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Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.
Rock-breaking analysis model of new drill bit with tornado-like bottomhole model
Jia-lin Tian,Chang-fu Yuan,Lin Yang,Chuan-hong Fu,Gang Liu,Zhi Yang,Chun-ming Wu 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.4
For improving the rock-breaking efficiency of oil and gas drill bits, a new drill bit is presented with tornado-like bottomhole model(named swirling cutting bit). The new drill bit cutter breaks rock with shocking and cutting effect during the drilling process, and theelements on largest ring cross the borehole center with high speed. It can effectively improve the center rock-breaking efficiency. Meanwhile,for all cutters on different rings breaking rock at the same time, it can optimize the rock-breaking volume of each element andimprove the bit service life. To analyze the interaction features between cutters and rock, the position equations are established by thecylindrical coordinates and complex movement principles, and then the velocity and acceleration equations can be obtained. Based on thenumerical example results, this paper analyzes the bottomhole model, the contact section, and the distribution features of velocities andaccelerations on different rings. By analyzing the acceleration results, we can study the failure mechanism of cutters. At the same time,lab experiments test the bottomhole model and rock-breaking features, and it verifies the accuracy of calculation method and equations. Moreover, the analysis method and models are also applicable to other types of bits or composite bits, and the inputting parameters needcorresponding adjustment for different type of bits.
U.S. INTEREST RATES AND PORTFOLIO INVESTMENTS IN LATIN AMERICA
Jia wen Yang People&Global Business Association 1997 Global Business and Finance Review Vol.2 No.1
This paper analyzes the relationship between U.S. interest rates and portfolio investments in four Latin American countries: Argentina, Brazil, Chile, and Mexico. The paper finds that U.S. interest rate fluctuations have a significant negative impact on capital flows to these countries, including direct investment and other capital as well as portfolio capital flows. Differences do exist across countries and they relate to country-specific macroeconomics policies and financial reforms. The findings of this study have important implications for international monetary and financial issues and macroeconomic policies in emerging markets.
The study of Harvest System for Organic Perishable Vegetable in Plugs
( Jia-ming Yang ),( Xie-zhi Li ),( Kuang-wen Hsieh ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Vegetable is the indispensable food for the daily life of mankind. Due to the demand for increasing the quality of vegetable in Taiwan, the protected culture must be developed for cultivation of vegetable. There are two common approaches of cultivation, including seeding and plug transplant, and both approaches require much labor. By applying the Organic Perishable Vegetable in Plugs planted, the labor problem in the past for plug seeding, sprout cultivation, transplantation and harvesting could be improved. Besides, the yield and quality could be increased. However, the short of labor is still a major problem for harvesting. This study would develop a set of harvesting machinery that is applicable for Organic Perishable Vegetable in Plugs. This could reduce the time and labor for harvesting in fields, and reach the objectives of saving of labor and increasing the productivity.
Vibration analysis of new drill string system with hydro-oscillator in horizontal well
Jia-lin Tian,Zhi Yang,You Li,Lin Yang,Chun-ming Wu,Gang Liu,Chang-fu Yuan 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.6
With the growth of oil and gas resource demand, the hydro-oscillator is widely used to enhance the Rate of penetration (ROP) and improve the efficacy in drilling various wells. The vibration model is the key issue of dynamics analysis and optimization of downhole tools. For the vibration analysis of the new drill string system with hydro-oscillator in the horizontal well, based on the design of the new hydro-oscillator and its operation conditions, the kinematics expressions are presented. Combined with the vibration force calculation results of the hydro-oscillator, the dynamics model of the new drill string system is established. Furthermore, the important features of vibration frequency, displacement, velocity and acceleration are discussed in the numerical example calculation results. By comparing the results of the calculation and experiment test, we can verify the correctness of the analysis model. With the hydro-oscillator vibration effect, the static friction between the drill string and wellbore is changed to the dynamic friction, so it can result in a significant increase in run length. At the same time, the ROP can be enhanced with the vibration effect. Moreover, with the parameters’ adjustment according to the operation conditions, the analysis method and model can also provide references to the study of similar downhole tools dynamics or mechanical properties.
Jia Huili,Yang Guanghui,Yang Jiaqiang 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.1
The multiphase induction motor (MIM) suff ers the problems of unsmoothness and slow dynamic response during the process of electronic pole-changing. To solve this issue, a cosine-response strategy based on proportional resonance (PR) current controller is proposed. Firstly, a current switching strategy with cosine-response is designed, which makes the MIM work more smoothly while switching between two planes. Then, the PR controller based on static coordinate system is adopted to replace the traditional proportional integral current loop controller, which realizes the zero steady-state error tracking of the current and improves MIM’s dynamic response. Experiments on a fi ve-phase induction motor verify that the proposed strategy can reduce the fl uctuations of the torque, speed, and total harmonic distortion of phase current. Besides, it can improve the dynamic response of the torque and speed when the pole-changing is switched.
Degradation reliability modeling of plain concrete for pavement under flexural fatigue loading
Jia, Yanshun,Liu, Guoqiang,Yang, Yunmeng,Gao, Ying,Yang, Tao,Tang, Fanlong Techno-Press 2020 Advances in concrete construction Vol.9 No.5
This study aims to establish a new methodological framework for the evaluation of the evolution of the reliability of plain concrete for pavement vs number of cycles under flexural fatigue loading. According to the framework, a new method calculating the reliability was proposed through probability simulation in order to describe a random accumulation of fatigue damage, which combines reliability theory, one-to-one probability density functions transformation technique, cumulative fatigue damage theory and Weibull distribution theory. Then the statistical analysis of flexural fatigue performance of cement concrete tested was carried out utilizing Weibull distribution. Ultimately, the reliability for the tested cement concrete was obtained by the proposed method. Results indicate that the stochastic evolution behavior of concrete materials under fatigue loading can be captured by the established framework. The flexural fatigue life data of concrete at different stress levels is well described utilizing the two-parameter Weibull distribution. The evolution of reliability for concrete materials tested in this study develops by three stages and may corresponds to develop stages of cracking. The proposed method may also be available for the analysis of degradation behaviors under non-fatigue conditions.
Numerical study on aerodynamics of banked wing in ground effect
Jia, Qing,Yang, Wei,Yang, Zhigang The Society of Naval Architects of Korea 2016 International Journal of Naval Architecture and Oc Vol.8 No.2
Unlike conventional airplane, a WIG craft experiences righting moment and adverse yaw moment in banked turning in ground effect. Numerical simulations are carried out to study the aerodynamics of banked wing in ground effect. Configurations of rectangular wing and delta wing are considered, and performance of endplates and ailerons during banking are also studied. The study shows that righting moment increase nonlinearly with heeling angle, and endplates enhance the righting. The asymmetric aerodynamic distribution along span of wing with heeling angle introduces adverse yaw moment. Heeling in ground effect with small ground clearance increases the vertical aerodynamic force and makes WIG craft climb. Deflections of ailerons introduce lift decrease and a light pitching motion. Delta wing shows advantage in banked turning for smaller righting moment and adverse yaw moment during banking.
Jia Yang,Qiong Kang,Bin Zhang,Xiyu Tian,Shuzheng Liu,Gang Qin,Qiang Chen 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
Ionic conductive hydrogel-based sensors have been capturing growing attention in various areas, but stillcannot satisfy the operating requirements of next generation wearable electronics. Herein, inspired bybiosystems, we demonstrate ionic conductive supramolecular hydrogels with simple one-step methodbased on salting-out effect and multiple hydrogen bond interactions. The supramolecular hydrogels exhibithigh toughness and strength, quick self-recovery, high sensitive sensing performance as well as goodself-healing, fatigue and frost resistances in mechanical and sensing properties, and can monitor largeand subtle movements and physiological activities of the human body sensitively, quickly and stably. Thus, it provides a convenient and promising way to obtain stretchable sensors of excellent comprehensiveproperties, which have tremendous application potential as wearable electronic devices in harshenvironments.