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      • KCI등재

        Ab initio calculations of electronic structures of SrMoO4 crystals containing F and F+ color centers

        Jigang Yin,Qiren Zhang,Tingyu Liu,Xiaofeng guo,Min Song,Xien Wang,Haiyan Zhang 한국물리학회 2009 Current Applied Physics Vol.9 No.6

        The electronic structures of SrMoO4 crystals containing F and F+ color centers with the lattice structure optimized are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory, using a numerically discrete variational (DV-Xα) method. From the calculation, it is concluded that F and F+ color centers have donor energy level in the forbidden band. The electronic transition energies from the donor level to the bottom of the conduction band are 1.855 eV and 2.161 eV, respectively, which correspond to the 670 nm and 575 nm absorption bands. It is predicted that the 670 nm and 575 nm absorption bands originate from the F and F+ centers in SrMoO4 crystals. The electronic structures of SrMoO4 crystals containing F and F+ color centers with the lattice structure optimized are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory, using a numerically discrete variational (DV-Xα) method. From the calculation, it is concluded that F and F+ color centers have donor energy level in the forbidden band. The electronic transition energies from the donor level to the bottom of the conduction band are 1.855 eV and 2.161 eV, respectively, which correspond to the 670 nm and 575 nm absorption bands. It is predicted that the 670 nm and 575 nm absorption bands originate from the F and F+ centers in SrMoO4 crystals.

      • SCIESCOPUSKCI등재

        Methodology of Mapping Quantitative Trait Loci for Binary Traits in a Half-sib Design Using Maximum Likelihood

        Yin, Zongjun,Zhang, Qin,Zhang, Jigang,Ding, Xiangdong,Wang, Chunkao Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.12

        Maximum likelihood methodology was applied to analyze the efficiency and statistical power of interval mapping by using a threshold model. The factors that affect QTL detection efficiency (e.g. QTL effect, heritability and incidence of categories) were simulated in our study. Daughter design with multiple families was applied, and the size of segregating population is 500. The results showed that the threshold model has a great advantage in parameters estimation and power of QTL mapping, and has nice efficiency and accuracy for discrete traits. In addition, the accuracy and power of QTL mapping depended on the effect of putative quantitative trait loci, the value of heritability and incidence directly. With the increase of QTL effect, heritability and incidence of categories, the accuracy and power of QTL mapping improved correspondingly.

      • KCI등재

        First-principles study on electronic states of SrWO4 crystals containing F-type color centers

        Min Song,Qiren Zhang,Tingyu Liu,Jigang Yin,Xiaofeng Guo,Haiyan Zhang,Xi’en Wang 한국물리학회 2009 Current Applied Physics Vol.9 No.4

        The electronic structures of the SrWO4 crystals containing F-type color centers are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory using a numerically discrete variational (DV-Xα) method. The calculations indicate that either F or F+ center has donor energy level within the forbidden band. The electronic transition energies from the two donor levels to the bottom of the conduction band are 1.82 eV and 2.28 eV corresponding to the 685 nm and 545 nm absorption bands, respectively. It is, therefore, concluded that the 545–685 nm absorption bands are originated from the F and F+ center in SrWO4 crystal respectively. The electronic structures of the SrWO4 crystals containing F-type color centers are studied within the framework of the fully relativistic self-consistent Dirac–Slater theory using a numerically discrete variational (DV-Xα) method. The calculations indicate that either F or F+ center has donor energy level within the forbidden band. The electronic transition energies from the two donor levels to the bottom of the conduction band are 1.82 eV and 2.28 eV corresponding to the 685 nm and 545 nm absorption bands, respectively. It is, therefore, concluded that the 545–685 nm absorption bands are originated from the F and F+ center in SrWO4 crystal respectively.

      • KCI등재

        Preclinical investigation of artesunate as a therapeutic agent for hepatocellular carcinoma via impairment of glucosylceramidase-mediated autophagic degradation

        Chen Wenjia,Ma Zhaochen,Yu Lingxiang,MAO Xia,Ma Nan,Guo Xiaodong,Yin Xiaoli,Jiang Funeng,Wang Qian,Wang Jigang,Fang Mingliang,Lin Na,Zhang Yanqiong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC). Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART regulates autophagic flux by targeting GBA in HCC remains to be defined. Herein, our data demonstrated that the dramatic overexpression of GBA was significantly associated with aggressive progression and short overall survival times in HCC. Subsequent experiments revealed an association between autophagic activity and GBA expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC and an orthotopic mouse model, and human HCC cell lines. Interestingly, probe labeling identified GBA as an ART target, which was further verified by both a glutathione-S-transferase pulldown assay and surface plasmon resonance analysis. The elevated protein expression of LC3B, the increased numbers of GFP-LC3B puncta and double-membrane vacuoles, and the enhanced expression of SQSTM1/p62 indicated that the degradation of autophagosomes in HCC cells was inhibited by ART treatment. Both the in vitro and in vivo data revealed that autophagosome accumulation through targeting of GBA was responsible for the anti-HCC effects of ART. In summary, this preclinical study identified GBA as one of the direct targets of ART, which may have promising potential to inhibit lysosomal autophagy for HCC therapy.

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