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Jisu Jeong,Jiye Lee,Juyeon Lim,Soyoung Cho,Soyoung An,Myungeun Lee,Nara Yoon,Miran Seo,So-yeon Lim,Sungha Park 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Increased endothelial permeability, one of the earliest signs of endothelial dysfunction, is associated with the development of cardiovascular diseases such as hypertension and atherosclerosis. Recent studies suggest that the receptor for advanced glycation end products (RAGE) regulates endothelial permeability in inflammation. In the present study, we investigated the regulatory mechanism of RAGE in endothelial hyperpermeability induced by angiotensin II (Ang II), a well-known inflammatory mediator, and the potential therapeutic effect of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands. For in vitro studies, Ang II-treated human umbilical vein endothelial cells (HUVECs) were treated with siRNA specific to either RAGE or sRAGE to disrupt RAGE-mediated signaling. Endothelial permeability was estimated using FITC-labeled dextran 40 and a resistance meter. To evaluate intercellular junction disruption, VE-cadherin expression was examined by western blotting and immunocytochemistry. Ang II increased the expression of the Ang II type 1 receptor (AT1R) and RAGE, and this increase was inhibited by sRAGE. sRAGE prevented Ang II-induced VE-cadherin disruption in HUVECs. For in vivo studies, Ang II-infused, atherosclerosis-prone apolipoprotein E knockout mice were utilized. Endothelial permeability was assessed by Evans blue staining of the aorta. Ang II increased endothelial barrier permeability, and this effect was significantly attenuated by sRAGE. Our data demonstrate that blockade of RAGE signaling using sRAGE attenuates Ang II-induced endothelial barrier permeability in vitro and in vivo and indicate the therapeutic potential of sRAGE in controlling vascular permeability under pathological conditions.
The “Art of Trellis Decoding” Is Fixed-Parameter Tractable
Jisu Jeong,Eun Jung Kim,Sang-il Oum Institute of Electrical and Electronics Engineers 2017 IEEE Transactions on Information Theory Vol. No.
<P>Given n subspaces of a finite-dimensional vector space over a fixed finite field F, we wish to find a linear layout V-1, V-2, ... , V-n of the subspaces such that dim((V-1 + V-2 + ... + V-i) boolean AND (Vi+1 + ... + V-n)) <= k for all i; such a linear layout is said to have width at most k. When restricted to 1-dimensional subspaces, this problem is equivalent to computing the trellis-width (or minimum trellis state-complexity) of a linear code in coding theory and computing the path-width of an F-represented matroid in matroid theory. We present a fixed parameter tractable algorithm to construct a linear layout of width at most k, if it exists, for input subspaces of a finite dimensional vector space over F. As corollaries, we obtain a fixed parameter tractable algorithm to produce a path-decomposition of width at most k for an input. F-represented matroid of path-width at most k, and a fixed-parameter tractable algorithm to find a linear rank-decomposition of width at most k for an input graph of linear rank-width at most k. In both corollaries, no such algorithms were known previously. Our approach is based on dynamic programming combined with the idea developed by Bodlaender and Kloks (1996) for their work on path-width and tree-width of graphs. It was previously known that a fixed-parameter tractable algorithm exists for the decision version of the problem for matroid path-width; a theorem by Geelen, Gerards, and Whittle (2002) implies that for each fixed finite field F, there are finitely many forbidden F-representable minors for the class of matroids of path-width at most k. An algorithm by Hlineny (2006) can detect a minor in an input F-represented matroid of bounded branch-width. However, this indirect approach would not produce an actual path-decomposition. Our algorithm is the first one to construct such a path-decomposition and does not depend on the finiteness of forbidden minors.</P>
Maximum matching width: New characterizations and a fast algorithm for dominating set
Jeong, Jisu,Sæther, Sigve Hortemo,Telle, Jan Arne Elsevier 2018 Discrete applied mathematics Vol.248 No.-
<P><B>Abstract</B></P> <P>A graph of treewidth k has a representation by subtrees of a ternary tree, with subtrees of adjacent vertices sharing a tree node, and any tree node sharing at most k + 1 subtrees. Likewise for branchwidth, but with a shift to the edges of the tree rather than the nodes. In this paper we show that the mm-width of a graph – maximum matching width – combines aspects of both these representations, targeting tree nodes for adjacency and tree edges for the parameter value. The proof of this new characterization of mm-width is based on a definition of canonical minimum vertex covers of bipartite graphs. We show that these behave in a monotone way along branch decompositions over the vertex set of a graph.</P> <P>We use these representations to compare mm-width with treewidth and branchwidth, and also to give another new characterization of mm-width, by subgraphs of chordal graphs. We prove that given a graph G and a branch decomposition of maximum matching width k we can solve the Minimum Dominating Set Problem in time <SUP> O ∗ </SUP> ( <SUP> 8 k </SUP> ) , thereby beating <SUP> O ∗ </SUP> ( <SUP> 3 tw ( G ) </SUP> ) whenever tw ( G ) > <SUB> log 3 </SUB> 8 × k ≈ 1 . 893 k . Note that mmw ( G ) ≤ tw ( G ) + 1 ≤ 3 mmw ( G ) and these inequalities are tight. Given only the graph G and using the best known algorithms to find decompositions, maximum matching width will be better for Minimum Dominating Set whenever tw ( G ) > 1 . 549 × mmw ( G ) .</P>
Jeong, Jisu,Patel, Pitambar,Hwang, Heejun,Chang, Sukbok American Chemical Society 2014 ORGANIC LETTERS Vol.16 No.17
<P>The Rh(III)-catalyzed C-8 selective direct alkylation and alkynylation of quinoline <I>N</I>-oxides has been developed. The reactions proceeded highly efficiently at room temperature over a broad range of substrates with excellent regioselectivity and functional group tolerance. This development demonstrates the synthetic utility of the <I>N</I>-oxide directing group as a stepping stone for remote C–H functionalization of quinolines.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/orlef7/2014/orlef7.2014.16.issue-17/ol502173d/production/images/medium/ol-2014-02173d_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ol502173d'>ACS Electronic Supporting Info</A></P>
Jeong, Jisu,Lee, Donggun,Chang, Sukbok The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.32
<P>Deoxygenation of various types of <I>N</I>-oxides including both heterocyclic and alkyl(aryl)amine derivatives has successfully been developed by the copper-catalyzed oxygen atom transfer using diazo compounds as the oxygen acceptor. The reaction proceeds smoothly over a broad range of substrates with excellent functional group tolerance under mild conditions.</P> <P>Graphic Abstract</P><P>Copper-catalyzed deoxygenation of <I>N</I>-oxides including both heterocyclic and amine derivatives was achieved by the catalytic oxygen atom transfer from <I>N</I>-oxides to <I>in situ</I> generated copper-carbenoid. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5cc01739d'> </P>
Jeong Jisu,박경용,Kim Jiyeon 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.11
Tripeptides containing lysine such as Arg-His-Lys (AHK) and Gly-His-Lys (GHK) are known to modulate biological regeneration. Here, we synthesized and evaluated the biological effects of dimeric peptide derivatives on the proliferation of human follicle dermal papilla cells (HFDPCs) in an in vitro model. Treatment of dimeric peptide derivatives stimulated the proliferation of HFDPCs more when compared to the group treated with AHK. Dimeric peptide derivatives also stimulated the phosphorylation of mitogen-activated protein kinases extracellular signal-regulated kinase (ERK1/2). In particular, peptide No. 20 ArgTrp-Lys (AWK’) was found to promote the phosphorylation of ERK1/2 most strongly. In addition, peptide No. 20 (AWK’) activated mRNA expression of hair regeneration-related genes such as VEGF, FGF-2, and FGF-7. Our results suggest that dimeric peptide derivatives exert a stimulating effect on HFDPC proliferation through activation of ERK1/2 signaling and without significant cytotoxicity. These results provide important data for the development of peptide-based hair-regenerative agents and treatment of alopecia.
Jisu Jeong,오동기,Munju Goh 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-
Polyurethane foam (PUF) is formed by reacting sugar, propolis, and polyisocyanate, and then blowingwith CO2, formed by reacting polyisocyanate with water. An optimum foaming rate of 1440% was foundfor 15 wt.% of sugar and 20 wt.% of propolis, and the synthesis and cell structure of polyurethane wereanalyzed by scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectroscopy. Under the optimized conditions, the apparent density and thermal conductivity of the PUF-containingpropolis were 0.04 – 0.147 g/mL and 0.028 – 0.029 W/(mK), respectively. The bacterial reduction ratewas 92.7% in the PUF containing 20 wt.% propolis. PUF can be broken down by enzymatic reactions inwater using invertase. The degradation reaction of invertase was kinetically analyzed. This study showedthat eco-friendly polymers can be synthesized using sugar and propolis and decomposed throughantibacterial activity and enzymatic green recycling.