Production of gluco-oligosaccharides from Weissella confusa CCK931

Jieun Bang,Seo Young Jeong,Seunghyun Bang,Jisun Park,Sungyoon Kim,Young-seo Park 한국산업식품공학회 2019 학술대회 및 심포지엄 Vol.2019 No.10

Parenting experiences among fathers of prematurely-born children with cerebral palsy in South Korea

Park, Jisun,Bang, Kyung-Sook Korean Academy of Child Health Nursing 2021 Child Health Nursing Research Vol.27 No.1

Purpose: The symptoms and impairments caused by cerebral palsy usually require long-term treatment, resulting in a substantial burden on the family of affected children. This study explored the experiences of fathers with prematurely-born children with cerebral palsy, with a focus on how such experiences influenced their families. Methods: A qualitative case study method was used. Nine subjects were recruited from April 2018 to June 2019 at one hospital, and each was interviewed three times by a neonatal nurse. Results: Five core experiences of fathers were identified: "regret for an insufficient initial response", "confronting my child born as a premature baby", "the position of being a dad who can't do anything", "the process of treatment like a tunnel with no exit", and "a father's getting meaning in life through children". These stories covered an individual's timeline and family interactions. Conclusion: Our findings suggest that fathers of prematurely-born children tend to suppress their emotions; therefore, a novel intervention program to encourage fathers' emotional expression and to support healthier interactions with their families is needed. Moreover, our findings could contribute basic information for the construction of a community-based support system to aid families, including prematurely-born children and other persons with impairments.

Euglycemic diabetic ketoacidosis development in a patient with type 2 diabetes receiving a sodium-glucose cotransporter-2 inhibitor and a carbohydrate-restricted diet

고관표,Jisun Bang,Soyeon Yoo,Sang Ah Lee 제주대학교 의과학연구소 2023 The Journal of Medicine and Life Science Vol.20 No.3

Sodium-glucose cotransporter-2 (SGLT2) inhibitors have become increasingly prescribed because of their proven protective effects on the heart and kidneys, and carbohydrate-restricted diets are popular therapeutic approaches for patients with obesity and diabetes. A 28-year-old obese woman with recently diagnosed diabetes developed euglycemic diabetic ketoacidosis (DKA) while on dapagliflozin, an SGLT2 inhibitor, and following a carbohydrate-restricted diet. She presented with nausea, vomiting, and epigastric pain. Hospital tests showed a blood glucose of 172 mg/dL, metabolic acidosis, and increased ketone levels, confirming euglycemic DKA. Treatment involved discontinuing dapagliflozin and administering fluids, glucose, and insulin. She recovered and was discharged on the fourth day. This is considered a case of euglycemic DKA induced by SGLT2 inhibitors and triggered by a carbohydrate-restricted diet. This case highlights the importance of physicians in confirming the symptoms and laboratory results of DKA, even in patients with normal blood glucose levels taking SGLT2 inhibitors and following carbohydrate-restricted diets. It is also crucial to advise patients to maintain an adequate carbohydrate intake.

Comprehensive clinical characterization of patients with BRCA1: c.5017_5019del germline variant

Yoon Ju Bang*,Won Kyung Kwon*,Jong-Won Kim,Jeong Eon Lee,Boo Yeon Jung,Mina Kim,Jisun Kim,Jeongshin An,Seung Pil Jung,Hong-Kyu Kim,Zisun Kim,Hyun Jo Youn,Jai Min Ryu,Sung-Won Kim 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.6

Purpose: We provide evidence for the reclassification of the BRCA1:c.5017_5019del variant by presenting the clinicopathological characteristics, clinical outcomes, and family history of breast or ovarian cancer in 17 patients with this variant. Methods: This study included breast or ovarian cancer patients tested for BRCA1/2 genes between January 2008 and June 2020 at 10 medical centers in Korea. We retrospectively reviewed 17 probands from 15 families who had the BRCA1:c.5017_5019del variant according to the electronic medical records. Results: We present 10 breast cancer patients and 7 ovarian cancer patients from 15 families identified as having BRCA1:c.5017_5019del and a total of 19 cases of breast cancer and 14 cases of ovarian cancer in these families. The ratio of breast-to-ovarian cancer was 1.3:1. Breast cancer patients with this variant showed a rich family history of breast or ovarian cancer, 8 patients (80.0%). The mean age at diagnosis was 45.4 years and 6 patients (60.0%) were categorized into hormone-receptor–negative breast cancer. Also, the ovarian cancer patients with this variant showed strong family histories of breast and/or ovarian cancer in 4 patients (57.1%). Conclusion: We presented clinical evidence for the reclassification of BRCA1:c.5017_5019del as a likely pathogenic variant (LPV). Reclassification as LPV could result in the prophylactic treatment and medical surveillance of probands, family testing recommendations, and appropriate genetic counseling of their families.

Late Onset Nephrogenic Systemic Fibrosis in a Patient with Stage 3 Chronic Kidney Disease: a Case Report

Lim Yu Jeong,Bang Jisun,Ko Youngsun,Seo Hyun-Min,Jung Woon Yong,Yi Joo Hark,Han Sang-Woong,유미연 대한의학회 2020 Journal of Korean medical science Vol.35 No.35

Nephrogenic systemic fibrosis (NSF) is a progressive systemic fibrosing disease that may occur after gadolinium contrast exposure. It can lead to severe complications and even death. NSF is highly prevalent among patients with advanced chronic kidney disease (CKD). In this report, however, we describe the case of a patient with NSF that occurred during early CKD. A 65-year-old man with stage 3a CKD was transferred to our hospital because of lower extremity edema. The medical history revealed that he was exposed to gadolinium 185 days earlier, and the result of his tibial skin biopsy was consistent with NSF. The patient underwent a combined therapy with ultraviolet-A1 phototherapy and methotrexate and steroid therapy for 6 months. The combined therapy stopped the systemic progression of NSF.

유치 치수치료가 치아 탈락에 미치는 영향에 관한 후향적 연구

방세정,한미란,김종빈,이준행,김종수,신지선,Sejung Bang,Miran Han,Jongbin Kim,Junhaeng Lee,Jongsoo Kim,Jisun Shin 대한소아치과학회 2023 大韓小兒齒科學會誌 Vol.50 No.1

The aim of this study was to retrospectively analyze the effects of pulp treatment on exfoliation of primary teeth and its related factors. In this study, 167 teeth of 97 patients aged 6 months to 12 years who were treated with pulp treatment at Dankook Dental Hospital were selected, and information related to pulp treatment and tooth loss was collected. The included subjects were 72 primary anterior teeth (43.1%) and 95 primary posterior teeth (56.9%), of which 56 were males (57.7%) and 41 females (42.3%). The mean follow-up period was 106.1 ± 38.7 months, and the mean age at pulp treatment was 34.8 ± 15.4 months for primary anterior teeth and 69.1 ± 25.1 months for primary posterior teeth. Unilaterally pulpectomized teeth were significantly exfoliated earlier than the same tooth on the opposite side (p < 0.05). Also, in the case of teeth with periapical lesions, despite pulp treatment, the probability of extraction due to infection has been increased on primary anterior teeth (p < 0.05), but not on posterior teeth (p > 0.05). Pulpectomized teeth were lost earlier, an average of 7.8 months for primary anterior teeth and 8.5 months for primary posterior teeth. Early loss of the primary tooth can lead to space loss and premature eruption of the successor, so this can be considered when planning or performing treatment of the primary tooth.

Comprehensive profiling of DNA methylation in Korean patients with colorectal cancer

( Hyeran Shim ),( Kiwon Jang ),( Yeong Hak Bang ),( Hoang Bao Khanh Chu ),( Jisun Kang ),( Jin-young Lee ),( Sheehyun Cho ),( Hong Seok Lee ),( Jongbum Jeon ),( Taeyeon Hwang ),( Soobok Joe ),( Jinyeo 생화학분자생물학회 2024 BMB Reports Vol.57 No.2

Alterations in DNA methylation play an important pathophysiological role in the development and progression of colorectal cancer. We comprehensively profiled DNA methylation alterations in 165 Korean patients with colorectal cancer (CRC), and conducted an in-depth investigation of cancer-specific methylation patterns. Our analysis of the tumor samples revealed a significant presence of hypomethylated probes, primarily within the gene body regions; few hypermethylated sites were observed, which were mostly enriched in promoter-like and CpG island regions. The CpG Island Methylator Phenotype- High (CIMP-H) exhibited notable enrichment of microsatellite instability-high (MSI-H). Additionally, our findings indicated a significant correlation between methylation of the MLH1 gene and MSI-H status. Furthermore, we found that the CIMP-H had a higher tendency to affect the right-side of the colon tissues and was slightly more prevalent among older patients. Through our methylome profile analysis, we successfully verified the methylation patterns and clinical characteristics of Korean patients with CRC. This valuable dataset lays a strong foundation for exploring novel molecular insights and potential therapeutic targets for the treatment of CRC.

Poster Session:PS 0217 ; Gastroenterology : The Infl uence of Agent Orange to the Synchronous or Metachronous Gastric Cancer in Patients Treated by Endoscopic Submucosal Dissection

( Seo Young Yang ),( Sung Hoon Kim ),( Woong Sun Yoo ),( Do Young Kim ),( Won Hyeong Park ),( Tae Gyun Kim ),( Jisun Jang ),( Jei So Bang ),( Soo Hyun Yang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Endoscopic submucosal dissection (ESD) is one of the therapeutic modalities for early gastric cancer. After the ESD, synchronous or metachronous lesions occur in some cases. Agent Orange (AO) is an herbicide used in the Vietnam War to defoliate forest areas. Many Korean veterans who participated in the war were exposed to it. But the infl uence of the material to stomach cancer remained uncertain. So, we investigate the infl uence of AO to the synchronous or metachronous gastric cancer in patients treated by ESD. Methods: From January 2008 to December 2012, 87 male early gastric cancer patients, including 38 AO exposure veterans, treated by ESD and followed up more than 12 months were enrolled, retrospectively. All patients were checked by gastrofi berscope and CT scan regularly for recurrence. Synchronous and metachronous lesion were defi ned as a new lesion found within 1 year and a new lesion found after 1 year of primary ESD treatment. We analyzed the relationship between the synchronous and metachronous lesion occurrence and the clinical characteristics including AO exposure. Results: The median age was 70 (52-85) and the medial follow-up duration was 25 months (12-63). Overall, synchronous lesion incidence rate was 4.6% (4 cases) and metachronous lesion incidence rate was 11.5% (10 cases). In analysis, the metachronous lesion incidence rate was higher in old age group (=65), statistically (0% vs. 14.5%, p <0.05). Otherwise, there was no relationship between the synchronous or metachronous gastric cancer occurrence and other clinical characteristics such as AO exposure, the tumor size, location, histologic and tumor type. Conclusions: Old age is suggested as a risk factor of the metachronous early gastric cancer. It is suggested that there was no infl uence of AO exposure to the synchronous and metachronous gastric cancer.

Poster Session : PS 0994 ; Safety and Outcome of De Nove Two Third PTFE Covered Nitinol Stent for Palliation of Biliary Obstruction Secondary to Peripancreatic Cancer

( Woong Sun Yoo ),( Won Hyeong Park ),( Seo Young Yang ),( Do Young Kim ),( Soo Hyun Yang ),( Sung Hoon Kim ),( Jei So Bang ),( Jisun Jang ),( Tae Gyun Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: One of the previous drawback of full covered metal stents on the peripancreatic cancer is the risk of failure of biliary drainge from cystic duct. Therefore, cholecystitis occurs frequently by complication. We devise some special self expanded metal stent (SEMSs) which were combining the advantages of previous covered stent. Methods: We enrolled fi ve patients (mean age 69.2 years) who underwent endoscopic retrograde biliary drainage with newly designed two third polytetrafl uoroethylene (PTFE) partially covered SEMs for palliation of biliary obstruction secondary to unresectable peripancreatic cancer at our institutions from August 2013 to February 2014. The de nove partially covered SEMs (Taewoong Corporation, Seoul, Korea) is made with stent consists of an inner polyurethane layer to prevent tumor ingrowth and an outer uncovered nitinol wire tube to allow the mesh of the stent to embed itself in the biliary duct wall. Differently then traditional covered stent, One-third of stent is not covered. Follow-up data focused on clinical remissions and complication especially cholecystitis. Additory complications included stent migration, bleeding, perforation and 30-day mortality. Results: In total, 5 stents were placed successfully in 5 of 5 patients. All patients (5/5) did not need to repeat procedures. One hundred percent of the patients experienced adequate palliative drainage for the remainder of their lives. No patients experienced delayed stent migration with stone formation. The 30-day mortality rate was 0% Conclusions: The de nove two third PTFE-covered nitinol stent seems to be safe to use with acceptable complication rates. The PTFE-covered lay is located on the halfway and only covered two third. The rest uncovered one third of stent play an important role in biliary drainage. But there is a need for further large studies to determine the patency.