아드만탄 기반의 새로운 설포네이트 폴리카보네이트 난연제 성능 연구

Jian Wei Guo,Yue Qin Wang,Li Juan Feng,Xing Zhong,Chu Fen Yang,Sa Liu,Ying De Cui 한국고분자학회 2013 폴리머 Vol.37 No.4

A novel sulfonate flame retardant, 1,3,5,7-tetrakis(phenyl-4-sodium sulfonate)adamantane (FR-A), was suc-cessfully synthesized from l-bromoadamantane in sequential four-step reactions involving Fiedel-Crafts phenylation, sul-phonation, hydrolysis, and neutralization. The success of synthesis was confirmed by FTIR spectra, ‘H NMR spectra, elemental analyses and mass spectra. The effect of FR-A on the flame retardacy of polycarbonate (PC) has been studied. Limiting oxygen index (LOI) and thermogravimetric analysis (TGA) showed that this novel sulfonate flame retardant had effective flame retardancy on polycarbonate (PC). With a small amount (0.08 Wt%) of FR-A. the flame retardancy of PC was improved obviously, which got to UL 94 V-0 rating. TGA and DTA curves demonstrated that the additive raised the degradation rate of PC by promoting the quick formation of an insulating carbon layer on the surface, and confirmed that the flame retardant mechanism of PC/FR-A system was similar to potassium diphenylsulfone sulfonate (KSS).

Experimental Study on Sustained-release 5-Fluorouracil Implantation in Canine Peritoneum and Para-aortic Abdominalis

Wei, Guo,Nie, Ming-Ming,Shen, Xiao-Jun,Xue, Xu-Chao,Ma, Li-Ye,Du, Cheng-Hui,Wang, Shi-Liang,Bi, Jian-Wei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Objective: To observe local and systemic toxicity after sustained-release 5-fluorouracil (5-Fu) implantation in canine peritoneum and para-aortic abdominalis and the changes of drug concentration in the local implanted tissue with time. Methods: 300 mg sustained-release 5-Fu was implanted into canine peritoneum and para-aorta abdominalis. Samples were taken 3, 5, 7 and 10 days after implantation for assessment of changes and systemic reactions. High performance liquid chromatography was applied to detect the drug concentrations of peritoneal tissue at different distances from the implanted site, lymphatic tissue of para-aortic abdominalis, peripheral blood and portal venous blood. Results: 10 days after implantation, the drug concentrations in the peritoneum, lymphatic tissue and portal vein remained relatively high within 5 cm of the implanted site. There appeared inflammatory reaction in the local implanted tissue, but no visible pathological changes such as cell degeneration and necrosis, and systemic reaction like anorexia, nausea, vomiting and fever. Conclusions: Sustained-release 5-Fu implantation in canine peritoneum and para-aortic abdominalis can maintain a relatively high tumour-inhibiting concentration for a longer time in the local implanted area and portal vein, and has mild local and systemic reactions. Besides, it is safe and effective to prevent or treat recurrence of gastrointestinal tumours and liver metastasis.

Effects of Stellate Ganglion Block on the Peri-operative Vasomotor Cytokine Content and Intrapulmonary Shunt in Patients with Esophagus Cancer

Guo, Wei,Jin, Xiao-Ju,Yu, Jun,Liu, Yang,Zhang, Jian-Ping,Yang, Da-Wei,Zhang, Lei,Guo, Jiang-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Objective: To investigate the effects of stellate ganglion block (SGB) on the peri-operative vasomotor cytokine content and intrapulmonary shunt in patients with esophagus cancer who underwent thoracotomy. Materials and Methods: Forty patients undergoing elective resection of esophageal cancer patients who had I~II American Society of Anesthesiologist (ASA) were randomly divided into total intravenous anesthesia group (group N, n=20) and total intravenous anesthesia combined with SGB group (group S, n=20, 0.12 mL/kg 1% lidocaine was used for SGB 10 min before induction). Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP) and continuous cardiac output (CCO) were continuously monitored. The blood from internal jugular vein was drawn respectively before induction ($T_0$), and 30 min ($T_1$), 60 min ($T_2$) and 120 min ($T_3$) after one-lung ventilation (OLV), and 30 min (T4) after two-lung ventilation. The contents of plasma endothelin (ET), nitric oxide (NO) and calcitonin gene-related peptide (CGRP) were detected with enzyme linked immunosorbent assay (ELISA). Meanwhile, arterial and mixed venous blood samples were collected for determination of blood gas and calculation of intrapulmonary shunt fraction (Qs/Qt). Results: During OLV, ET contents were increased significantly in two groups (P<0.05), and no significant difference was presented (P>0.05). NO content in group S was obviously higher than in group N at T3 (P<0.05), whereas CGRP content in group N was markedly lower than in group S at each time point (P<0.05). Qs/Qt was significantly increased in both groups after OLV, but there was no statistical significant regarding the Qs/Qt at each time point between two groups. Conclusions: Total intravenous anesthesia combined with SGB is conducive to regulation of perioperative vasomotor cytokines in thoracotomy, and has little effect on intrapulmonary shunt at the time of OLV.

Field Emission from TiO2/Ti Nanotube Array Films Modified with Carbon Nanotubes

Cheng-Wei Wang,Rui-Sheng Guo,Jian-Biao Chen,Yan Li,Jian Wang,Wei-Min Liu 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.6

Well-aligned TiO2/Ti nanotube array films were synthesized by using anodic oxidation of titanium in 0.5-wt% HF and were modified with carbon nanotubes (CNTs) assembled by using catalyzed chemical vapor deposition (CVD) at 650 ˚C. The morphology and the quality of the films were assessed with field emission scanning electron microscopy and Raman spectrometry (325 nm). The field emission characteristics of such TiO2/Ti nanostructures were investigated before and after being modified with CNTs. The results show that the TiO2/Ti nanotube arrays possess a moderate turn-on electric field of 7.4 V/µm, a field emission current density of 2.7 mA/cm2 at 23 V/µm. It is noteworthy that the turn-on field of the TiO2/Ti nanotube arrays modified with CNTs is decreased significantly to 1.3 V/µm, and the emission current density is increased to 10 mA/cm2 at 5.6 V/µm. This novel structure shows high emission efficiency as a field emitter. Well-aligned TiO2/Ti nanotube array films were synthesized by using anodic oxidation of titanium in 0.5-wt% HF and were modified with carbon nanotubes (CNTs) assembled by using catalyzed chemical vapor deposition (CVD) at 650 ˚C. The morphology and the quality of the films were assessed with field emission scanning electron microscopy and Raman spectrometry (325 nm). The field emission characteristics of such TiO2/Ti nanostructures were investigated before and after being modified with CNTs. The results show that the TiO2/Ti nanotube arrays possess a moderate turn-on electric field of 7.4 V/µm, a field emission current density of 2.7 mA/cm2 at 23 V/µm. It is noteworthy that the turn-on field of the TiO2/Ti nanotube arrays modified with CNTs is decreased significantly to 1.3 V/µm, and the emission current density is increased to 10 mA/cm2 at 5.6 V/µm. This novel structure shows high emission efficiency as a field emitter.

Effect of Cu doping on the SCR activity of CeO2 catalyst prepared by citric acid method

Rui-Tang Guo,Wen-long Zhen,Wei-Guo Pan,Yue Zhou,Jie-nan Hong,Hong-jian Xu,Qiang Jin,Cheng-gang Ding,Shi-yi Guo 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4

CeO2–CuO catalyst prepared by citric acid method was investigated for selective catalytic reduction of NO with NH3. The activity of the CeO2 catalyst was enhanced about 8–27% in the temperature range of 125–225 ℃ at a space velocity of 28,000 h 1 by the addition of Cu. It was found that the state of Cu species had great impact on the SCR performance of CeO2–CuO catalyst. Cu2+ can enhance the low temperature activity of SCR reaction, while CuO would promote NH3 oxidation before SCR reaction at high temperature, which would cause the decrease of its high temperature SCR activity.

Metastasis associated genomic aberrations in stage II rectal cancer

Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11

Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.

Listeria monocytogenes Serovar 4a is a Possible Evolutionary Intermediate Between L. monocytogenes Serovars 1/2a and 4b and L. innocua

Jian Shun Chen,Ling Li Jiang,Xue Yan Chen,Xiao Kai Luo,Yang Chen,Ying Yu,Guo Ming Tian,Dong You Liu,Wei Huan Fang 한국미생물 · 생명공학회 2009 Journal of microbiology and biotechnology Vol.19 No.3

Use of multi-hybrid machine learning and deep artificial intelligence in the prediction of compressive strength of concrete containing admixtures

Jian, Guo,Wen, Sun,Wei, Li Techno-Press 2022 Advances in concrete construction Vol.13 No.1

Conventional concrete needs some improvement in the mechanical properties, which can be obtained by different admixtures. However, making concrete samples costume always time and money. In this paper, different types of hybrid algorithms are applied to develop predictive models for forecasting compressive strength (CS) of concretes containing metakaolin (MK) and fly ash (FA). In this regard, three different algorithms have been used, namely multilayer perceptron (MLP), radial basis function (RBF), and support vector machine (SVR), to predict CS of concretes by considering most influencers input variables. These algorithms integrated with the grey wolf optimization (GWO) algorithm to increase the model's accuracy in predicting (GWMLP, GWRBF, and GWSVR). The proposed MLP models were implemented and evaluated in three different layers, wherein each layer, GWO, fitted the best neuron number of the hidden layer. Correspondingly, the key parameters of the SVR model are identified using the GWO method. Also, the optimization algorithm determines the hidden neurons' number and the spread value to set the RBF structure. The results show that the developed models all provide accurate predictions of the CS of concrete incorporating MK and FA with R² larger than 0.9972 and 0.9976 in the learning and testing stage, respectively. Regarding GWMLP models, the GWMLP1 model outperforms other GWMLP networks. All in all, GWSVR has the worst performance with the lowest indices, while the highest score belongs to GWRBF.

Molecular characterization and comparative analysis of two waxy alleles in barley

Jian Ma,Qian-Tao Jiang,Laroche Andre,Zhen-Xiang Lu,Guo-Yue Chen,Ya-Xi Liu,You-Liang Zheng,Yu-Ming Wei 한국유전학회 2010 Genes & Genomics Vol.32 No.6

Two alleles of the barley waxy locus were characterized from non-waxy cultivar Bowman and waxy cultivar CDC Candle,respectively. Their nucleotide and protein sequences were compared with other known waxy genes. The comparison results indicated that there were 100 polymorphic sites, among which 69 were in the non-coding region and 31 were in the coding region. Out of 100 polymorphic sites, 45 were transversion,35 were transition and 20 were indels. A 397 bp deletion and a 193 bp insertion in the promoter region and a 15bp insertion in the coding region were found in CDC Candle,but not in Bowman. A deletion (11 bp) was detected in Bowman, which exhibited no effects on normal waxy expression. In summary, the 397 bp deletion was supposed to account for the reduction of GBSS I, resulting in the low amylose in CDC Candle; whereas other polymorphic sites might be not correlated with amylose synthesis.

Robust Adaptive Dynamic Surface Control of Multi-link Flexible Joint Manipulator with Input Saturation

Wei Yao,Yu Guo,Yi-Fei Wu,Jian Guo 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.2

This paper investigates the tracking control for multi-link flexible joint manipulator system with disturbance, uncertain stiffness and input saturation. A robust adaptive dynamic surface control scheme is developed with an auxiliary dynamic system. The auxiliary dynamic system is employed to handle input saturation. To compensate for disturbance, an adaptive law for disturbance upper bound estimation is designed. The value of uncertain stiffness is updated by another adaptive law. It is proved that the proposed control scheme can realize precise tracking of link angles and guarantee the uniform ultimate boundedness of all the signals in the closed-loop by appropriately choosing the parameters to be designed. Finally, simulation results demonstrate the effectiveness of the proposed control method.