http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jun-Hao Xu (검색결과 34 건)
- 무료
- 기관 내 무료
- 유료
-
-
-
( Xin-fei Xu ),( Jiong-jie Yu ),( Ju-dong Li ),( Hao Xing ),( Jun Han ),( Zhen-li Li ),( Han Wu ),( Han Zhang ),( Jian-hong Zhong ),( Yi- Sheng Huang ),( Ya-hao Zhou ),( Ting-hao Chen ),( Hong Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Late recurrence (> 2 years) after liver resection of hepa tocellular carcinoma (HCC) is usually considered as multi-centric tumors or de novo cancer formation. We aimed to investigate risk factors, patterns and outcomes of late recurrence after HCC resection. Methods: From a multicenter database from 2001 to 2015, 734 patients who were alive and recurrence-free at 2 years after curative resection of initial HCC were enrolled into this retrospective study. Univariate and multivariate Cox-regression analysis were used to identify independent risk factors of late recurrence. Patterns, treatments and outcomes of late recur rence were investigated and analyzed. Results: During a median follow-up of 78.0 months after surgery, 303 patients (41.3%) developed late recurrence. Mul tivariate analysis revealed that cirrhosis, macroscopic vascular invasion, satellites, and tumor size > 5cm were independent risk factors of late recurrence. Among them, 273 (90.1%) were sole intrahepatic recurrence, 30 (9.9%) were concurrent intra hepatic and extrahepatic recurrence, and none of them was sole extrahepatic recurrence; 165 (54.4%) patients received curative treatments for recurrent HCC, including re-resection, transplantation and local ablation. Multivariate analysis showed regular postoperative surveillance and receiving curative treat ments were two independent protective factors of prolonging survival for those patients with late recurrence. Conclusions: Late recurrence is correlated with cirrhosis and certain tumor-related characteristics of initial HCC. The pat terns of late recurrence suggest that postoperative surveillance after 2 years of surgery could be adjusted and more targeted. Regular postoperative surveillance improves the probability to receive curative treatments again, yielding to better outcomes for patients with late recurrence.
-
Jun Du,Junfang Xia,Hao Wu,Wenqiang Xu 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.1
The agricultural digging device for lotus root make waterjet scour away the soil around lotus root to help it float up to water surface by buoyancy on harvesting . The performance of the waterjet was investigated by CFD-DEM simulation and experiment for its optimization. The Hertz-Mindlin with JKR model was used as the soil around lotus root was cohesive. The simulation shoes that the digging depth increases with the increase of the jetting angle and the decrease of the diameter of nozzle. The preliminary trial verified this trend, and it revealed that the digging depth determined the digging ratio. In the field experiment, the effects of type of nozzle, diameter of nozzle and jetting angle on digging depth, digging ratio, breaking ratio and surface damage ratio were studied. The results showed that a larger diameter with a larger jetting angle for a suitable type of nozzle can obtain a high digging ratio with a lower breaking ratio and surface damage ratio.
-
Xu, Ying,Tian, Xin-Peng,Liu, Yu-Juan,Li, Jie,Kim, Chang-Jin,Yin, Hao,Li, Wen-Jun,Zhang, Si International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.3
<P>A marine bacterium, designated SCSIO 03483<SUP>T</SUP>, was isolated from a marine sediment sample collected from the Nansha Islands in the South China Sea. The strain produced roundish colonies with diffusible yellow-coloured pigment on nutrient agar medium or marine agar 2216. Optimal growth occurred in the presence of 0–4 % (w/v) NaCl, at pH 7.0 and a temperature range of 28–37 °C. 16S rRNA gene sequence analysis indicated that the isolate belonged to the family <I>Flavobacteriaceae</I> and showed relatively high sequence similarity with <I>Imtechella halotolerans</I> K1<SUP>T</SUP> (92.7 %). Phylogenetic analysis based on nearly complete 16S rRNA gene sequences revealed that the isolate shared a lineage with members of the genera <I>Imtechella</I>, <I>Joostella</I> and <I>Zhouia</I>. Phospholipids were phosphatidylethanolamine, two unidentified aminolipids and three unknown polar lipids. The major respiratory quinone was MK-6 and the major fatty acids were iso-C<SUB>15 : 0</SUB>, iso-C<SUB>17 : 0</SUB> 3-OH and summed feature 3 (C<SUB>16 : 1</SUB>ω6<I>c</I>/C<SUB>16 : 1</SUB>ω7<I>c</I>). The DNA G+C content of strain SCSIO 03483<SUP>T</SUP> was 38.4 mol%. On the basis of phenotypic, chemotaxonomic and molecular data, strain SCSIO 03483<SUP>T</SUP> represents a novel species in a new genus in the family <I>Flavobacteriaceae</I>, for which the name <I>Sinomicrobium oceani</I> gen. nov., sp. nov. is proposed. The type strain of <I>Sinobacterium oceani</I> is SCSIO 03483<SUP>T</SUP> ( = KCTC 23994<SUP>T</SUP> = CGMCC 1.12145<SUP>T</SUP>).</P>
-
In Vitro and In Vivo Studies of Different Liposomes Containing Topotecan
Hao, Yan-Li,Deng, Ying-Jie,Chen, Yan,Wang, Xiu-Min,Zhong, Hai-Jun,Suo, Xu-Bin The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.5
Liposome as a carrier of topotecan (TPT), a promising anticancer drug, has been reported in attempt to improve the stability and antitumor activity of TPT. However, the biodistr ibution pattern of TPT liposome in vivo and PEG-modified liposome containing TPT have not been studied systemically. In this paper, the in vitro stability and in vivo biodistribution behavior of several liposomes containing TPT with different lipid compositions and PEG-modification were studied. Compared with the 'fluid' liposome (S-Lip) composed of soybean phosphatidylcholine (SPC), the 'solid' liposome (H-Lip) composed of hydrogenated soybean phosphatidylcholine HSPC decreased the leaking efficiency of TPT from liposome and enhanced the stability of liposome in fetal bovine serum (FBS) or human blood plasma (HBP). The results of biodistribution studies in S$_{180}$ tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. Compared with free TPT, S-Lip and H-Lip resulted in 5- and 19- fold increase in the area under the curve (AUC$_{0\rightarrow\propto}$), respectively. PEG- modified H-Lip (H-PEG) showed 3.7-fold increase in AUC$_{0\rightarrow\propto}$ compared with H-Lip, but there was no significant increase in t$_{1/2}$ and AUC$_{0\rightarrow\propto}$ for PEG-modified S-Lip (S-PEG) compared with S-Lip. Moreover, the liposomal encapsulation changed the biodistribution behavior, and H-Lip and H-PEG dramatically increased the accumulation of TPT in tumor, and the relative tumor uptake ratios were 3.4 and 4.3 compared with free drug, respectively. There was also a marked increase in the distribution of TPT in lung when the drug was encapsulated into H-Lip and H-PEG. Moreover, H-PEG decreased the accumulation of TPT in bore marrow compared with unmodified H-Lip. All these results indicated that the membrane fluidity of liposome has an important effect on in vitro stability and in vivo biodistribution pattern of liposomes containing TPT, and PEG-modified 'solid' liposome may be an efficient carrier of TPT.
-
A Hybrid Modular Multilevel Converter Topology with an Improved Nearest Level Modulation Method
Jun Wang,Xu Han,Hao Ma,Zhihong Bai 전력전자학회 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.1
In this paper, a hybrid modular multilevel converter (MMC) topology with an improved nearest level modulation method is proposed for medium-voltage high-power applications. The arm of the proposed topology contains N series connected half-bridge submodules (HBSMs), one full-bridge submodule (FBSM) and an inductor. By exploiting the FBSM, half-level voltages are obtained in the arm voltages. Therefore, an output voltage with a 2N+1 level number can be generated. Moreover, the total level number of the inserted submodules (SMs) is a constant. Thus, there is no pulse voltage across the arm inductors, and the SM capacitor voltage is rated. With the proposed voltage balancing method, the capacitor voltage of the HBSM is twice the voltage of the FBSM, and each IGBT of the FBSM has a relatively low switching frequency and an equalized conduction loss. The capacitor voltage balancing methods of the two kinds of SMs are implemented independently. As a result, the switching frequency of the HBSM is not increased compared to the conventional MMC. In addition, according to a theoretical calculation of the total harmonic distortion of the electromotive force (EMF), the voltage quality with the presented method can be significantly enhanced when the SM number is relatively small. Simulation and experimental results obtained with a MMC-based inverter verify the validity of the developed method.
-
De-Jun Cheng,Jie Zhang,Zhong-Tai Hu,Sheng-Hao Xu,Xi-Feng Fang 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.10
This paper aims to propose a digital twin-driven (DTD) approach that consists of the machining data (MD) in twin data (TD), design of MD acquisition methodology, construction of intelligent algorithm, real-virtual data interaction analysis and fusion technology, which improvs the predictability and management of on-line quality control of marine diesel engine (MDE) critical parts. Firstly, this paper introduces the theoretical framework of DTD on-line quality control in machining process. Secondly, we construct the process of DTD on-line quality control and introduce the digital twin model of on-line quality control based on TD-driven; the operation of data-driven quality on-line control based on digital twin including description and modeling of MD; acquisition of MD based on digital twin; TD-driven on-line tool life prediction and data fusion on-line machining parameters optimization methods. Finally, a case study is applied to validate the accuracy and availability of the DTD approach. The proposed approach provides a new way for the on-line quality control of MDE critical parts in machining process.
-
A Hybrid Modular Multilevel Converter Topology with an Improved Nearest Level Modulation Method
Wang, Jun,Han, Xu,Ma, Hao,Bai, Zhihong The Korean Institute of Power Electronics 2017 JOURNAL OF POWER ELECTRONICS Vol.17 No.1
In this paper, a hybrid modular multilevel converter (MMC) topology with an improved nearest level modulation method is proposed for medium-voltage high-power applications. The arm of the proposed topology contains N series connected half-bridge submodules (HBSMs), one full-bridge submodule (FBSM) and an inductor. By exploiting the FBSM, half-level voltages are obtained in the arm voltages. Therefore, an output voltage with a 2N+1 level number can be generated. Moreover, the total level number of the inserted submodules (SMs) is a constant. Thus, there is no pulse voltage across the arm inductors, and the SM capacitor voltage is rated. With the proposed voltage balancing method, the capacitor voltage of the HBSM is twice the voltage of the FBSM, and each IGBT of the FBSM has a relatively low switching frequency and an equalized conduction loss. The capacitor voltage balancing methods of the two kinds of SMs are implemented independently. As a result, the switching frequency of the HBSM is not increased compared to the conventional MMC. In addition, according to a theoretical calculation of the total harmonic distortion of the electromotive force (EMF), the voltage quality with the presented method can be significantly enhanced when the SM number is relatively small. Simulation and experimental results obtained with a MMC-based inverter verify the validity of the developed method.
-
Minimization of Surface Roughness and Machining Deformation in Milling of Al Alloy Thin-Walled Parts
De-Jun Cheng,Feng Xu,Sheng-Hao Xu,Chun-Yan Zhang,Sheng-Wen Zhang,Su-Jin Kim 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.9
This study focused on investigating the surface roughness in the feed direction (R a -Fd), surface roughness in the transversedirection (R a -Td), and thin-walled parts deformation (TWD) during milling of Al alloy 5083. The response surface method(RSM) was used to conduct experiments and establish the models of R a -Fd , R a -Td , and TWD under various cutting parameters. The significance of cutting parameters on R a -Fd , R a -Td , and TWD was analyzed by analysis of variance. It was observedthat the R a -Fd and R a -Td are mainly influenced by the spindle speed, depth of cut, transverse size and feed rate, while the TWD is mainly influenced by the depth of cut. A comparison of RSM-optimum function and artificial bee colony (ABC)algorithm optimum programming was conducted to obtain the best cutting conditions leading to minimum R a -Fd, R a -Td and TWD simultaneously. From the presented results, ABC algorithm was able to obtain the better cutting strategy. Finally, theperformance of the proposed cutting strategy was verified by confirmation experiments.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
