성 폴리인산의 함량은 인산이 제한된 배지와 인산이 정상적으로 처리된 배지에서 유사한 양상을 보였다. Alkaline phosphatase, tripolyphosphatase 와 polyphosphatase의 활성은 인산이 처리되지 않는 배지에서 매우 높게 나타났으며, 특히 alkaline phosphatase의 활성은 인산이 처리된 배지에서는 거의없었다. 전기 영동에 의한 총단백질 양상을 보면, 인산이 처리되지 않는 배지에서 성장한 세포에서는 인산이 첨가된 배지에서 보이지 않은 3개의 새로운 band가 나타났다. 분자량은 약 35kD, 40kD 그리고 63kD로 추정할 수 있었다. 결론적으로 인산농도의 차이가 Rhodospirillum rubrum 세포의 생장과 세포내의 인산화합물 및 인산대사에 관련된 효소의 활성, 총단백질 양상에 영향을 미치고 있음을 알 수 있었다. The effects of inorganic orthophosphate on the growth, the content of phosphate compounds, the activities of enzymes related to phosphate metabolism and patterns of total cellular proteins were investigated in Rhodospirillum rubrum grown on the media of different concentrations of phosphate. The growth in the phosphate-free medium was very low but very high in the standard and phosphate-excess media. The cellular contents of all tested phosphate compounds were much decreased in phosphate-free medium. The total phosphate and polyphosphate contents were much higher in phosphate-excess medium than in other media. Generally, the contents of all kind of phosphate-excess medium than in other media. Generally, the contents of all kind of phosphate compounds in the cell were in order of added phosphate concentration of the medium but the content of lipid phosphate in the cells grown on the phosphate-limited medium and the contents of lipid phosphate in the cells grown on the phosphate-limited medium and the contents of acid insoluble polyphosphate of cells grown on the phosphate-limited and standard medium were shown similar with those on the phosphate-free medium. The activities of alkaline phosphatase. tripolyphosphatase and polyphosphatase were much higher in the cells on phosphate-free medium than in any other media, expecially the activities of alkaline phosphatase in the cells grown on the media except phosphate-free were near to zero. The SDS-PAGE pattern of total protein from cells grown on the phosphate-free medium exhibited three new bands which were not seen in the cells grown on the phosphate-added media. The molecular weight of the three new bands were postulated as about 35kD, 40kD and 63kD respectively. In conclusion, the different concentration of phosphate in the culture medium influenced the cells for the growth, the levels of phosphate compounds, the activities of enzymes related to phosphate metabolism and the pattern of total cellular proteins in many ways in the photosynthetic bacterium, Rhodospirillum rubrum.

신경회로망 제어기를 이용한 PID 파라미터 추정에 관한 연구

權重東,裵銀敬,金恩基,全基英,李承桓,吳鳳煥,李勳九,金容珠,韓慶熙 明知大學校 産業技術硏究所 2006 産業技術硏究所論文集 Vol.25 No.-

In this paper, supposed to solve these problem to PID parameters controller algorithm using ANN. In the proposed algorithm, the parameters of the controller were adjusted to reduce by on-line system the error of the speed of IM. In this process, EBPA NN was constituted to an output error value of an IM and conspired an input and output. The performance of the self-tuning controller is compared with that of the PH) controller tuned by conventional method (Ziehler-Nichols). The effectiveness of the proposed control method is verified thought the Matlab Simulink and experimental results.