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      • Lack of Association of Common Polymorphisms in MUC1 Gene with H. pylori Infection and Non-cardia Gastric Cancer Risk in a Chinese Population

        Zhang, Bin,Hao, Guang-Yu,Gao, Fang,Zhang, Jian-Zu,Zhou, Cheng-Jiang,Zhou, Li-She,Wang, Ying,Jia, Yan-Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

        Several lines of evidence support the notion that MUC1 is often aberrantly expressed in gastric cancer, and it is a ligand for Helicobacter pylori. Genetic variation in MUC1 gene may confer susceptibility to H. pylori infection and gastric cancer. We assessed the association of common polymorphisms in MUC1 gene with H. pylori infection and non-cardia gastric cancer using an LD-based tag SNP approach in north-western Chinese Han population. A total of four SNPs were successfully genotyped among 288 patients with non-cardia gastric cancer and 281 age- and sex-matched controls. None of the tested SNPs was associated with H. pylori infection. SNP rs9426886 was associated with a decreased risk of non-cardia gastric cancer, but lost significance after adjustment for multiple testing. Overall, our data indicated that common genetic variations in MUC1 gene might not make a major contribution to the risk of H. pylori infection and non-cardia gastric cancer in our studied population.

      • KCI등재

        Post-fire Study on Mechanical Properties of Damaged Ultra-high Strength Concrete

        Xiao Lyu,Guang-Hao Jia,Gan-Ping Shu,Xin Zhang,Er-Feng Du,Wen-Ming Wang 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.6

        In order to study the eff ect of steel tube, pre-load and temperature on residual performance of heated ultra-high strength concrete (UHSC), an experimental program was carried out to investigate the physical and mechanical properties of UHSC post-fi re in room temperature. With total of 54 standard cylindrical concrete specimens subjected to various temperatures ranging from 62 °C to 496 °C, their residual compressive strength, elastic modulus, peak strain was measured after natural cooling down. By comparing the test results of standard cylindrical concrete specimens with the results of the bare specimens in and after fi re, it is known that the residual compressive strength of standard cylindrical concrete specimens decayed more serious after exposing to same temperature. Seen from the results, the temperature which the specimens suff ered was found to be responsibility to the reduction of the compressive strength, elastic modulus, peak strain. As the temperature up to 300 °C, the strength reduction coeffi cient of UHSC was 0.67 ~ 0.68 and the elastic modulus reduction coeffi cient of UHSC was 0.41 ~ 0.51 with peak strain coeffi cient ε cr ( T ) /ε 0 1.57 ~ 1.67. Finally, based on the analysis of test results, simple formulae were proposed to describe the eff ect of temperature on residual performance of heated UHSC which infi lled the steel tube.

      • SCIESCOPUSKCI등재

        Genome-wide identification and analysis of long noncoding RNAs in longissimus muscle tissue from Kazakh cattle and Xinjiang brown cattle

        Yan, Xiang-Min,Zhang, Zhe,Liu, Jian-Bo,Li, Na,Yang, Guang-Wei,Luo, Dan,Zhang, Yang,Yuan, Bao,Jiang, Hao,Zhang, Jia-Bao Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.11

        Objective: In recent years, long noncoding RNAs (lncRNAs) have been identified in many species, and some of them have been shown to play important roles in muscle development and myogenesis. However, the differences in lncRNAs between Kazakh cattle and Xinjiang brown cattle remain undefined; therefore, we aimed to confirm whether lncRNAs are differentially expressed in the longissimus dorsi between these two types of cattle and whether differentially expressed lncRNAs regulate muscle differentiation. Methods: We used RNA-seq technology to identify lncRNAs in longissimus muscles from these cattle. The expression of lncRNAs were analyzed using StringTie (1.3.1) in terms of the fragments per kilobase of transcript per million mapped reads values of the encoding genes. The differential expression of the transcripts in the two samples were analyzed using the DESeq R software package. The resulting false discovery rate was controlled by the Benjamini and Hochberg's approach. KOBAS software was utilized to measure the expression of different genes in Kyoto encyclopedia of genes and genomes pathways. We randomly selected eight lncRNA genes and validated them by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Results: We found that 182 lncRNA transcripts, including 102 upregulated and 80 downregulated transcripts, were differentially expressed between Kazakh cattle and Xinjiang brown cattle. The results of RT-qPCR were consistent with the sequencing results. Enrichment analysis and functional annotation of the target genes revealed that the differentially expressed lncRNAs were associated with the mitogen-activated protein kinase, Ras, and phosphatidylinositol 3-kinase (PI3k)/Akt signaling pathways. We also constructed a lncRNA/mRNA coexpression network for the PI3k/Akt signaling pathway. Conclusion: Our study provides insights into cattle muscle-associated lncRNAs and will contribute to a more thorough understanding of the molecular mechanism underlying muscle growth and development in cattle.

      • KCI등재

        High-j Proton h11/2 and g7/2 Intruder Bands in 113In

        Ma Ke Yan,Lu Jing Bin,Ma Ying Jun,Li Jian,Yang Dong,Sun Wu Ji,Wang Hao,Pan Hao Nan,Wang Jia Qi,Yang Qing Yu,Zhang Da Ming,Zhu Li Hua,Wu Xiao Guang,Zheng Yun,Li Cong Bo 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.12

        Excited states of 113In have been populated through the heavy-ion fusion evaporation reaction 110Pd(7Li, 4n)113In. A new band with the configuration of a proton d5/2 orbital is identified. Two ΔI = 2 intruder bands, built on the πh11/2 and the πg7/2 orbitals, have been extended to spins (63/2-)ħ and (55/2+)ħ, respectively. The negative-parity πh11/2 intruder band shows a smooth increase in aligned spin, which is attributed to a strong proton-neutron interaction. The properties of the positive-parity πg7/2 band are discussed based on tilted axis cranking model calculations, and the features of the antimagnetic rotation for this band are shown after backbend. Furthermore, the contributions of the two-shears-like mechanism, the neutron (gd)ν shell and the core rotation are investigated for the positive-parity πg7/2 band.

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