강연 - 미국 원자력 미래에 대한 전망

Kelly, John E. 한국원자력산업회의 2018 원자력산업 Vol.38 No.7

존 켈리 회장은 7월 12일 경주시 힐튼호텔에서 열린 '원자력 안전 및 해체산업 육성 국제 포럼'에 참석하여 'Perspectives on the Future of Nuclear Power in the United States'를 주제로 특별강연을 했다. 켈리 회장은 강연을 통해 미 행정부의 원자력정책, 미국 원자력산업의 단기 도전 과제, 전력 생산에서의 이산화탄소 감축과 원전 역할, 원전의 지속적인 운영, 미국에서 진행되는 신형 원자로 설계 등을 피력했다. 켈리 회장은 이날 언론과의 인터뷰에서 "한국은 원자력산업 강국인데, 원전 안전성에 대한 과학적인 근거보다 정치적 이슈로 신규 원전을 짓지 않고 수명 연장 대신 조기 폐쇄를 결정한 것은 우려할 사안"이라고 말하고 "원전산업 축소는 장기적으로 기업의 전력 확보가 어려워져 경제적 타격을 입는다. 특히 한국은 원전을 수출하면서 탈원전정책을 펴면 수출에 지장을 받지 않을까 걱정된다."고 밝혔다. 켈리 회장은 MIT 원자력공학박사로 미국 에너지부(DOE) 원자력에너지 기술책임자를 지냈다. 본고는 발표 내용을 정리한 것이다.

Physical Dependence on Nicotine in Gum : A Placebo Substitution Trial

Hughes, John R.,Hatsukami, Dorothy K.,Skoog, Kelli P. MediMedia Korea 1986 JAMA-Korea Vol.1 No.9

Application of a novel 3-fluid nozzle spray drying process for the microencapsulation of therapeutic agents using incompatible drug-polymer solutions

Tara Sunderland,John G. Kelly,Zebunnissa Ramtoola 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4

The aim of this study was to evaluate a novel3-fluid concentric nozzle (3-N) spray drying process for themicroencapsulation of omeprazole sodium (OME) usingEudragit L100 (EL100). Feed solutions containing OMEand/or EL100 in ethanol were assessed visually for OMEstability. Addition of OME solution to EL100 solutionresulted in precipitation of OME followed by degradationof OME reflected by a colour change from colourless topurple and brown. This was related to the low pH of 2.8 ofthe EL100 solution at which OME is unstable. Precipitationand progressive discoloration of the 2-fluid nozzle (2-N)feed solution was observed over the spray drying timecourse. In contrast, 3-N solutions of EL100 or OME inethanol were stable over the spray drying period. Microparticlesprepared using either nozzle showed similarcharacteristics and outer morphology however the internalmorphology was different. DSC showed a homogenousmatrix of drug and polymer for 2-N microparticles while3-N microparticles had defined drug and polymer regionsdistributed as core and coat. The results of this studydemonstrate that the novel 3-N spray drying process canallow the microencapsulation of a drug using an incompatiblepolymer and maintain the drug and polymer inseparate regions of the microparticles.

급냉응고 처리된 초내열 합금 A-286 의 기계적 성질 및 강화기구

이성학,신기삼,Kelly, Thomas F,Flinn, John E 대한금속재료학회(대한금속학회) 1996 대한금속·재료학회지 Vol.34 No.3

Mechanical test data of superalloy A-286 show that there is a significant increase in tensile strength after rapid solidification processing (RSP). The mechanism of mechanical property improvement upon RSP was studied by TEM quantitative defect analysis and the data analysis using strengthening models. The most prominent microstructural alterations by RSP are found in the precipitates and in the grain growth behavior. On average, the precipitates in RSP samples are smaller, have higher volume fractions, and are much more stable than their conventionally processed counterparts. The increased tensile strength of the RSP samples is found to be the result of the increased volume fraction and number density of second phase particles. However, the strengthening came mostly through grain growth inhibition by the second phase particles, which in turn increased the strength via Hall-Petch relationship. This study shows the importance of recrystallization and thus the method of consolidation for effective strengthening.

RAPID SOLIDIFICATION PROCESSING OF STRUCTURAL ALLOYS

Thomas F . Kelly,John E . Flinn 대한금속재료학회 ( 구 대한금속학회 ) 1992 Advanced Material and Processing Vol.- No.-

Full Endoscopic Ligamentum Flavum Sparing Unilateral Laminotomy for Bilateral Recess Decompression: Surgical Technique and Clinical Results

권우근,Katherine A. Kelly,Malia McAvoy,Sananthan Sivakanthan,John Ogunlade,Natalie Kai Yi Yap,Sharon Durfy,Christoph P. Hofstetter 대한척추신경외과학회 2022 Neurospine Vol.19 No.4

Objective: Interlaminar endoscopic spine surgery has been introduced and utilized for lumbar lateral recess decompression. We modified this technique and utilized it for bilateral lateral recess stenoses without significant central stenosis. Here we present the surgical details and clinical outcome of ligamentum flavum sparing unilateral laminotomy for bilateral recess decompression (ULBRD). Methods: Prospectively collected registry for full-endoscopic surgeries was reviewed retrospectively. One hundred eighty-two consecutive cases from a single center between September 2015 and March 2021 were reviewed and 57 of them whom underwent ULBRD were enrolled for analysis. Basic patient demographic data, perioperative details, surgeryrelated complications, and clinical outcome were reviewed. The detailed surgical technique is presented as well. Results: Among the 57 patients enrolled, 37 were males while the other 20 were females. The mean age was 58.53 ± 14.51 years, and a bimodal age distribution at the age of mid-fifties and mid-sixties or older was noted. The later age-peak was related to coexistence of degenerative scoliosis. The average operative time per lamina was 70.34 ± 20.51 minutes and mean length of stay was 0.56 ± 0.85 days. Four perioperative complications were reported (7.0%) and the overall reoperation rate at the index level within 1 year was 8.8%. The preoperative back/leg visual analogue scale scores and functional outcome scales including EuroQol-5 dimension questionnaire, Oswestry Disability Index presented significant improvement immediately after surgery and were maintained until final follow-up. Conclusion: ULBRD for bilateral lateral recess stenoses without significant central stenosis resulted in good clinical outcomes with acceptably low perioperative complications rates. Sufficient decompression was achieved with the central ligamentum flavum being preserved.

Nano-LC FTICR Tandem MassSpectrometry for Top-DownProteomics: Routine Baseline Unit Mass Resolution of Whole Cell LysateProteins up to 72 kDa

Tipton, JeremiahD.,Tran, John C.,Catherman, Adam D.,Ahlf, Dorothy R.,Durbin, Kenneth R.,Lee, Ji Eun,Kellie, John F.,Kelleher, Neil L.,Hendrickson, ChristopherL.,Marshall, Alan G. American ChemicalSociety 2012 ANALYTICAL CHEMISTRY - Vol.84 No.5

<P>Current high-throughput top-down proteomic platformsprovide routineidentification of proteins less than 25 kDa with 4-D separations.This short communication reports the application of technologicaldevelopments over the past few years that improve protein identificationand characterization for masses greater than 25 kDa. Advances in separationscience have allowed increased numbers of proteins to be identified,especially by nanoliquid chromatography (nLC) prior to mass spectrometry(MS) analysis. Further, a goal of high-throughput top-down proteomicsis to extend the mass range for routine nLC MS analysis up to 80 kDabecause gene sequence analysis predicts that ∼70% of the humanproteome is transcribed to be less than 80 kDa. Normally, large proteinsgreater than 50 kDa are identified and characterized by top-down proteomicsthrough fraction collection and direct infusion at relatively lowthroughput. Further, other MS-based techniques provide top-down proteincharacterization, however at low resolution for intact mass measurement.Here, we present analysis of standard (up to 78 kDa) and whole celllysate proteins by Fourier transform ion cyclotron resonance massspectrometry (nLC electrospray ionization (ESI) FTICR MS). The separationplatform reduced the complexity of the protein matrix so that, at14.5 T, proteins from whole cell lysate up to 72 kDa are baselinemass resolved on a nano-LC chromatographic time scale. Further, theresults document routine identification of proteins at improved throughputbased on accurate mass measurement (less than 10 ppm mass error) ofprecursor and fragment ions for proteins up to 50 kDa.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancham/2012/ancham.2012.84.issue-5/ac202651v/production/images/medium/ac-2011-02651v_0004.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ac202651v'>ACS Electronic Supporting Info</A></P>

Skin Thickness of the Anterior, Anteromedial, and Anterolateral Thigh: A Cadaveric Study for Split- Skin Graft Donor Sites

Jeffrey CY Chan,John Ward,Fabio Quondamatteo,Peter Dockery,John L Kelly 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.6

Background: The depth of graft harvest and the residual dermis available for reepithelizationprimarily influence the healing of split-skin graft donor sites. When the thigh region ischosen, the authors hypothesize based on thickness measurements that the anterolateralregion is the optimal donor site. Methods: Full-thickness skin specimens were sampled from the anteromedial, anterior, andanterolateral regions of human cadavers. Skin specimens were cut perpendicularly with acustom-made precision apparatus to avoid the overestimation of thickness measurements. The combined epidermal and dermal thicknesses (overall skin thickness) were measured usinga digital calliper. The specimens were histologically stained to visualize their basementmembrane, and microscopy images were captured. Since the epidermal thickness varies acrossthe specimen, a stereological method was used to eliminate observer bias. Results: Epidermal thickness represented 2.5% to 9.9% of the overall skin thickness. There wasa significant difference in epidermal thickness from one region to another (P<0.05). Theanterolateral thigh region had the most consistent and highest mean epidermal thickness(60±3.2 μm). We observed that overall skin thickness increased laterally from the anteromedialregion to the anterior and anterolateral regions of the thigh. The overall skin thicknessmeasured 1,032±435 μm in the anteromedial region compared to 1,220±257 μm in theanterolateral region. Conclusions: Based on skin thickness measurements, the anterolateral thigh had the thickestepidermal and dermal layers. We suggest that the anterolateral thigh region is the optimaldonor site for split-skin graft harvests from the thigh.

Conducting polymer composites with cellulose and protein fibres

James H. Johnston,John Moraes,Thomas Borrmann,David Flynn,Fern M. Kelly 한국물리학회 2006 Current Applied Physics Vol.6 No.3

Conducting polymer–fibre composites with polypyrrole cellulose (paper) and protein (wool) fibres have been produced by polymerizing pyrrole with ferric chloride as the oxidant around separated individual cellulose (wood) fibres from bleached Pinus radiata Kraft pulp, and merino wool fibres respectively to generate new composite materials that retain the inherent properties of the polymer and individual fibres. For the polypyrrole–cellulose composite, the polypyrrole consisted of spheres of about 100 nm in size fused together to form a continuous coating that fully encapsulates the cellulose fibre and associated finer fibrils. For the polypyrrole–wool composite the polypyrrole formed a similar coating of about 200 nm spheres. Electrical conductivities of the composites were substantially increased over those of the precursor fibres.

분말야금법에 의해 제조된 초내열합금 ( A - 286 ) 에서의 결정립계 형성 및 성장

신기삼,이성학,Thomas F . Kelly,John E . Flinn 대한금속재료학회 1995 대한금속재료학회 학술대회 개요집 Vol.1995 No.1