piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination

Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.

Subsurface Channel Detection Using Color Blending of Seismic Attribute Volumes

Jianhua Cao,Yang Yue,Kunyu Zhang,Jucheng Yang,Xiankun Zhang 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.12

Color is the critical factor in seismic data interpretation and geological targets visualization. And recently, ideas of color blending have brought the enlightenment in attribute combinations for reservoir characterization in petroleum engineering. In this paper, we present this approach of color blending in different color modes and its application in subsurface channel detection by using seismic attributes data. The color models include RGB model, CMY model and HSV model. We firstly calculate sensitive attributes from three dimensional seismic data, including envelop, coherence and spectral decomposition, etc. Then three types of normalized seismic attributes are set as input into the primary color channel of the color models respectively, and then mixed together to create one color blended volume in three dimensional visualization environment. The blended volume has plenty of geological information coming from the three input attributes, resulting in better resolution for channels than the single attribute. Applications in one survey of DQ oilfield show that channels are vividly imaged with special lighted color on the blended volume slices. The spatial distribution characteristics of channels, including the shapes and branches, are clearly depicted. And for the three blending methods, the RGB model is mostly preferred although the CMY model has almost similar performances in channel detection, while HSV model is slightly inferior in this case.

A Comparison of TDMA, Dirty Paper Coding, and Beamforming for Multiuser MIMO Relay Networks

Li, Jianing,Zhang, Jianhua,Zhang, Yu,Zhang, Ping The Korea Institute of Information and Commucation 2008 Journal of communications and networks Vol.10 No.2

A two-hop multiple-input multiple-output (MIMO) relay network which comprises a multiple antenna source, an amplify-and-forward MIMO relay and many potential users are studied in this paper. Consider the achievable sum rate as the performance metric, a joint design method for the processing units of the BS and relay node is proposed. The optimal structures are given, which decompose the multiuser MIMO relay channel into several parallel single-input single-output relay channels. With these structures, the signal-to-noise ratio at the destination users is derived; and the power allocation is proved to be a convex problem. We also show that high sum rate can be achieved by pairing each link according to its magnitude. The sum rate of three broadcast strategies, time division multiple access (TDMA) to the strongest user, dirty paper coding (DPC), and beamforming (BF) are investigated. The sum rate bounds of these strategies and the sum capacity (achieved by DPC) gain over TDMA and BF are given. With these results, it can be easily obtained that how far away TDMA and BF are from being optimal in terms of the achievable sum rate.

Extraction of density-of-states in amorphous InGaZnO thin-film transistors from temperature stress studies

Xing-Wei Ding,Jianhua Zhang,Weimin Shi,Hao Zhang,Chuanxin Huang,Jun Li,Xueyin Jiang,Zhilin Zhang 한국물리학회 2014 Current Applied Physics Vol.14 No.12

The instability of amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) with different active layer thicknesses under temperature stress has been investigated through using the density-of-states (DOS). Interestingly, the a-IGZO TFT with 22 nm active layer thickness showed a better stability than the others, which was observed from the decrease of interfacial and semiconductor bulk trap densities. The DOS was calculated based on the experimentally-obtained activation energy (EA), which can explain the experimental observations. We developed the high-performance Al2O3 TFT with 22 nm IGZO channel layer (a high mobility of 7.4 cm2/V, a small threshold voltage of 2.8 V, a high Ion/Ioff 1.8 107, and a small SS of 0.16 V/dec), which can be used as driving devices in the next-generation flat panel displays.

Convex analysis in the semiparametric model with Bernstein polynomials

Jianhua Ding,Zhongzhan Zhang 한국통계학회 2015 Journal of the Korean Statistical Society Vol.44 No.1

In this paper, we propose Bernstein polynomial estimation for the partially linear modelwhen the nonparametric component is subject to convex (or concave) constraint. Weemploy a nested sequence of Bernstein polynomials to approximate the convex (orconcave) nonparametric function. Bernstein polynomial estimation can be obtained as asolution of a constrained least squares method and hence we use a quadratic programmingalgorithm to compute efficiently the estimator. We show that the estimator of theparametric part is asymptotically normal. The rate of convergence of the nonparametricfunction estimator is established under very mild conditions. The small sample propertiesof our estimation are provided via simulation study and compared with regression splinesmethod. A real data analysis is conducted to illustrate the application of the proposedmethod.

Effect of Time Interval on Speed Estimation using Single Loop Detector Measurements

Jianhua Guo,Wei Huang,Yun Wei,Lin Zhang 대한토목학회 2013 KSCE JOURNAL OF CIVIL ENGINEERING Vol.17 No.5

Considering the importance of estimating speed from single loop detector measurements for many Intelligent Transportation System (ITS) related applications, a variety of algorithms have been developed in the literature for specific time intervals. However,the performance of these algorithms over a spectrum of time intervals has not yet received appropriate attention in the transportation research community. In this study, a Kalman filter based algorithm is selected as a typical representative and investigated over a spectrum of 30 time intervals starting from 1-minute to 30-minute with one minute increment. Empirical results using real world data show that the selected algorithm has workable performances for most of the time intervals under investigation. Specifically, the performances of the selected approach improve for intervals from 1-minute to 5-minute, stay stable for intervals between 5-minute and 15-minute, and decrease slightly for longer time intervals greater than 15-minute. The results demonstrate the ability of the selected algorithm to be readily implemented in a variety of transportation applications with specific time interval needs. Future work is recommended to develop a framework of coupling speed estimating algorithms and real world transportation applications through investigating other single loop speed estimation approaches and ITS application related time interval needs.

Enhanced Nitrogen Photo Fixation Performance of Transition Metal-Doped Urchin-Like W18O49 Under Visible-Light Irradiation

Jianhua Ge,Jing Xu,Yujie Liu,Long Zhang,Lan Wang,Dehan Wu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.11

Nitrogen photo fixation mediated by various photocatalysts has received extensive concerns in recent years. In this work, a general strategy is proposed to enhance nitrogen photo fixation performance with some W18O49-based photocatalysts under visible-light irradiation. A series of photocatalysts were successfully synthesized in the presence of some noble-metal-free transition metals (Fe, Co and Ni) to modify the urchin-like W18O49. The resulting photocatalysts were systematically characterized using XRD, SEM, EDS, XPS, PL, N2 adsorption–desorption isotherms, and DRS. Structural characterization of the photocatalysts revealed that the crystal morphology features were preserved, optional harvesting properties were enhanced, BET specific surface area was extended, and migration efficiency of the photo-induced charge carriers was significantly improved in the modified-W18O49 materials. Therefore, a progressed nitrogen photo fixation performance was observed. The maximum production of NH4 + was approximately reached to 2752 μg · g -1 catal. under the optimum reaction conditions. Furthermore, a plausible nitrogen photo fixation mechanism in the presence of the synthesized composites is also proposed.

Theoretical Prediction of Heat Transport in Few-Layer Graphene/ Epoxy Composites

Jianhua Zeng,Jiao Li,Peng Yuan,Ping Zhang 한국고분자학회 2018 Macromolecular Research Vol.26 No.11

Graphene is widely employed to improve the overall thermal conductivity of polymer composites because of its remarkable thermal conductivity. However, the magnitude of its improvement of thermal conductivity is far below the values expected from the remarkably high thermal conductivity of graphene and is very much less than the production cost of graphene, greatly limiting its large-scale applications in the field of thermal management. Therefore, understanding heat transport behaviors within the polymer composites and studying the related influential factors are very important. Here, heat transport behaviors within few-layer graphene (FLG)/epoxy composites are studied using molecular dynamics (MD) simulations. The influences of interfacial thermal resistance, FLG volume fraction and FLG length on overall thermal conductivity of the composites are specifically analyzed, finding that there is a significant interfacial thermal resistance between FLG and epoxy because of the mismatch of the phonon vibration power spectrum (VPS). Furthermore, the interfacial thermal resistance, FLG volume fraction, and FLG length play important roles in improving the overall thermal conductivity of FLG/epoxy composites. Our findings provide a better understanding of the heat transport behaviors within polymer composites and should be useful for future development of various thermal management applications.

Subsidence estimation of breakwater built on loosely deposited sandy seabed foundation: Elastic model or elasto-plastic model

Jianhua Shen,Huaicheng Wu,Yuting Zhang 대한조선학회 2017 International Journal of Naval Architecture and Oc Vol.9 No.4

In offshore area, newly deposited Quaternary loose seabed soils are widely distributed. There are a great number of offshore structures has been built on them in the past, or will be built on them in the future due to the fact that there would be no very dense seabed soil foundation could be chosen at planed sites sometimes. However, loosely deposited seabed foundation would bring great risk to the service ability of offshore structures after construction. Currently, the understanding on wave-induced liquefaction mechanism in loose seabed foundation has been greatly improved; however, the recognition on the consolidation characteristics and settlement estimation of loose seabed foundation under offshore structures is still limited. In this study, taking a semi-coupled numerical model FSSI-CAS 2D as the tool, the consolidation and settlement of loosely deposited sandy seabed foundation under an offshore breakwater is investigated. The advanced soil constitutive model Pastor- Zienkiewics Mark III (PZIII) is used to describe the quasi-static behavior of loose sandy seabed soil. The computational results show that PZIII model is capable of being used for settlement estimation problem of loosely deposited sandy seabed foundation. For loose sandy seabed foundation, elastic deformation is the dominant component in consolidation process. It is suggested that general elastic model is acceptable for subsidence estimation of offshore structures on loose seabed foundation; however, Young's modulus E must be dependent on the confining effective stress, rather than a constant in computation.

Application of a modified structural clay model considering anisotropy to embankment behavior

Zhang, Hao,Chen, Qiushi,Chen, Jinjian,Wang, Jianhua Techno-Press 2017 Geomechanics & engineering Vol.13 No.1

Natural clays exhibit features such as structural and anisotropy. In this work, a constitutive model that is able to replicate these two salient features of natural clays is presented. The proposed model is based on the classical S-CLAY1 model, where the anisotropy of the soil is captured through the initial inclination and rotation of the yield surface. To account for the structural of the soil, the compression curve of the reconstituted soil is taken as the reference. All parameters of the proposed constitutive model have clear physical meanings and can be conveniently determined from conventional triaxial tests. This proposed model has been used to simulate the behavior of soft soil in the undrained triaxial tests and the performance of Murro embankment in terms of settlement and horizontal displacements during embankment construction and consolidation stage. Results of numerical simulations using proposed model have been compared with the field measurement data. The comparisons show that the two features significantly influence the prediction results.