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RISS 인기검색어
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- 저자 : Soumyajit Roy (검색결과 4 건)
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Roy, Soumyajit,Mallick, Supriya,Raza, Md. Waseem,Haresh, Kunhi Parambath,Gupta, Subhash,Sharma, Daya Nand,Julka, Pramod Kumar,Rath, Goura Kisore Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Burden of cancer is progressively increasing in developing countries like India which has also led to a steep rise in toxicity due to anti-cancer therapy. A cross-sectional analysis was here conducted for patients with different malignancies (except leukaemia) who while undergoing radical anti-cancer therapy were admitted to our oncology ward from January-July 2013. In a total of 280 patients, the total number of toxicity events was 473. Nine patients expired over this time period. Among the events, grade 2 anaemia the most common (n=189) while the most common grades of neutropenia and thrombocytopenia were grade 4 (n=114) and grade 2 (n=48), respectively. Among the tracable microbial etiologies, gram negative bacteria were the most commonly found pathogens. Treatment interruptions took place in 240 patients (median duration=8.8 days). Prolonged hospital admission, intensive care and artificial ventilation support was needed to be given in 48, 7 and 13 patients respectively. Advanced NSCLC, KPS <70, pancytopenia and artificial ventilation requirement were found to have a significant impact on death. Such studies show the prevailing practice from institutes of our country and may guide us formulating a guideline for managing such toxicities for this part of the world.
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Impact of Treatment Time on Chemoradiotherapy in Locally Advanced Cervical Carcinoma
Pathy, Sushmita,Kumar, Lalit,Pandey, Ravindra Mohan,Upadhyay, Ashish,Roy, Soumyajit,Dadhwal, Vatsla,Madan, Renu,Chander, Subhash Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Background: Adverse effects of treatment prolongation beyond 8 weeks with radiotherapy for cervical cancer have been established. Clinical data also show that cisplatin increases the biologically effective dose of radiotherapy. However, there are no data on the effect of overall treatment time in patients with locally advanced cervical cancer treated with concomitant chemo-radiotherapy (CCRT) in an Indian population. The present study concerned the feasibility of concurrent chemotherapy and interspacing brachytherapy during the course of external radiotherapy to reduce the overall treatment time and compare the normal tissue toxicity and loco-regional control with a conventional schedule. Materials and Methods: Between January 2009 and March 2012 fifty patients registered in the Gynaecologic Oncology Clinic of Institute Rotary Cancer Hospital with locally advanced cervical cancer (FIGO stage IIB-IIIB) were enrolled. The patients were randomly allocated to treatment arms based on a computer generated random number. Arm I (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions, and weekly cisplatin $40mg/m^2$. High dose rate intra-cavitary brachytherapy (HDR-ICBT) was performed after one week of completion of external beam radiotherapy (EBRT). The prescribed dose for each session was 7Gy to point A for three insertions at one week intervals. Arm II (n=25) treatment consisted of irradiation of the whole pelvis to a dose of 50 Gy in 27 fractions. Mention HDR-ICBT ICRT was performed after 40Gy and 7Gy was delivered to point A for three insertions (days 23, 30, 37) at one week intervals. Cisplatin $20mg/m^2/day$ was administered from D1-5 and D24-28. Overall treatment time was taken from first day of EBRT to last day of HDR brachytherapy. The overall loco-regional response rate (ORR) was determined at 3 and 6 months. Results: A total of 46 patients completed the planned treatment. The overall treatment times in arm I and arm II were $65{\pm}12$ and $48{\pm}4$ days, respectively (p=0.001). At three and six months of follow-up the ORR for arm I was 96% while that for arm II was 88%. No statistically significant difference was apparent between the two arms. The overall rate of grade ${\geq}3$ toxicity was numerically higher in arm I (n=7) than in arm II (n=4) though statistical significance was not reached. None of the predefined prognostic factors like age, performance status, baseline haemoglobin level, tumour size, lymph node involvement, stage or histopathological subtype showed any impact on outcome. Conclusions: In the setting of concurrent chemoradiotherapy a shorter treatment schedule of 48 days may be feasible by interspacing brachytherapy during external irradiation. The response rates and toxicities were comparable.
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Jichao Wang,Jichao Wang,Cheng Chen,Philippe M. Heynderickx,Soumyajit Roy,Francis Verpoort 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
An efficient and facile approach to synthesize a bi-functional electrocatalyst via combining carbon foamwith cobalt-centered zeolitic imidazolate framework (ZIF-67) is reported. The carbon foam was synthesizedvia dehydration of sugar utilizing zinc nitrate, forming Co3ZnC in the carbon matrix. To obtain Cohybridized and Co particles covered with carbon nanotubes embedded in a carbon matrix (Co-Zn-CNTs), physical mixing of both defines the critical point after pyrolysis. Higher content of N-related speciesand transition metal species in polyvalent states and well-grown multi-wall carbon nanotubes forcharge transfer are achieved after the pyrolysis process. The obtained Co-Zn-CNTs catalyst was employedas cathode and anode for overall water splitting (HER and OER) and showed excellent performances. Thisdevelopment offers a low-cost and straightforward strategy to synthesize catalyst material for large-scalefuel cells and water splitting technologies. This development affords a precise method for effectivelyimproving the electrocatalyst performance derived from the ZIF-67 precursor.
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