N-functionalized hierarchical carbon composite derived from ZIF-67 and carbon foam for efficient overall water splitting

Jichao Wang,Jichao Wang,Cheng Chen,Philippe M. Heynderickx,Soumyajit Roy,Francis Verpoort 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

An efficient and facile approach to synthesize a bi-functional electrocatalyst via combining carbon foamwith cobalt-centered zeolitic imidazolate framework (ZIF-67) is reported. The carbon foam was synthesizedvia dehydration of sugar utilizing zinc nitrate, forming Co3ZnC in the carbon matrix. To obtain Cohybridized and Co particles covered with carbon nanotubes embedded in a carbon matrix (Co-Zn-CNTs), physical mixing of both defines the critical point after pyrolysis. Higher content of N-related speciesand transition metal species in polyvalent states and well-grown multi-wall carbon nanotubes forcharge transfer are achieved after the pyrolysis process. The obtained Co-Zn-CNTs catalyst was employedas cathode and anode for overall water splitting (HER and OER) and showed excellent performances. Thisdevelopment offers a low-cost and straightforward strategy to synthesize catalyst material for large-scalefuel cells and water splitting technologies. This development affords a precise method for effectivelyimproving the electrocatalyst performance derived from the ZIF-67 precursor.

Investigation of Hetero - Material - Gate in CNTFETs for Ultra Low Power Circuits

Wang, Wei,Xu, Min,Liu, Jichao,Li, Na,Zhang, Ting,Jiang, Sitao,Zhang, Lu,Wang, Huan,Gao, Jian The Institute of Electronics and Information Engin 2015 Journal of semiconductor technology and science Vol.15 No.1

An extensive investigation of the influence of gate engineering on the CNTFET switching, high frequency and circuit level performance has been carried out. At device level, the effects of gate engineering on the switching and high frequency characteristics for CNTFET have been theoretically investigated by using a quantum kinetic model. It is revealed that hetero - material - gate CNTFET(HMG - CNTFET) structure can significantly reduce leakage current, enhance control ability of the gate on channel, and is more suitable for use in low power and high frequency circuits. At circuit level, using the HSPICE with look - up table(LUT) based Verilog - A models, the performance parameters of circuits have been calculated and the optimum combinations of ${\Phi}_{M1}/{\Phi}_{M2}/{\Phi}_{M3}$ have been concluded in terms of power consumption, average delay, stability, energy consumption and power - delay product(PDP). We show that, compared to a traditional CNTFET - based circuit, the one based on HMG - CNTFET has a significantly better performance (SNM, energy, PDP). In addition, results also illustrate that HMG - CNTFET circuits have a consistent trend in delay, power, and PDP with respect to the transistor size, indicating that gate engineering of CNTFETs is a promising technology. Our results may be useful for designing and optimizing CNTFET devices and circuits.

Investigation of Hetero - Material - Gate in CNTFETs for Ultra Low Power Circuits

Wei Wang,Min Xu,Jichao Liu,Na Li,Ting Zhang,Sitao Jiang,Lu Zhang,Huan Wang,Jian Gao 대한전자공학회 2015 Journal of semiconductor technology and science Vol.15 No.1

An extensive investigation of the influence of gate engineering on the CNTFET switching, high frequency and circuit level performance has been carried out. At device level, the effects of gate engineering on the switching and high frequency characteristics for CNTFET have been theoretically investigated by using a quantum kinetic model. It is revealed that hetero - material - gate CNTFET(HMG - CNTFET) structure can significantly reduce leakage current, enhance control ability of the gate on channel, and is more suitable for use in low power and high frequency circuits. At circuit level, using the HSPICE with look - up table(LUT) based Verilog - A models, the performance parameters of circuits have been calculated and the optimum combinations of ФM1/ФM2/ФM3 have been concluded in terms of power consumption, average delay, stability, energy consumption and power - delay product(PDP). We show that, compared to a traditional CNTFET - based circuit, the one based on HMG - CNTFET has a significantly better performance (SNM, energy, PDP). In addition, results also illustrate that HMG - CNTFET circuits have a consistent trend in delay, power, and PDP with respect to the transistor size, indicating that gate engineering of CNTFETs is a promising technology. Our results may be useful for designing and optimizing CNTFET devices and circuits.

Analysis and Compare for Control Charts Under the Changed Alarm Rule

Wang, Haiyu,Xu, Jichao,Park, Young H. 한국품질경영학회 2003 The Asian Journal on Quality Vol.4 No.2

This paper mainly studies to build control charts under different alarm rule. For different alarm rule, the control limit parameters of a control chart should be changed, then some kinds of control schemes under different alarm rule were compared and the methods of calculating ARL for different control schemes were given.

Impact of information intervention on travel mode choice of urban residents with different goal frames

Geng Jichao,Yang Li,Wang Keliang 대한경영학회 2018 대한경영학회 학술발표대회 발표논문집 Vol.2018 No.2

Multifunctional nanozyme‑reinforced copper‑coordination polymer nanoparticles for drug‑resistance bacteria extinction and diabetic wound healing

Jiahui Zhao,Tengfei Xu,Jichao Sun,Haitao Yuan,Mengyun Hou,Zhijie Li,Jigang Wang,Zhen Liang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background Drug-resistant bacterial infections in chronic wounds are a persistent issue, as they are resistant to antibiotics and can cause excessive inflammation due to generation of reactive oxygen species (ROS). An effective solution would be to not only combat bacterial infections but also scavenge ROS to relieve inflammation at the wound site. Scaffolds with antioxidant properties are attractive for their ability to scavenge ROS, and there is medical demand in developing antioxidant enzyme-mimicking nanomaterials for wound healing. Methods In this study, we fabricated copper-coordination polymer nanoparticles (Cu-CPNs) through a self-assembly process. Furthermore, ε-polylysine (EPL), an antibacterial and cationic polymer, was integrated into the Cu-CPNs structure through a simple one-pot self-assembly process without sacrificing the glutathione peroxidase (GPx) and superoxide dismutase (SOD)-mimicking activity of Cu-CPNs. Results The resulting Cu-CPNs exhibit excellent antioxidant propertiesin mimicking the activity of glutathione peroxidase and superoxide dismutase and allowing them to effectively scavenge harmful ROS produced in wound sites. The in vitro experiments showed that the resulting Cu-CPNs@EPL complex have superior antioxidant properties and antibacterial effects. Bacterial metabolic analysis revealed that the complex mainly affects the cell membrane integrity and nucleic acid synthesis that leads to bacterial death. Conclusions The Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex’s ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site.

Heterologous prime-boost immunization with live SPY1 and DnaJ protein of Streptococcus pneumoniae induces strong Th1 and Th17 cellular immune responses in mice

Yulan Qiu,XueMei Zhang,Hong Wang,Xinyuan Zhang,Yunjun Mo,Xiaoyu Sun,Jichao Wang,YiBing Yin,WenChun Xu 한국미생물학회 2017 The journal of microbiology Vol.55 No.10

diseases in children under 5-year-old. Vaccine has been used as an indispensable strategy to prevent S. pneumoniae infection for more than 30 years. Our previous studies confirmed that mucosal immunization with live attenuated strain SPY1 can protect mice against nasopharyngeal colonization of S. pneumoniae and lethal pneumococcal infection, and the protective effects are comparable with those induced by commercially available 23-valent polysaccharide vaccine. However, live attenuated vaccine SPY1 needs four inoculations to get satisfactory protective effect, which may increase the risk of virulence recovery. It is reported that heterologous primeboost approach is more effective than homologous primeboost approach. In the present study, to decrease the doses of live SPY1 and improve the safety of SPY1 vaccine, we immunized mice with SPY1 and DnaJ protein alternately. Our results showed that heterologous prime-boost immunization with SPY1 and DnaJ protein could significantly reduce the colonization of S. pneumoniae in the respiratory tract of mice, and induce stronger Th1 and Th17 cellular immune responses than SPY1 alone. These results indicate heterologous prime-boost immunization method not only elicits better protective effect than SPY1 alone, but also reduces the doses of live SPY1 and decreases the risk of SPY1 vaccine. This work is the first time to study the protective efficiency with two different forms of S. pneumoniae candidate vaccine, and provides a new strategy for the development of S. pneumoniae vaccine.

Expression of Thymosin ${\alpha}1$-thymopentin Fusion Peptide in Pichia pastoris and its Characterization

Gao, Demin,Zhang, Xulong,Zhang, Jian,Cao, Jichao,Wang, Fengshan 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11

Thymopentin plays an important role in improving imbalanced immune systems of patients, however, it has a limited half-life in plasma. To get more stable and active thymopentin analogs, a fusion thymosin ${\alpha}1$-thymopentin ($T{\alpha}1$-TP5) gene was synthesized and cloned into vector $pGAPZ{\alpha}A$. $T{\alpha}1$-TP5 fusion peptide was expressed in pichia pastoris and purified by metal chelating chromatography and gel filtration chromatography. The circular dichroism spectra (CD) indicated that the secondary structure of $T{\alpha}1$-TP5 fusion peptide is dominated by a-helix and random coil. In vitro analysis showed that the plasma half-life of $T{\alpha}1$-TP5 fusion peptide is $140{\pm}14\;min$, which is longer than that of TP5 ($5.6{\pm}0.7\;min$) and $T{\alpha}1$ ($127{\pm}11\;min$). The in vitro activity assay presented that $T{\alpha}1$-TP5 fusion peptide has greater activity in promoting proliferation of Kunming mouse splenocytes, and in vivo experiment it showed better activity in promoting the phagocytosis of macrophages and secretion of IL-2 than both $T{\alpha}1$ and TP5. Our findings suggest that $T{\alpha}1$-TP5 fusion peptide might be a potential therapeutic agent.

Expression of Thymosin α1-thymopentin Fusion Peptide in Pichia pastoris and its Characterization

Demin Gao,Xulong Zhang,Jian Zhang,Jichao Cao,Fengshan Wang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11

Thymopentin plays an important role in improving imbalanced immune systems of patients, however, it has a limited half-life in plasma. To get more stable and active thymopentin analogs, a fusion thymosin α1-thymopentin (Tα1-TP5) gene was synthesized and cloned into vector pGAPZαA. Tα1-TP5 fusion peptide was expressed in pichia pastoris and purified by metal chelating chromatography and gel filtration chromatography. The circular dichroism spectra (CD) indicated that the secondary structure of Tα1-TP5 fusion peptide is dominated by a-helix and random coil. In vitro analysis showed that the plasma half-life of Tα1-TP5 fusion peptide is 140 ±14 min, which is longer than that of TP5 (5.6±0.7 min) and Tα1 (127±11 min). The in vitro activity assay presented that Tα1-TP5 fusion peptide has greater activity in promoting proliferation of Kunming mouse splenocytes, and in vivo experiment it showed better activity in promoting the phagocytosis of macrophages and secretion of IL-2 than both Tα1 and TP5. Our findings suggest that Tα1-TP5 fusion peptide might be a potential therapeutic agent.