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Li Cui,Weiquan Bu,Jie Song,Liang Feng,Tingting Xu,Dan Liu,Wenbo Ding,Jianhua Wang,Changyang Li,Binge Ma,Yi Luo,Ziyu Jiang,Chengcheng Wang,Juan Chen,Jian Hou,Hong-mei Yan,Lei Yang,Xiao-bin Jia 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.3
Alantolactone is a sesquiterpene lactone isolatedfrom Inula helenium L. Although alantolactone possessesanti-inflammation and apoptosis-induction activities, theunderlying mechanism of anti-cancer effect on humanbreast cancer cells remains largely unknown. In this study,we explored the possibility of alantolactone as an apoptosis-inducing cytotoxic agent using MDA-MB-231 cells asin vitro model. Alantolactone significantly induced itsapoptosis, demonstrated by cell cycle analysis, annexinV-APC/7-AAD double staining and dUTP nick end labeling. Additionally, alantolactone triggered the mitochondrial-mediated caspase cascade apoptotic pathway, whichwas confirmed by increased Bax/Bcl-2 ratio, loss of MMP,release of cytc from mitochondria to cytoplasm, activationof caspase 9/3, and subsequent cleavage of PARP. Z-VADFMKpartially prevented apoptosis induced by alantolactone. Alantolactone provoked the production of ROS, whileNAC (a scavenger of ROS) reversed alantolactone-mediateddepolarization of MMP and apoptosis. Alantolactonemodulated the activities of MAPKs. As expected, cotreatmentwith SB203580, SP600125 or U0126 could reducedthe apoptotic rate. Furthermore, alantolactone decreasedthe protein expressions of p-NF-kB p65 and p-STAT3,increased p-c-Jun level in a dose-dependent manner. Thesefindings suggested that alantolactone possessed anticanceractivity via ROS-mediated mitochondrial dysfunctioninvolving MAPK pathway, and had an effect on the transcriptionfactors of NF-kB, AP-1 and STAT3.
Multiple Peer-To-Peer Relay Network Robust Beamforming Based on Lorentz-Positive Matrices
Jianhua Li,Yunshan Hou 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10
Aiming at minimizing the total transmit power of relay nodes in the multiple peer-to-peer relay network in the presence of channel estimation error, a relay beamforming method based on Lorentz positive matrix is proposed. Firstly, assuming the channel state information of the second hop in the relay network is uncertain and the signal to noise ratios of the destination nodes are given, the expression of total relay nodes transmit power minimization optimization problem is deduced. Secondly, some real valued variables are defined and the concept of Lorentz cone is used to transform the optimization problem into a real valued problem. Finally, using the equivalent linear matrix inequality description of Lorentz positive matrices, the relay transmit power minimization problem is transformed into a real valued convex optimization problem. The proposed method overcomes the problem existing in the conventional robust relay beamforming methods based on semi definite relaxation technique, which sometimes yield solution matrix of with a rank greater than 1. Simulation results show that in the case of different relay nodes and channel error coefficients, the proposed method yields minimum relay transmit power in line with the results of the robust relay beamforming method based on semi definite relaxation technique, which validates the effectiveness of the proposed method.
Analysis on the temperature dependent electrical properties of graphene/ Al–ZnO Schottky contact
Yapeng Li,Yingfeng Li,Jianhua Zhang,Xiangyu Zou,Yongshan Wang 한국물리학회 2019 Current Applied Physics Vol.19 No.10
The electrical characteristics of the graphene/Al–ZnO schottky contact with the temperature of 180 K–300 K have been discussed in detail. Based on the TE model, the barrier height increased and the ideal factor decreased with the increasing of temperature from 180 K to 300 K, which can be interpreted by the lateral inhomogeneities of schottky barrier height. Combined with the single gauss distribution function of barrier height, the lateral inhomogeneities distribution of barrier height at the interface was confirmed. By DLTS measurement, one electron trap centers were observed at the interface.
퍼블릭 아트를 통한 역사문화지구의 아이덴티티 표현 연구
이지엔화(Li Jianhua),윤지영(Yoon Jiyoung) 한국실내디자인학회 2018 한국실내디자인학회 학술대회논문집 Vol.20 No.3
This study takes the identity of public art in historical and cultural areas as the research object. Through the theoretical investigation and research on the public art of historical and cultural regions, the author draws three researches on the public art identity study of historical and cultural regions represented by Jingdezhen Taoxichuan.Three evaluation factors that shape spatial identity were drawn:1.physical space 2.historical and cultural environment3.economy and industry.The identity of Taoxichuan public art in Jingdezhen, China was analyzed and evaluated, and related issues and suggestions were put forward. The survey results are as follows: The characteristic of Taoxichuan in Jingdezhen is the architectural form of the Bauhaus jagged roof and the tall chimney.And it takes the original state-owned cosmic porcelain factory site as the historical basis,Giving cultural significance to the entire region.And divided into different regions according to the development background and the needs of the times,Through the connection of history, culture and resources, the public art is involved in the planning and design of the environmental space, combined with the overall planning of the space.and it has had a positive impact on the characteristics of the city and the development of the economy.However, the number of public art is small, the overall layout is scattered, and a system has not yet been formed through some form, theme and other unification.
Zhao Lei,Wang Jianhua,Li Xiaofeng 보안공학연구지원센터(IJSIP) 2014 International Journal of Signal Processing, Image Vol.7 No.6
The traditional Snake model and GVF-Snake model set high requirements on noise and initial contour in wood cell contour extraction. To solve this problem, on the premise of considering the image texture and gray-scale information, the area information is directly introduced into the active contour extraction model through force equilibrium equation. Experiments show that the contour extracted with this method is not only more close to real cell contour, but also improved in anti-noise property. In particular, in the convergence of high noise and deep sunken areas, it has some advantages not found in other traditional methods.
Xinyan Xie,Fang Hou,Li Li,Yanlin Chen,Lingfei Liu,Xiu Luo1,Huaiting Gu,Xin Li,Jiajia Zhang,Jianhua Gong,Ranran Song 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.5
Objective: To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. Methods: We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal cortex, and examined the expression of the genes in ASD cases and healthy controls using the GSE38322 data set. Following, we performed a case-control study in a Chinese population. Results: The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of human brain and contribute to the risk of ASD. Later genetic analysis in the Chinese population showed that the GRIK2 rs6922753 for the T allele, TC genotype and dominant model played a significant protective role in ASD susceptibility (respectively: OR=0.840, p=0.023; OR=0.802, p=0.038; OR=0.791, p=0.020). The NLGN1 rs9855544 for the G allele and GG genotype played a significant protective role in ASD susceptibility (respectively: OR=0.844, p=0.019; OR=0.717, p=0.022). After adjusting p values, the statistical significance was lost (p>0.05). Conclusion: Our results suggested that GRIK2 rs6922753 and NLGN1 rs9855544 might not confer susceptibility to ASD in the Chinese population.
A Comparison of TDMA, Dirty Paper Coding, and Beamforming for Multiuser MIMO Relay Networks
Li, Jianing,Zhang, Jianhua,Zhang, Yu,Zhang, Ping The Korea Institute of Information and Commucation 2008 Journal of communications and networks Vol.10 No.2
A two-hop multiple-input multiple-output (MIMO) relay network which comprises a multiple antenna source, an amplify-and-forward MIMO relay and many potential users are studied in this paper. Consider the achievable sum rate as the performance metric, a joint design method for the processing units of the BS and relay node is proposed. The optimal structures are given, which decompose the multiuser MIMO relay channel into several parallel single-input single-output relay channels. With these structures, the signal-to-noise ratio at the destination users is derived; and the power allocation is proved to be a convex problem. We also show that high sum rate can be achieved by pairing each link according to its magnitude. The sum rate of three broadcast strategies, time division multiple access (TDMA) to the strongest user, dirty paper coding (DPC), and beamforming (BF) are investigated. The sum rate bounds of these strategies and the sum capacity (achieved by DPC) gain over TDMA and BF are given. With these results, it can be easily obtained that how far away TDMA and BF are from being optimal in terms of the achievable sum rate.
Theoretical Prediction of Heat Transport in Few-Layer Graphene/ Epoxy Composites
Jianhua Zeng,Jiao Li,Peng Yuan,Ping Zhang 한국고분자학회 2018 Macromolecular Research Vol.26 No.11
Graphene is widely employed to improve the overall thermal conductivity of polymer composites because of its remarkable thermal conductivity. However, the magnitude of its improvement of thermal conductivity is far below the values expected from the remarkably high thermal conductivity of graphene and is very much less than the production cost of graphene, greatly limiting its large-scale applications in the field of thermal management. Therefore, understanding heat transport behaviors within the polymer composites and studying the related influential factors are very important. Here, heat transport behaviors within few-layer graphene (FLG)/epoxy composites are studied using molecular dynamics (MD) simulations. The influences of interfacial thermal resistance, FLG volume fraction and FLG length on overall thermal conductivity of the composites are specifically analyzed, finding that there is a significant interfacial thermal resistance between FLG and epoxy because of the mismatch of the phonon vibration power spectrum (VPS). Furthermore, the interfacial thermal resistance, FLG volume fraction, and FLG length play important roles in improving the overall thermal conductivity of FLG/epoxy composites. Our findings provide a better understanding of the heat transport behaviors within polymer composites and should be useful for future development of various thermal management applications.