Two-Dimensional Shear Wave Elastography Predicts Liver Fibrosis in Jaundiced Infants with Suspected Biliary Atresia: A Prospective Study

Chen Huadong,Zhou Luyao,Liao Bing,Cao Qinghua,Jiang Hong,Zhou Wenying,Wang Guotao,Xie Xiaoyan 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6

Objective: This study aimed to evaluate the role of preoperative two-dimensional (2D) shear wave elastography (SWE) in assessing the stages of liver fibrosis in patients with suspected biliary atresia (BA) and compared its diagnostic performance with those of serum fibrosis biomarkers. Materials and Methods: This study was approved by the ethical committee, and written informed parental consent was obtained. Two hundred and sixteen patients were prospectively enrolled between January 2012 and October 2018. The 2D SWE measurements of 69 patients have been previously reported. 2D SWE measurements, serum fibrosis biomarkers, including fibrotic markers and biochemical test results, and liver histology parameters were obtained. 2D SWE values, serum biomarkers including, aspartate aminotransferase to platelet ratio index (APRi), and other serum fibrotic markers were correlated with the stages of liver fibrosis by METAVIR. Receiver operating characteristic (ROC) curves and area under the ROC (AUROC) curve analyses were used. Results: The correlation coefficient of 2D SWE value in correlation with the stages of liver fibrosis was 0.789 (p < 0.001). The cut-off values of 2D SWE were calculated as 9.1 kPa for F1, 11.6 kPa for F2, 13.0 kPa for F3, and 15.7 kPa for F4. The AUROCs of 2D SWE in the determination of the stages of liver fibrosis ranged from 0.869 to 0.941. The sensitivity and negative predictive value of 2D SWE in the diagnosis of ≥ F3 was 93.4% and 96.0%, respectively. The diagnostic performance of 2D SWE was superior to that of APRi and other serum fibrotic markers in predicting severe fibrosis and cirrhosis (all p < 0.005) and other serum biomarkers. Multivariate analysis showed that the 2D SWE value was the only statistically significant parameter for predicting liver fibrosis. Conclusion: 2D SWE is a more effective non-invasive tool for predicting the stage of liver fibrosis in patients with suspected BA, compared with serum fibrosis biomarkers.

Interval finite element method based on the element for eigenvalue analysis of structures with interval parameters

Yang, Xiaowei,Chen, Suhuan,Lian, Huadong Techno-Press 2001 Structural Engineering and Mechanics, An Int'l Jou Vol.12 No.6

A new method for solving the uncertain eigenvalue problems of the structures with interval parameters, interval finite element method based on the element, is presented in this paper. The calculations are done on the element basis, hence, the efforts are greatly reduced. In order to illustrate the accuracy of the method, a continuous beam system is given, the results obtained by it are compared with those obtained by Chen and Qiu (1994); in order to demonstrate that the proposed method provides safe bounds for the eigenfrequencies, an undamping spring-mass system, in which the exact interval bounds are known, is given, the results obtained by it are compared with those obtained by Qiu et al. (1999), where the exact interval bounds are given. The numerical results show that the proposed method is effective for estimating the eigenvalue bounds of structures with interval parameters.

The Prognostic Value of CD8+ and CD45RO+ T Cells Infiltration and Beclin1 Expression Levels for Early Postoperative Cholangitis of Biliary Atresia Patients after Kasai Operation

Hong Jiang,Pengfei Gao,Huadong Chen,Zhihai Zhong,Man Shu,Zhichong Zhang,Jinbiao She,Juncheng Liu 대한의학회 2018 Journal of Korean medical science Vol.33 No.30

Background: Postoperative cholangitis is a common but severe complication after Kasai portoenterostomy for biliary atresia (BA). This study aimed to identify its prognostic factors Methods: Two sets of liver paraffin-embedded tissue samples were collected from BA patients who received Kasai portoenterostomy (n = 25 and n = 31, respectively). Patients were divided into non-cholangitis and cholangitis groups. The infiltration of CD4+ , CD8+ , CD45RO+ , CD68+ cells and expression of Beclin1 were quantitatively evaluated in immunohistochemical analysis. Results: Cholangitis group had a significantly lower CD8+ T cell infiltration but a higher CD45RO+ cell infiltration, and a lower Beclin1 level than non-cholangitis group (all P < 0.01). Multivariate logistic regression analysis indicated that infiltration of CD8+ cells (odds ratio [OR], 0.112; 95% confidence interval [CI], 0.022–0.577) and CD45RO+ cells (OR, 3.88; 95% CI, 1.37–11.03), and Beclin1 level (OR, 0.088; 95% CI, 0.018–0.452) were independent influence factors for early postoperative cholangitis. Receiver operating characteristic (ROC) analysis showed that area under ROC curve (AUROC) values for CD8+ cells, CD45RO+ cells and Beclin1 were 0.857, 0.738 and 0.900, respectively. Conclusion: Our findings demonstrated the CD8+ cells, CD45RO+ cells and Beclin1 level possessed the prognostic value for early postoperative cholangitis following Kasai operation, which may be helpful to develop new prevention and treatment strategies for postoperative cholangitis.

Investigation of aerodynamic behaviour of a high-speed train on different railway infrastructure scenarios under crosswind

Jiqiang Niu,Yingchao Zhang,Zheng-Wei Chen,Rui Li,Huadong Yao 한국풍공학회 2022 Wind and Structures, An International Journal (WAS Vol.35 No.6

The aerodynamic behaviour of a CRH high-speed train under three infrastructure scenarios (flat ground, embankment, and viaduct) in the presence of a crosswind was simulated using a 1/8th scaled train model with three cars and the IDDES framework. The time-averaged and instantaneous flow field around the model were examined. The employed numerical algorithm was verified through a wind tunnel test, and the grid and timestep resolution analyses were conducted to ensure the reliability of the data. It was noted that the flow around the rail line was different under different infrastructure scenarios, especially in the case of the embankment, which degraded the aerodynamic performance of the train under the crosswind. The flow around the train on the flat ground and viaduct was different, although the aerodynamic performance of the train was similar in both cases. Moreover, the viaduct accidents were noted to have the most critical consequences, thereby requiring the most attention. The aerodynamic performance of the train on the windward track of the embankment under the crosswind was worse than that of the train on the leeward track. But for the other two infrastructure scenarios, the aerodynamic performance of the train on the windward track is relatively dangerous, which is mainly caused by the head car. These observations suggest that the aerodynamic behaviour of the train on an embankment under a crosswind must be carefully considered and that certain wind protection measures must be adopted around rail lines in windy areas.

White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer’s Disease in the Elderly in China

Shuai Ye,Shuyang Dong,Jun Tan,Le Chen,Hai Yang,Yang Chen,Zeyan Peng,Yingchao Huo,Juan Liu,Mingshan Tang,Yafei Li,Huadong Zhou,Yong Tao 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.