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      • 젊은 남자에게 발생한 통상성 간질성 폐렴과 동반된 폐암 1예

        박종숙,이준혁,박성우,장안수,박춘식,박재성,백상현,고은석,신화균 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

        Usual interstitial pneumonia(UIP) is relatively rare disease of lung parenchyme under the age of 50. Lung cancer is reported to occur as a complication of UIP, but has not been reported in young age patient with UIP in Korea. A 35-year-old man was admitted to the hospital because of dyspnea, cough and mild fever. He had been suffered from dyspnea during 3 years. The dyspnea worsened recent 1 month ago. He had been treated with pneumonia at another hospital during 4 months before this admission. Chest radiographs and High resolution CT showed subpleural and basal dominant reticular opacities in both lung with no change until now. He was smoker and his occupation was car engine-man dealing with benzene. UIP is suspected by history and radiologic findings. Operation for open lung biopsy was performed to obtain lung specimen via video-assisted thoracoscopic surgery. Patient's pathologic examination showed UIP combined with adenocarcinoma in RLL superior segment and posterobasal segment and RLL lobectomy was done. After operation, the patient has been in cancer free condition so far. We report a case of UIP combined with lung cancer in young man with brief review of the literature.

      • KCI등재
      • SCOPUSKCI등재

        김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

        이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

        표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

      • 家族計劃에 依한 出生抑制兒數 推定

        朴仁和,金正根 서울大學校 保健大學院 1978 보건학논집 Vol.15 No.1

        The purpose of thos study is to estimate births averted and to measure impact on fertility by family planning programs. The data used in this study were collected from 'the Community Pregnancy Study'in three Myons of Chunseong Gun, Kangwon Province, during the period from May 1973 to April 1976. 1,246 cases practicing one other methods of contraception among 3,630 fecund women, who were under surveillance by the cohort study, were the objects of this study. In this analysis, estimated number of births averted was performed, especially upon the acceptors of IUD, by the Model developed by potter(1969). The analysis was carried out separately for five age groups: under 25, 25-29 30-34, 35-39, and 40 and over, Results for the total population were derived as weighted averages of age-specific results. The results were as follows: (1) R: Mean span of useful retention of IUD, using 'PER' (Pregnancy, Expulsion, Removal) and 'Mortality' as competing risks, was 20.1 months. (2) I: Mean length of interruption of childbearing by each IUD inserted allowing for the overlap between IUD retention and amenorrhea (A), and the effect of accidental pregnancies (PW), was 16.7 months. (3) The allocation of useful retention of IUD to successive years following insertion: After initial year, the number of births averted was declined. This decline was more rapid in the younger age group, due to the shorter retention span of IUD. Therefore, exception might be taken to Chow's allegation that “impact from IUD will be fairly uniform over the 5 years following insertion.” (4) The level of potential fertility without contraception: Potential fertility cannot be measured directly from 'Age-Specific Marital Fertility Rate of total women belonging to the same age group. In this analysis, the estimate of D was based on the acceptors own experiences for pregnancy. D: The mean length of the birth interval in the absence of contraception was 40 months. (5) The number of births averted by the segment of IUD was 0.36, which was measured by the ration of I to D. The effectiveness of birth averted by age group was better in the younger age group than that of the older. This Supported Lee and Isbister's generalization that “more is accomplished by securing younger participants in an IUD program” (6) In the application of the Potter's Models the most important parameters for the estimation of births averted were thought to be R, the typical lenght of retention and D, the degree of potential fertility. Consequently, the demographic effectiveness of contraceptive in a given population depends on R and D. (7) The total mumber of births averted during the period of this study was estimated as 359 by all contraceptives. The IUD, which contributed to 45 percent of total number of birth averted, was superior to other methods. (8) The impact on 'Fertility Rate' during this study was 16 percent decrease when compared with 'the Expected Fertility Rate' in the absence of family planning programs.

      • Caffeine 과 Glucose 투여가 지구성 운동중 대사 및 호흡기능에 미치는 효과

        박해근,전종귀,홍성표,민창기 忠南大學校體育科學硏究所 1986 體育科學硏究誌 Vol.4 No.1

        Twelve male students (major in physical education; non-coffee drinkers; 6 endurance athletes; 6 non-athletes) were studied to determine the effects of caffeine, and Glucose feedings on submaximal endurance performance. Each subject performed three submaximal cycling trials at an absolute intensity of 900kpm. The trials were randomized to negate any possible order or training effects. For the caffeine trial, 2.5 mg/kg body weight of caffeine in 250ml of artificially sweetened barley tea was ingested twice one hour and 30.min prior to the ride. In the glucose trial, 0.5g/kg. body weight of glucose in 250m1 of barley tea was ingested twice one hour and 30 min prior to the ride. During the control trial, 250ml of artificially sweetened barley tea was ingested twice one hour and 30 min prior to the ride. obtained data from the three trials were analyzed with one way ANOVA for repeated measures design. Significant differences between means were located using a multivariate comparison. The level of significance was established at p<0. 05. The results were summerized as follows : Ingestion of glucose elevated blood glucose and insulin levels at rest , but no significant differences in blood glucose concentration were found between the three trials . Glucose ingestion resulted in rapid hypoglycemia and inhibition of FFA mobilization during exercise. Caffeine ingestion increased significantly in VE, Vo2 and plasma osmolarity during the exercise. But caffeine ingestion failed to elevate plasma FFA concentration, HR and blood pressure significantly. Glucose or caffeine ingestion did not change in blood lactate, Hb , plasma Na+ concentration, Hit and RQ during exercise. In the above results, It was suggested that ingestion of caffeine prior to the exercise fail to increase in lipid metabolism during exorcise and may have some detrimental effects on endurance performance besides psychological ergogenic effect of caffeine, and that glucose ingestion prior to the exercise elevate blood glucose and insulin level at rest but may have detrimental effect of endurance performance because of rapid hypoglycemia caused by hyperinsulinemia.

      • 성인형 당뇨병에서의 심혈관 합병증과 지질대사와의 관계

        박헌진,안정기,이종선,김영건 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

        Hypwelipiswmia is commonly observed in the diabetics, especially with cardiovascular complications. We studied lipid profiles and cardiovascular complication in the 191 adult onset DM patients. The results are as follows: 1. The age distribution was from 24 years old to 82 years old. Male patients were 99 persons, famale patients were 92 persons. The mean disease duration was less than 2 years in the 77 patients, more than 5 years in the 79 patients. 2. Upon the classification between sexes, the mean age was 55±1(SEM) years in the male group, 53±1(SEM) years in the female group. The mean disease durtion was 6.4±1(SEM) years in the female group, longer in the male group (P<0.05). The triglyceride level was 210±16(SEM)㎎% in the male group, 214±13(SEM)㎎% in the female group. The fasting blood sugar level was 147±6(SEM)㎎/dl in the male group, 158±8(SEM)㎎/dl n the female group. The cholesterol level was 229±5(SEM)㎎/dl in the male group, 248±5(SEM)㎎/dl in the female group, higher in the female group (P<0.05). 3. The cardiovascurlar complicatioin (Hypertension, Myocardial infarction, Myocardial ischemia, Angina, Gangrene, Proliferative retinopathy) were present in the 60 patients from 191 patients. Hypertension was present in the 48 patients, and the most prevalent. The mean age and carrdiovascular complication were higher in the more than 5 years of mean disease duration group(mean age 57.99±1.14(SEM)㎎ year) than less than 5 years group(mean age 52.12±0.10(SEM)㎎ year) (P<0.001, P<0.01). 4. The mean disease duration (7.40±1.01(SEM) years), mean triglyceride levels(271±1.01(SEM)㎎%), and mean cholestrerol levels( 257±8㎎.dl) in the cardiovascularly complicated group were higher than those of non-complicated group (P<0.01). 5. The triglycerdie level was high in the obese group (230±14SEM㎎%) than non-obese group (184±15SEM㎎%) (P<0.05). The obese patients were more prevalent in the female group than male group significantly. 6. Considering obesity and cardiovascular complications, the triglyceride value was higher in the obese complicated group(300±30SEM㎎%) than obese non-complicated (197±14SEM㎎ %) or non-obese non-complicated (168±13SEM㎎ %) group (P<0.001). The cholesterol level was higher in the obese complicated group (267±10SEM㎎/dl) than obese non-complicated (230±5SEM㎎/dl) or non-obese non-complicated group(229±7SEM㎎/dl) (P<0.05). 7. Classifying upon insulin response pattern, the obese patients were found in the response pattern, low response pattern, flat type pattern(no response pattern) in the decreasing number of order (P<0.01). The cardiovascular complications were found in the low response group, response group, and flat type pattern (no response) in the decreasing number of order ( P<0.05). The combined cases of obesity and cardiovascular complications were found in the low response group, response group and flat type group(no response) pattern in the decreasing number of order (P<0.01). The mean disease duration was longer in the flat type group (no response) (4.48±0.6SEM years) than the response group(2.43±0.90SEM years) (P<0.05). The mean triglyceride value was higher in the response group (267.38±154.75SEM㎎%) than the flat type(no response group) (198.35±154.05SD㎎%) (P<0.05). So, we conclude that in the NIDDM, obesity control(die control, ideal body weight mainterice, and hyperlipidemia control) is essential for better DM control and cardiovascular complication control.

      • 교통사고에 의해 발생한 뇌내 좌상 1례

        박혜연,전소분,김선아,정금선,조종기,송근호,이영원 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

        A two years old intact female Minature Schnauzer was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with an intermittent seizure by traffic accident. No specific finding was found by radiography and computer tomography (CT). Hematologic and blood chemical examination revealed that PCV (62.5%), BUN (72.6 mg/dl), CK (1769 U/l), ALT (169 U/l) and ALP (353 U/l) were increased. This dog was recovered by medical treatment.

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