Efficient Algorithm for Real-time Generation of Reflection Lines

Ju Yup Kang,Kun Woo Lee,Sang Kun Park,Tae Wan Kim 대한기계학회 2001 KSME International Journal Vol.15 No.2

임플란트 고정체의 매식 경사에 따른 응력분석

이태엽 ( Tae Yup Lee ) , 강재석 ( Jae Seok Kang ) , 이숭훈 ( Seung Hoon Lee ) , 안옥주 ( Ouk Ju Ahn ) , 강동완 ( Doog Wan Kang ) 조선대학교 구강생물학연구소 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.2

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Time Series Changes in Cataract Surgery in Korea

Ju Hwan Song,Jung Youb Kang,Ki Yup Nam,Seung Uk Lee,Sang Joon Lee 대한안과학회 2018 Korean Journal of Ophthalmology Vol.32 No.3

Purpose: We analyzed time series changes in cataract surgeries in Korea, and provide basic data to enhance the efficiency of medical services for cataract surgery. Methods: Among cataract surgery statistics registered in the Korean National Health Insurance Cooperation from 2006 to 2012, we used data regarding the number of patients and operations and the number of patients and operations per 100,000 people. We analyzed various time series changes, including differences by sex and age. Results: The total numbers of patients from 2006 to 2012 by year were 207,370; 228,170; 250,289; 268,548; 289,867; 308,111; and 302,182, respectively. The total numbers of operations from 2006 to 2012 by year were 272,920; 305,807; 338,332; 365,874; 398,338; 428,158; and 420,905, respectively. The number of patients and operations per 100,000 people were highest in men 80 to 84 years old and women 75 to 79 years old. Comparing the number of operations in 2006 and after, the patient age group with the highest increase rate changed from over 85 years old to 75–79 years old since 2010 in men and from over 85 years old to 50–54 years old since 2009 in women. For each year investigated, the number of operations performed was higher than the number of patients who received operations. Conclusions: Over the study period, the number of cataract surgeries increased, while the age of cataract patients decreased. Additionally, the number of cataract-related surgeries increased in relation to the number of patients.

Clinical Characteristics and Treatment Outcomes of 3 Subtypes of Achalasia According to the Chicago Classification in a Tertiary Institute in Korea

( Ju Yup Lee ),( Na Young Kim ),( Sung Eun Kim ),( Yoon Jin Choi ),( Kyu Keun Kang ),( Dong Hyun Oh ),( Hee Jin Kim ),( Kwung Jun Park ),( A Young Seo ),( Hyuk Yoon ),( Cheol Min Shin ),( Young Soo Pa 대한소화기기능성질환·운동학회 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.4

Background/Aims Achalasia is classified into 3 types according to the Chicago classification. The aim of this study was to investigate characteristics and treatment outcomes of 3 achalasia subtypes in Korean patients. Methods Fifty-five patients diagnosed with achalasia based on conventional or high-resolution esophageal manometry were consecutively enrolled. Their clinical characteristics, manometric, endoscopic and esophagographic findings and treatment responses were analyzed among the 3 subtypes of achalasia. Results Of 55 patients, 21 (38.2%) patients had type I, 28 (50.9%) patients had type II and 6 (10.9%) patients had type III. The median follow-up period was 22.4 (interquartile range, 3.6-67.4) months. Type III patients were older than type I and II patients (70.0 vs. 46.2 and 47.6 years, P = 0.023). The width of the esophagus in type I patients was wider with more frequent bird`s beak appearance on esophagogram than the other 2 types (P = 0.010 and 0.006, respectively). Of the 50 patients who received the evaluation for treatment response at 3 months, 7 patients (36.8% vs. 26.9%) were treated with pneumatic dilatation and 4 patients (21.1% vs. 15.4%) with laparoscopic Heller`s myotomy in type I and II groups, respectively. The treatment responses of pneumatic dilatation and Heller`s myotomy in type I group were 71.4 and 50.0% and in type II were 85.7 and 75.0%, respectively, and all 5 patients in type III group showed good response to medical therapy. Conclusions Clinical characteristics of 3 achalasia subtypes in Korean patients are consistent with other studies. Treatment outcomes are variable among 3 subtypes. (J Neurogastroenterol Motil 2013;19:485-494)

A well-ordered flower-like gold nanostructure for integrated sensors via surface-enhanced Raman scattering

Kim, Ju-Hyun,Kang, Taejoon,Yoo, Seung Min,Lee, Sang Yup,Kim, Bongsoo,Choi, Yang-Kyu IOP Pub 2009 Nanotechnology Vol.20 No.23

<P>A controllable flower-like Au nanostructure array for surface-enhanced Raman scattering (SERS) was fabricated using the combined technique of the top-down approach of conventional photolithography and the bottom-up approach of electrodeposition. Au nanostructures with a mean roughness ranging from 5.1 to 49.6 nm were obtained by adjusting electrodeposition time from 2 to 60 min. The rougher Au nanostructure provides higher SERS enhancement, while the highest SERS intensity obtained with the Au nanostructure is 29 times stronger than the lowest intensity. The SERS spectra of brilliant cresyl blue (BCB), benzenethiol (BT), adenine and DNA were observed from the Au nanostructure. </P>

Carotid intima-media thickness in mainly non-obese women with polycystic ovary syndrome and age-matched controls

( Jin Ju Kim ),( Young Min Choi ),( Jin Hwa Kang ),( Kyu Ri Hwang ),( Soo Jin Chae ),( Sun Mie Kim ),( Seung Yup Ku ),( Seok Hyun Kim ),( Jung Gu Kim ),( Shin Yong Moon ) 대한산부인과학회 2013 Obstetrics & Gynecology Science Vol.56 No.4

Objective: Metabolic disturbances are well-recognized clinical features of polycystic ovary syndrome (PCOS). Carotid intima-media thickness (CIMT) has been widely used as a surrogate marker of atherosclerosis and cardiovascular disease (CVD). CIMT in women with PCOS has been investigated in many studies, but there has been only one report in the Korean population. The aim of the present study was to compare the presence of subclinical atherosclerosis in young untreated Korean women with PCOS and age-matched controls, specifically by measuring their CIMT. Methods; CIMT was measured by one radiologist in 56 PCOS patients and 56 controls. To compare the CIMT according to PCOS phenotypes, women with PCOS were divided into two subgroups according to the presence of hyperandrogenism. Results; Although PCOS patients were more obese and had higher blood pressure and insulin resistance index than the age-matched controls, the CIMT was not different between the two groups (0.49 ± 0.09 mm in PCOS patients vs. 0.50 ± 0.11 mm in controls, respectively, p = 0.562). When the CIMT in the control group was compared with hyperandrogenic and non-hyperandrogenic PCOS groups, also no significant differences were found. Conclusion; Despite the significant differences in some vascular risk factors between women with PCOS and controls, PCOS patients did not have a significantly higher CIMT (even in the hyperandrogenic subgroups). Although our study did not show the increased risk of subclinical atherosclerosis in PCOS patients, the role of CIMT continues to be investigated considering the importance of screening and monitoring CVD risk factors in women with PCOS.

민간직업 잠수부의 골괴사에 대한 역학적 조사 및 혈청 표지자 분석

이주엽 ( Ju Yup Lee ),송주현 ( Joo Hyoun Song ),이한용 ( Han Yong Lee ),고해석 ( Hae Seok Koh ),정진영 ( Jin Young Jeong ),유기원 ( Kee Won Rhuy ),강용구 ( Yong Koo Kang ),김승준 ( Seung Jun Kim ) 대한고관절학회 2006 Hip and Pelvis Vol.18 No.3

목적: 민간 직업 잠수부의 골괴사에 대한 역학 조사를 통해 골괴사 발생의 위험 인자를 알아보고, 골괴사와 관련이 있다고 알려진 혈청 표지자 분석을 통하여 이들에서 발생하는 골괴사와 혈전 기호증 및 저섬유소 용해증 사이의 상관 관계를 알아보고자 하였다. 대상 및 방법: 키조개를 채취하는 직업 잠수부중 골괴사가 발생한 10명(제1군)과 발생하지 않은 32명(제2군), 총 42명을 대상으로 잠수경력, 연간 잠수횟수, 하루 평균 잠수횟수, 평균 잠수 시간 및 깊이, 잠수 방식 등을 조사하여 두 군 사이에서 상기 항목들의 통계학적 유의성을 알아보았다. 또한 연구대상 잠수부 전체에서 고지혈증 표지자, 혈전 기호증 표지자, 저섬유소 용해 표지자 그리고 homocystein 등을 측정하고, 20명의 의사로 이루어진 대조군(제3군)과 비교하여, 이압성 골괴사와 혈청 표지자 사이의 연관성 여부를 알아보았다. 결과: 제1군과 2군 사이에서 통계학적으로 유의성을 보였던 항목은 평균 잠수 시간으로 1군은 평균 124분, 2군은 62.1분 이었으며(P<0.05), 나머지 항목들은 통계학적 유의성이 없었다. 혈청 표지자 분석에서는 1군과 2군 사이에서는 모든 표지자가 통계학적 유의성을 보이지 않았으나, 3군과 1, 2군 사이의 비교에서는 1, 2군에서 protein C와 S의 활성도가 유의하게 감소되어 있었고(Protein C : P<0.05, Protein S : P<0.05), plasminogen activator inhibitor-1(PAI-1)의 유의한 증가가 관찰되었다(P<0.05). 결론: 민간 직업 잠수부에 대한 조사 결과, 골괴사가 발생한 잠수부들의 평균 잠수 시간이 두 배 이상으로 길었으며, 대조군과의 혈청 표지자 분석에서는 잠수부들에서 protein C와 S의 활성도가 감소되어 있었고, PAI-1의 증가가 관찰되었다. Purpose: To evaluate the risk factors for the development of osteonecrosis in civilian professional divers by an epidemiologic study and to determine the correlation between osteonecrosis in divers and coagulopathy by analysis of serologic markers that are related to thrombophilia and hypofibrinolysis. Materials and Methods: Forty-two divers, who collected pen shells (Atrina pinnata), and among whom 10 had osteonecrosis (group 1), were compared with 32 divers without osteonecrosis (group 2). Both groups were evaluated based on the number of years of diving experience, number of dives per year, mean number of dives per day, mean diving time and depth, and diving methods. We determined any statistically significant differences among these variables. We measured the levels of serologic markers that were related to hyperlipidemia, thrombophilia, and hypofibrinolysis from the divers and a control group of 20 physicians (group 3). The levels of the serologic markers were compared between groups 1 and 2 and between the divers and the control group, in order to determine the relationship between the serologic markers and the development of dysbaric osteonecrosis. Results: None of the variables demonstrated any statistically significant differences, except for the mean diving time, in which group 1 had a mean diving time of 124 minutes and group 2 had a mean diving time of 62.1 minutes (P<0.05). In the analysis of the serologic markers, there were no statistically significant differences between groups 1 and 2; however, in comparison with the group 3, the divers demonstrated significantly decreased activity levels of proteins C and S (Protein C: P<0.05; Protein S: P<0.05), and an increase in the levels of plasminogen activator inhibitor-1 (PAI-1) (P<0.05). Conclusion: The divers with osteonecrosis had a longer mean diving time than did those divers without osteonecrosis. In the serologic marker analysis, the divers with osteonecrosis demonstrated significantly decreased activity levels of Proteins C, S and a significant increase in the levels of PAI-1, compared with the control group.

A novel COCH mutation associated with autosomal dominant nonsyndromic hearing loss disrupts the structural stability of the vWFA2 domain.

Cho, Hyun-Ju,Park, Hong-Joon,Trexler, Maria,Venselaar, Hanka,Lee, Kyu-Yup,Robertson, Nahid G,Baek, Jeong-In,Kang, Beom Sik,Morton, Cynthia C,Vriend, Gert,Patthy, L?szl?,Kim, Un-Kyung Springer 2012 Journal of molecular medicine Vol.90 No.11

<P>Mutations in COCH have been associated with autosomal dominant nonsyndromic hearing loss (DFNA9) and are frequently accompanied by vestibular hypofunction. Here, we report identification of a novel missense mutation, p.F527C, located in the vWFA2 domain in members of a Korean family with late-onset and progressive hearing loss. To assess the molecular characteristics of this cochlin mutant, we constructed both wild-type and mutant cochlin constructs and transfected these into mammalian cell lines. Results of immunocytochemistry analysis demonstrated localization of the cochlin mutant in the endoplasmic reticulum/Golgi complex, whereas western blot analyses of cell lysates revealed that the mutant cochlin tends to form covalent complexes that are retained in the cell. Biochemical analyses of recombinant vWFA2 domain of cochlin carrying the p.F527C mutation revealed that the mutation increases propensity of the protein to form covalent disulfide-bonded dimers and affects the structural stability but not the collagen-affinity of the vWFA2 domain. We suggest that the instability of mutant cochlin is the major driving force for cochlin aggregation in the inner ear in DFNA9 patients carrying the COCH p.F527C mutation.</P>

Isolation and Identification of Flavonoids from Gujeolcho (Chrysanthemum zawadskii var. latilobum) as Inhibitor of Histamine Release

Shim, Sun-Yup,Kang, Hye-Sook,Sun, Hyeon-Jin,Lee, Young-Ju,Park, Jeong-Ro,Chun, Soon-Sil,Song, Young-Hwan,Byun, Dae-Seok 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.2

In an ongoing search of compounds from natural sources that exhibit anti-allergic properties, 3 flavonoids were isolated from the ethyl acetatefraction of methanol extracts of gujeolcho (Chrysanthemum zawadskii var. latilobum), with guided histamine release inhibitory effects. The isolated compounds were identified as eriodictyol-7-O-${\beta}$-D-glucuronide, 5,7-dihydroxy-4-chromene, and 6-methoxyluteolin based on spectroscopic evidences including NMR and MS spectra. These results suggest that gujeolcho extracts and 3 compounds would be candidates as therapeutic or preventive agents for allergic reaction.

The effect of alpha lipoic acid in a porcine in-stent restenosis model

Lim, Sang Yup,Bae, Eun Hui,Jeong, Myung Ho,Kim, Ju Han,Hong, Young Joon,Sim, Doo Sun,Kim, Yong Sook,Park, In Kyu,Ahn, Youngkeun,Song, Sun-Jung,Cho, Dong Lyun,Kim, Kyoung Seok,Kang, Jung Chaee Elsevier 2009 Journal of cardiology Vol.54 No.3

<P><B>Summary</B></P><P><B>Background</B></P><P>The aim of this study was to investigate the effect of alpha lipoic acid (α-LA) on a porcine in-stent restenosis (ISR) model.</P><P><B>Methods</B></P><P>In protocol 1, porcine vascular smooth muscle cells (PVSMC) were stimulated by granulocyte-colony stimulating factor (G-CSF) in the presence or absence of α-LA. MTT (3-[4,5-dimethylthiazole-2-yl] 2,5-diphenyl tetrazolium bromide) assay and western blotting were used to determine the cell growth inhibitory rate and anti-inflammatory effect associated with nuclear factor-κb (NF-κb) and extracellular signal-regulated kinase (ERK). In protocol 2, 28 days after balloon overdilation injuries, 24 bare metal stents were placed in coronary artery of 12 pigs. The pigs were randomly divided to receive control diet with or without α-LA (100mg/kg). In protocol 3, 8 control stents and 8 α-LA coated stents were randomly implanted in 2 coronary arteries of 8 pigs and follow-up coronary angiogram and histopathologic assessment were performed 4 weeks after stenting.</P><P><B>Results</B></P><P>Protocol 1. The proliferation of PVSMC was inhibited and protein expression of NF-κb and ERK were attenuated by α-LA pretreatment. Protocol 2<I>.</I> On histopathologic analysis, the neointimal area (4.0±1.0mm<SUP>2</SUP> vs. 1.5±0.7mm<SUP>2</SUP>, <I>p</I><0.001) and histopathologic area of stenosis (66.7±10.7% vs. 24.2±9.7%, <I>p</I><0.001) were reduced in the α-LA feeding group compared to controls. Protocol 3. On histopathologic analysis, the neointimal area (3.9±0.8mm<SUP>2</SUP> vs. 1.0±0.4mm<SUP>2</SUP>, <I>p</I><0.001), and the histopathologic area of stenosis (67.1±8.8% vs. 17.4±10.0%, <I>p</I><0.001) were reduced in the α-LA coated stent group compared to the control stent group.</P><P><B>Conclusions</B></P><P>α-LA feeding and α-LA coated stents inhibit neointimal hyperplasia in porcine ISR, possibly through inhibiting the activation of NF-κb pathway and proliferation of PVSMC.</P>