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위 (胃) 내시경 (內視鏡) 검사 (檢査) 14 , 389 예에 대한 임상 (臨床) 연구
함준수(Joon Soo Hahm),박경남(Kyung Nam Park),이민호(Min Ho Lee),이성준(Seong Joon Lee),오수철(Soo Chun Oh),한덕호(Duck Ho Han),이종철(Jong Chul Lee),기춘석(Chun Suhk Kee) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A Clinical studies were carried out on 14,389 cases who had taken gastrofiberscopic examination, biopsy and X-ray from May, 1969 to May, 1984 in Han-Yang University Hospital. The results obtained were as follows; 1) Of total 14,389 cases, 7,916 were male and 6,473 were female. 55.1%, of the cases were in the 3rd and 4th decade. 2) Of total 14, 389 cases, 13, 615 showed abnormal endoscopic findings. In abnormal cases, male to female ratio was l.2: l.3) The incidence of single organ involved was 84.8% and multiple organs involved was In single organ involved cases, the most common site of disease was stomach and in multiple organ involved cases, the prevalent sites of lesions were stomach and duodenum. 4) The most frequent disease of stomach was gastritis followed by gastric ulcer. In the cases of duodenum, the most common disease was duodenal ulcer and the next was duodenitis. 5) The most prevalent disease was the chronic gastritis, and the frequency of the other upper gastrointestinal diseases was acute gastritis, gastric ulcer, stomach cancer and duodenal ulcer in orders. 6) The most frequent type of chronic gastritis was superficial gastritis. 7) Among the total cases which had been taken blood-typing, the incidence of most upper gastrointestinal diseases was not related to each blood type. But blood group 0 was common in peptic ulcer disease and blood group A in stomach cancer. 8) The clinical symptoms and signs were of no significant aid for the differential diagnosis of the various upper gastrointestinal diseases.
Estimated incidence of juvenile-onset recurrent respiratory papillomatosis in Korea
Jin-Kyoung Oh,Hwa Young Choi,Minji Han1,Yuh-Seog Jung,Sang Joon Lee,Moran Ki 한국역학회 2021 Epidemiology and Health Vol.43 No.-
OBJECTIVES: Recurrent respiratory papillomatosis (RRP) is caused by human papillomavirus (HPV) types 6 and 11 and is potentially preventable through vaccination. This study estimated the incidence of juvenile-onset RRP before the implementation of the national HPV vaccination program in Korea. METHODS: We conducted a cohort study using claims data provided by a mandatory insurance program to estimate the incidence of RRP and associated healthcare use. Patients with juvenile RRP were defined as those aged ≤12 years with ≥2 admissions or ≥2 outpatient visits during which they received the International Classification of Diseases, 10th revision code for benign neoplasms of the larynx (D14.1). RESULTS: During 2002-2014, 123 children (74 boys and 49 girls) were diagnosed with RRP. The patients had a mean of 6.5 person-years of follow-up. The incidence was estimated at 0.30/100,000 person-years. The median age at diagnosis was 4.0 years (mean, 4.3). Thirty-six (29.3%) patients underwent surgery, including 23 patients (18.7%) who underwent 2 or more surgical procedures. Severe disease, measured by more frequent surgical procedures and shorter time intervals between consecutive operations, was associated with a younger age at diagnosis. CONCLUSIONS: The estimated incidence of juvenile-onset RRP in Korea was similar to that reported in other countries. The RRP burden should continue to be monitored using National Health Insurance Service claims data.
Han Jeong Joon,Yang Hoon Joo,Hwang Soon Jung 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.4
BACKGROUND: Bone morphogenetic protein 2 (BMP-2) and low-intensity pulsed ultrasound (LIPUS) have been used to enhance bone healing in distraction osteogenesis (DO). The aim of this study was to assess the synergistic effect of BMP-2 and LIPUS on bone regeneration in DO and to determine the optimal treatment strategy for enhanced bone regeneration. METHODS: Rat mesenchymal stromal cells were treated with various application protocols of BMP-2 and LIPUS, and cell proliferation, alkaline phosphatase activity, and osteogenesis-related marker expression were evaluated. In vivo experiments were performed in a rabbit DO model according to the application protocols with different timings of BMP-2 and LIPUS application. RESULTS: Application of BMP-2 after LIPUS pretreatment (BMP-2 after LIPUS) showed greater cell proliferation than LIPUS treatment alone, and higher ALP activity than all other treatment protocols. BMP-2 after LIPUS also exhibited increased gene expression levels of ALP, Cbfa1, and Osterix compared with LIPUS treatment alone. In vivo experiments revealed no significant differences in bone healing based on the timing of LIPUS treatment in DO. The combination of BMP-2 and LIPUS resulted in increased bone volume and bone mineral density compared with BMP-2 or LIPUS. Regarding the timing of BMP-2 application, the application of BMP-2 after LIPUS pretreatment led to greater bone volume than the application of BMP-2 before LIPUS. CONCLUSION: The results of this study suggest that the combined treatment of BMP-2 and LIPUS can lead to enhanced bone healing in DO and that effective bone healing can be achieved through the application of LIPUS before BMP-2.
( Joon Seong Ahn ),( Dong Hyun Sinn ),( Geum Youn Gwak ),( Jong Man Kim ),( Choon Hyuck Kwon ),( Jae Won Joh ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: The degree of steatosis of donated liver is one of decisive factors that determine graft function in recipient and recovery of remnant liver in living donor. Hence, the assessment of hepatic steatosis is a critical element to judge donor compatibility. We evaluated the prevalence and predictors of steatosis among liver donors who had no evidence of fatty liver on screening ultrasonography (US-negative). Methods: Degree of hepatic steatosis was reviewed for 492 US-negative liver donors (age: 30.1 ± 9.9, male: 301 (61.2%)). Clinical and laboratory variables were analyzed to identify predictors for steatosis. Results: The prevalence of severe (≥ 60%), moderate (30 ∼ 59%), mild (5 ∼ 29%) and no steatosis (<5%) were 0.6% (3/492), 10.8% (53/492), 39.6% (195/492) and 49.0% (241/492), respectively. In multivariate analysis, BMI [kg/㎡, OR (95% CI): 1.15, p = 0.021] and serum triglyceride level [mg/dl, OR (95% CI): 1.01, p = 0.004] were independent factors associated with steatosis ≥ 30%. The optimal cutoff for steatosis ≥ 30% by receiver operator curve analysis was 23 kg/㎡ for BMI and 88 mg/dl for triglyceride. Steatosis ≥ 30% was significantly more prevalent for liver-donors with high BMI (15.2% vs. 9.0% for BMI ≥ 23 vs. < 23 kg/m2, p = 0.034) and with high serum triglyceride level (15.5% vs. 8.7% for triglyceride ≥ 88 vs. < 88 mg/dl, p = 0.021). Based on these two parameters, the prevalence of steatosis ≥ 30% was 6.6%, 13.0% and 28.6% for none, one and both risk factors, respectively. Conclusions: About a half of US-negative liver donors have steatosis ≥ mild degree and one-tenth of them has ≥ moderate degree. USG assessment is not sufficient to exclude donors with significant steatosis especially for those with high BMI and triglyceride level, and thus, pre-operative liver biopsy should be positively considered for them.
A Geochemical Boundary in the East Sea (Sea of Japan): Implications for the Paleoclimatic Record
Han, Sang-Joon,Hyun, Sang-Min,Huh, Sik,Chun, Jong-Hwa Korea Institute of Ocean ScienceTechnology 2002 Ocean and Polar Research Vol.24 No.2
Sediment from six piston cores from the East Sea (Sea of Japan) was analyzed for evidence of paleoceanographic changes and paleoclimatic variation. A distinct geochemical boundary is evident in major element concentrations and organic carbon content of most cores near the 10-ka horizon. This distinctive basal Holocene change is interpreted to be largely the result of changing sediment sources, an interpretation supported by TiO_2/Al_2O_3$ ratios. Organic carbon and carbonate contents also differ significantly between the Holocene and glacial intervals. The C/N ratio of organic matter is greater than 10 during the glacial period, but is less than 10 for the Holocene, suggesting that the influx of terrigenous organic matter was more volumetrically important than marine organic matter during glacial times. The chemical index of weathering (CIW) is higher for the Holocene than the glacial interval, and changes markedly at the basal Holocene geochemical boundary. Silt fractions are higher in the glacial interval, suggesting a strong effect of climate on silt particle transportation: terrigenous aluminosilicates and continental organic carbon transport were higher during glacial times than during the Holocene. Differences in sediment composition between the Holocene and glacial period are interpreted to have been climatically induced.
Han Joon Kim 대한자기공명의과학회 2022 Investigative Magnetic Resonance Imaging Vol.26 No.1
Purpose: To evaluate the clinical benefit of 2D contrast-enhanced T2 fluidattenuated inversion recovery (CE-T2 FLAIR) image for detecting leptomeningeal metastasis (LM) in the brain metastasis work-up for lung cancer. Materials and Methods: From June 2017 to July 2019, we collected all consecutive patients with lung cancer who underwent brain magnetic resonance image (MRI), including contrast-enhanced 3D fast spin echo T1 black-blood image (CE-T1WI) and CE-T2 FLAIR; we recruited clinico-radiologically suspected LM cases. Two independent readers analyzed the images for LM in three sessions: CE-T1WI, CE-T2 FLAIR, and their combination. Results: We recruited 526 patients with suspected lung cancer who underwent brain MRI; of these, we excluded 77 (insufficient image protocol, unclear pathology, different contrast media, poor image quality). Of the 449 patients, 34 were clinicoradiologically suspected to have LM; among them, 23 were diagnosed with true LM. The calculated detection performance of CE-T1WI, CE-T2 FLAIR, and combined analysis obtained from the 34 suspected LM were highest in the combined analysis (AUC: 0.80, 0.82, and 0.89, respectively). The inter-observer agreement was also the highest in the combined analysis (0.68, 0.72, and 0.86, respectively). In quantitative analyses, CNR of CE-T2 FLAIR was significantly higher than that of CE-T1WI (Wilcoxon signed rank test, P < 0.05). Conclusion: Adding CE-T2 FLAIR might provide better detection for LM in the brainmetastasis screening for lung cancer.