Cerebral infarct volume measurements to improve patient selection for endovascular treatment

Han, Miran,Choi, Jin Wook,Rim, Nae-Jung,Kim, Sun Yong,Suh, Hong-Il,Lee, Kyu Sun,Hong, Ji Man,Lee, Jin Soo Williams & Wilkins Co 2016 Medicine Vol.95 No.35

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Patients who have large cerebral infarctions may not be good candidates for endovascular treatment. Various methods for determining infarct volume have been used in clinical studies. We evaluated the effectiveness of several methods for measuring infarct volume, especially regarding futile outcomes despite endovascular treatment.</P><P>Patients with acute ischemic stroke in unilateral anterior circulation territory who were treated with intra-arterial thrombectomy were included. For assessing infarct volume, the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) scoring system was applied to images obtained by noncontrast computed tomography (NCCT), postcontrast CT (PCCT), and diffusion-weighted imaging (DWI). DWI stroke volume was semiquantitatively measured with the manually outlined hyperintense lesion. Infarct core volume was calculated with a threshold apparent diffusion coefficient value of 600 × 10<SUP>–6</SUP> mm<SUP>2</SUP>/s. Intraclass correlation coefficients (ICC) were estimated to assess inter-reader reliability for ASPECTS scoring and DWI stroke volume. Receiver operating characteristic (ROC) curve analyses, and univariable and multivariable comparative analyses, were performed with each evaluation method to predict futile outcome (modified Rankin Scale score 5–6).</P><P>The mean age of the included 79 patients was 65.1 ± 15.7 years. Among them, 55 (69.6%) patients demonstrated successful reperfusion after intra-arterial thrombectomy, but 34 (43.0%) patients had futile outcomes. Inter-reader agreement was excellent for measurement of the DWI stroke volume (ICC, 0.973), DWI ASPECTS (0.940), and PCCT ASPECTS (0.859), but was moderate for NCCT ASPECTS (0.694). Regarding prediction of futile outcomes, area under ROC curve was 0.551 on NCCT ASPECTS and it was significantly smaller than that in PCCT ASPECTS (area under ROC 0.651, <I>P</I> = 0.030), DWI ASPECTS (0.733, <I>P</I> = 0.003), DWI stroke volume (0.702, <I>P</I> = 0.022), and infarct core volume (0.702, <I>P</I> = 0.021). Besides old age and high National Institutes of Health Stroke Scale score on admission, MRI parameters such as DWI ASPECTS and infarct core volume indicating large volumes were independently associated with futile outcomes in multivariable analyses.</P><P>DWI ASPECTS can be a good parameter predicting futility, which is easily measured and has high prediction power.</P></▼2>

Averaged head phantoms from magnetic resonance images of Korean children and young adults

Han, Miran,Lee, Ae-Kyoung,Choi, Hyung-Do,Jung, Yong Wook,Park, Jin Seo IOP 2018 Physics in medicine & biology Vol.63 No.3

<P>Increased use of mobile phones raises concerns about the health risks of electromagnetic radiation. Phantom heads are routinely used for radiofrequency dosimetry simulations, and the purpose of this study was to construct averaged phantom heads for children and young adults. Using magnetic resonance images (MRI), sectioned cadaver images, and a hybrid approach, we initially built template phantoms representing 6-, 9-, 12-, 15-year-old children and young adults. Our subsequent approach revised the template phantoms using 29 averaged items that were identified by averaging the MRI data from 500 children and young adults. In females, the brain size and cranium thickness peaked in the early teens and then decreased. This is contrary to what was observed in males, where brain size and cranium thicknesses either plateaued or grew continuously. The overall shape of brains was spherical in children and became ellipsoidal by adulthood. In this study, we devised a method to build averaged phantom heads by constructing surface and voxel models. The surface model could be used for phantom manipulation, whereas the voxel model could be used for compliance test of specific absorption rate (SAR) for users of mobile phones or other electronic devices.</P>

근로 장애인의 스트레스와 직무적성이 직무만족도에 미치는 영향: 장애정도의 조절효과

한미란(Han, Miran),최인화(Choi, Inhwa) 한국생활과학회 2021 한국생활과학회지 Vol.30 No.6

This study examines the effects of perceived stress and job aptitude on job satisfaction among employees with disabilities. Additionally, the moderating effect of the degree of disability is determined. Hierarchical multiple regression analyses was performed on data consisting of 619 employees with disabilities who had a college degree or higher. The data was compiled from “The 4th Panel Survey of Employment for the Disabled (PSED) (2019)” by the Korea Employment Agency for Persons with Disabilities. The results of this study were as follows. First, age, cohabitation, employment status, daily stress, educational major-job match, and job aptitude were shown to significantly affect job satisfaction. Second, the degree of disability has a significant moderating effect on both the daily stress and job aptitude with job satisfaction. This study highlights the approaches through which job satisfaction of employees with disabilities can be improved.

Anti-melanogenic effect of Water Soluble Royal Jelly on Melanin Biosynthesis

Sangmi Han,Jungmin Kim,Miran Jo,Myeonglyeol Lee,Manyoung Lee,Inpyo Hong,Soonok Woo,Hasik Sim,Yongsoo Choi 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Royal jelly (RJ) is one of the most attractive functional foods that have been a commercial product, especially in dietetics and cosmetics in many countries. However, RJ has been evoked with dermatitis, acute asthma and anaphylaxis because of major RJ proteins. Therefore, to access water soluble royal jelly (WSRJ) that removed allergy-induced proteins as an effective whitening agent for cosmetics and potential external treatment for topical use, we investigated its ability to inhibit melanin biosynthesis. B16F1 cells were treated with 10 nM α-melanocyte-stimulating hormone (α -MSH) for 48hr, and then were treated with various doses of WSRJ for 36hr. WSRJ (1-10ug/ml) inhibited direct tyrosinase activity and cellular tyrosinase activity, which lead to the decrease of melanin synthesis in α-MSH stimulated B16F1 melanoma cells. In addition, we examined RT-PCR and Western blotting for melanogenesis-related genes such as tyrosinase, tyrosinase related protein 1 (TRP-1) and 2. WSRJ suppressed mRNA and protein expression of tyrosinase, tyrosinase related protein (TRP)-1 and TRP-2 in α-MSH stimulated B16F1 cells, and similar to positive control, arbutin. Our findings suggest that WSRJ induced the downregulation of melanogenesis by inhibiting tyrosinase, TRP-1 and 2 activations. It may serve as a new candidate in the new skin-whitening agents.

Widget 인터페이스 영향요인 분석

한미란(Miran Han),이성주(Sungjoo Lee),박범(Peom Park) 한국산업정보학회 2010 한국산업정보학회논문지 Vol.15 No.2

Widget은 Web 2.0 및 모바일 컨버젼스 패러다임을 주도하는 차세대 지능형 플랫폼으로 평가 받고 있다. 향후 이러한 widget의 발전을 예상할 때, 현재 사용자들의 인식에 대한 분석은 앞으로 widget의 방향성을 결정하는데 무엇보다 필요할 것이다. 따라서 본 연구의 목적은 widget의 사용에 영향을 주는 인터페이스 요인을 규명하여 인터페이스 요인에 따른 widget의 사용의도를 설명함으로써 widget 활성화를 위한 전략적 방안을 모색하는 것이다. 분석 결과 일관성, 직관성, 최소한의 조작, 개인화가 인지된 용이성에 정의 영향을 주며, 개인화와 시각적 매력은 인지된 즐거움에 영향을 줌을 확인하였다. 또한 인지된 용이성은 인지된 즐거움에 영향을 주며, 인지된 즐거움은 사용의도에 직접적인 영향을 주었다. 그러나 인지된 용이성이 사용의도에 직접적인 영향을 준다는 가설은 기각되었다. A Widget platform is acknowledged to be a next generation intelligent platform that is well suited to Web 2.0 and mobile convergence environments. With prospects of growth, examining users’ perceptions of current widgets can be a valuable source of information in setting directions for Widget’s future development. This study identifies user interface factors that affect widget usability and investigates a strategic approach to promoting the use of widgets by analyzing user’s “intention to use” in connection with the identified interface factors. The experimental results show the consistency, intuition, minimal action, and personalization have a positive(+) effect on perceived ease of use and that personalization and design have a causal effect on perceived enjoyment. Inaddition, perceived ease of use has an influence on perceived enjoyment that, inturn, has a direct influence on intention to use. On the other hand, the hypothesis that perceived ease of use has a direct effect on intention to use was rejected.

근로 장애인의 스트레스와 직무적성이 직무만족도에 미치는 영향: 장애정도의 조절효과

한미란(Han, Miran),최인화(Choi, Inhwa) 한국생활과학회 2021 한국생활과학회 학술대회 Vol.2021 No.5

마우스 트래킹 기반 작업흐름도를 이용한 웹 Widget 인터페이스 사용성 평가

한미란(Miran Han),박범(Peom Park) 대한인간공학회 2010 大韓人間工學會誌 Vol.29 No.5

The use of web widgets on desktop and mobile devices has been increasing rapidly. Web widgets provide access to activities and information from various sources across the web. As the number of supported widgets increases, managing widgets and finding relevant or interesting widgets becomes more complex. In addition, interacting with widgets in web service systems can be difficult, especially for novice users. Up to this point, there has been little research on web widget usability. This paper performs an experimental study regarding user interfaces of web widgets based on the mouse tracking and work-flow analysis. In the experiment, four sites providing widget services are chosen - iGoogle, Netvibes, My yahoo, and Wizard. The experiment participants perform three assigned tasks in the chosen sites, and their mouse operations are recorded using Camtasia, a screen casting software. Mouse tracking analysis is performed based on the recorded data in order to analyze common user behaviors. In addition, work-flow diagrams representing the operational flows to carry out the given tasks in each web site are constructed so as to visually and systematically analyze detailed usage patterns. The experimental study results presented in this paper can contribute to developing guidelines for highly usable and accessible interface design of web widgets.

Stability of Purified Bee Venom on the Treatment Temperature

Sangmi Han,Miran Cho,JoungMin Kim,Myeonglyeol Lee,Manyoung Lee,Inpyo Hong,Soonok Woo,Hasik Sim,Yongsu Choi 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

For the investigation of the stability of purified bee venom(PBV) during the treatment in the temperature range of 50℃ to 120℃ for 24 hours, respectively, melittin contents, antibacterial effects, and cell regenerations were investigated. The changes in the melittin contents of PBV were not significantly different by treatment temperature below 70℃ for 24 houes and 80℃ for 4 hours. However the melttin contents is great decline after 24 hours above 80℃ for 24 hours. Antibacterial effects is not change below 80℃ for 4 houes but significantly decrease above 80℃ for 24 hours. Cell regenerations of PBV on human dermal fibroblast decreased at 80℃ for 24 houes, showing a significant difference from the below 80℃ for 4 houes. Through the temperature stability of PBV results of this study, it was treated that the melittin contents, antibacterial effects and cell regeneration effects of PBV could be maintained above 80℃ for 4 hours.

Water soluble royal jelly enhances migration and proliferation of human dermal fibroblasts in vitro wound healing model

Sangmi Han,JungMin Kim,Miran Cho,Myeonglyeol Lee,Manyoung Lee,Inpyo Hong,Soonok Woo,Hasik Sim,Yongsu Choi,Younhee Jo 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Royal jelly (RJ) is exclusive food that is secreted from the hypopharyngeal and mandibular glands of worker honeybees, and it is well known to be a necessary for the growth of the queen honeybee Although fresh royal jelly have been demonstrated to enhance wound healing, the wound healing effects of water soluble royal jelly (WSRJ) have not been elucidated. We investigated whether WSRJ promotes the migration, attachment, and proliferation of human dermal fibroblasts (HDFs) during in vitro wound healing. HDFs were treated with 1-5ug/ml WSRJ and RJ for up to 24hr following wound formation. Cell migration was assessed by measuring recovery from wound margin, while cell attachment and proliferation were determined by MTT assay. By observing the numbers of cell attached, we confirmed that not only WSRJ but also RJ did not affect on the initial cell adhesion. WSRJ (5 ug/ml) enhanced cell migration rate approximately 84.3% in HDFs at 24hr, whereas RJ (5 ug/ml) increased cell migration rate 71.3% in HDFs at 24hr, which is similar to cell migration rate of WSRJ 1 ug/ml (73.7%). In cell proliferation assays, WSRJ induced an increase in the number of HDFs, compared with control and RJ. In conclusion, WSRJ promotes cell migration with increased cell proliferation in an in vitro wound healing model.

Taste Characteristics of Water Filtered by Various Filter System Using Electronic Taste Analyzer

Min Seo Han,Miran Kim,Sang Sook Kim,JeongAe Heo,Han Sub Kwak 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10