위암 환자에서 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김삼용,김영건 충남대학교 암연구소 1991 癌共同硏究所 硏究誌 Vol.1 No.1

We performed a variety of lymphocyte stimulation tests, delayed hypersensitivity skin tests, and enumeration of several lymphocyte subpopulations in 21 patients with gastric cancer who did not receive any form of anticancer therapy, and in 20 healthy controls. The gastric cancer patients had significantly decreased number and total score of positive reactions in delayed hypersensitivity skin tests compared with the healthy controls. The percent of CD_(4) positive lymphocytes in the gastric cancer patients was significantly decreased compared to the normal control subjects, but it had no correlation with the total score of delayed cutaneous hypersensitivity reactions. The ratio of helper to suppressor cells was lower in the cancer group. The uptake of 3H-thymidine was markedly depressed in cancer patients when stimulated with various mitogens. There was little correlation between any of the stimulation tests and any of the lymphocyte subpopulation proportions to delayed hypersensitivity cutaneous reactions. Optimal proliferative response was found in lymphocytes stimulated with 10 micrograms of concanavalin-A and 10 microgram of phytohemagglutinin. Advanced stage patients had greatly depressed delayed hypersensitivity skin reactions and proliferative responses to mitogens compared with localized diseases. These results suggest that gastric cancer patients have depressed cellular immune functions, which mainly result from the decreased helper cells and defects in functional proliferative response to mitogens. Interleukin-2 and interferon-gamma restored the in vitro proliferative response of lymphocyte in patients with gastric cancer.

위암 환자에게 세포성 면역 기능에 관한 연구

이재익,윤일국,이종선,김종완,장준,안정기,송민호,정현용,이헌영,김상용,김영건 忠南大學校 癌共同硏究所 1991 癌共同硏究所 硏究誌 Vol.1991 No.-

소 수정란의 공배양 및 동결이 체외발생에 미치는 영향에 관한 연구

이종진,이명헌,남윤이,이만휘,이봉구,김상근 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

The studies on the carried out to investigate the effects of co-culture with cumulus cells and oviduct epithelial cells on the in vitro fertilization and cleavage rate of bovine follicular oocytes, and to determine the optimum thawing temperature and equilibration time of frozen bovine embryos and on survival rate and in vitro developmental rate of bovine embryos. The ovaries were obtained from slaughtered Korean native cows. The follicular oocytes were cultured in TCM-199 medium containing 10 IU/㎖의 PMSG(Sigma, USA), 10 IU/㎖의 hCG, 1 ㎍/㎖의 β-estradiol(Sigma, USA) and 10% FCS(Sigma, USA) for 24-48 hrs in incubator with 5% CO_2 in air at 38.5℃ and then matured oocytes were again cultured for 12-18 hrs with motile capacitated sperm by preincubation of heparin. The bovine embryos following dehydration by cryoprotective agents and a various concentrations of sucrose were directly plunged into liquid nitrogen and thawed in 30℃ water. The results are summarized as followes : 1. The in vitro fertilization and in vitro developmental rates of bovine oocytes co-cultured with cumulus cells in TCM-199 media were 75.0%-76.8% and 17.3%-27.6%, respectively. And in-vitro fertilization rates of cumulus-enclosed oocytes(55.4%) were significantly(p<0.05) higher than cumulus-denuded oocytes(23.1%). 2. The in vitro fertilization and in vitro developmental rates of bovine oocytes co-cultured with 1 ×10^4 cells/㎖, 1 ×10^6 cells/㎖, 1 ×10^8 cells/㎖ and 1 ×10^15 cells/㎖ oviduct epithelial cells in TCM-199 media were 74.5%-77.8% and 15.7%-21.2%, respectively. 3. The in-vitro fertilization and in vitro developmental rates of bovine oocytes co-cultured in TCM-199 media containing PMSG, hCG, PMSG + hCG, PMSG + β-estradiol, hCG + β-estradiol 0 to 40 hrs after insemination were 74.0%-77.4% and 18.9% - 23.1, respectively. 4. The survival rates of bovine embryos thawed after rapid freezing in the media containing various kinds of cryoprotective agents added 0.25M and 0.50M sucrose were 14.7% - 35.1% and 17.6% - 31.6%, respectively. The survival rates of bovine embryos thawed after rapid freezing in the freezing media containing a various concentration of sucrose added 1.5M and 2.0M glycerol, 1.5M and 2.0M DMSO, and 1.5M and 2.0M propanediol were 23.5% -31.4% and 20.6% - 34.1%, respectively. 5. The temperature thawed at 30℃ after rapid freezing of bovine embryos resulted in a significantly higher embryos survival rate than did at 20℃ and 35℃. 6. The equilibration time on the survival rates of bovine embryos was attained after short period of time(2.5-5 min.) in the freezing medium higher than ling period of time(10-20min.).

Gene pyramiding effect of two major bakanae disease resistance gene using qBK1 and qBKWD

Sais-Beul Lee,Tae-Heon Kim,Su-Min Jo,Jun-Hyun Cho,Ji-Yoon Lee,Jong-Hee Lee2,Dongjin Shin,You-Chun Song,Myung-Kyu Oh,Dong-Soo Park 한국작물학회 2017 한국작물학회 학술발표대회 논문집 Vol.2017 No.-

대학생의 정치적 태도에 관한 연구

이창섭,이종호,김헌 충남대학교 체육과학연구소 2000 體育科學硏究誌 Vol.18 No.1

The purpose of this study was to analyze and compare three individual facets of political attitudes by a university student classification and gender, exercise experiences. The subjects were 402 university students randomly chosen from various student classifications 165 students were among physical education department and 237 among general department students. For the purpose of this study, this study used a survey instrument modified by the researcher and based on the various variables identified in an extensive review of related literature. The survey instrument contains three factors; political orientation, political participation and political interest. An independent samples t-test was used to analyze the col1ected data. The results revealed that significant differences were found between the perception of the two types of students on the dimensions political interest : (1) Regarding the comparison of political orientation between university student classification, physical education students showed slightly more progressive than the other university student group ; (2) Pertaining to the comparison of political participation and political interest between university student groups, physical education students showed higher than the other group. According to gender, significant differences were existed in the two factors, political orientation and political participation. No significant differences was existed between athletes and non-athletes in the three facets of political attitudes.

수면확성기의 음향특성에 관한 연구

이창헌,문종욱,박용석,최찬문,서두옥 제주대학교 해양연구소 1998 해양자원연구소연구보고 Vol.22 No.-

To obtain the fundamental data on a surface speaker made to lure fish school by pure sound, three surface speakers were made of moving coil driver units of 75W and 50W respectively. Their frequency characteristic was measured in the range of 200 - 4mHz that could be used in luring fish school. The results of the measurements in air and sea are follows. 1. The input and output wave forms of a surface speaker were similar to each other in measurement frequencies in air. Then sound pressure of a surface speaker made of 75W driver units among them was over 130dB(0dB re 20μ Pa) in the range of 300 - 400Hz maximally. 2. When the surface speaker with 75W driver units emitted the measurement frequencies at sea. Sound pressure classified by the depth of water were over 140dB at 1m and 120dB at 20m(0dB re 1μ Pa) respectively.

수중 가청음에 의한 쏨벵이의 청각능력 : 2. 청각 임계비

이창헌,박용석,문종욱,강창익,김고환,서두옥 제주대학교 해양연구소 1999 해양자원연구소연구보고 Vol.23 No.-

수중 가청음은 어군의 행동 제어와 해양목장화에서 음향 순치에 많이 이용되고 있다. 수중 가청음에 의한 어류반응 해석을 하기 위해서는 물고기의 청각능력을 정확히 파악할 필요가 있으며,오래전부터 여러물고기의 청각능력을 관련된 연구가 수행되었다.

제Ⅲ급 부정교합자의 안정위시와 /s/ 발음시 혀의 위치에 관한 두부방사선계측학적 연구

이기헌,김종철 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.2

Tongue posture at rest position of Class Ⅲ malocclusion is very important in malocclusion and phonation. Because Class Ⅲ malocclusion showes low tongue position, speech defect is commonly occured. This study was attempted to evaluate the correlationship between the tongue posture at rest position and during /s/ phonation and facial skeleton in centric occlusion. Thirty subjects with Class Ⅲ malocclusion who had no orofacial defects such as cleft palate, medical history of neurologic pathology, hearing defect and any previous speech therapy were selected. Ninety sheets of lateral cephalometric radiographs taken at rest position, during /s/ phonation and centric occlusion were traced, measured and statistically analysed. The results obtained were as follows ; 1. In Class Ⅲ malocclusion, the posture of tongue was positively correlated with the position of hyoid body. The hyoid body was positioned anteriorly and inferiorly as the vertical facial skeleton was increased in centric occlusion. 2. In Class Ⅲ malocclusion, the vertical position of tongue tip at rest position was not correlated with facial skeleton in centric occlusion, but the horizontal had low correlation with mandibular body length, APDI, and 1 to SN. 3. In Class Ⅲ malocclusion, there was the tendency that the dorsal position of the tongue was lowered as the vertical facial skeleton was increased. 4. In Class Ⅲ malocclusion, the vertical and horizontal position of tongue tip during /s/ phonation was not correlated with facial skeleton in centric occlusion.

환경설문지의 요인분석에 관한 연구

李鍾憲 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

Factor analysis is a statistical techique used to identify a relatively small number of factors that can be used to represent relationships among sets of many interrelated variables. Before examining the mechanics of a factor analysis solution, let's consider the characteristics of a successful factor analysis. One goal is to represent relationships among sets of variables parsimoniously. That is, we would like to explain the obaerved correlations using as few factors as possible. If many factors needed, little simplification or summarization occurs. We would also like the factors to be meaningful. A good factor solution is both simple and interpretable. 1. Initial statistics The proportion of variance accounted for by the common factors, or the communality of variable, is I for all the variables, as how in initial statistics. The total variance explained by each factor is listed in the column labeled Eigenvalue. The next columm contains the percentage of the total variance attributable to each factor. For example, initial statistics shows that almost 57.4% of the total variance is attributable to the first 7 factors. The remaining 13 factors together account for only 43.6% of the variance. One criterion suggests that only factors that account for variance greater than I(the eigenvalue is greater than I)should be included. Initial statistics : Variable Communality * Factor Eigenvalue Pct of Var Cum Pct A1 1.00000 * 1 3.33974 16.7 16.7 A2 1.00000 * 2 1.60573 8.0 24.7 . . . . . . . . . . . . . . . . . . . . . A7 1.00000 * 7 1.03290 5.2 57.4 A8 1.00000 * 8 .95317 4.8 62.2 . . . . . . . . . . . . . . . . . . . . . A20 1.00000 * 20 3.32196 1.6 100.0 2. Factor Matrix Each row of Factor Matrix contains the coefficients used to express a standardized variable in terms of the factors. To judge how well the seven-factor model describes the original variables, we can compute the proportion of the variance of each vartables explained by the seven-factor model. Since the factors are uncorrelated, the total proportion of variance explained is just the sum of the variance proportions explained by each factor. The communalities for the variables are shown in final statistics, together with the percentage of variance accounted for by each of the reained factors. Communalities can range from 0 to 1, with 0 indicating that the common factors explain nono of the variance, and 1 indicating that all the variance is explained by the common factors. For example, final statistics show that communalities can range from 0.37997 to 0.76682. Factor Matrix : FACTOR 1 FACTOR 2 FACTOR 3 FACTOR 4 FACTOR 5 FOCTOR 6 FOCTOR 7 A1 .36175 -.39003 -.04299 -.05807 -.19549 -.21475 -.18400 A2 .33452 -.11943 -.02122 -.08045 -.59513 -.28405 -.07647 . . . . . . . . . . . . . . . . . . . . . . . . A20 .50913 .20666 .38223 .05503 .17468 -.07815 -.33196 Final Statistics : Variable Communality * Factor Eigenvalue Pct of Var Cum Pct A1 .40640 * 1 3.33974 16.7 16.7 . . . . . . . . . . . . . . A9 .37997 * . . . . . . · A15 .76682 * . . . . . . A20 .59787 * 3. Rotated Factor Matrix : In the Rotated Factor Matrix, variables A8, A12, A13 are highly realted to Factor 1. Variables A5, A6, A7 are highly related to Factor 2. Variables A17, A18 are highly related to Factor 3. Variables A14, A15 are highly related to Factor 4. Variables A3, A4 are highly related to Factor 5. Variables A10, A11 are highly related to Factor 6 Variables 16 is highly related to Factor 7. The goal of rotation is to transform complicated matrices like that in Factor Matrix into simpler ones like that in Rotated Factor Matrix. Rotation redistributes the explained variance for the individual factors. Rotated Factor Matrix : FACTOR 1 FACTOR 2 FACTOR 3 FACTOR 4 FACTOR 5 FACTOR 6 FACTOR 7 A1 .10315 .16332 .47914 -.22112 .04079 .27740 -.10954 . . . . . . . . . . . . . . . . . . . . . . . . A20 .49691 -.02261 .37254 .37254 .22259 -.24454 .23885

위치정보를 이용한 최단경로탐색 알고리즘 개선

이종헌,강민제,이상준 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.2

The shortest path problem arises whenever we try to determine the shortest. cheapest. or most reliable path between one or many pairs of nodes in a network. The path search algorithm for the CNS(Car Navigation System) process the actual road map with complex data and should return the result within acceptable response time. In this paper. we studied the improvement of existing shortest path algorithm using the positioning information. The proposed algorithm was analyzed by the simulation with the real road map data in Jeju city. From the simulation result. it is known that the proposed algorithm required less memory usage and less computational time than the others.