폐경후 골다공증 환자에서 체질량지수에 따른 Alendronate의 효과

조영석,나소영,이효진,홍우정,김군순,김도희,구본정,송민호,김영건,노흥규 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

배경 : 폐경후 골다공증은 심각한 문제로 대두되고 있다. 현재 Alendronate는 폐경후 골다공증의 치료제로서 널리 쓰이고 있다. 저자는 Alendronate의 골밀도에 효과를 알아보고 골다공증의 위험인자에 따른 Alendronate의 반응 정도를 평가하기 위하여 본 연구를 수행하였다. 방법 : Alendronate를 평균 12개월간 복용한 35명의 폐경후 골다공증환자에서 체질량지수와 폐경후 기간에 따른 치료효과를 조사하였다. 결과 : 전체 대상군에서 Alendronate 10㎎을 12개월간 투여한후 골밀도의 평균 변화율은 요추와 대퇴골 경부에서 각각 7.83±7.39%와 2.99±9.22%이었다. 과체중군에서 평균변화율은 요추와 대퇴골 경부에서 각각 7.15±4.5%와 3.05±2.86%였다. 양군간에 통계적 유의성이 있는 차이는 없었다. 폐경후 7년이 경과되지 않은 군에서의 평균변화율은 요추와 대퇴골 경부에서 각각 6.9±5.3%와 5.71±0.08%였다. 양군간에 통계적인 유의성이 있는 차이는 없었다. 결론 : 마른체형이 골다공증의 발병에는 영향이 있으나, Alendronate 치료효과의 차이는 없는 것을 확인할 수 있었다. 더불어 폐경이 있고 7년이 초과된 군과 년이 경과되지 않은 군에서의 Alendronate 치료효과의 차이는 없는 것을 확인할수 있었다. 이는 골흡수가 상당히 진행된 상태에서도 Alendronate가 치료효과를 가지고 있음을 반영한다고 할 수 있겠다. Postmenopausal osteoporosis is a serious health problem. The aminophosphonate Alendronate is widely used for treatment of postmenopausal osteoporosis. We studied the effect of l0㎎ of alendronate given daily for mean 12 months on bone mineral density in 35 women(mean age 61yrs. mean BMI 23.24㎏/m^(2)) with osteoporosis. An over weight group is defined such that BMI was above 23㎏/m^(2). All the women received 1500㎎ calcium carbonate daily. The bone mineral density of L-spine and femoral neck was measured by dual-energy X-ray absorptiometry. Alendronate increased BMD at mean 12 months at the L-spine (7.15±4.5%) and femoral neck(3.05±2.86%) in normal women. Alendronate increased bone mineral density at 12 months at the L-spine(6.00±5.3%) and femoral neck(4.17±4.87%) in overweight women. There was no difference between two groups. In the less than 7 years group of postmenopausal duration. alendronate increased bone mineral density at 12 months at the L-spine(6.9±4.9%) and femoral neck(3.18±7.1%). In the more than 7 years group of postmenopausal duration, alendronate increased hone mineral density at 1% months at the L-spine(6.5±5.3%) and femoral neck(5.71±0.08%). There was no difference between two groups. In postmenopausal women with osteoporosis, therapy with alendronate produced significant increases in BMD of the L-spine and femoral neck in both group. There was no difference between normal and over-weight groups. and between less than 7 years group and more than 7 years group of postmenopausal duration.

그레이브스병에서 방사성 요오드 치료에 따른 갑상선 자극 호르몬 수용체 결합억제 면역글로불린(Thyrotropin Binding Inhibitory Immunoglobulin, TBII)의 변화

조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.

히스토그램의 결합에 의한 칼라 영상의 고속 양자화

김진홍,조철효,김두영 동아대학교 공과대학 부설 한국자원개발연구소 1993 硏究報告 Vol.17 No.2

Many images display devices allow only a limited number of colors to be simultaneously displayed. Usually, this set of available colors, called a color map, may be selected by a user from a wide variety of available colors. This color quantization problem is considered in two parts : the selection of an optimal color map and optimal mapping of each pixel of the image to a color from color map. After convert RGB color images to YUV color images, this paper presents an analysis of quantization process of color images using suggested method of color map generation by histogram. The result compared JPEG and proposed method.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

초기 횡경사선박의 파랑중 전복거동에 관한 연구

김진안,조효제,진창배 부산대학교 1994 生産技術硏究所論文集 Vol.47 No.

It is an important problem to consider the mechanism of capsizing of a ship in waves in the design of ship. Especially, the inclined vessels which were caused by the cargo shift or inclining initially by the wind force etc, are easy to be capsized in comparison with the upright vessel. In this paper, we investigate the characteristics of roll motion of the inclined vessel in following seas by meas of the analysis of parametric oscillation. We derived the nonlinear equation of motion to express the roll motion of the inclined vessel and compared with behaviour of the upright vessel. It is known that capsizing phenomena of the inclined vessel which occur instantaneously in the following seas, can be explained well by the solution of the nonlinear equation. 파랑중 선박의 전복 메카니즘을 규명하는 것은 선박의 안전한 설계를 위하여 다루어져야 할 또하나의 중요한 문제이다. 특히 적하물의 이동이나 바람에 의한 경사모멘트 등에 의하여 경사된 선박의 경우에는 직립선에 비하여 전복될 위험이 많은 것으로 알려져 있다. 따라서, 본 논문에서는 파라메트릭 진동의 관점에서 추파중을 항해하는 초기 경사선의 횡요운동 특성을 조사하여, 선체의 전복 현상을 고찰한다. 위를 위하여 우선 초기 경사선에 대한 비선형 운동방정식을 유도하여 그 운동방정식의 해를 직립선에 대한 것과 서로 비교 검토하였다. 그 결과 추파중을 항해하는 초기경사선이 아주 짧은 시간에 전복하는 현상은 본 논문에서 설정한 비선형 운동방정식으로서 충분히 설명할 수 있음을 보였다.

비소세포폐암에서 동시화학방사선요법을 받는 중 생긴 기관폐루1례

강건희,조성우,김성록,유영진,이효락 인제대학교 2008 仁濟醫學 Vol.29 No.-

최근 근치적 절제가 불가능한 국소진행성 비소세포 폐암에서 화학요법을 방사선요법과 동시에 투여하는 치료방법에 대한 연구가 활발이 이루어지고 있으며 이러한 치료과정 중 생긴 여러 부작용에 대한 연구도 이루어지고 있지만 아직까지 기관폐루가 생겼다고 보고는 없다. 따라서 치료과정 중 기관폐루가 의심되는 소견이 있을 경우 이에 대한 조기 진단과 치료를 통하여 부작용에 따른 사망률을 최소화하여야 하겠다. The incidence of lung cancer is increasing steadily and various methods have been attempted to enhance the cure rate of locally advanced non small cell lung cancer, which is hardly removable surgically, but the results are not satisfactory yet. Recently, research is being made actively on the simultaneous application of chemotherapy and radiotherapy for locally advanced non small cell lung cancer that cannot be radically resected and the we experienced a case of patient diagnosed with bronchopulmonary fistula during the treatment process, and therefore report it here.

Ascorbate Peroxidase 유전자의 도입에 의한 식물의 형질전환

이인애,이효신,배은경,김기용,이병헌,손대영,조진기 Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

This study was conducted to obtain the transformed tobacco (Nicotiana tubacum) plants with cytosolic ascorbate peroxidase gene(ApxSC7) using Agrobacterium tumefaciens LBA4404. A cDNA encoding the cytosolic ascorbate peroxidase of strawberry, ApxSC7, was introduced into tobacco plants via Agrobacterium-mediated gene transfer system. The expression vector, pIG-AP8, harboring ApxSC7 gene was used for production of transgenic tobacco plants. A large number of transgenic plants were regenerated on a medium containing hygromycin. Integration of ApxSC7 gene was confirmed by PCR and Southern blot analyses with genomic DNA. Northern blot analyses revealed that the pIGap8 gene was constitutively expressed.

Wavelet 변환을 이용한 계층적 영상코딩에 관한 연구

金斗泳,金珍洪,趙哲孝 東亞大學校 附設 情報通信硏究所 1994 情報通信硏究所論文誌 Vol.2 No.1

최근에 통신망을 이용한 데이터 전송이 많이 사용되어지므로 많은 양의 정보가 전송되는 경우에 통신 회선의 점유시간이 늘어나는 문제점이 발생하게 된다. 이런 문제점을 해결하기 위해 영상정보의 저장 및 전송율을 위해서는 영상 압축 방법이 필요하다. 그래서 통신회선을 통해 영상을 압축 전송하고, 표시할 수 있도록 JPEG(Joint Photographic Experts Group)에서 컬러 정지 영상의 부호화 방법을 정의하고 표준화하였다. 본 논문에서는 JPEG에서 제시된 DCT/양자화 과정을 사용하지 않고 점진적으로 송신할 수 있으면서 계층적 구조를 갖는 Wavelet변환 방법을 도입하고 압축율을 향상시키기 위해서 Wavelet변환 후 저역 분할 대역에 긴 런(run)을 형성하도록 새로운 가역 차분변환(=DPCM) 방법과 고역분할 대역에서는 영상의 Edge정보를 가지고 있으므로 빈도분포를 분류하여 영상의 특성에 맞게 임계값을 정하는 방법과 Edge의 방향에 따라 주사 방법을 혼합하여 처리한다. 그리고 256개 이하의 색상을 가진 컬러 모니터에 컬러 영상을 표시하기 위해서 컬러 양자화 방법중 Bottom-Up 방법을 채택하면서 화질 및 속도를 고려하여 고속 컬러 양자화 방법을 제안한다.

벼 Small HSP의 발현에 의한 대장균의 고온 stress 하에서의 내성의 증가

이병현,이효신,원성혜,조진기 경북대학교 농업과학기술연구소 1999 慶北大農學誌 Vol.17 No.-

This study was conducted to detect the allelopathic effect of water and ethanol extracts from 4 plant species (Lactuca sativa L., Ambrosia elatior L., Oenothenra odorata Jasp., Ginkgo biloba L.) on germination and growth of lettuce seeds. A little bit higher inhibitory effect was obtained in ethanol extracts rather than water extracts. Allelopathic effects varied in the source of extracts and concentrations of 4 plant species and the highest allelopathic effect appeared in 10% solution, regardless of plant species.

Agrobacterium을 이용한 내열성 유전자의 벼로의 형질전환 및 발현

이병현,이효신,원성혜,조진기 경북대학교 농업과학기술연구소 1999 慶北大農學誌 Vol.17 No.-

To investigate the function of chloroplast-localized small HSP in rice, the cDNA, Oshsp21, was introduced into rice plants via Agrobacterium-mediated gene transfer system. Calli induced from rice immature embryos were co-cultivated with a A. tumafaciens EHA101 that contained a plasmid, pIHSP21. The efficiency of plant regeneration from the calli co-cultivated with the Agrobacterium was about 30%. PCR and Southern blot analyses using genomic DNA revealed that gene for the chloroplast small HSP was introduced into the genome of rice. Expression of transgene was investigated by northern blot analysis. Results indicate that the transgene, Oshsp21, was constitutively expressed at normal growth temperature.