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Jia Lyu,Yihua Wang,Linglong Liu,Chunming Wang,Yulong Ren,Cheng Peng,Feng Liu,Yunlong Wang,Mei Niu,Di Wang,Ming Zheng,Kunneng Zhou,Shaolu Zhao,Fuqing Wu,Haiyang Wang,Jianmin Wan 한국식물학회 2017 Journal of Plant Biology Vol.60 No.5
Differentiation from proplastids into chloroplasts isa light- and energy-dependent process. How this process isregulated is still poorly understood at the molecular level. We herein report a new putative plastidial adenine nucleotidetransporter, BRITTLE1-3 (referred to as OsBT1-3), encoded bythe rice (Oryza sativa) White Stripe Leaf 2 (WSL2) gene. Loss of OsBT1-3 function results in defective chloroplastbiogenesis, severely reduced photosynthetic efficiency, andfinally a white stripe leaf phenotype in the first four leaves. The expression levels of genes related to chlorophyllbiosynthesis and photosynthesis are drastically reduced,accompanied with over accumulation of reactive oxygenspecies (ROS) in the wsl2 mutant. OsBT1-3 is targeted tothe chloroplasts and it expresses in almost all tissues inplants, especially in young leaves. OsBT1-3 consists of 419amino acids and exhibits features of all mitochondrialcarrier proteins, including a typical transmembrane-spanningdomain and a highly conserved sequence motif designatedas the ‘mitochondrial energy transfer signatures’. Phylogeneticanalysis shows that OsBT1-3 is a putative plastidialadenine nucleotide transporter and is most closely relatedto ZmBT1-2. Together, these observations suggest that thenew putative adenine nucleotide transporter, OsBT1-3,plays an essential role in regulating chloroplast biogenesisand maintenance of ROS homeostasis during rice seedlingde-etiolation.
Development of signal analysis method for the motional Stark effect diagnostic on EAST
FU, Jia,LYU, Bo,LIU, Haiqing,LI, Yingying,LIU, Dongmei,WEI, Yongqing,FAN, Chao,SHI, Yuejiang,WU, Zhenwei,WAN, Baonian IOP Publishing 2017 Plasma science & technology Vol.19 No.10
<P>A pilot single-channel Motional Stark Effect (MSE) diagnostic has been developed on EAST since 2015. The dual photo-elastic modulators (PEM) were employed to encode the polarization angle into a time-varying signal. The pitch angle was related to the ratio of modulation amplitude at the second harmonic frequency. A digital harmonic analyzer (DHA) technique was developed for extracting the second harmonic amplitude. The results were validated with a hardware phase lock-in amplifier, and is also consistent with the software dual phase-locking algorithm.</P>
Post-fire Study on Mechanical Properties of Damaged Ultra-high Strength Concrete
Xiao Lyu,Guang-Hao Jia,Gan-Ping Shu,Xin Zhang,Er-Feng Du,Wen-Ming Wang 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.6
In order to study the eff ect of steel tube, pre-load and temperature on residual performance of heated ultra-high strength concrete (UHSC), an experimental program was carried out to investigate the physical and mechanical properties of UHSC post-fi re in room temperature. With total of 54 standard cylindrical concrete specimens subjected to various temperatures ranging from 62 °C to 496 °C, their residual compressive strength, elastic modulus, peak strain was measured after natural cooling down. By comparing the test results of standard cylindrical concrete specimens with the results of the bare specimens in and after fi re, it is known that the residual compressive strength of standard cylindrical concrete specimens decayed more serious after exposing to same temperature. Seen from the results, the temperature which the specimens suff ered was found to be responsibility to the reduction of the compressive strength, elastic modulus, peak strain. As the temperature up to 300 °C, the strength reduction coeffi cient of UHSC was 0.67 ~ 0.68 and the elastic modulus reduction coeffi cient of UHSC was 0.41 ~ 0.51 with peak strain coeffi cient ε cr ( T ) /ε 0 1.57 ~ 1.67. Finally, based on the analysis of test results, simple formulae were proposed to describe the eff ect of temperature on residual performance of heated UHSC which infi lled the steel tube.
Potential Mechanisms of Perillae folium Against COVID-19: A Network Pharmacology Approach
XuHan Chen,Xu Xu,Jia Lv,JinQin Huang,LingLing Lyu,Liping Liu 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.6
In China, Perillae folium is widely used to treat colds, especially in the early stages of cold; the effect of taking P. folium is readily noticeable at that time. The active compounds and targets of P. folium were screened from Traditional Chinese Medicine Systems Pharmacology, Chinese Pharmacopoeia, and UniProt. Targets related to the initiation and progression of 2019 Coronavirus Disease (COVID-19) were retrieved from Online Mendelian Inheritance in Man and GeneCards. The potential therapeutic targets of P. folium on COVID-19 were the cross targets between them. Enrichment analysis of Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were conducted by using the Database for Annotation, Visualization and Integrated Discovery website. Molecular docking between key compounds and core targets was performed with AutoDock. The effects of P. folium extract and rosmarinic acid on inflammatory cytokines were tested by a cellular inflammatory model. The “Perillae folium-compound-target-COVID-19” network contained 11 kinds of compounds and 33 matching targets. There were 261 items in the GO functions (P < .05) and 67 items linked to the KEGG signaling pathways (P < .05). Luteolin and rosmarinic acid were key compounds of P. folium. Their docking with the core targets mitogen-activated protein kinase 1 (MAPK1) and chemokine (C-C motif) ligand 2 (CCL2), respectively, showed that they had good affinity with each other. Cell experiments demonstrated that P. folium extract had inhibitory effects on interleukin-6 and tumor necrosis factor (TNF)-α in cells, and was better than rosmarinic acid. Luteolin, rosmarinic acid, and other individual active compounds in P. folium, which may participate in PI3K-Akt, TNF, Jak-STAT, COVID-19, and other multisignaling pathways through multiple targets such as MAPK1 and CCL2, and play a therapeutic role in COVID-19.
Xiaolei Zhang,Ziying Wang,Yangsai Lyu,Jia Li,Kun Song,Ningning Xing,Dickon H.L. Ng 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
Near-infrared (NIR) light-powered nanomotors with active motion have attracted extensive attention inthe chemo-photothermal therapy of cancer. However, there are also some limitations such as complicatedsynthesis process, low permeability of drugs and viscous physiological environment. Herein, wedeveloped a facile route to synthesize novel NIR light-powered DOX/Au-m-HTAS nanomotor based onnatural halloysite (HNTs) for active chemo-photothermal therapy. Such nanomotor exhibited NIR lightcontrolled on/off motion with a maximum speed of 64.5 lm/s. Owing to the synergetic NIR lightpoweredmotion and chemo-photothermal therapy, DOX/Au-m-HTAS nanomotor could effectivelyadhere tumor cells, leading to deeper cell penetration, higher cellular uptake, and better ablation oftumor cells. Meanwhile, DOX/Au-m-HTAS nanomotors also had enhanced ability for CT imaging of localtumor, demonstrating the enhanced anticancer efficiency. This strategy provided a new insight into thechemo-photothermal synergistic therapy of tumors.
Ehab Safwat,Weiguo Zhang,Mei Wu,Yongxi Lyu,Qianlei Jia 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10
This paper focuses on autonomous path-following flight under uncertainty and external disturbances. Integrated UAV waypoints guidance scheme based on carrot chasing guidance law is presented. In order to follow a desired path a Virtual Track Point (VTP) is introduced on the path and make the UAV chase it. The UAV updates its heading direction toward the VTP. As time progresses, the UAV will move toward the path and asymptotically follow the path. Nonlinear Dynamic Inversion (NDI) awards the flight control system researchers a straight forward method of deriving control laws for nonlinear systems. The control inputs are used to cancel unwanted terms in the equations of motion using negative feedback of these terms. The two-timescale assumption that separates the fast dynamics which are the three angular rates of the aircraft from the slow dynamics which include the angle of attack, side-slip angle, and bank angle is adopted. NDI control law is designed for the fast variables using the deflection of aerodynamic control surfaces as inputs. Next, NDI is applied to the control of the slow states using the outputs of the fast loop as inputs. Simulation results for the nonlinear flight control system are given to illustrate the effectiveness of the technique. The validation of the designed flight system controller is demonstrated through real flight test.