발열이 있는 호중구 감소증 환자에서의 위험도 예측인자

정중식,권운용,김규석,임용수,이중의,서길준,윤여규 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: Most febrile neutropenic patients are treated in an aggressive manner. However, identification of low-risk patients may enable clinicians to administer risk-based treatment. The object of this study is to certify the factors associated with increased risk at the time of visiting the emergency department. Methods: This is a retrospective study. We reviewed the medical records of 101 febrile neutropenic patients who had visited the emergency department of Seoul National University Hospital from January 1998 to August 1999. We assumed 22 risk prediction factors that could be assessed at admission to the emergency department and 5 factors that could be assessed during treatment course. To find independent risk-prediction factors, we analyzed these factors respectively by using multiple regression analysis. Results: Tachycardia(aOR=136.5), altered mentality(aOR=28.8), decreased renal function(aOR=20.1), and significant comorbidity(aOR=17,2) are the independent factors associated with higher mortality. Altered mentality(aOR=31.6) and decreased renal function(CCr < 75㎖/min, aOR=5.4) are those associated with a higher incidence of septic shock. Independent factors associated with persistent(more than 3 days) fever are the early(within 10 days) onset of fever after last chemotherapy(aOR=8.8) and the existence of new pulmonary infiltrates on a simple chest X-ray(aOR=4.3). Conclusion: The stability of vital signs, the change of mentality, the renal function, the existence of significant comorbidity, the existence of new pulmonary infiltrates, and the rate of neutropenia are clinically useful risk-prediction factors in febrile neutropenia at the time of visiting the emergency department.

다단 원판형 드래그펌프의 배기특성에 관한 실험적 연구

황영규,허중식,권명근 성균관대학교 기계기술연구소 2001 성균관대학교 논문집 기계기술편 Vol.4 No.1

In this paper, the pumping performance of the multi-stage(two-stage) disk-type drag pump which works in the pressure range from 4 to 0.003 Torr was studied experimentally, and rotational speed of the pump is 24,000rpm and nitrogen is used as a test gas. An experimental study on pumping characteristics of various multi-stage disk-type drag pump is performance. The inlet pressures are measured for various outlet pressures of teat pump. The maximum compression ratios for nitrogen are 1000(multi-stage disk-type drag pump), 740(helical-type drag pump), 90(BSC disk-type drag pump) and 85(OSC disk-type drag pump), respectively. The ultimate pressure of the multi-stage disk-type drag pump is 3.7×10-5 Torr at 0.003 Torr for outlet pressure. The maximum value of compression ratio is 1000 at 0.6 Torr for outlet pressure.

외과계 감염증에 대한 Sulperazon(Sulbactam/cefoperazone) 및 Cefoperazone의 임상효과 비교연구

박규주,노동영,김상준,권오중,정중기,홍인규 대한화학요법학회 1990 대한화학요법학회지 Vol.8 No.2

Despite recent advances in development of antibiotics and antiseptic techniques, infection still remains to be one of the major problems in the surgical field. Due to development of bacterial resistance to commonly used antibiotics, there is always a need to develop a new antimicrobial agent which would overcome such resistance. Sulperazon (Sulbactam/Cefoperazone) is a combination drug of potent β-lactamase inhigitor, sulbactam, and cefoperazone which has broad antibacterial spectrum, which was developed to combat against β-lactamase producing microorganisms. In an effort to evaluate the efficacy and safety of sulperazone, we have randomly divided 40 patients (12 with perforated appendicitis, 10 with peritionitis, 6 with GB empyema, 6 with periproctal abscess, 3 with wound infection, 1 liver abscess, 1 pancreatic abscess, and 1 acute cholangitis) into 2 groups (20 patients in each group). One group received daily dose of 2 to 3 grams of sulperazon and the other group received daily dose of 2 to 3 grams of cefoperazone. Following results were obtained : 1. Clinical effect of sulperazon was cure in 16 patients (80%), improvement in 3 patients (15%), compaired to cure in 14 patients (70%), improvement in 4 patients (20%) for the cefoperazone group. 2. Using disc diffusion method, sulperazon was sensitive to all of the isolated microorganisms except β-hemolytic streptococci, which was moderately sensitive. Cefoperazone was sensitive to only E. coli, Pseudomonas aeruginosa and Serratia. 3. Microbiological effect of sulperazon was eradication of offending microorganisms in 16 patients (80%), compared to 14 patients (70%) in Cefoperazone group. 4. Overall clinical efficacy of sulperazon was 95%, compared to 80% for cefoperazone. 5. Adverse effects due to sulperazon was nausea and diarrhea which occurred in 1 patient respectively. 2 patients receiving cefoperazone experienced diarrhea. It can be concluded that sulperazon is a safe and effective antibiotic agent which can be used in surgical infection patients.

BA, NAA, 2,4-D 및 배지의 무기물 농도가 포도의 기내 생장에 미치는 영향

金善圭,全盛皓,李重燮 충북대학교 농업과학기술연구소 1997 農業科學硏究 Vol.14 No.-

Shoot tip and node segments derived from cuttings of two grape cultivars (Aramon, Aligote) were cultured in vitro on full - and one half strength MS media supplemented with BA, NAA, and 2,4-D alone and in combination, and the growth was investigated. Full strength, shoot tip, and NAA enhanced the shoot growth. BA alone and/or in combination with NAA was favorable for shoot multiplication regardless of media strength and bud position. Varietal differences were recognized in callus formation in favor of Aramon, and all growth regu-lators, especially BA+ NAA+2,4-D, were effective for callus formation in Aramon. Bud position ef-fect was negligible but half stremgth media was more effective. In Aligote, 2,4-D was most effective for callus formation regardless of media strength.

엔드밀 형상에 따른 가공특성 분석을 이용한 형상설계 S/W 개발

한창규,고성림,유중학,서천석,김경배 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

The tool geometry parameters and cutting process have complex relationships. Until now, various cutting test were needed to acquire optimal design of end mill for the purpose of high speed machining, due to the insufficient knowledge about cutting process in high speed machining. Using various tools with different geometry, relationships between tool geometry parameter (rake angle, clearance angle, length of cutter) and cutting process (cutting force, surface accuracy, surface roughness) have been studied. Acquired data can be used to design optimal tool for high speed machining and developed tool geometry design S/W.

Effect of Cyclohexane and Xylene Mixture Treatment on the Liver Damage in Rats

신중규 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2003 Journal of biomedical laboratory sciences Vol.9 No.2

To investigate the cyclohexane and xylene mixture treatment on the liver damage, the rats were treated by the mixture of cyclohexane and xylene (CH+X) and then, liver damage was demonstrated by liver function findings based on liver weight/body weight, serum level of alanine aminotransferase (ALT), xanthine oxidase (XO) and then compared with cyclohexane treated group (CH group) and xylene-treated group (X). The CH+X group showed merely severer liver damge than CH or X group. On the other hand, CH+X group showed lower activity of hepatic cytochrome P-450 dependent aniline hydroxylase (CYPdAH) than CH or X group, but no statical differences were demonstrated among three experimental groups. Especially the hepatic GSH content was merely declined than CH or X group and the activity of hepatic GST was higher in CH+X group than CH or X group. In conclusion, cyclohexane and xylene mixture treated animals showed merely severer liver damage than cyclohexane or xylene treated group and such a fact may be caused by inhibition of cyclohexane or xylene metabolism and oxygen free radical.

뇌 해마가 제거된 흰쥐의 유두체 및 내후야에서 HPLC에 의한 아미노산 신경전달물질 분석

김종규,신중호 순천향대학교 1991 논문집 Vol.14 No.2

뇌 해마가 glutamic acid, aspartic acid 및 그외 amino acid를 흥분성 신경전달물질로 사용하는지를 알기 위하여 대뇌피질을 거쳐 양쪽 해마를 제거한 흰쥐(해마군, 11마리), 해마를 덮는 대뇌피질 부분만을 제거한 흰쥐(대뇌피질 대조군, 8마리) 및 정상대조군(10마리)을 마련한 다음, HPLC를 이용하여 OPA pre-column 유도체화법으로 유두체와 내후야 조직의 아미노산들을 측정하였다. 1. 유두체 조직의 aspartic acid는 두 대조군보다 해마군에서 유의하게 감소되었으나, 두 대조군 사이에는 이렇다 할 차이가 없었다. glutamic acid는 정상 대조군보다 해마군에서 유의하게 증가되었으며, 대뇌피질 대조군에 비해서는 증가된 경향은 보였으나, 유의성은 없었고, 두 대조군 사이에는 아무런 차이가 없었다. serine, glycine, threnonine 및 alanine은 세무리 사이에서 차이가 없었다. 2. 내후야 조직에서 aspartic acid 및 glutamic acid는 두 대조군보다 해마군에서 모두 유의하게 감소 되었으나, 두 대조군들 사이에는 차이가 없었다. glycine은 해마군이 정상 대조군보다 유의하게 감소되었으나, 대뇌피질 대조군보다는 감소된 경향을 보였을뿐 유의성은 없었고, 두 대조군 사이에서는 아무런 차이가 없었다. alanine은 정상 대조군보다 대뇌피질 대조군에서 유의한 감소를 보였으며, 해마군은 정상 대조군에 비하여 감소 경향만 보였고, 해마군과 대뇌피질 대조군 사이에서는 유의한 차이가 없었다. 그리고 serine 및 threonine은 세 무리 사이에 아무런 차이가 없었다. 이상의 결과들을 종합하건데 아미노산인 aspartic acid와 glutamic acid는 해마, 유두체 및 내후야의 많은 신경섬유들이 흥분성 전달물질로 작용할 것으로 추측되어진다. A study was planned to analyze amino acid in target structure of hippocampectomized rats by HPLC. Twenty nine male rats were divided into 3 groups, of which 11 rats had their hippocampal tissue on both sides removed through an opening in the parieto-occipital cortex (hippocampal group), 8 rats received damage to the parieto-occipital cortex only(cortical control group), and 10 rats served as normal control animals. One week later, the animals were sacrificed by decapitation in the cold room. 2-3mg of tissue was obtained from the mammillary body and entorhinal area in one side of the brain. The tissue samples were homogenized in 200ul of 0.5M perchlocric acid in 1mM EDTA with ground-glass homogenizers. After centrifugation at 3,500 rpm for 15 min, an aliquot of 80ul supernatant was neutralized with 20ul of 2M KHCO₃, and then centrifuged again at 3,500 rpm for 10 min. An aliquots of 20ul was taken and diluted with 350ul of β-mercaptopropionic acid in 10ml of 100mM sodium borate buffer(pH 9.1) and 350ul of OPA solved in ethanol which was diluted with 10ml of 100mM sodium borate buffer(pH 9.1). Then 200ul of the resulting sample was injected with SIL-6B auto injector. LC-9A liquid chromatograph, FLD-6A fluorescence detector, CTO-6A column oven and SCL-6B system controller was employed. We used OPA pre-column derivatization method. Peak areas were automatically integrated and calculated by CR6A chromatopac. 1. In mammillary body, aspartic acid decreased significantly in the hippocampal group than in the normal control group(t test, p<0.05) and the cortical control group(p<0.04), while there were no significant difference between the 2 control groups. Glutamic acid increased significantly in the hippocampal group compared with the value obtained from the normal control group(p<0.03), while the difference between the hippocampal group and cortical control group values and between the 2 control group values were nonsignificant. In serine, glycine, threonine and alanine, the differences among 3 group values were nonsignificant. 2. In entorhinal area, aspartic acid and glutamic acid reduced significantly in the hippocampal group than in the normal control group(p<0.02) and the cortical control group(p<0.04), while no significant difference existed between the 2 control groups. Glycine reduced significantly in the hippocampal group compared with the value obtained from the normal control group(p<0.01). while the difference between the hippocampal group and cortical control group values and between the 2 control group values were nonsignififcant. Alanine increased significantly in the normal control group compared with the value obtained from the cortical control group(p<0.05), while no significant difference existed between the normal control group and the hippocampal group. However, the difference between the hippocampal group and the 2 control group values was nonsignificant. In serine and threonine, the difference was nonsignificant among 3 groups. It is inferred from the above mentioned results that the amino acids aspartic acid and glutamic acid are excitatory transmitter substances used by a large number of neurons in hippocampus, mammillary body and entorhinal area.

사망 진단서(시체 검안서) 작성의 문제점

김규석,임용수,이중의,서길준,윤여규,어은경,염석란,정연권,이윤성 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: This study was conducted to analyze the current problems in completing death certificates and to identify the correct method for completing death certificates Methods: We reviewed 262 death certificates in three hospitals from March 1 to April 30, 2000, and 119 death certificates in one hospital from March 1 to 31, 2000. We identified major and minor errors and analyzed and compared them retrospectively. Results: A total of 381 death certificates were reviewed: 59 in Seoul National University Hospital,101 in Ewha Woman's University Hospital, and 102 in Gachon Medical College Hospital, which has no education program for completing death certificates in postgraduate training, and 119 in Samsung Medical Center which has an education program for completing death certificates. 358 certificates(94.0%) had at least one error. There were only 23 death certificates(6.0%) without an error. In 182 cases(47.8%), there was one major error. In 321 death certificates(84.3%), there were more than two errors. A comparison of Samsung Medical Center with the other hospitals showed that the number of total errors was statistically different(p=0.001). Conclusion: There were few death certificates without an error in this study. In a hospital which has postgraduate training in completing death certificates, there are fewer errors than in other hospitals which have no training course. Emergency physicians actually certify many deaths, so they must know the correct method of completing death certificates for statistics on morbidity and mortality.

이동량 보상 및 분류 벡터 양자화기

박규태,전중남,신태민,연창모 연세대학교 산업기술연구소 1987 논문집 Vol.19 No.2

This study describes an interframe image coding method using motion compensated and classified vector quantization(MC-CVQ). In motion compensated vector quantization(MCVQ), it is very important to encode the significant block. Therefore, we propose the MC-CVQ which encodes the significant block in the motion compensated error image by the classified vector quantizer. We classify the significant blocks according to the positions of the significant vectors, and also classify the significant vectors into 15 classes according to the positions of the significant pels. The computer simulation shows that the signal-to-noise ratio and the average bits of MC-CVQ are 0.2-0.25 bits/pel and 35 to 37 dB, respectively.

면역화학분석법을 이용한 뇌종양의 증식능력 측정 : A Kinteics Study with Bromodeoxyuridine and Proliferating Cell Nuclear Antigen

이규성,이규창,정상섭,최중언,서정호,김태승,양우익 대한신경외과학회 1992 Journal of Korean neurosurgical society Vol.21 No.12

Bromodeoxyuridine(BUdR) labeling study provides valuable cell kinetic information for individual tumors and could suggest the prognosis of each patient with the tumor. Recently, a monoclonal antibody against the proliferating cell nuclear antigen(PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed. One of the main purpose of this study was to correlate the histological grade of brain tumor with the BUdR labeling study and the PCNA method in the same patient. The relationship between labeling indices of BUdR incorporated into S-phase and behavior of the tumor was studied in 96 patients. In 31 among those patients. PCNA expressed by cycling cells was also investigated. Both of the LIs showed good correlation with histological grade of the tumor. When both LIs were studied in the same patient, the values of the PCNA LI were parallel but higher than those of the BUdR LI, and the relation PCNA LI=2.2×BUdR LI+0.8(r²=0.86) was obtained. The results of this study show that PCNA could replace the BUdR method for identifying the proliferating cells, and the major advantage of PCNA method is that it could be done without any pretreatment and avoid injection of the teratogenic agent for diagnostic purpose.