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      • KCI등재후보

        유방암 줄기세포 개념 및 제한점

        김종빈,안정신,임우성,문병인,Kim, Jong Bin,An, Jeong Shin,Lim, Woosung,Moon, Byung-In 제주대학교 의과학연구소 2018 The Journal of Medicine and Life Science Vol.15 No.2

        Cancer, a leading mortality disease following cardiovascular disease worldwide, has high incidence as one out of every four adults in Korea. It was known to be caused by several reasons including somatic mutation, activation of oncogene and chromosome aneuploidy. Cancer cells show a faster growth rate and have metastatic and heterogeneous cell populations compared to normal cells. Cancer stem cells, the most invested field in cancer biology, is a theory to explain heterogeneous cell populations of cancer cells among several characteristics of cancer cells, which is providing the theoretical background for incidence of cancer and treatment failure by drug resistance. Cancer stem cells initially explain heterogeneous cell populations of cancer cells based on the same markers of normal stem cells in cancer, in which only cancer stem cells showed heterogeneity of cancer cells and tumor initiating ability of leukemia. Based on these results, cancer stem cells were reported in various solid cancers such as breast cancer, liver cancer, and lung cancer. Breast cancer stem cells were first reported in solid cancer which had tumor initiating ability and further identified as anti-cancer drug resistance. There were several identification methods in breast cancer stem cells such as specific surface markers and culture methods. The discovery of cancer stem cells not only explains heterogeneity of cancer cells, but it also provides theoretical background for targeting cancer stem cells to complete elimination of cancer cells. Many institutes have been developing new anticancer drugs targeting cancer stem cells, but there have not been noticeable results yet. Many researchers also reported a necessity for improvement of current concepts and methods of research on cancer stem cells. Herein, we discuss the limitations and the perspectives of breast cancer stem cells based on the current concept and history.

      • 2002~2016년도 제주도 소아의 성홍열 발생의 시계열분석

        신인혜,배종면,Shin, In-Hye,Bae, Jong-Myon 제주대학교 의과학연구소 2019 The Journal of Medicine and Life Science Vol.16 No.3

        The Korea Centers for Diseases Control and Prevention interpreted that recent outbreaks of scarlet fever in Korea since 2011 was resulted from the expansion of scarlet fever notification criteria. To suggest a relevant hypothesis regarding this emerging outbreak, a time series analysis(TSA) of scarlet fever incidence between 2002 and 2016 was conducted. The raw data was the nationwide insurance claims database administered by the Korean National Health Insurance Service. The inclusion criteria were children aged ≤14 years residing in Jeju Province, Korea who received any form of healthcare for scarlet fever from 2002 to 2016. The season was defined as winter (December, January, February; Q1), spring (March, April, May; Q2), summer (June, July, August; Q3), and autumn (September, October, November; Q4). There were seasonal variations with showing peak season on Q1 and Q3. And three phases as 2002 Q2~2005 Q2, 2005 Q2~2009 Q4, and 2010 Q1~2016 Q4 were found between 2002 and 2016. The results from TSA suggested that the recent outbreak of scarlet fever among children in Jeju Province might be a phenomenon from 'unknown birth-related environmental factors' changed after 2010.

      • KCI등재후보

        20년간 제주에서 부검 사례를 통한 아동학대에 대한 고찰

        김수완,강현욱,김혁 제주대학교 의과학연구소 2022 The Journal of Medicine and Life Science Vol.19 No.2

        Child abuse is defined as any type of maltreatment and neglect by an adult, which is violent or threatening for a child, including physical violence directed to the child. Children could be abused not only by a parent or caregiver, but also by other adults on whom they are dependent, such as day nursery workers, teachers, and sports coaches. While doctors are the most responsible people for reporting any type of child abuse, their care and awareness seem to be very poor and weak. We reviewed 30 autopsy cases of child abuse, in particular during the past 20 years in Jeju Island. We expect that doctors will report any child abuse more actively after reading this review article.

      • 균일한 두피 방사선 치료를 위한 bolus 적용 방법: Sutured bolus

        서명호,이솔민,김귀언,최진현,박소현,김영석,Seo, Myung Ho,Lee, Sol Min,Kim, Gwi Eon,Choi, Jinhyun,Park, So Hyun,Kim, Young Suk 제주대학교 의과학연구소 2019 The Journal of Medicine and Life Science Vol.16 No.1

        Total scalp irradiation is a challenging treatment because of unique concave target volume and difficulty with bolus applying. There are few reports about bolus applying methods to the entire scalp in detail. Application of conventional bolus (wax or superflab) is widely used, and it is considered effective. However, the curvature and irregularity of the scalp can produce significant air gap, resulting in inadequate radiation dose distribution. We describe a new method to applying the bolus to the entire scalp. We sutured 1 cm thickness superflab bolus on the thermoplastic mask using cotton string. This method can reduce the air gap between the bolus and scalp and be reproducible.

      • KCI등재후보

        연령표준화 발생률을 이용한 지역별 연도별 감염병 발생 수준 비교: 2011~2016년 제주도 쯔쯔가무시 발생 신고자료

        김진희,김은희,배종면,Kim, Jinhee,Kim, Eun Hee,Bae, Jong-Myon 제주대학교 의과학연구소 2018 The Journal of Medicine and Life Science Vol.15 No.2

        The aim was to evaluate different results from using crude incidence rate (CIR) instead of agestandardized incidence rate (AIR) when comparing groups having different age structures. After selecting a report using CIRs, AIRs and their 95% confidence intervals(CI) was calculated from the raw data. The statistically significant difference between CIR and AIR was decided based on AIR's 95% CI. Comparing with CIRs, AIRs were under-estimated. In addition, there were no statistical significance of annual trends(P=0.59). These findings are an additional evidence using AIR when comparing level of occurring infectious diseases on groups with different age structures.

      • KCI등재후보

        대장암 동물 모델에 대한 이해

        임도영,Lim, Do Young 제주대학교 의과학연구소 2018 The Journal of Medicine and Life Science Vol.15 No.2

        Colorectal cancer (CRC) is a third leading cause of cancer-related death in cancer patients. Sporadic and inflammation-related colon carcinogenesis are major mechanism of colorectal cancer. In vivo CRC models have been developed and implicated to understand their mechanisms upon a different type of CRC. Moreover, recently animal models have played important roles in chemopreventive and preclinical trials over the years. In this mini-review, the aim is to introduce various animal models of CRC and help the understanding to establish in vivo experimental plans according to the cancer type of CRC.

      • KCI등재후보

        1개 분식점에서 발생한 살모넬라 식중독 집단 발생 역학조사

        조은숙,이승혁,배종면,Cho, Eun-Suk,Lee, Seung Hyuk,Bae, Jong-Myon 제주대학교 의과학연구소 2021 The Journal of Medicine and Life Science Vol.18 No.2

        Many people reported suspected food poisoning after consuming food at the same snack bar on June 18, 2020. Thus, an in-depth epidemiological investigation was conducted to identify the infectious agent and establish additional food poisoning prevention measures. The study included people who reported to the local public health center after June 18 with acute gastroenteritis symptoms within 4 days of consuming food from the snack bar. The onset of symptoms and food items consumed by individuals were then investigated via phone calls and on-site visits. Afterward, the infectious agent was identified from human samples (stool or rectal swab) of four restaurant employees and 89 people and from environmental samples (materials, cooking utensils, and water). The analysis revealed that the incubation period ranged from 2 hours to 92 hours, with a median and mode of 16 hours and 12 hours, respectively. Moreover, the epidemic curve had a unimodal shape because of common exposure, which reached its peak on June 18. After monitoring for 8 days, which is more than twice the maximum incubation period of 92 hours, the end of the epidemic was declared on June 28 as no additional cases were reported. Analysis of human and environmental samples revealed Salmonella bareilly of the pulsed-field gel electrophoresis pulsotype SAPX01.017 as the causative agent. Therefore, it was concluded that the food poisoning outbreak was caused by S. bareilly.

      • 뇌병증 또는 근염으로 발현된 소아 인플루엔자 감염 2례

        이은영,강영준,Lee, EunYoung,Kang, Youngjoon 제주대학교 의과학연구소 2020 The Journal of Medicine and Life Science Vol.17 No.3

        Influenza is a common disease that causes epidemics yearly due to the influenza virus. If patients with influenza present with rare symptoms, the diagnosis may be delayed and the condition is difficult to treat. A 5-year-old boy presented to the emergency room with fever and cramps. Brain computed tomography showed low attenuation in the thalamus and brain stem, which was suggestive of encephalopathy caused by influenza virus. Another 5-year-old girl visited the emergency room with mild fever and painful calf edema. She was diagnosed with myositis caused by influenza and treated accordingly.

      • KCI등재후보

        경막외 진통은 비경막외 진통에 비해 초산부의 분만을 지연시키는가?: 후향성 관찰 연구

        장소영,이애령,윤소희,최윤숙,박종국,조우진,Jang, So Young,Lee, Ae Ryoung,Yun, So-hui,Choi, Yun Suk,Park, Jong Cook,Cho, Woo Jin 제주대학교 의과학연구소 2018 The Journal of Medicine and Life Science Vol.15 No.2

        We conduct this study to compare the difference in duration of labor in nulliparous women received epidural analgesia or non-epidural analgesia for labor pain. This retrospective, observational study based on the review of the medical records from February 2014 to July 2017. Epidural analgesia was initiated with a 10 mL epidural bolus of 1% lidocaine and was maintained with a 0.1% mixture of ropivacaine with fentanyl. Non-epidural analgesia was initiated with pethidine 12.5 mg bolus, followed by additional boluses as needed. The primary outcome was the duration of the labor. 149 healthy nulliparous women at term pregnancies with no evidence of fetal distress were enrolled in this study. 92 women received non-epidural analgesia (Group NE) and 57 women received epidural analgesia (Group E). There were no significant differences between the two groups in maternal demographic characteristics. Using a Kaplan-Meier survival analysis, there was no significant difference in the overall duration of the labor(P=0.233). The duration of the first stage of labor was $187.6{\pm}167.3min$ in Group NE, $248.6{\pm}168.7min$ in Group E (Mean${\pm}$SD, P=0.032). The duration of the second stage of labor was $67.1{\pm}57.8min$ in Group NE, $64.1{\pm}47.5min$ in Group E (Mean${\pm}$SD, P=0.693). Epidural analgesia delayed the first stage of labor in this study. But there were no significant differences between the two groups in the duration of the second stage and the total duration of labor.

      • 응급실에서 자살 시도자의 치료

        노현정,강영준,Roh, Hyeonjeong,Kang, Youngjoon 제주대학교 의과학연구소 2019 The Journal of Medicine and Life Science Vol.16 No.3

        The rate of suicide is the 5th leading cause of death in Korea. Moreover, suicide is the 1st cause of death in from 2nd to 4th decade. In order to treat suicide attempters who have visited the emergency room and to prevent retries, it is necessary to understand the nature of the suicide and to take the right approach. Suicide is more than doubled in women, and retry rates are high among patients with a history of suicide. Suicidal means are throat, fall, gas poisoning, poisoning and drowning. All suicide attempters should suspect and treat cervical spine injury and airway management, and rapid hyperbaric oxygen therapy is recommended for carbon monoxide addicts. Interviewing a suicide attempter requires a sympathetic attitude and examines the underlying depression or adaptation disorders. Interdisciplinary care with mental health departments is necessary, and interventions in emergency roombased suicide attempt management work can be helpful to connect with the community.

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