http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Jisu Ryu (검색결과 52 건)
- 무료
- 기관 내 무료
- 유료
-
-
Jisu Ryu,Moongee Jeon 아시아영어교육학회 2020 The Journal of Asia TEFL Vol.17 No.3
This study aims to investigate the text difficulty of the reading materials of Korean middle school English textbooks with Coh-Metrix, a software developed by the Institute for Intelligent Systems at the University of Memphis to analyze the linguistic and psycholinguistic features of English text and textbooks with a wide range of indices on cohesion and language. In this study, the textbook corpus consisted of the text files extracted from 13 English textbooks. These files were used for analyzing the text difficulty among grades with Coh-Metrix. The Coh-Metrix indices selected for this study contained basic counts, word frequency, word features, lexical diversity, pronouns, connectives, readability, syntax complexity, syntax similarity, reference cohesion, semantic cohesion, and situation model measures. The results showed that there were significant differences among grades for basic counts, word features, first pronouns, causal and temporal connectives, readability, reference and semantic cohesion, the number of words before main verbs, syntactic similarity, and situation model measures. The differences among grades, however, were not significant for word frequency, lexical diversity, second and third person pronouns, additive connectives, and NP density measures. The findings have educational implications for textbook design and language learning for English learners.
-
-
-
Excitatory neuron–specific SHP2-ERK signaling network regulates synaptic plasticity and memory
Ryu, Hyun-Hee,Kim, TaeHyun,Kim, Jung-Woong,Kang, Minkyung,Park, Pojeong,Kim, Yong Gyu,Kim, Hyopil,Ha, Jiyeon,Choi, Ja Eun,Lee, Jisu,Lim, Chae-Seok,Kim, Chul-Hong,Kim, Sang Jeong,Silva, Alcino J.,Kaang AAAS 2019 Science signaling Vol.12 No.571
<P><B>Cell type–specific RASopathy</B></P><P>The neurodevelopmental disorder Noonan syndrome is often caused by activating mutations in the phosphatase SHP2 that enhance RAS signaling. However, SHP2 is present in multiple neuron types as well as glia; thus, where the mutant protein has its pathological effects is unclear. Ryu <I>et al.</I> examined one NS-associated SHP2 mutation in isolated cell types from mice and determined that its presence in only excitatory neurons resulted in electrophysiological and cognitive effects. This was because certain adaptor proteins that interact with SHP2 to mediate RAS signaling are abundant in excitatory but not inhibitory neurons. These findings reveal that cell type–specific variations within the RAS signaling network underlie the phenotypes of NS and possibly other “RASopathies”.</P><P>Mutations in RAS signaling pathway components cause diverse neurodevelopmental disorders, collectively called RASopathies. Previous studies have suggested that dysregulation in RAS–extracellular signal–regulated kinase (ERK) activation is restricted to distinct cell types in different RASopathies. Some cases of Noonan syndrome (NS) are associated with gain-of-function mutations in the phosphatase SHP2 (encoded by <I>PTPN11</I>); however, SHP2 is abundant in multiple cell types, so it is unclear which cell type(s) contribute to NS phenotypes. Here, we found that expressing the NS-associated mutant SHP2<SUP>D61G</SUP> in excitatory, but not inhibitory, hippocampal neurons increased ERK signaling and impaired both long-term potentiation (LTP) and spatial memory in mice, although endogenous SHP2 was expressed in both neuronal types. Transcriptomic analyses revealed that the genes encoding SHP2-interacting proteins that are critical for ERK activation, such as GAB1 and GRB2, were enriched in excitatory neurons. Accordingly, expressing a dominant-negative mutant of GAB1, which reduced its interaction with SHP2<SUP>D61G</SUP>, selectively in excitatory neurons, reversed SHP2<SUP>D61G</SUP>-mediated deficits. Moreover, ectopic expression of GAB1 and GRB2 together with SHP2<SUP>D61G</SUP> in inhibitory neurons resulted in ERK activation. These results demonstrate that RAS-ERK signaling networks are notably different between excitatory and inhibitory neurons, accounting for the cell type–specific pathophysiology of NS and perhaps other RASopathies.</P>
-
-
Effects of Task Complexity and Planning on L2 Speaking Performances and Focus on Form
Jisu Ryu,Byungmin Lee 한국응용언어학회 2018 응용 언어학 Vol.34 No.4
Despite the synergistic effects of task complexity and planning on speaking performances and focus on form, as implied in previous studies, past research solely looked at their individual effects. Thus, this study explored effects of task complexity and planning on L2 spoken performances and focus on form. Korean EFL low-intermediate learners (n=40) completed picture description tasks in four different conditions (i.e., simple no planning [SN], complex no planning [CN], simple planning [SP] and complex planning [CP]) with post-task questionnaires. Results showed that task complexity and planning had interaction effects on lexical complexity and accuracy. In addition, positive main effects of task complexity were found on syntactic complexity. Positive main effects of planning were identified on syntactic complexity and fluency. In addition to performance scores, individual learners’ responses to the questionnaires provided further evidence of how they manage attentional resources. Despite the learners’ predisposition to meaning, the successful channelling of attention to form was achieved through increasing task complexity (i.e., from SP to CP). Despite theoretical dichotomy of prior research in the field (i.e., Cognition Hypothesis vs. Trade-off Hypothesis), the current study proposes the potential complementarity of these two frameworks: cognitively demanding tasks coupled with planning time may likely lead to enhanced performances in terms of complexity, accuracy, and fluency of Korean EFL low-intermediate learners. Pedagogical implications are also discussed.
-
Structure and properties of graphene oxide/cellulose hybrid fibers via divalent metal ions treatment
Ryu, Jisu,Lim, Jin Seong,Ahn, Seokhoon,Jo, Seong Mu,Ko, Frank K.,Lee, Joong Hee,Hwang, Jun Yeon Springer-Verlag 2018 Cellulose Vol.25 No.1
<P>Cellulose hybrid fibers (CeHFs), hybridized via graphene oxide (GO) and metal ions (Ca2+), are synthesized by dry-jet wet spinning. The synthesized GO-Ca2+-CeHFs exhibit the tensile strength and the breaking elongation of 551 +/- 37.5 MPa and 5.9 +/- 0.4%, respectively, while the GO/cellulose composite fibers (GO-CeFs) show the tensile strength of 403 +/- 76.0 MPa and the elongation of 4.5 +/- 0.5%; thus, the GO-Ca2+-CeHFs demonstrate improved mechanical properties over GO-CeFs by 37 and 31% in terms of tensile strength and elongation, respectively. These results are attributed to the metal ions that form a good interfacial interaction between the functional groups of cellulose and GO. In addition, the tensile strength of GO-Ba2+-CeHFs is as high as 580 +/- 25 MPa, which is induced by the difference in the ionic radius. Therefore, the high mechanical properties of the synthesized cellulose-based fibers have the potential to be used as sustainable alternative to the synthetic fibers used in the industrial applications.</P>
-
Jisu Ryu,Yong-Moon Lee 한국분석과학회 2021 학술대회논문집 Vol.2021 No.11
Aroma compounds are the commonly detected allergens used in fine perfumes, cosmetics and other household products. When aroma compounds are absorbed through the skin, some compounds may cause allergic contact dermatitis (ACD) as a representative disease caused by skin sensitization, which is part of T-cell-mediated immunotoxicity. Therefore, to evaluate the potential of skin sensitization on aroma compounds is an important process to avoid the skin trouble. An increasing ethical demand to replace animal experiments resulted in the regulatory requirement in Europe to assess the safety of cosmetic ingredients without testing on animals (EU 2009). In this study, skin sensitization to 38 aroma compounds was evaluated by the direct peptide reactivity assay (DPRA) using HPLC/UV, an animal substitution test developed into a test guideline (TG) in 2015 (OECD 442C). The peptides used in DPRA were cysteine(Ac-RFAACAA_COOH) and lysine(Ac-RFAAKAA_COOH) and the loss rate of peptides was evaluated by reacting with the 100 mM test substance for 24 hours and by measuring the reduced peak area at HPLC/UV 220 nm. The independent dataset in the (Q)SAR programs of Toolbox, Derek, and VEGA were combined to determine the skin sensitization potential. The aroma compounds showing obscure criterion either by DPRA or by (Q)SAR programs were determined by a human patch test. Collectively, 16 aroma compounds were finally classified positive in skin sensitization by the DPRA linked (Q)SAR. This evaluation process provided the high score in selectivity, sensitivity and negative predictability. Therefore, this method will be useful to determine the skin sensitization potential in aroma chemicals used in cosmetics. These results were supported by “Regional Innovation Strategy (RIS)” through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE).
-
류지수(Jisu Ryu),전문기(Moongee Jeon) 한국영어어문교육학회 2020 영어어문교육 Vol.26 No.3
This study aims to analyze the linguistic continuity of the listening passages of middle school English textbooks revised by the 2015 National Curriculum with Coh-Metrix, a computer system designed to analyze various psycholinguistic features of text corpora. Specifically, a total of 310 listening scripts were constructed to examine the continuity among three grades for 23 Coh-Metrix measures. The measures selected for this study included basic counts (the number of words, the number of sentences, word length, sentence length), word frequency, word features (imageability, concreteness, age of acquisition), lexical diversity (type-token ratio), personal pronouns, connectives (causal connectives, additive connectives, temporal connectives), readability scores (Flesch Reading Ease score, Flesch-Kincaid Grade Level), syntactic complexity, referential cohesion, and semantic cohesion. The results showed that the continuity was appropriately established for the number of words and sentences, sentence length, additive connectives, words before main verbs, Flesch-Kincaid Grade Level, and word features. It, however, was not reflected for word length, word frequency, lexical diversity, noun phrase density, semantic and reference cohesion, causal and temporal connectives, pronouns, and Flesch Reading Ease score. The findings provide several pedagogical implications for the educational policy of National Curriculum and the development of English language teaching materials.
KCI
DBpia연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
