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Effects of insulin-sensitizing agents and insulin resistance in women with polycystic ovary syndrome
Hwang, Kyu Ri,Choi, Young Min,Kim, Jin Ju,Chae, Soo Jin,Park, Kyung Eui,Jeon, Hye Won,Ku, Seung Yup,Kim, Seok Hyun,Kim, Jung Gu,Moon, Shin Yong The Korean Society for Reproductive Medicine 2013 Clinical and Experimental Reproductive Medicine Vol.40 No.2
Objective: The aim of this study was to investigate the effect of insulin sensitizing agents on hormonal and metabolic parameters as well as menstrual patterns in women with polycystic ovary syndrome (PCOS). Methods: One hundred and twenty-three patients with PCOS were included. Metformin was administered to patients at 1,500 mg or 1,700 mg daily for 3 months. If the patients had no improvement of the menstrual cycle or metformin-related adverse effects developed, the patients changed medication to a daily dose of either 15 mg pioglitazone or up to 45 mg. Then resumption of a regular menstrual cycle or recovery of ovulation was evaluated. Hormonal and metabolic profiles were compared between the response and non-response group to insulin sensitizing agents. Results: One hundred and five patients with PCOS were treated with metformin for 3 months. Forty-eight patients (45.7%) showed improvement of menstrual cycle regularity after 3 months of metformin use, whereas 57 patients (54.3%) had no change. The mean free testosterone measured after 3 months of treatment was significantly lower in metformin responders than in non-responders. The other parameters did not differ between the groups. Of the 23 patients who used pioglitazone for 3 to 6 months, 19 patients (82.6%) showed improvement in their menstrual cycles. Conclusion: Metformin treatment seems to be effective for the improvement of menstrual cyclicity irrespective of insulin resistance in women with PCOS. When metformin related adverse effect occurred, pioglitazone would be effective for aiding the resumption of the menstrual cycle.
Hwang, Kyu Ri,Choi, Young Min,Kim, Jin Ju,Lee, Sung Ki,Yang, Kwang Moon,Paik, Eun Chan,Jeong, Hyeon Jeong,Jun, Jong Kwan,Yoon, Sang Ho,Hong, Min A KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.12
<P>The balance between coagulation and fibrinolysis is an essential part in early pregnancy. Mutations in methylenetetrahydrofolate reductase (<I>MTHFR</I>) gene lead to decreased activity of the enzyme and hyperhomocysteinemia, which then induces platelet aggregation by promoting endothelial oxidative damage, possibly resulting in adverse effect on maintenance of pregnancy. We investigated the role of <I>MTHFR</I> single nucleotide polymorphisms (SNPs), C677T and A1298C, in Korean patients with recurrent pregnancy loss (RPL). We conducted a prospective case-control study in the Korean population. Subjects included 302 women with 2 or more consecutive, unexplained, spontaneous miscarriages before 20 weeks of gestation and 315 control women without a history of recurrent miscarriages. The genotyping for C677T and A1298C polymorphisms was performed using the TaqMan assay. Continuous variables were compared using Student's t-test, and χ<SUP>2</SUP> test was used to evaluate differences in the genotype distributions between the RPL and the controls. The genotype distribution of both polymorphisms in the RPL group did not differ from those of the controls. For further analysis, if RPL patients were divided according to the numbers of pregnancy losses (≥ 2 and ≥ 3) neither group was significantly different compared with controls. <I>MTHFR</I> gene C677T and A1298C polymorphisms are not associated with idiopathic RPL in Korean women, suggesting that those may not be susceptible allelic variants or be deficient to cause RPL.</P>
A study of sexual assault: Based on data from Boramae One-stop Service Center
( Kyu Ri Hwang ),( Kyung Hee Han ),( Mi Sun Shin ),( Ji Hyun Kim ),( Jae Jun Shin ),( Kyoung Jun Song ),( Hye Won Jeon ) 대한산부인과학회 2010 Journal of Womens Medicine Vol.3 No.3
Objective: To examine sexual assault cases reported to one-stop service center in Boramae Hospital epidemiologically and medically. Methods: We reviewed the medical records of 291 female patients, who visited Boramae One-stop service center between December 2008 and December 2009. After taking informed consents, we inspected medical records, physical examinations, and collected rape kits. Serologic tests and sexually transmitted infections were checked and followed up. Medication for emergency contraception was prescribed to victims reporting within 72 hours after sexual assault. Results: Eighty-nine point seven percent of all victims were women under 35 years. There was no significant seasonal variation. One hundred forty-eight cases occurred between midnight and 6 AM. The most frequent attack location was specific places including accommodation (29.6%). Two hundred fifty-six victims (88.0%) visited to the center within 3 days of the assault. Acquaintances accounted for 49.5% of perpetrators. In the majority of cases (79.4%), victims were not physically injured. As a result of serologic tests, 5 cases were positive for hepatitis B antigen (1.7%), 2 cases were positive for Venereal Disease Research Laboratory (0.75%), and all patients were negative for human immunodeficiency virus. More than half of the patients (59.8%) had a positive result in test for bacterial vaginosis. Withdrawal bleeding after emergency postcoital contraception was not presented in 82 cases of 225 victims. One victim (0.6%) was pregnant despite of taking emergency contraception. Conclusion: This study provides latest information about epidemiological and medical results of sexual assaults.
체외수정시술시 에스트로겐 수용체 유전자 PvuII 및 XbaI 다형성이 과배란유도 및 임신 결과에 미치는 영향
황규리 ( Kyu Ri Hwang ),최영민 ( Young Min Choi ),윤지성 ( Ji Sung Yoon ),이원돈 ( Won Don Lee ),구승엽 ( Seung Yup Ku ),지병철 ( Byung Chul Jee ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),김정구 ( Jung Gu Kim ),문신용 ( S 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.8
목적: 체외수정시술을 받는 불임 여성에서 에스트로겐 수용체 유전자의 PvuII 및 XbaI 다형성이 난포 및 획득된 난자의 개수, 배란유도제의 총 투여량, 이식된 배아의 개수 등의 과배란유도 결과와 착상율 및 임신율에 미치는 영향을 살펴보고자 하였다. 연구 방법: 2001년 3월부터 2003년 10월까지 과배란유도 및 체외수정시술을 시행하였으며, 배란 장애가 없는 40세 미만의 189명의 불임 환자를 대상으로, 이들 환자에서 에스트로겐 수용체 유전자의 Objective: The purpose of this study was to investigate the association of the estrogen receptor α gene polymorphism (PvuII and XbaI) with outcomes of controlled ovarian hyperstimulation for in- vitro fertilization and embryo transfer (IVF-ET). Methods: T
자궁내막증 환자에서 Interleukin-10 유전자 -592 다형성 양상
황규리 ( Kyu Ri Hwang ),최영민 ( Young Min Choi ),김종미 ( Jong Mee Kim ),김진주 ( Jin Ju Kim ),박경아 ( Kyoung Ah Park ),지병철 ( Byung Chul Ji ),구승엽 ( Seung Yup Ku ),서창석 ( Chang Suk Suh ),김석현 ( Seok Hyun Kim ),김정구 ( 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.7
목적: 한국 여성에서 interleukin-10 (IL-10) 유전자 -592 다형성과 자궁내막증의 연관성에 대하여 조사하고자 하였다. 연구 방법: 수술 소견 또는 조직검사상 자궁내막증으로 진단된 254명의 여성을 환자군으로 하였으며, 복강경 검사 또는 개복술을 시행하였으나 자궁내막증의 증거를 발견할 수 없었던 236명을 대조군으로 하였다. 이들 대상인들에서 IL-10 유전자 -592 다형성 양상을 PCR 및 RFLP를 이용하여 분석하였다. 결과: 자궁내막증 환자군과 대조군 사이에 IL-10 유전자 -592 다형성의 유전자형 및 대립유전자의 분포 양상은 유의한 차이가 없었다 (AA: AC: CC, 41.3%: 51.2%: 7.5% vs 44.9%: 50.8%: 4.2%). 또한 자궁내막증 환자군을 I-II기와 III-IV기로 세분하였을 때에도 IL-10 유전자 -592 다형성의 유전자형 및 대립유전자의 분포 양상은 대조군과 유의한 차이가 없었다. 결론: 한국 여성에서 IL-10 유전자 -592 다형성은 자궁내막증 발생과 연관이 없는 것으로 사료된다. Objective: To explore the association of the interleukin-10 (IL-10) gene -592 promoter polymorphism with endometriosis in a Korean population. Methods: This study comprised 254 women with surgically or histologically diagnosed endometriosis, 236 control women with no evidence of endometriosis by laparoscopy or laparotomy. Following extraction of genomic DNA, genotyping of the IL-10 gene -592 polymorphism was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Results: The distribution of genotypes and allele frequencies of IL-10 gene -592 polymorphism in the endometriosis group did not differ from those in the control group (A/A: A/C: C/C, 41.3%: 51.2%: 7.5% vs. 44.9%: 50.8%: 4.2%). And when classified by stage, there was also no significant difference in the distribution of IL-10 gene -592 polymorphism between patients with stage I-II (ASRM, 1997) endometriosis or patients with stage III-IV endometriosis and controls. Conclusion: These results suggest that IL-10 gene -592 promoter polymorphism is not associated with the risk for endometriosis in the Korean women.
다낭성 난소 증후군 환자에서 메트포민 치료의 효과와 인슐린 저항성
황규리 ( Kyu Ri Hwang ),최영민 ( Young Min Choi ),최두석 ( Doo Seok Choi ),백광현 ( Kwang Hyun Baek ),전혜원 ( Hye Won Jeon ),배광범 ( Kwang Bum Bae ),손영수 ( Young Soo Son ),구승엽 ( Seung Yup Ku ),지병철 ( Byung Chul Jee ),서 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.10
목적 : 한국의 다낭성 난소 증후군 여성에 있어서 배란 및 월경 회복에 미치는 메트포민의 효과와 인슐린 저항성의 관련 여부를 파악하고자 한다. 연구 방법 : 2001년 9월부터 2003년 9월까지 서울대학교병원 산부인과에 내원한 여성 중 다낭성 난소 증후군으로 진단된 23명을 대상으로 메트포민을 하루 1500㎎ 투약하였다. 3개월간 복용 후 규칙적인 월경 또는 배란의 유무를 조사하여 메트포민의 반응을 평가하였고 반응군과 무반응군의 인슐린 저항성을 비교하 Objective : This study was performed to investigate the effect of metformin treatment and insulin resistance in the patients with polycystic ovary syndrome. Methods : Twenty three patients with polycystic ovary syndrome were included at Seoul National Uni
Kyu Ri Hahn,Woosuk Kim,Hyo Young Jung,Hyun Jung Kwon,Sung Min Nam,Tae Hyeong Kim,Jong Whi Kim,Dae Young Yoo,Dae Won Kim,Jung Hoon Choi,Yeo Sung Yoon,In Koo Hwang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks. At six weeks after diet feeing, gerbils received transient forebrain ischemia with or without hypothermic preconditioning. Cuprizone treatment for 8 weeks increased the number of astrocytes, microglia, and pro-inflammatory cytokine levels in the hippocampus. In addition, cuprizone treatment significantly decreased the number of proliferating cells and neuroblasts in the dentate gyrus. Brain ischemia caused cell death, disruption of myelin basic proteins, and reactive gliosis in CA1. In addition, ischemia significantly increased pro-inflammatory cytokines and the number of proliferating cells and differentiating neuroblasts in the dentate gyrus. In contrast, hypothermic conditioning attenuated these changes in CA1 and the dentate gyrus. However, cuprizone treatment decreased cell survival induced by hypothermic preconditioning after ischemia and increased the number of reactive microglia and astrocytes in CA1 as well as of macrophages in the subcallosal zone. These changes occurred because the protective effect of hypothermia in ischemic damage was disrupted by cuprizone administration. Furthermore, cuprizone decreased ischemia-induced proliferating cells and neuroblasts in the dentate gyrus