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- 저자 : Juncheng Jiang (검색결과 4 건)
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JunCheng Guo,YiJun Yang,Min Guo,XiaoDan Wang,Yang Juan,YunSuo Gao,LinQiu Fu,XiangLing Jiang,LinMei Fu,Tao Huang 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4
Objective-To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). Methods-A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the pvalues were corrected with the permutation test. Results-The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). Conclusion-The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.
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Hong Jiang,Pengfei Gao,Huadong Chen,Zhihai Zhong,Man Shu,Zhichong Zhang,Jinbiao She,Juncheng Liu 대한의학회 2018 Journal of Korean medical science Vol.33 No.30
Background: Postoperative cholangitis is a common but severe complication after Kasai portoenterostomy for biliary atresia (BA). This study aimed to identify its prognostic factors Methods: Two sets of liver paraffin-embedded tissue samples were collected from BA patients who received Kasai portoenterostomy (n = 25 and n = 31, respectively). Patients were divided into non-cholangitis and cholangitis groups. The infiltration of CD4+ , CD8+ , CD45RO+ , CD68+ cells and expression of Beclin1 were quantitatively evaluated in immunohistochemical analysis. Results: Cholangitis group had a significantly lower CD8+ T cell infiltration but a higher CD45RO+ cell infiltration, and a lower Beclin1 level than non-cholangitis group (all P < 0.01). Multivariate logistic regression analysis indicated that infiltration of CD8+ cells (odds ratio [OR], 0.112; 95% confidence interval [CI], 0.022–0.577) and CD45RO+ cells (OR, 3.88; 95% CI, 1.37–11.03), and Beclin1 level (OR, 0.088; 95% CI, 0.018–0.452) were independent influence factors for early postoperative cholangitis. Receiver operating characteristic (ROC) analysis showed that area under ROC curve (AUROC) values for CD8+ cells, CD45RO+ cells and Beclin1 were 0.857, 0.738 and 0.900, respectively. Conclusion: Our findings demonstrated the CD8+ cells, CD45RO+ cells and Beclin1 level possessed the prognostic value for early postoperative cholangitis following Kasai operation, which may be helpful to develop new prevention and treatment strategies for postoperative cholangitis.
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A Simulation Study on the Impact of Abandoned Trolley Cases on Pedestrian Evacuation
Dongyue Xu,Jinghong Wang,Juan Liu,Yan Wang,Juncheng Jiang 대한토목학회 2023 KSCE JOURNAL OF CIVIL ENGINEERING Vol.27 No.3
Many pedestrians empirically think that discarding luggage can improve evacuation efficiency, but it is unclear whether discarding luggage is an effective evacuation strategy. Previous models also oversimplified the interference of abandoned luggage on pedestrians. Hence, an extended social force model integrates pedestrian interaction with abandoned luggage like trolley cases was firstly proposed. A simulation based on a real metro station was carried out to examine the effectiveness of evacuation strategy like abandoning trolley cases at the bottleneck such as gate machine and metro carriage door, and the influence mechanism of abandoned trolley cases on pedestrians was investigated. The results show that discarding the trolley cases at the gate machine and at the metro carriage door cannot improve evacuation efficiency but increase the evacuation time by 78.7% and 14.9% at these two positions when the carrying ratio is 50%, respectively. When the occupancy rate of trolley case at the gate machine and metro carriage door is below 19% and 11%, pedestrians tend to detour the abandoned trolley cases and this behavior significantly increased the collisions between pedestrians at bottlenecks, and when the occupancy rate exceeds, they tend to push aside the trolley cases and the evacuation efficiency is further reduced.
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Jinghong Wang,Wenyu Yan,Han Xu,Youran Zhi,Zhirong Wang,Juncheng Jiang 대한토목학회 2018 KSCE Journal of Civil Engineering Vol.22 No.3
Emergency evacuation in subway fires is one of the hot issues in public safety. Based on Bayesian theory, a dynamic evacuation risk analysis model considering both psychological and behavioral responses of evacuees was proposed in this contribution. A subway fire scene was modeled using the Event Tree Analysis (ETA) according to the questionnaire survey at Nanjing Xinjiekou station. In this fire scenario, three control events (the fire alarm, the exhaust system and the evacuation route) were related to fire evacuation control and two control events (active escape and passive escape), which were specifically defined, were related to personnel characteristics. Subsequently, the probability of the final state of each scene was calculated by Monte Carlo simulation. Combined with the statistics of accidents and safe evacuation of subway fire cases from 1976 to 2013, the posterior probability distribution of safety evacuation was obtained after real-time dynamic updating of its precursor probability through Bayesian theory. Results show that the posterior probability of safety evacuation to succeed is around 0.8. This indicates that there is still a probability of 0.2 resulting in injury or fatalities in subway accidents even though most passengers are safely evacuated. It also suggests that utilization of 0.2 as the safety threshold would be an appropriate choice.
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