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A Bibliometric Analysis of Acupuncture Treatment of Osteoarthritis over the past 20 Years: 2003−2022
Jisu Lee,Chun Hyonjun,Joo Sungjun,Kim Yubin,Jeon Seonghyeon,Yeum Hyewon 대한침구의학회 2023 대한침구의학회지 Vol.40 No.4
This study uses bibliometric methods to analyze publications regarding the use of acupuncture in osteoarthritis over the past 20 years and presents an overview of global research trends. Publications related to acupuncture in osteoarthritis from 2003 to 2022 were retrieved from the Web of Science Core Collection Database. An analysis of the extracted records was conducted according to their publication year, research area, journal title, country, organization, author, and keywords. The VOSviewer program was used to visualize the research trends on acupuncture in osteoarthritis. An analysis of 380 articles indicated a consistent increase in the use of acupuncture for osteoarthritis treatment over the past 20 years. Many articles have been published in research areas such as “integrative complementary medicine” and “general internal medicine.” The most prolific journal was Evidence- Based Complementary and Alternative Medicine. In terms of article publication, the most productive country and research organization were China and the Beijing University of Chinese Medicine, respectively. The most frequently occurring keywords were “acupuncture,” “knee osteoarthritis,” and “pain.” This study used a bibliometric analysis to provide an overview of global research trends on acupuncture in osteoarthritis. These findings may suggest the future direction of research on the treatment of acupuncture in osteoarthritis.
Jisu Jeong,Jiye Lee,Juyeon Lim,Soyoung Cho,Soyoung An,Myungeun Lee,Nara Yoon,Miran Seo,So-yeon Lim,Sungha Park 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Increased endothelial permeability, one of the earliest signs of endothelial dysfunction, is associated with the development of cardiovascular diseases such as hypertension and atherosclerosis. Recent studies suggest that the receptor for advanced glycation end products (RAGE) regulates endothelial permeability in inflammation. In the present study, we investigated the regulatory mechanism of RAGE in endothelial hyperpermeability induced by angiotensin II (Ang II), a well-known inflammatory mediator, and the potential therapeutic effect of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands. For in vitro studies, Ang II-treated human umbilical vein endothelial cells (HUVECs) were treated with siRNA specific to either RAGE or sRAGE to disrupt RAGE-mediated signaling. Endothelial permeability was estimated using FITC-labeled dextran 40 and a resistance meter. To evaluate intercellular junction disruption, VE-cadherin expression was examined by western blotting and immunocytochemistry. Ang II increased the expression of the Ang II type 1 receptor (AT1R) and RAGE, and this increase was inhibited by sRAGE. sRAGE prevented Ang II-induced VE-cadherin disruption in HUVECs. For in vivo studies, Ang II-infused, atherosclerosis-prone apolipoprotein E knockout mice were utilized. Endothelial permeability was assessed by Evans blue staining of the aorta. Ang II increased endothelial barrier permeability, and this effect was significantly attenuated by sRAGE. Our data demonstrate that blockade of RAGE signaling using sRAGE attenuates Ang II-induced endothelial barrier permeability in vitro and in vivo and indicate the therapeutic potential of sRAGE in controlling vascular permeability under pathological conditions.
Jisu Lee,Hyunsoo Jang,Gyeong Bok Jung,Jae-Joon Lee,Jung-Heun Ha 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Red meat is an excellent dietary protein source; however, red meat contains relatively higher saturated fatty acids (SFA), which increase the risk for metabolic complications. In this study, a partial replacement of high-fat (SFA) with n-3 enhanced (n3E) beef tallow was provided to db/db mice to understand how n3E beef tallow consumption would affect CVDs and tunicamycin (a N-linked glycosylation blocker)-inducible ER stress and inflammation. Db/db mice were fed either normal diet, HFD, normal or n3B beef tallow for 6 weeks. 1) Consumption of n3E altered lipid metabolism. The n3E consumption attenuated serum lipid levels by decreasing serum TC and non-HDL-C than HFD. Moreover, n3E decreased TG accumulation in the epididymal adipose tissue. 2) n3E consumption remarkably attenuated tunicamycin-inducible hepatic ER stress than HFD. n3E consumption noticeably decreased p-PERK, ATF4, CHOP, BiP and XBP-1 protein expressions. 3) Moreover, n3E attenuated hepatic inflammation by attenuation phosphorylation of JNK and ERK. In conclusion, n-3 enhanced beef tallow consumption remarkably decreased lipid accumulation and tunicamycin-inducible ER stress and phosphorylation of MAPKs.
Reduced Pyronin B as a solution-processable and heating-free n-type dopant for soft electronics
Lee, Eun Kwang,Kim, Yonghee,Back, Jisu,Lee, Eunsung,Oh, Joon Hak The Royal Society of Chemistry 2018 Journal of Materials Chemistry C Vol.6 No.25
<P>Air-stable and heating-free doping processes are highly desirable for realizing advanced flexible electronics on plastic substrates. A synthetic protocol for a high-performance n-type organic dopant using an organic cationic dye, Pyronin B, <I>via</I> a simple chemical reduction method with NaBH4 in various organic non-polar solvents is developed, in which the cationic dye Pyronin B is transformed into its leuco form. The reduced Pyronin B (rPyB, leuco form) spontaneously interacts with carbon nanomaterials, such as graphene and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM), <I>via</I> hydride-mediated electron transfer doping, which is confirmed by electron spin resonance (ESR) analysis. After coating rPyB onto graphene, the non-polar solvents are removed by simple evacuation (∼1 × 10<SUP>−3</SUP> Torr) without an annealing step. The work function of graphene is reduced from 4.52 eV to 3.98 eV after doping. Multiple coatings of rPyB on graphene field-effect transistors (FETs) result in air stability for 90 days under ambient conditions. Selective n-type doping using a polydimethylsiloxane (PDMS) stamp and rPyB has also been performed on a large-area 16 × 16 graphene FET array. Our findings demonstrate a viable methodology for the cost-effective synthesis of an n-type dopant and its application in soft electronics.</P>
Non-permanent tattoo application of internet of things three-dimensional printer for beauty-art
Lee Jisu,Aditya Abhilash,Kim Jihye,Kim Namsoo Peter 대한미용의학회 2021 대한미용의학회지 Vol.5 No.1
Background: The emphasis on non-face-to-face or untact operation services is on the rise due to the ongoing widespread of COVID-19 epidemics, which have caused severe damage worldwide. Untact technology has been applied not only to everyday life but also to the beauty art industry that relies on customer service with contact. Objective: A safe non-permanent tattoo ink is necessary to overcome the stigma of permanent tattoos and tattoo removal procedures. The purpose of this study is to efficiently deliver non-permanent tattoo ink into the skin through sophisticated untact printing techniques and safe silver compound ink, further minimizing the side effects due to unsanitary conditions. Methods: Silver-gelatin compound ink serves as an excellent alternative for conventional permanent tattoos with additives. Pistontype extruder (PTE) system and internet of things (IoT) integrated precision-controlled non-permanent and untact system using silver nanoparticle ink. Results: Complex and sophisticated designs were three-dimensional (3D) printed using a non-permanent tattoo ink containing an optimum concentration of Ag+ under 5 N compression force through a 100 μm radius nozzle and diffused up to 200 μm into the stratum corneum through skin contact. Intradermal diffusion simulation and disappearance of the ink within two weeks of the human skin replacement cycle were successfully demonstrated. Conclusion: The integration of IoT and 3D printers has enabled a hygienic untact tattoo printing technique that has been verified through repeated testing. This study could arouse positive possibilities and interests in the rapidly changing beauty art fields. It provides a new tattoo methodology and further research ideas for the 3D printing applications in tattoo production.
Field free switching of ferrimagnetic GdCo with artificially broken symmetry
Jisu Kim,Seyeop Jeong,Taekhyeon Lee,Suhyeok An,Kab-Jin Kim,Ki-Seung Lee,Chun-Yeol You,Soogil Lee,Byong-Guk Park,Sanghoon Kim 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2
During the last decade, current-induced magnetization switching by spin-orbit torque (SOT) is of great importance to nanoelectronics due to energy-efficient control of spintronic memory and logic devices. However, it has a problem that an external magnetic field is required to switch magnetization of a device when magnetic layers are perpendicularly magnetized. This implies that there should be limitation of scalability and low energy efficiency because of necessity to use the external magnetic field. Therefore, field-free switching of a magnetization should be achieved for realization of the energy efficient and ultra-fast SOT-driven devices. Here, we report field-free SOT switching of ferrimagnetic GdCo thin films with a He ion microscope (HIM) technique. The Pt(5)/Gd36Co64(5)/Ta(3) structure is irradiated by He ions with the dose range from 5 to 50 ions/nm². We find that magnetic properties of the GdCo layer such as coercivity (HC) and magnetization compensation temperature (TM) strongly depend on ion dose of a He irradiation. Based on the idea that ferrimagnetic properties can be controlled using He ion irradiation method, we introduced a lateral gradient of magnetization by the HIM to form a broken mirror symmetry in the device. The mirror symmetry breaking was observed after the local modulation; TM and perpendicular magnetic anisotropy (PMA) properties were locally modulated by He ion irradiation. As the magnetic mirror symmetry is broken, we observed the field-free SOT switching behavior. The Sz component of the spin current generated by the broken mirror symmetry was also observed. We will discuss details about structural change in the ferrimagnetic GdCo by the He ion irradiation.